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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3684
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc11a2
Name: solute carrier family 11 member 2
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc11a2increases expressionISOSLC11A2 (Homo sapiens)6480464CTDOzone results in increased expression of SLC11A2 mRNAPMID:24862973
Slc11a2multiple interactionsISOSlc11a2 (Mus musculus)6480464CTD[Air Pollutants results in increased abundance of Ozone] which results in increased expression of SLC11A2 mRNA; SLC11A2 protein inhibits the reaction [Ozone results in increased abundance of Aldehydes]; SLC11A2 protein inhibits the reaction [Ozone results in increased secretion of CXCL15 protein]PMID:16905637 PMID:34911549
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