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Gene: Ptk2 (protein tyrosine kinase 2) Rattus norvegicus
Symbol: Ptk2
Name: protein tyrosine kinase 2
Description: Exhibits several functions, including enzyme binding activity; identical protein binding activity; and integrin binding activity. Involved in several processes, including cellular chloride ion homeostasis; positive regulation of cell population proliferation; and regulation of cell migration. Localizes to several cellular components, including basolateral plasma membrane; focal adhesion; and nuclear lumen. Used to study hepatocellular carcinoma; hypertension; and nephritis. Biomarker of hypertension; ischemia; and uremia. Human ortholog(s) of this gene implicated in leiomyoma; lung small cell carcinoma; and pulmonary hypertension. Orthologous to human PTK2 (protein tyrosine kinase 2); PARTICIPATES IN long term potentiation; integrin mediated signaling pathway; vascular endothelial growth factor signaling pathway; INTERACTS WITH 1-octadec-9-enoylglycero-3-phosphate; 2,4-dinitrotoluene; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: FADK 1; FAK; focal adhesion kinase; focal adhesion kinase 1; focal adhesion kinase-related nonkinase; FRNK; p125FAK; pp125FAK; Protein tyrosine kinase; protein-tyrosine kinase 2; PTK2 protein tyrosine kinase 2
Homo sapiens (human) : PTK2 (protein tyrosine kinase 2)  HGNC  Alliance
Mus musculus (house mouse) : Ptk2 (PTK2 protein tyrosine kinase 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ptk2 (protein tyrosine kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : PTK2 (protein tyrosine kinase 2)
Canis lupus familiaris (dog) : PTK2 (protein tyrosine kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ptk2 (protein tyrosine kinase 2)
Sus scrofa (pig) : PTK2 (protein tyrosine kinase 2)
Chlorocebus sabaeus (African green monkey) : PTK2 (protein tyrosine kinase 2)
Heterocephalus glaber (naked mole-rat) : Ptk2 (protein tyrosine kinase 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.07114,436,419 - 114,611,317 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7114,437,361 - 114,590,119 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07114,371,979 - 114,525,553 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47110,933,298 - 111,084,554 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17110,967,527 - 111,118,784 (-)NCBI
Celera7101,534,957 - 101,690,471 (-)NCBICelera
Cytogenetic Map7q34NCBI
RH 3.4 Map7725.6RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Ptk2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3443
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.