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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3684
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc11a2
Name: solute carrier family 11 member 2
Acc ID: CHEBI:22977
Term: cadmium atom
Definition: A zinc group element atom that has formula Cd.
Chemical ID: MESH:D002104
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc11a2increases expressionEXP 6480464CTDCadmium results in increased expression of SLC11A2 mRNA; Cadmium results in increased expression of SLC11A2 proteinPMID:32879253
Slc11a2multiple interactionsEXP 6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SLC11A2 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SLC11A2 protein; Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SLC11A2 mRNA]; Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SLC11A2 protein]PMID:31390532
Slc11a2affects expressionISOSlc11a2 (Mus musculus)6480464CTDCadmium affects the expression of SLC11A2 mRNAPMID:25294218
Slc11a2affects transportISOSLC11A2 (Homo sapiens)6480464CTDSLC11A2 affects the transport of CadmiumPMID:11439223
Slc11a2affects uptakeISOSLC11A2 (Homo sapiens)6480464CTDSLC11A2 protein affects the uptake of CadmiumPMID:28904291
Slc11a2decreases expressionISOSLC11A2 (Homo sapiens)6480464CTDCadmium results in decreased expression of SLC11A2 mRNAPMID:11439223
Slc11a2increases uptakeISOSLC11A2 (Homo sapiens)6480464CTDSLC11A2 protein results in increased uptake of CadmiumPMID:12388109
Slc11a2multiple interactionsISOSLC11A2 (Homo sapiens)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SLC11A2 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SLC11A2 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SLC11A2 mRNAPMID:32645461 PMID:35301059
Slc11a2multiple interactionsISOSlc11a2 (Mus musculus)6480464CTD[ABCG2 gene mutant form results in increased susceptibility to [Cadmium Chloride results in increased abundance of Cadmium]] which results in decreased expression of SLC11A2 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SLC11A2 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SLC11A2 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SLC11A2 mRNAPMID:32645461 PMID:35212737 PMID:37941438
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