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Gene: Ptk2 (protein tyrosine kinase 2) Rattus norvegicus
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Symbol: Ptk2
Name: protein tyrosine kinase 2
Description: Exhibits several functions, including enzyme binding activity; identical protein binding activity; and integrin binding activity. Involved in several processes, including cellular chloride ion homeostasis; positive regulation of cell population proliferation; and regulation of cell migration. Localizes to several cellular components, including the basolateral plasma membrane; focal adhesion; and nucleus. Used to study hepatocellular carcinoma; hypertension; and nephritis. Biomarker of hypertension; ischemia; and uremia. Human ortholog(s) of this gene implicated in leiomyoma; lung small cell carcinoma; and pulmonary hypertension. Orthologous to human PTK2 (protein tyrosine kinase 2); PARTICIPATES IN long term potentiation; integrin mediated signaling pathway; vascular endothelial growth factor signaling pathway; INTERACTS WITH 1-octadec-9-enoylglycero-3-phosphate; 2,4-dinitrotoluene; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: FADK 1; FAK; focal adhesion kinase; focal adhesion kinase 1; focal adhesion kinase-related nonkinase; FRNK; p125FAK; pp125FAK; Protein tyrosine kinase; protein-tyrosine kinase 2; PTK2 protein tyrosine kinase 2
Orthologs:
Homo sapiens (human) : PTK2 (protein tyrosine kinase 2)  HGNC  Alliance
Mus musculus (house mouse) : Ptk2 (PTK2 protein tyrosine kinase 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ptk2 (protein tyrosine kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : PTK2 (protein tyrosine kinase 2)
Canis lupus familiaris (dog) : PTK2 (protein tyrosine kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ptk2 (protein tyrosine kinase 2)
Sus scrofa (pig) : PTK2 (protein tyrosine kinase 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.07114,436,419 - 114,611,317 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07114,371,979 - 114,525,553 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47110,933,298 - 111,084,554 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17110,967,527 - 111,118,784 (-)NCBI
Celera7101,534,957 - 101,690,471 (-)NCBICelera
Cytogenetic Map7q34NCBI
RH 3.4 Map7725.6RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Ptk2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3443
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-10-08
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.