Azin1 (antizyme inhibitor 1) - Rat Genome Database

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Gene: Azin1 (antizyme inhibitor 1) Rattus norvegicus
Analyze
Symbol: Azin1
Name: antizyme inhibitor 1
RGD ID: 61934
Description: Predicted to have ornithine decarboxylase activator activity and ornithine decarboxylase activity. Involved in several processes, including estrous cycle; negative regulation of protein catabolic process; and positive regulation of centrosome duplication. Colocalizes with centrosome. Biomarker of pneumocystosis. Human ortholog(s) of this gene implicated in esophagus squamous cell carcinoma; hepatocellular carcinoma; and liver cirrhosis. Orthologous to human AZIN1 (antizyme inhibitor 1); PARTICIPATES IN polyamine metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AZI; Oazi; Oazin; ornithine decarboxylase antizyme inhibitor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2769,654,773 - 69,681,578 (-)NCBI
Rnor_6.0 Ensembl777,345,646 - 77,372,398 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0777,345,646 - 77,372,398 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0777,448,669 - 77,475,344 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4774,159,130 - 74,189,447 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1774,179,861 - 74,210,177 (-)NCBI
Celera766,713,070 - 66,739,866 (-)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-butoxyethanol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (EXP)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-D-glucosamine  (EXP)
bisphenol A  (EXP,ISO)
buspirone  (EXP)
cadmium sulfate  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
flutamide  (EXP)
folic acid  (ISO)
graphite  (EXP)
L-methionine  (ISO)
methapyrilene  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
nefazodone  (EXP)
nickel subsulfide  (EXP)
nickel sulfate  (ISO)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP,ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sulfasalazine  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
tetraphene  (ISO)
titanium dioxide  (ISO)
valproic acid  (EXP,ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
centrosome  (IDA)
cytoplasm  (IBA)
nucleus  (IEA,ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Chen L, etal., Nat Med. 2013 Feb;19(2):209-16. doi: 10.1038/nm.3043. Epub 2013 Jan 6.
2. Fernandes JRD, etal., Gen Comp Endocrinol. 2017 May 15;246:9-22. doi: 10.1016/j.ygcen.2017.03.005. Epub 2017 Mar 16.
3. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. GOA data from the GO Consortium
5. Kim SW, etal., J Cell Sci. 2006 Jun 15;119(Pt 12):2583-91. doi: 10.1242/jcs.02966. Epub 2006 May 30.
6. Koguchi K, etal., Biochim Biophys Acta 1997 Sep 12;1353(3):209-16.
7. Liao CP, etal., J Biol Chem. 2009 Mar 20;284(12):8174-84. doi: 10.1074/jbc.M805787200. Epub 2009 Jan 20.
8. Mangold U, etal., Oncogene. 2008 Jan 24;27(5):604-13. doi: 10.1038/sj.onc.1210685. Epub 2007 Jul 30.
9. MGD data from the GO Consortium
10. Murakami Y, etal., J Biol Chem 1996 Feb 16;271(7):3340-2.
11. NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Okugawa Y, etal., J Transl Med. 2018 Dec 18;16(1):366. doi: 10.1186/s12967-018-1740-z.
13. Olsen RR and Zetter BR, Mol Cancer Res. 2011 Oct;9(10):1285-93. doi: 10.1158/1541-7786.MCR-11-0178. Epub 2011 Aug 17.
14. Peng LJ, etal., Zhonghua Gan Zang Bing Za Zhi. 2011 Mar;19(3):169-73. doi: 10.3760/cma.j.issn.1007-3418.2011.03.005.
15. Qin YR, etal., Cancer Res. 2014 Feb 1;74(3):840-51. doi: 10.1158/0008-5472.CAN-13-2545. Epub 2013 Dec 3.
16. RGD automated data pipeline
17. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. RGD automated import pipeline for gene-chemical interactions
19. Shigeyasu K, etal., JCI Insight. 2018 Jun 21;3(12). pii: 99976. doi: 10.1172/jci.insight.99976. eCollection 2018 Jun 21.
20. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
21. Zhu D, etal., Kidney Blood Press Res. 2016;41(1):9-17. doi: 10.1159/000368542. Epub 2016 Jan 8.
Additional References at PubMed
PMID:2713421   PMID:16916800   PMID:17900240   PMID:18508777   PMID:19426728   PMID:19449338   PMID:19920120   PMID:25961839  


Genomics

Comparative Map Data
Azin1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2769,654,773 - 69,681,578 (-)NCBI
Rnor_6.0 Ensembl777,345,646 - 77,372,398 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0777,345,646 - 77,372,398 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0777,448,669 - 77,475,344 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4774,159,130 - 74,189,447 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1774,179,861 - 74,210,177 (-)NCBI
Celera766,713,070 - 66,739,866 (-)NCBICelera
Cytogenetic Map7q22NCBI
AZIN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8102,826,308 - 102,893,864 (-)EnsemblGRCh38hg38GRCh38
GRCh388102,826,302 - 102,864,200 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378103,838,530 - 103,876,428 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368103,907,712 - 103,945,573 (-)NCBINCBI36hg18NCBI36
Build 348103,909,226 - 103,945,551NCBI
Celera8100,025,705 - 100,063,568 (-)NCBI
Cytogenetic Map8q22.3NCBI
HuRef899,039,532 - 99,077,262 (-)NCBIHuRef
CHM1_18103,878,797 - 103,916,687 (-)NCBICHM1_1
Azin1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391538,487,674 - 38,523,506 (-)NCBIGRCm39mm39
GRCm39 Ensembl1538,487,671 - 38,519,510 (-)Ensembl
GRCm381538,487,430 - 38,519,294 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1538,487,427 - 38,519,266 (-)EnsemblGRCm38mm10GRCm38
MGSCv371538,417,185 - 38,449,021 (-)NCBIGRCm37mm9NCBIm37
MGSCv361538,432,019 - 38,463,855 (-)NCBImm8
Celera1539,113,891 - 39,145,734 (-)NCBICelera
Cytogenetic Map15B3.1NCBI
Azin1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541727,231,696 - 27,259,564 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541727,231,695 - 27,259,564 (-)NCBIChiLan1.0ChiLan1.0
AZIN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.18101,639,950 - 101,678,604 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8101,639,950 - 101,678,604 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0899,483,027 - 99,521,151 (-)NCBIMhudiblu_PPA_v0panPan3
AZIN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1134,363,996 - 4,396,069 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl134,361,340 - 4,396,040 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha134,364,236 - 4,396,246 (-)NCBI
ROS_Cfam_1.0134,523,489 - 4,555,507 (-)NCBI
UMICH_Zoey_3.1134,365,307 - 4,397,317 (-)NCBI
UNSW_CanFamBas_1.0134,482,535 - 4,514,517 (-)NCBI
UU_Cfam_GSD_1.0134,495,739 - 4,527,724 (-)NCBI
Azin1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530333,375,842 - 33,406,444 (+)NCBI
SpeTri2.0NW_00493647040,801,943 - 40,832,543 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AZIN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl434,209,008 - 34,257,136 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1434,221,368 - 34,257,261 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2437,079,181 - 37,109,691 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AZIN1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1897,679,775 - 97,717,486 (-)NCBI
ChlSab1.1 Ensembl897,679,468 - 97,696,928 (-)Ensembl
Vero_WHO_p1.0NW_02366603942,881,918 - 42,921,274 (+)NCBI
Azin1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476319,643,980 - 19,667,125 (-)NCBI

Position Markers
A001V45  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2769,656,097 - 69,656,204 (+)MAPPER
Rnor_6.0777,346,971 - 77,347,077NCBIRnor6.0
Rnor_5.0777,449,969 - 77,450,075UniSTSRnor5.0
RGSC_v3.4774,160,426 - 74,160,532UniSTSRGSC3.4
Celera766,714,395 - 66,714,501UniSTS
Cytogenetic Map7q22UniSTS
WI-9274  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21548,855,525 - 48,855,642 (+)MAPPER
mRatBN7.2769,655,461 - 69,655,578 (+)MAPPER
Rnor_6.0777,346,335 - 77,346,451NCBIRnor6.0
Rnor_6.01555,565,025 - 55,565,141NCBIRnor6.0
Rnor_5.0777,449,333 - 77,449,449UniSTSRnor5.0
Rnor_5.01559,286,894 - 59,287,010UniSTSRnor5.0
RGSC_v3.4774,159,790 - 74,159,906UniSTSRGSC3.4
RGSC_v3.41554,317,220 - 54,317,336UniSTSRGSC3.4
Celera766,713,759 - 66,713,875UniSTS
Cytogenetic Map7q22UniSTS
RH143277  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2769,680,631 - 69,680,771 (+)MAPPER
Rnor_6.0777,371,453 - 77,371,592NCBIRnor6.0
Rnor_5.0777,474,451 - 77,474,590UniSTSRnor5.0
RGSC_v3.4774,188,553 - 74,188,692UniSTSRGSC3.4
Celera766,738,920 - 66,739,059UniSTS
RH 3.4 Map7633.7UniSTS
Cytogenetic Map7q22UniSTS
RH140733  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21548,855,193 - 48,855,329 (+)MAPPER
mRatBN7.2769,655,122 - 69,655,265 (+)MAPPER
Rnor_6.0777,345,996 - 77,346,138NCBIRnor6.0
Rnor_6.01555,564,686 - 55,564,828NCBIRnor6.0
Rnor_5.0777,448,994 - 77,449,136UniSTSRnor5.0
Rnor_5.01559,286,555 - 59,286,697UniSTSRnor5.0
RGSC_v3.4774,159,451 - 74,159,593UniSTSRGSC3.4
Celera766,713,420 - 66,713,562UniSTS
RH 3.4 Map7633.3UniSTS
Cytogenetic Map7q22UniSTS
G19701  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2769,656,097 - 69,656,204 (+)MAPPER
Rnor_6.0777,346,971 - 77,347,077NCBIRnor6.0
Rnor_5.0777,449,969 - 77,450,075UniSTSRnor5.0
RGSC_v3.4774,160,426 - 74,160,532UniSTSRGSC3.4
Celera766,714,395 - 66,714,501UniSTS
Cytogenetic Map7q22UniSTS
Azin1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2769,658,063 - 69,659,554 (+)MAPPER
Rnor_6.0777,348,937 - 77,350,427NCBIRnor6.0
Rnor_5.0777,451,935 - 77,453,425UniSTSRnor5.0
Celera766,716,361 - 66,717,851UniSTS
Cytogenetic Map7q22UniSTS
Azin1rgdv877215464-A  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0777,371,405 - 77,371,405 (+)RGDRnor6.0


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)72920071124838025Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)712328467106995532Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)72536563393155402Rat
61439Cia8Collagen induced arthritis QTL 85.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)73257294277572942Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)73586772980867729Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)73586772993155402Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73854770683547706Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)74087268285872682Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)74087268285872682Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74530157390301573Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)748118835128611831Rat
634326Hc3Hypercalciuria QTL 32.1urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)75025210395252103Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)750704769128085642Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)75079381895793818Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)751251919118477612Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)751251919145729302Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)751252005111589099Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)75320034498200344Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)75425951299259512Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)755072862123602998Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)755072862123602998Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)755072862123602998Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)755495689100495689Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)755495689100495689Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)755495689100495689Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)755495689100495689Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)755495689100495689Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)755495689100495689Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)755495689100495689Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)761047589113228378Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)768518460113518460Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)769399586111043530Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)769399586111043530Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)770421228115421228Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)771448715145729302Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:406
Count of miRNA genes:215
Interacting mature miRNAs:273
Transcripts:ENSRNOT00000007999
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 10 74 35 41 11 8
Low 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000007999   ⟹   ENSRNOP00000007999
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl777,345,646 - 77,372,398 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079644   ⟹   ENSRNOP00000069785
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl777,345,646 - 77,372,398 (-)Ensembl
RefSeq Acc Id: NM_001301702   ⟹   NP_001288631
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2769,654,773 - 69,681,578 (-)NCBI
Rnor_6.0777,345,646 - 77,372,398 (-)NCBI
Celera766,713,070 - 66,739,866 (-)NCBI
Sequence:
RefSeq Acc Id: NM_022585   ⟹   NP_072107
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2769,654,773 - 69,681,578 (-)NCBI
Rnor_6.0777,345,646 - 77,372,398 (-)NCBI
Rnor_5.0777,448,669 - 77,475,344 (-)NCBI
RGSC_v3.4774,159,130 - 74,189,447 (-)RGD
Celera766,713,070 - 66,739,866 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006241568   ⟹   XP_006241630
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2769,654,798 - 69,681,573 (-)NCBI
Rnor_6.0777,345,671 - 77,372,393 (-)NCBI
Rnor_5.0777,448,669 - 77,475,344 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006241569   ⟹   XP_006241631
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2769,654,798 - 69,681,573 (-)NCBI
Rnor_6.0777,345,671 - 77,372,393 (-)NCBI
Rnor_5.0777,448,669 - 77,475,344 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008765457   ⟹   XP_008763679
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0777,345,671 - 77,372,393 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017595068   ⟹   XP_017450557
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2769,654,798 - 69,666,970 (-)NCBI
Rnor_6.0777,345,671 - 77,358,161 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_072107   ⟸   NM_022585
- UniProtKB: Q6P7R3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241631   ⟸   XM_006241569
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006241630   ⟸   XM_006241568
- Peptide Label: isoform X1
- UniProtKB: Q6P7R3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008763679   ⟸   XM_008765457
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: NP_001288631   ⟸   NM_001301702
- UniProtKB: Q6P7R3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450557   ⟸   XM_017595068
- Peptide Label: isoform X1
- UniProtKB: Q6P7R3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000069785   ⟸   ENSRNOT00000079644
RefSeq Acc Id: ENSRNOP00000007999   ⟸   ENSRNOT00000007999
Protein Domains
Orn_Arg_deC_N   Orn_DAP_Arg_deC

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695302
Promoter ID:EPDNEW_R5827
Type:single initiation site
Name:Azin1_1
Description:antizyme inhibitor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0777,372,366 - 77,372,426EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61934 AgrOrtholog
Ensembl Genes ENSRNOG00000005333 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000007999 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000069785 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007999 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000079644 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.40.37.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.20.20.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6918922 IMAGE-MGC_LOAD
InterPro Ala_racemase/Decarboxylase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Azin1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  De-COase2_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  De-COase2_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  De-COase2_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Orn/DAP/Arg_de-COase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Orn_de-COase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLP-binding_barrel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:58961 UniProtKB/TrEMBL
MGC_CLONE MGC:72823 IMAGE-MGC_LOAD
NCBI Gene 58961 ENTREZGENE
PANTHER PTHR11482 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11482:SF7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Orn_Arg_deC_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Orn_DAP_Arg_deC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Azin1 PhenoGen
PRINTS ODADCRBXLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ORNDCRBXLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ODR_DC_2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50621 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51419 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt AZIN1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6P7R3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Azin1  antizyme inhibitor 1  Oazin  ornithine decarboxylase antizyme inhibitor  Symbol and Name updated 1299863 APPROVED
2004-09-10 Oazin  ornithine decarboxylase antizyme inhibitor  Oazi  ornithine decarboxylase antizyme inhibitor   Symbol updated 1299863 APPROVED
2002-06-10 Oazi  ornithine decarboxylase antizyme inhibitor       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction binds to the antizyme releasing ornithine decarboxylase from ornithine decarboxylase-antizyme complex 633334