![]()
Imported Disease Annotations - ClinVarTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | prostate cancer | | ISO | RGD:1353483 | 8554872 | ClinVar Annotator: match by term: Malignant tumor of prostate | ClinVar | PMID:23265383 | |
|
![]()
Imported Disease Annotations - ClinVarTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | prostate cancer | | ISO | RGD:1353483 | 8554872 | ClinVar Annotator: match by term: Malignant tumor of prostate | ClinVar | PMID:23265383 | |
|
|
|
|
|
|
|
|
|
|
|
# | Reference Title | Reference Citation |
1. | Chronic treatment with aripiprazole induces differential gene expression in the rat frontal cortex. | Cheng MC, etal., Int J Neuropsychopharmacol. 2007 Sep 17;:1-10. |
2. | Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk. | Chubb D, etal., Nat Genet. 2013 Oct;45(10):1221-5. doi: 10.1038/ng.2733. Epub 2013 Aug 18. |
3. | Polycomb genes are associated with response to imatinib in chronic myeloid leukemia. | Crea F, etal., Epigenomics. 2015 Aug;7(5):757-65. doi: 10.2217/epi.15.35. Epub 2015 Sep 7. |
4. | Chromobox protein homologue 7 protein, with decreased expression in human carcinomas, positively regulates E-cadherin expression by interacting with the histone deacetylase 2 protein. | Federico A, etal., Cancer Res. 2009 Sep 1;69(17):7079-87. doi: 10.1158/0008-5472.CAN-09-1542. Epub 2009 Aug 25. |
5. | CBX7 is a tumor suppressor in mice and humans. | Forzati F, etal., J Clin Invest. 2012 Feb 1;122(2):612-23. doi: 10.1172/JCI58620. Epub 2012 Jan 3. |
6. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
7. | PRC1 complex diversity: where is it taking us? | Gil J and O'Loghlen A, Trends Cell Biol. 2014 Jul 22. pii: S0962-8924(14)00102-0. doi: 10.1016/j.tcb.2014.06.005. |
8. | Polycomb CBX7 has a unifying role in cellular lifespan. | Gil J, etal., Nat Cell Biol 2004 Jan;6(1):67-72. Epub 2003 Nov 30. |
9. | [Downregulation of chromobox protein homolog 7 expression in multiple human cancer tissues] | Guan ZP, etal., Zhonghua Yu Fang Yi Xue Za Zhi. 2011 Jul;45(7):597-600. |
10. | Expression parameters of the polycomb group proteins BMI1, SUZ12, RING1 and CBX7 in urothelial carcinoma of the bladder and their prognostic relevance. | Hinz S, etal., Tumour Biol. 2008;29(5):323-9. doi: 10.1159/000170879. Epub 2008 Nov 5. |
11. | Loss of the CBX7 protein expression correlates with a more aggressive phenotype in pancreatic cancer. | Karamitopoulou E, etal., Eur J Cancer. 2010 May;46(8):1438-44. doi: 10.1016/j.ejca.2010.01.033. Epub 2010 Feb 23. |
12. | CBX7 inhibits breast tumorigenicity through DKK-1-mediated suppression of the Wnt/beta-catenin pathway. | Kim HY, etal., FASEB J. 2015 Jan;29(1):300-13. doi: 10.1096/fj.14-253997. Epub 2014 Oct 28. |
13. | Tracing dynamics and clonal heterogeneity of Cbx7-induced leukemic stem cells by cellular barcoding. | Klauke K, etal., Stem Cell Reports. 2015 Jan 13;4(1):74-89. doi: 10.1016/j.stemcr.2014.10.012. Epub 2014 Nov 26. |
14. | Altered expression of polycomb group genes in glioblastoma multiforme. | Li G, etal., PLoS One. 2013 Nov 15;8(11):e80970. doi: 10.1371/journal.pone.0080970. eCollection 2013. |
15. | Epigenetic control of female puberty. | Lomniczi A, etal., Nat Neurosci. 2013 Mar;16(3):281-9. doi: 10.1038/nn.3319. Epub 2013 Jan 27. |
16. | Identification of a New Pathway for Tumor Progression: MicroRNA-181b Up-Regulation and CBX7 Down-Regulation by HMGA1 Protein. | Mansueto G, etal., Genes Cancer. 2010 Mar;1(3):210-24. doi: 10.1177/1947601910366860. |
17. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
18. | CBX7 Expression in Oncocytic Thyroid Neoplastic Lesions (Hurthle Cell Adenomas and Carcinomas). | Monaco M, etal., Eur Thyroid J. 2014 Dec;3(4):211-6. doi: 10.1159/000367989. Epub 2014 Oct 15. |
19. | Loss of the CBX7 gene expression correlates with a highly malignant phenotype in thyroid cancer. | Pallante P, etal., Cancer Res. 2008 Aug 15;68(16):6770-8. doi: 10.1158/0008-5472.CAN-08-0695. |
20. | GOA pipeline | RGD automated data pipeline |
21. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
22. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
23. | Comprehensive gene review and curation | RGD comprehensive gene curation |
24. | Role of the chromobox protein CBX7 in lymphomagenesis. | Scott CL, etal., Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5389-94. Epub 2007 Mar 20. |
25. | Expression of chromobox homolog 7 (CBX7) is associated with poor prognosis in ovarian clear cell adenocarcinoma via TRAIL-induced apoptotic pathway regulation. | Shinjo K, etal., Int J Cancer. 2014 Jul 15;135(2):308-18. doi: 10.1002/ijc.28692. Epub 2014 Jan 10. |
26. | Occupying chromatin: Polycomb mechanisms for getting to genomic targets, stopping transcriptional traffic, and staying put. | Simon JA and Kingston RE, Mol Cell. 2013 Mar 7;49(5):808-24. doi: 10.1016/j.molcel.2013.02.013. |
27. | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11. |
28. | Oncogenic role of the chromobox protein CBX7 in gastric cancer. | Zhang XW, etal., J Exp Clin Cancer Res. 2010 Aug 19;29:114. doi: 10.1186/1756-9966-29-114. |
PMID:15489334 | PMID:16537902 | PMID:19636380 | PMID:21282530 | PMID:22056776 | PMID:23870131 |
Cbx7 (Rattus norvegicus - Norway rat) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
CBX7 (Homo sapiens - human) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Cbx7 (Mus musculus - house mouse) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Cbx7 (Chinchilla lanigera - long-tailed chinchilla) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
CBX7 (Pan paniscus - bonobo/pygmy chimpanzee) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
CBX7 (Canis lupus familiaris - dog) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Cbx7 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
CBX7 (Sus scrofa - pig) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
CBX7 (Chlorocebus sabaeus - green monkey) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Cbx7 (Heterocephalus glaber - naked mole-rat) |
|
The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
The detailed report is available here: | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
alimentary part of gastrointestinal system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | appendage | |
High | |||||||||||||
Medium | 3 | 4 | 7 | 14 | 2 | 17 | 18 | 12 | 10 | ||||
Low | 39 | 50 | 41 | 5 | 41 | 8 | 9 | 57 | 17 | 29 | 1 | 8 | |
Below cutoff |
RefSeq Transcripts | NM_199117 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
XM_006242020 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_006242021 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_006242022 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_006242025 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039079590 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039079591 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039079592 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039079593 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XR_355830 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | AC128476 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
AC134056 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
BC062392 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CH473950 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
JACYVU010000186 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
RefSeq Acc Id: | ENSRNOT00000022631 ⟹ ENSRNOP00000022631 | ||||||||||||
RefSeq Status: | |||||||||||||
Type: | CODING | ||||||||||||
Position: |
|
RefSeq Acc Id: | ENSRNOT00000077731 ⟹ ENSRNOP00000074584 | ||||||||||||
RefSeq Status: | |||||||||||||
Type: | CODING | ||||||||||||
Position: |
|
RefSeq Acc Id: | ENSRNOT00000115396 ⟹ ENSRNOP00000076579 | ||||||||
RefSeq Status: | |||||||||
Type: | CODING | ||||||||
Position: |
|
RefSeq Acc Id: | NM_199117 ⟹ NP_954548 | ||||||||||||||||||||||||
RefSeq Status: | VALIDATED | ||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||
Position: |
|
||||||||||||||||||||||||
Sequence: |
RefSeq Acc Id: | XM_006242020 ⟹ XP_006242082 | ||||||||||||||||
RefSeq Status: | |||||||||||||||||
Type: | CODING | ||||||||||||||||
Position: |
|
||||||||||||||||
Sequence: |
RefSeq Acc Id: | XM_006242021 ⟹ XP_006242083 | ||||||||||||||||
RefSeq Status: | |||||||||||||||||
Type: | CODING | ||||||||||||||||
Position: |
|
||||||||||||||||
Sequence: |
RefSeq Acc Id: | XM_006242022 ⟹ XP_006242084 | ||||||||||||||||
RefSeq Status: | |||||||||||||||||
Type: | CODING | ||||||||||||||||
Position: |
|
||||||||||||||||
Sequence: |
RefSeq Acc Id: | XM_006242025 ⟹ XP_006242087 | ||||||||||||||||
RefSeq Status: | |||||||||||||||||
Type: | CODING | ||||||||||||||||
Position: |
|
||||||||||||||||
Sequence: |
RefSeq Acc Id: | XM_039079590 ⟹ XP_038935518 | ||||||||
RefSeq Status: | |||||||||
Type: | CODING | ||||||||
Position: |
|
RefSeq Acc Id: | XM_039079591 ⟹ XP_038935519 | ||||||||
RefSeq Status: | |||||||||
Type: | CODING | ||||||||
Position: |
|
RefSeq Acc Id: | XM_039079592 ⟹ XP_038935520 | ||||||||
RefSeq Status: | |||||||||
Type: | CODING | ||||||||
Position: |
|
RefSeq Acc Id: | XM_039079593 ⟹ XP_038935521 | ||||||||
RefSeq Status: | |||||||||
Type: | CODING | ||||||||
Position: |
|
RefSeq Acc Id: | XR_355830 | ||||||||||||||||
RefSeq Status: | |||||||||||||||||
Type: | NON-CODING | ||||||||||||||||
Position: |
|
||||||||||||||||
Sequence: |
Protein RefSeqs | NP_954548 | (Get FASTA) | NCBI Sequence Viewer |
XP_006242082 | (Get FASTA) | NCBI Sequence Viewer | |
XP_006242083 | (Get FASTA) | NCBI Sequence Viewer | |
XP_006242084 | (Get FASTA) | NCBI Sequence Viewer | |
XP_006242087 | (Get FASTA) | NCBI Sequence Viewer | |
XP_038935518 | (Get FASTA) | NCBI Sequence Viewer | |
XP_038935519 | (Get FASTA) | NCBI Sequence Viewer | |
XP_038935520 | (Get FASTA) | NCBI Sequence Viewer | |
XP_038935521 | (Get FASTA) | NCBI Sequence Viewer | |
GenBank Protein | AAH62392 | (Get FASTA) | NCBI Sequence Viewer |
EDM15771 | (Get FASTA) | NCBI Sequence Viewer | |
EDM15772 | (Get FASTA) | NCBI Sequence Viewer | |
P60889 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_954548 ⟸ NM_199117 |
- UniProtKB: | P60889 (UniProtKB/Swiss-Prot) |
- Sequence: |
RefSeq Acc Id: | XP_006242082 ⟸ XM_006242020 |
- Peptide Label: | isoform X1 |
- Sequence: |
RefSeq Acc Id: | XP_006242087 ⟸ XM_006242025 |
- Peptide Label: | isoform X5 |
- UniProtKB: | P60889 (UniProtKB/Swiss-Prot) |
- Sequence: |
RefSeq Acc Id: | XP_006242083 ⟸ XM_006242021 |
- Peptide Label: | isoform X1 |
- Sequence: |
RefSeq Acc Id: | XP_006242084 ⟸ XM_006242022 |
- Peptide Label: | isoform X2 |
- Sequence: |
RefSeq Acc Id: | ENSRNOP00000074584 ⟸ ENSRNOT00000077731 |
RefSeq Acc Id: | ENSRNOP00000022631 ⟸ ENSRNOT00000022631 |
RefSeq Acc Id: | XP_038935519 ⟸ XM_039079591 |
- Peptide Label: | isoform X4 |
RefSeq Acc Id: | XP_038935521 ⟸ XM_039079593 |
- Peptide Label: | isoform X7 |
RefSeq Acc Id: | XP_038935518 ⟸ XM_039079590 |
- Peptide Label: | isoform X3 |
RefSeq Acc Id: | XP_038935520 ⟸ XM_039079592 |
- Peptide Label: | isoform X6 |
RefSeq Acc Id: | ENSRNOP00000076579 ⟸ ENSRNOT00000115396 |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-P60889-F1-model_v2 | AlphaFold | P60889 | 1-158 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
RGD ID: | 13695491 | ||||||||
Promoter ID: | EPDNEW_R6016 | ||||||||
Type: | single initiation site | ||||||||
Name: | Cbx7_1 | ||||||||
Description: | chromobox 7 | ||||||||
SO ACC ID: | SO:0000170 | ||||||||
Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
Experiment Methods: | Single-end sequencing. | ||||||||
Position: |
|
|
||||||||||||||||||
|
||||||||||||||||||
|
||||||||||||||||||
|
||||||||||||||||||
|
||||||||||||||||||
|
||||||||||||||||||
|
||||||||||||||||||
|
||||||||||||||||||
|
||||||||||||||||||
|
||||||||||||||||||
|
||||||||||||||||||
|
||||||||||||||||||
|
||||||||||||||||||
|
||||||||||||||||||
|
||||||||||||||||||
|
||||||||||||||||||
|
||||||||||||||||||
|
||||||||||||||||||
|
||||||||||||||||||
|
||||||||||||||||||
|
||||||||||||||||||
|
||||||||||||||||||
|
||||||||||||||||||
|
||||||||||||||||||
|
||||||||||||||||||
|
||||||||||||||||||
|
||||||||||||||||||
|
||||||||||||||||||
|
||||||||||||||||||
|
||||||||||||||||||
|
||||||||||||||||||
|
||||||||||||||||||
|
||||||||||||||||||
|
||||||||||||||||||
|
||||||||||||||||||
|
||||||||||||||||||
|
||||||||||||||||||
|
||||||||||||||||||
|
||||||||||||||||||
|
||||||||||||||||||
|
||||||||||||||||||
|
||||||||||||||||||
|
||||||||||||||||||
|
||||||||||||||||||
|
||||||||||||||||||
|
||||||||||||||||||
|
||||||||||||||||||
|
Database | Acc Id | Source(s) |
AGR Gene | RGD:735027 | AgrOrtholog |
BioCyc Gene | G2FUF-32731 | BioCyc |
Ensembl Genes | ENSRNOG00000016875 | Ensembl, ENTREZGENE, UniProtKB/TrEMBL |
Ensembl Protein | ENSRNOP00000022631 | ENTREZGENE |
ENSRNOP00000022631.6 | UniProtKB/TrEMBL | |
ENSRNOP00000074584 | ENTREZGENE | |
ENSRNOP00000074584.2 | UniProtKB/TrEMBL | |
ENSRNOP00000076579.1 | UniProtKB/TrEMBL | |
Ensembl Transcript | ENSRNOT00000022631 | ENTREZGENE |
ENSRNOT00000022631.7 | UniProtKB/TrEMBL | |
ENSRNOT00000077731 | ENTREZGENE | |
ENSRNOT00000077731.2 | UniProtKB/TrEMBL | |
ENSRNOT00000115396.1 | UniProtKB/TrEMBL | |
IMAGE_CLONE | IMAGE:5621139 | IMAGE-MGC_LOAD |
InterPro | CBX7 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
CBX7_C | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Chromo-like_dom_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Chromo/chromo_shadow_dom | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Chromo_dom_subgr | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Chromo_domain | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Chromodomain_CS | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
KEGG Report | rno:362962 | UniProtKB/Swiss-Prot |
MGC_CLONE | MGC:72633 | IMAGE-MGC_LOAD |
NCBI Gene | 362962 | ENTREZGENE |
PANTHER | PTHR47277 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Pfam | CBX7_C | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Chromo | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PhenoGen | Cbx7 | PhenoGen |
PRINTS | CHROMODOMAIN | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PROSITE | CHROMO_1 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
CHROMO_2 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
SMART | CHROMO | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Superfamily-SCOP | SSF54160 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
UniProt | A0A8I5Y0I1_RAT | UniProtKB/TrEMBL |
A0A8L2QCQ7_RAT | UniProtKB/TrEMBL | |
A0A8L2UR72_RAT | UniProtKB/TrEMBL | |
CBX7_RAT | UniProtKB/Swiss-Prot, ENTREZGENE |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
---|---|---|---|---|---|---|---|
2015-12-02 | Cbx7 | chromobox 7 | Cbx7 | chromobox homolog 7 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2004-09-10 | Cbx7 | chromobox homolog 7 | chromobox 7 | Name updated | 1299863 | APPROVED |