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Gene: Slc11a2 (solute carrier family 11 member 2) Rattus norvegicus
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Symbol: Slc11a2
Name: solute carrier family 11 member 2
Description: Exhibits lead ion transmembrane transporter activity; transition metal ion binding activity; and transition metal ion transmembrane transporter activity. Involved in several processes, including response to lead ion; response to manganese ion; and transition metal ion transport. Localizes to the apical part of cell; cytoplasm; and integral component of membrane. Used to study hypochromic anemia and pneumonia. Biomarker of brain ischemia; duodenal ulcer; and iron deficiency anemia. Human ortholog(s) of this gene implicated in Parkinson's disease; amyotrophic lateral sclerosis; anemia; and hypochromic anemia. Orthologous to human SLC11A2 (solute carrier family 11 member 2); PARTICIPATES IN hypoxia inducible factor pathway; iron uptake pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: divalent cation transporter 1; divalent metal transporter 1; DMT-1; DMT1; natural resistance-associated macrophage protein 2; NRAMP 2; Nramp2; solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2; Solute carrier family 11 member 2 (natural resistance-associated macrophage protein 2)
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.07142,025,812 - 142,062,892 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07139,833,529 - 139,870,819 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47139,094,505 - 139,127,427 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17139,170,941 - 139,203,864 (-)NCBI
Celera7127,985,198 - 128,017,825 (-)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Slc11a2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3684
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.