RGD Reference Report - Restless legs syndrome-associated MEIS1 risk variant influences iron homeostasis. - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Restless legs syndrome-associated MEIS1 risk variant influences iron homeostasis.

Authors: Catoire, H  Dion, PA  Xiong, L  Amari, M  Gaudet, R  Girard, SL  Noreau, A  Gaspar, C  Turecki, G  Montplaisir, JY  Parker, JA  Rouleau, GA 
Citation: Catoire H, etal., Ann Neurol. 2011 Jul;70(1):170-5. doi: 10.1002/ana.22435. Epub 2011 Jun 27.
RGD ID: 5688410
Pubmed: (View Article at PubMed) PMID:21710629
DOI: Full-text: DOI:10.1002/ana.22435

Restless legs syndrome (RLS) is a frequent sleep disorder that is linked to disturbed iron homeostasis. Genetic studies identified MEIS1 as an RLS-predisposing gene, where the RLS risk haplotype is associated with decreased MEIS1 mRNA and protein expression. We show here that RNA interference treatment of the MEIS1 worm orthologue increases ferritin expression in Caenorhabditis elegans and that the RLS-associated haplotype leads to increased expression of ferritin and DMT1 in RLS brain tissues. Additionally, human cells cultured under iron-deficient conditions show reduced MEIS1 expression. Our data establish a link between the RLS MEIS1 gene and iron metabolism.

Annotation

Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Slc11a2  (solute carrier family 11 member 2)

Genes (Mus musculus)
Slc11a2  (solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2)

Genes (Homo sapiens)
SLC11A2  (solute carrier family 11 member 2)


Additional Information