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Gene: Col2a1 (collagen type II alpha 1 chain) Rattus norvegicus
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Symbol: Col2a1
Name: collagen type II alpha 1 chain
Description: Predicted to have several functions, including MHC class II protein binding activity; identical protein binding activity; and platelet-derived growth factor binding activity. Involved in several processes, including cartilage development; cellular response to hormone stimulus; and cellular response to mechanical stimulus. Localizes to the collagen-containing extracellular matrix and cytoplasm. Used to study degenerative disc disease; hypothyroidism; and osteoarthritis. Biomarker of degenerative disc disease and osteonecrosis. Human ortholog(s) of this gene implicated in Stickler syndrome; bone disease (multiple); chondrosarcoma; cleft palate; and eye disease (multiple). Orthologous to human COL2A1 (collagen type II alpha 1 chain); PARTICIPATES IN syndecan signaling pathway; cell-extracellular matrix signaling pathway; Entamoebiasis pathway; INTERACTS WITH (R)-carnitine; (R)-mevalonic acid; (R)-pantothenic acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: alpha-1 type II collagen; CG2A1A; collagen alpha-1(II) chain; collagen type II (Col2A1) gene, enhancer region; collagen, type II, alpha 1; COLLII; Procollagen II alpha 1; procollagen, type II, alpha 1
Orthologs:
Homo sapiens (human) : COL2A1 (collagen type II alpha 1 chain)  HGNC  Alliance
Mus musculus (house mouse) : Col2a1 (collagen, type II, alpha 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Col2a1 (collagen type II alpha 1 chain)
Pan paniscus (bonobo/pygmy chimpanzee) : COL2A1 (collagen type II alpha 1 chain)
Canis lupus familiaris (dog) : COL2A1 (collagen type II alpha 1 chain)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Col2a1 (collagen type II alpha 1 chain)
Sus scrofa (pig) : COL2A1 (collagen type II alpha 1 chain)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.07139,454,945 - 139,484,403 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07139,646,698 - 139,675,832 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47136,679,219 - 136,707,976 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17136,755,655 - 136,784,413 (-)NCBI
Celera7125,589,749 - 125,618,504 (-)NCBICelera
Cytogenetic Map7q36NCBI
RH 3.4 Map71096.2RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Col2a1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2375
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-09-10
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.