Mirlet7b (microRNA let-7b) - Rat Genome Database

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Gene: Mirlet7b (microRNA let-7b) Rattus norvegicus
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Symbol: Mirlet7b
Name: microRNA let-7b
RGD ID: 2325607
Description: Predicted to enable mRNA base-pairing translational repressor activity. Predicted to be involved in several processes, including negative regulation of programmed cell death; regulation of cellular catabolic process; and regulation of cellular response to transforming growth factor beta stimulus. Predicted to act upstream of or within several processes, including BMP signaling pathway; embryo implantation; and negative regulation of gene expression. Predicted to be located in extracellular exosome. Predicted to be part of RISC complex. Orthologous to human MIRLET7B (microRNA let-7b); INTERACTS WITH 2,5-hexanedione; 2-acetamidofluorene; 3,7-dihydropurine-6-thione.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: rno-let-7b
RGD Orthologs
Human
Mouse
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87118,684,038 - 118,684,122 (+)NCBIGRCr8
mRatBN7.27116,804,186 - 116,804,270 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7116,804,186 - 116,804,270 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7118,554,775 - 118,554,859 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07120,780,394 - 120,780,478 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07120,749,968 - 120,750,052 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07126,590,627 - 126,590,711 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7126,590,627 - 126,590,711 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07126,301,336 - 126,301,420 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera7113,097,039 - 113,097,123 (+)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14691248   PMID:15345052   PMID:16381832   PMID:16766679   PMID:17604727   PMID:18556655   PMID:18723672   PMID:19520079   PMID:20403161   PMID:22844247   PMID:23104698   PMID:23152446  
PMID:23185045   PMID:24088962   PMID:24205035   PMID:25751060   PMID:26699387   PMID:27889560   PMID:28436683   PMID:29264965   PMID:29795132   PMID:30628484   PMID:31342956   PMID:32184167  
PMID:32648622  


Genomics

Comparative Map Data
Mirlet7b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87118,684,038 - 118,684,122 (+)NCBIGRCr8
mRatBN7.27116,804,186 - 116,804,270 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7116,804,186 - 116,804,270 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7118,554,775 - 118,554,859 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07120,780,394 - 120,780,478 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07120,749,968 - 120,750,052 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07126,590,627 - 126,590,711 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7126,590,627 - 126,590,711 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07126,301,336 - 126,301,420 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera7113,097,039 - 113,097,123 (+)NCBICelera
Cytogenetic Map7q34NCBI
MIRLET7B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382246,113,686 - 46,113,768 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2246,113,686 - 46,113,768 (+)EnsemblGRCh38hg38GRCh38
GRCh372246,509,566 - 46,509,648 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362244,888,229 - 44,888,311 (+)NCBINCBI36Build 36hg18NCBI36
Celera2230,416,940 - 30,417,022 (+)NCBICelera
Cytogenetic Map22q13.31NCBI
HuRef2229,453,774 - 29,453,856 (+)NCBIHuRef
CHM1_12246,468,480 - 46,468,562 (+)NCBICHM1_1
T2T-CHM13v2.02246,598,374 - 46,598,456 (+)NCBIT2T-CHM13v2.0
Mirlet7b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391585,591,520 - 85,591,604 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1585,591,520 - 85,591,604 (+)EnsemblGRCm39 Ensembl
GRCm381585,707,319 - 85,707,403 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1585,707,319 - 85,707,403 (+)EnsemblGRCm38mm10GRCm38
MGSCv371585,537,749 - 85,537,833 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1587,840,101 - 87,840,185 (+)NCBICelera
Cytogenetic Map15E2NCBI
cM Map1540.42NCBI

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Vimrno-let-7b-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830

Predicted Targets
Summary Value
Count of predictions:18103
Count of gene targets:8423
Count of transcripts:9087
Interacting mature miRNAs:rno-let-7b-3p, rno-let-7b-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
1582240Sffal1Serum free fatty acids level QTL 13.40.0021blood free fatty acid amount (VT:0001553)serum free fatty acids level (CMO:0000547)7116677010124049952Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)7116677189127103496Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 1 1 31 1 9 5 1
Low 1 23 24 12 16 12 7 9 25 25 20 5 7
Below cutoff 4 4 4 4 2 2

Sequence


RefSeq Acc Id: ENSRNOT00000053759
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7116,804,186 - 116,804,270 (+)Ensembl
Rnor_6.0 Ensembl7126,590,627 - 126,590,711 (+)Ensembl
RefSeq Acc Id: NR_031802
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87118,684,038 - 118,684,122 (+)NCBI
mRatBN7.27116,804,186 - 116,804,270 (+)NCBI
Rnor_6.07126,590,627 - 126,590,711 (+)NCBI
Rnor_5.07126,301,336 - 126,301,420 (+)NCBI
Celera7113,097,039 - 113,097,123 (+)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325607 AgrOrtholog
BioCyc Gene G2FUF-32528 BioCyc
Ensembl Genes ENSRNOG00000035636 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000053759 ENTREZGENE
miRBase MI0000829 ENTREZGENE
NCBI Gene 100313990 ENTREZGENE
PhenoGen Mirlet7b PhenoGen
RatGTEx ENSRNOG00000035636 RatGTEx
RNAcentral URS0000324096 RNACentral
  URS00005918D5 RNACentral
  URS0000728199 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-06-02 Mirlet7b  microRNA let-7b      Symbol and Name status set to provisional 70820 PROVISIONAL