Zfp41 (zinc finger protein 41) - Rat Genome Database

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Gene: Zfp41 (zinc finger protein 41) Rattus norvegicus
Analyze
Symbol: Zfp41
Name: zinc finger protein 41
RGD ID: 1307587
Description: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Orthologous to human ZFP41 (ZFP41 zinc finger protein); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; amphetamine; bisphenol A.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: GLI-Kruppel family member GLI4 (oncogene HKR4); LOC100910508; LOC315081; RGD1307587; similar to GLI-Kruppel family member GLI4; uncharacterized LOC100910508; zinc finger protein 41 homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27107,307,303 - 107,320,164 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7107,306,867 - 107,320,270 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.07116,653,618 - 116,665,414 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7116,653,664 - 116,661,942 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07116,547,221 - 116,557,679 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera7103,670,181 - 103,681,977 (+)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Zfp41
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27107,307,303 - 107,320,164 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7107,306,867 - 107,320,270 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.07116,653,618 - 116,665,414 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7116,653,664 - 116,661,942 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07116,547,221 - 116,557,679 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera7103,670,181 - 103,681,977 (+)NCBICelera
Cytogenetic Map7q34NCBI
ZFP41
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388143,246,939 - 143,262,705 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl8143,246,821 - 143,262,705 (+)EnsemblGRCh38hg38GRCh38
GRCh378144,329,109 - 144,344,875 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368144,400,484 - 144,416,250 (+)NCBINCBI36Build 36hg18NCBI36
Celera8140,638,670 - 140,654,116 (+)NCBICelera
Cytogenetic Map8q24.3NCBI
HuRef8139,582,722 - 139,598,464 (+)NCBIHuRef
CHM1_18144,369,242 - 144,385,085 (+)NCBICHM1_1
T2T-CHM13v2.08144,394,326 - 144,410,099 (+)NCBIT2T-CHM13v2.0
Zfp41
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391575,488,137 - 75,499,297 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1575,488,528 - 75,501,676 (+)EnsemblGRCm39 Ensembl
GRCm381575,615,200 - 75,627,448 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1575,616,679 - 75,629,827 (+)EnsemblGRCm38mm10GRCm38
MGSCv371575,447,115 - 75,455,725 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361575,443,977 - 75,452,548 (+)NCBIMGSCv36mm8
Celera1577,116,839 - 77,125,449 (+)NCBICelera
Cytogenetic Map15D3NCBI
Zfp41
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554541,979,990 - 1,994,537 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554541,979,990 - 1,994,537 (+)NCBIChiLan1.0ChiLan1.0
ZFP41
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.18143,017,045 - 143,032,032 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8143,020,023 - 143,020,622 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v08139,994,105 - 139,999,368 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ZFP41
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11337,015,733 - 37,027,459 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1336,968,206 - 36,980,022 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01337,487,187 - 37,499,041 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1337,487,572 - 37,494,182 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11337,161,437 - 37,171,005 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01337,278,242 - 37,290,066 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01337,755,082 - 37,767,144 (+)NCBIUU_Cfam_GSD_1.0
Zfp41
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244053031,349,306 - 1,358,796 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049364708,775,403 - 8,784,882 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZFP41
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_0236660392,467,726 - 2,472,814 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Zfp41
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473513,467,332 - 13,481,117 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473513,467,332 - 13,482,028 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Zfp41
50 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:106
Count of miRNA genes:94
Interacting mature miRNAs:98
Transcripts:ENSRNOT00000009823
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)780221299109401111Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)780221299112308525Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)794811085116738842Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7103146217116738842Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat

Markers in Region
AI598513  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27107,315,480 - 107,315,632 (+)MAPPERmRatBN7.2
Rnor_6.07116,661,760 - 116,661,911NCBIRnor6.0
Rnor_5.07116,555,361 - 116,555,512UniSTSRnor5.0
RGSC_v3.47113,569,033 - 113,569,184UniSTSRGSC3.4
Celera7103,678,323 - 103,678,474UniSTS
RH 3.4 Map7781.6UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 26 16 10 15 10 57 21 37 4
Low 3 17 41 31 4 31 8 11 17 14 4 7 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000009823   ⟹   ENSRNOP00000009823
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7116,655,145 - 116,655,741 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000076606   ⟹   ENSRNOP00000068439
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7107,307,956 - 107,320,270 (+)Ensembl
Rnor_6.0 Ensembl7116,653,664 - 116,661,942 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000103443   ⟹   ENSRNOP00000078177
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7107,307,344 - 107,317,813 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000104546   ⟹   ENSRNOP00000089045
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7107,306,867 - 107,320,270 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000107500   ⟹   ENSRNOP00000097386
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7107,307,361 - 107,320,270 (+)Ensembl
RefSeq Acc Id: XM_008765625   ⟹   XP_008763847
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27107,307,303 - 107,320,164 (+)NCBI
Rnor_6.07116,653,618 - 116,665,414 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008765626   ⟹   XP_008763848
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27107,307,303 - 107,320,164 (+)NCBI
Rnor_6.07116,653,618 - 116,665,414 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039080529   ⟹   XP_038936457
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27107,307,303 - 107,320,164 (+)NCBI
RefSeq Acc Id: XM_039080530   ⟹   XP_038936458
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27107,307,311 - 107,320,164 (+)NCBI
Protein Sequences
Protein RefSeqs XP_008763847 (Get FASTA)   NCBI Sequence Viewer  
  XP_008763848 (Get FASTA)   NCBI Sequence Viewer  
  XP_038936457 (Get FASTA)   NCBI Sequence Viewer  
  XP_038936458 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_008763848   ⟸   XM_008765626
- UniProtKB: D3ZZK5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008763847   ⟸   XM_008765625
- UniProtKB: D3ZZK5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000009823   ⟸   ENSRNOT00000009823
RefSeq Acc Id: ENSRNOP00000068439   ⟸   ENSRNOT00000076606
RefSeq Acc Id: XP_038936457   ⟸   XM_039080529
- UniProtKB: D3ZZK5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936458   ⟸   XM_039080530
- UniProtKB: D3ZZK5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000097386   ⟸   ENSRNOT00000107500
RefSeq Acc Id: ENSRNOP00000089045   ⟸   ENSRNOT00000104546
RefSeq Acc Id: ENSRNOP00000078177   ⟸   ENSRNOT00000103443
Protein Domains
C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZZK5-F1-model_v2 AlphaFold D3ZZK5 1-198 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695389
Promoter ID:EPDNEW_R5911
Type:initiation region
Name:Zfp41_1
Description:zinc finger protein 41
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07116,653,598 - 116,653,658EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307587 AgrOrtholog
BioCyc Gene G2FUF-32989 BioCyc
Ensembl Genes ENSRNOG00000007489 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000068439 ENTREZGENE
  ENSRNOP00000068439.1 UniProtKB/TrEMBL
  ENSRNOP00000078177.1 UniProtKB/TrEMBL
  ENSRNOP00000089045.1 UniProtKB/TrEMBL
  ENSRNOP00000097386 ENTREZGENE
  ENSRNOP00000097386.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000076606 ENTREZGENE
  ENSRNOT00000076606.2 UniProtKB/TrEMBL
  ENSRNOT00000103443.1 UniProtKB/TrEMBL
  ENSRNOT00000104546.1 UniProtKB/TrEMBL
  ENSRNOT00000107500 ENTREZGENE
  ENSRNOT00000107500.1 UniProtKB/TrEMBL
InterPro Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report rno:100910508 UniProtKB/TrEMBL
NCBI Gene Zfp41 ENTREZGENE
Pfam zf-C2H2 UniProtKB/TrEMBL
PhenoGen Zfp41 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt D3ZZK5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-09 Zfp41  zinc finger protein 41  LOC100910508  uncharacterized LOC100910508  Data Merged 737654 APPROVED
2012-07-05 LOC100910508  uncharacterized LOC100910508      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 Zfp41  zinc finger protein 41   Zfp41_predicted  zinc finger protein 41 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Zfp41_predicted  zinc finger protein 41 (predicted)  RGD1307587_predicted  similar to GLI-Kruppel family member GLI4; GLI-Kruppel family member GLI4 (oncogene HKR4) (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1307587_predicted  similar to GLI-Kruppel family member GLI4; GLI-Kruppel family member GLI4 (oncogene HKR4) (predicted)  LOC315081_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC315081_predicted  similar to GLI-Kruppel family member GLI4; GLI-Kruppel family member GLI4 (oncogene HKR4) (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL