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Gene: Slc11a2 (solute carrier family 11 member 2) Rattus norvegicus
Symbol: Slc11a2
Name: solute carrier family 11 member 2
RGD ID: 3684
Description: Exhibits lead ion transmembrane transporter activity; transition metal ion binding activity; and transition metal ion transmembrane transporter activity. Involved in several processes, including cellular response to tumor necrosis factor; response to lead ion; and transition metal ion transport. Localizes to apical part of cell; bounding membrane of organelle; and integral component of membrane. Used to study hypochromic anemia and pneumonia. Biomarker of brain ischemia; duodenal ulcer; and iron deficiency anemia. Human ortholog(s) of this gene implicated in Parkinson's disease; amyotrophic lateral sclerosis; anemia; and hypochromic anemia. Orthologous to human SLC11A2 (solute carrier family 11 member 2); PARTICIPATES IN hypoxia inducible factor pathway; iron uptake pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: divalent cation transporter 1; divalent metal transporter 1; DMT-1; DMT1; natural resistance-associated macrophage protein 2; NRAMP 2; Nramp2; solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2; Solute carrier family 11 member 2 (natural resistance-associated macrophage protein 2)
Homo sapiens (human) : SLC11A2 (solute carrier family 11 member 2)  HGNC  Alliance
Mus musculus (house mouse) : Slc11a2 (solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2)  MGI  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : SLC11A2 (solute carrier family 11 member 2)
Canis lupus familiaris (dog) : SLC11A2 (solute carrier family 11 member 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc11a2 (solute carrier family 11 member 2)
Sus scrofa (pig) : SLC11A2 (solute carrier family 11 member 2)
Chlorocebus sabaeus (African green monkey) : SLC11A2 (solute carrier family 11 member 2)
Heterocephalus glaber (naked mole-rat) : Slc11a2 (solute carrier family 11 member 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.07142,025,812 - 142,062,892 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7142,025,815 - 142,063,212 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07139,833,529 - 139,870,819 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47139,094,505 - 139,127,427 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17139,170,941 - 139,203,864 (-)NCBI
Celera7127,985,198 - 128,017,825 (-)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Slc11a2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3684
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.