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Gene: Col2a1 (collagen type II alpha 1 chain) Rattus norvegicus
Symbol: Col2a1
Name: collagen type II alpha 1 chain
RGD ID: 2375
Description: Predicted to have several functions, including MHC class II protein binding activity; identical protein binding activity; and platelet-derived growth factor binding activity. Involved in several processes, including cartilage development; cellular response to hormone stimulus; and cellular response to mechanical stimulus. Localizes to collagen-containing extracellular matrix and cytoplasm. Used to study degenerative disc disease; hypothyroidism; and osteoarthritis. Biomarker of degenerative disc disease and osteonecrosis. Human ortholog(s) of this gene implicated in Stickler syndrome (multiple); bone disease (multiple); cleft palate; eye disease (multiple); and multiple epiphyseal dysplasia with myopia and deafness. Orthologous to human COL2A1 (collagen type II alpha 1 chain); PARTICIPATES IN syndecan signaling pathway; cell-extracellular matrix signaling pathway; Entamoebiasis pathway; INTERACTS WITH (R)-carnitine; (R)-mevalonic acid; (R)-pantothenic acid.
Type: protein-coding
Also known as: alpha-1 type II collagen; CG2A1A; collagen alpha-1(II) chain; collagen type II (Col2A1) gene, enhancer region; collagen, type II, alpha 1; COLLII; Procollagen II alpha 1; procollagen, type II, alpha 1
Homo sapiens (human) : COL2A1 (collagen type II alpha 1 chain)  HGNC  Alliance
Mus musculus (house mouse) : Col2a1 (collagen, type II, alpha 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Col2a1 (collagen type II alpha 1 chain)
Pan paniscus (bonobo/pygmy chimpanzee) : COL2A1 (collagen type II alpha 1 chain)
Canis lupus familiaris (dog) : COL2A1 (collagen type II alpha 1 chain)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Col2a1 (collagen type II alpha 1 chain)
Sus scrofa (pig) : COL2A1 (collagen type II alpha 1 chain)
Chlorocebus sabaeus (African green monkey) : COL2A1 (collagen type II alpha 1 chain)
Heterocephalus glaber (naked mole-rat) : Col2a1 (collagen type II alpha 1 chain)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.07139,454,945 - 139,484,403 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7139,455,242 - 139,483,997 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07139,646,698 - 139,675,832 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47136,679,219 - 136,707,976 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17136,755,655 - 136,784,413 (-)NCBI
Celera7125,589,749 - 125,618,504 (-)NCBICelera
Cytogenetic Map7q36NCBI
RH 3.4 Map71096.2RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Col2a1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2375
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.