Derl1 (derlin 1) - Rat Genome Database

Name: Derl1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Derl1 (derlin 1) Rattus norvegicus

Analyze

Symbol:

Derl1

Name:

derlin 1

RGD ID:

1311835

Description:

Predicted to have several functions, including enzyme binding activity; identical protein binding activity; and misfolded protein binding activity. Predicted to be involved in several processes, including ERAD pathway; endoplasmic reticulum unfolded protein response; and protein destabilization. Predicted to colocalize with signal recognition particle and signal recognition particle receptor complex. Orthologous to human DERL1 (derlin 1); PARTICIPATES IN amyotrophic lateral sclerosis pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4-phenylbutyric acid; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

Der1-like domain family, member 1; derlin-1; LOC362912; RGD1311835; similar to RIKEN cDNA 1110021N07

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DERL1 (derlin 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Derl1 (Der1-like domain family, member 1)	HGNC	Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Derl1 (derlin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DERL1 (derlin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DERL1 (derlin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Derl1 (derlin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DERL1 (derlin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	DERL1 (derlin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Derl1 (derlin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	DERL1 (derlin 1)	Alliance	DIOPT (HGNC\|PhylomeDB\|TreeFam)
Mus musculus (house mouse):	Derl1 (Der1-like domain family, member 1)	Alliance	DIOPT (PhylomeDB\|TreeFam)
Danio rerio (zebrafish):	derl1 (derlin 1)	Alliance	DIOPT (PhylomeDB\|TreeFam)
Drosophila melanogaster (fruit fly):	Der-1	Alliance	DIOPT (PhylomeDB\|TreeFam)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	7	97,737,176 - 97,759,852 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	97,737,178 - 97,759,852 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	98,344,206 - 98,366,882 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	94,573,472 - 94,596,148 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	7	94,607,703 - 94,630,378 (-)	NCBI
Celera	7	86,177,037 - 86,199,719 (-)	NCBI		Celera
Cytogenetic Map	7	q33	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Stevens-Johnson syndrome (ISO)

trichorhinophalangeal syndrome type I (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

1H-pyrazole (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-hydroxypropanoic acid (ISO)

4-hydroxyphenyl retinamide (ISO)

4-phenylbutyric acid (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP)

carbon nanotube (ISO)

clobetasol (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

diclofenac (ISO)

doxorubicin (EXP,ISO)

endosulfan (EXP)

folic acid (ISO)

glafenine (EXP)

hexadecanoic acid (ISO)

lead(0) (ISO)

lead(2+) (ISO)

methapyrilene (EXP)

methylmercury chloride (ISO)

N-methyl-4-phenylpyridinium (ISO)

nimesulide (EXP)

oleic acid (ISO)

paracetamol (ISO)

pentachlorophenol (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

rac-lactic acid (ISO)

resveratrol (ISO)

silver atom (ISO)

silver(0) (ISO)

Soman (EXP)

streptozocin (EXP)

tert-butyl hydroperoxide (ISO)

tetrachloromethane (ISO)

vinclozolin (EXP)

zebularine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to unfolded protein (ISO)

endoplasmic reticulum unfolded protein response (IBA,ISO)

ER-associated misfolded protein catabolic process (ISO)

ERAD pathway (ISO)

positive regulation of protein binding (ISO)

positive regulation of protein ubiquitination (ISO)

proteasome-mediated ubiquitin-dependent protein catabolic process (ISO)

protein destabilization (ISO)

response to unfolded protein (ISO)

retrograde protein transport, ER to cytosol (ISO)

ubiquitin-dependent ERAD pathway (IBA,ISO)

Cellular Component

Derlin-1 retrotranslocation complex (ISO)

Derlin-1-VIMP complex (ISO)

early endosome (ISO)

endoplasmic reticulum (ISO)

endoplasmic reticulum quality control compartment (IEA,ISO)

Hrd1p ubiquitin ligase ERAD-L complex (IBA)

integral component of endoplasmic reticulum membrane (IBA,ISO)

integral component of membrane (ISO)

late endosome (ISO)

Molecular Function

ATPase binding (ISO)

identical protein binding (ISO)

MHC class I protein binding (ISO)

misfolded protein binding (IBA)

protease binding (ISO)

protein binding (ISO)

protein-containing complex binding (ISO)

signal recognition particle binding (IEA,ISO)

ubiquitin protein ligase binding (ISO)

ubiquitin-specific protease binding (IBA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

amyotrophic lateral sclerosis pathway (IEA)

Endoplasmic Reticulum-associated degradation pathway (IEA)

References

References - curated


1.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA data from the GO Consortium
3.	MGD data from the GO Consortium
4.	Pipeline to import KEGG annotations from KEGG into RGD
5.	RGD automated import pipeline for gene-chemical interactions
6.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:15215855	PMID:15215856	PMID:16186510	PMID:16449189	PMID:17000876	PMID:17872946	PMID:18555783	PMID:19509052	PMID:19946888	PMID:21186355	PMID:24019521	PMID:24089527
PMID:25239945	PMID:25660456	PMID:26565908	PMID:26692333	PMID:31113930

Genomics

Comparative Map Data

Derl1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	7	97,737,176 - 97,759,852 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	97,737,178 - 97,759,852 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	98,344,206 - 98,366,882 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	94,573,472 - 94,596,148 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	7	94,607,703 - 94,630,378 (-)	NCBI
Celera	7	86,177,037 - 86,199,719 (-)	NCBI		Celera
Cytogenetic Map	7	q33	NCBI

DERL1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	8	123,013,170 - 123,042,302 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	8	123,013,170 - 123,042,302 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	8	124,025,404 - 124,054,663 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	124,094,769 - 124,123,722 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	8	124,094,768 - 124,123,722	NCBI
Celera	8	120,214,755 - 120,243,831 (-)	NCBI
Cytogenetic Map	8	q24.13	NCBI
HuRef	8	119,350,888 - 119,380,143 (-)	NCBI		HuRef
CHM1_1	8	124,065,598 - 124,094,857 (-)	NCBI		CHM1_1

Derl1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	57,732,898 - 57,755,814 (-)	NCBI	GRCm39		mm39
GRCm38	15	57,869,502 - 57,892,418 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	57,869,502 - 57,892,448 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	57,701,057 - 57,723,973 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	15	57,699,585 - 57,722,501 (-)	NCBI			mm8
Celera	15	59,390,196 - 59,413,106 (-)	NCBI		Celera
Cytogenetic Map	15	D1	NCBI

Derl1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955540	1,917,655 - 1,944,214 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955540	1,918,230 - 1,944,186 (-)	NCBI	ChiLan1.0	ChiLan1.0

DERL1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	8	122,463,063 - 122,492,137 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	122,463,063 - 122,492,137 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	8	119,707,397 - 119,736,502 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

DERL1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	13	21,419,352 - 21,482,133 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	13	21,423,501 - 21,452,594 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Derl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936470	24,262,401 - 24,286,713 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DERL1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	16,310,364 - 16,346,745 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	16,310,407 - 16,341,405 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	17,236,667 - 17,252,340 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DERL1
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	117,587,373 - 117,617,233 (-)	NCBI
ChlSab1.1 Ensembl	8	117,586,496 - 117,617,194 (-)	Ensembl

Derl1
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624735	31,832,711 - 31,857,687 (+)	NCBI

Position Markers

RH132372

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	7	97,738,100 - 97,738,317	NCBI	Rnor6.0
Rnor_5.0	7	98,345,130 - 98,345,347	UniSTS	Rnor5.0
RGSC_v3.4	7	94,574,396 - 94,574,613	UniSTS	RGSC3.4
Celera	7	86,177,961 - 86,178,178	UniSTS
Cytogenetic Map	7	q32-q33	UniSTS
RH 3.4 Map	7	608.7	UniSTS

RH138651

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	7	97,737,396 - 97,737,529	NCBI	Rnor6.0
Rnor_5.0	7	98,344,426 - 98,344,559	UniSTS	Rnor5.0
RGSC_v3.4	7	94,573,692 - 94,573,825	UniSTS	RGSC3.4
Celera	7	86,177,257 - 86,177,390	UniSTS
Cytogenetic Map	7	q32-q33	UniSTS

RH141575

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	7	q32-q33	UniSTS

UniSTS:237297

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	7	97,738,386 - 97,738,704	NCBI	Rnor6.0
Rnor_6.0	9	8,773,985 - 8,774,299	NCBI	Rnor6.0
Rnor_5.0	9	7,795,012 - 7,795,326	UniSTS	Rnor5.0
Rnor_5.0	7	98,345,416 - 98,345,734	UniSTS	Rnor5.0
RGSC_v3.4	7	94,574,682 - 94,575,000	UniSTS	RGSC3.4
Celera	7	86,178,247 - 86,178,565	UniSTS
Cytogenetic Map	7	q32-q33	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	2920071	124838025	Rat
1643004	Pain2	Pain QTL 2	1		mechanical nociception trait (VT:0002734)	self mutilation severity score (CMO:0002145)	7	12328467	106995532	Rat
61357	Bp38	Blood pressure QTL 38	1.6	0.052	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	48118835	128611831	Rat
631504	Cm27	Cardiac mass QTL 27	3.45		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	7	50704769	128085642	Rat
1358361	Sradr5	Stress Responsive Adrenal Weight QTL 5	5.55		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	7	51251919	118477612	Rat
1300179	Kidm5	Kidney mass QTL 5	3.51		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	51251919	145729302	Rat
1300149	Cm6	Cardiac mass QTL 6	4.09		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	7	51252005	111589099	Rat
61428	Scl3	Serum cholesterol level QTL 3	3.2		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	7	53200344	98200344	Rat
738030	Anxrr8	Anxiety related response QTL 8	4.1		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	54259512	99259512	Rat
2316947	Rf58	Renal function QTL 58	7.8		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	7	55072862	123602998	Rat
2316952	Pur22	Proteinuria QTL 22	5.2		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	7	55072862	123602998	Rat
2316955	Stl24	Serum triglyceride level QTL 24	7.1		blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	7	55072862	123602998	Rat
2300178	Bmd54	Bone mineral density QTL 54	5.3	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	7	55495689	100495689	Rat
2293644	Bmd29	Bone mineral density QTL 29	5.4	0.0001	femur size trait (VT:1000369)	femoral neck cross-sectional area (CMO:0001697)	7	55495689	100495689	Rat
2293667	Bss42	Bone structure and strength QTL 42	7.25	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra cross-sectional area (CMO:0001689)	7	55495689	100495689	Rat
2293678	Bss24	Bone structure and strength QTL 24	6.71	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	7	55495689	100495689	Rat
2293685	Bmd21	Bone mineral density QTL 21	4.2	0.0003	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	7	55495689	100495689	Rat
2293696	Bmd32	Bone mineral density QTL 32	5.1	0.0001	femur strength trait (VT:0010010)	femoral neck polar moment of inertia (CMO:0001670)	7	55495689	100495689	Rat
2293707	Bss32	Bone structure and strength QTL 32	7.64	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	7	55495689	100495689	Rat
1300151	Bp181	Blood pressure QTL 181	3.36		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	7	61047589	113228378	Rat
2317035	Aia16	Adjuvant induced arthritis QTL 16	2.71		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	7	68518460	113518460	Rat
1576303	Ept7	Estrogen-induced pituitary tumorigenesis QTL 7	3.7		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	7	69399586	111043530	Rat
1559283	Emca4	Estrogen-induced mammary cancer QTL 4	3.7		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	7	69399586	111043530	Rat
1298528	Bp169	Blood pressure QTL 169		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	70421228	115421228	Rat
70173	Niddm19	Non-insulin dependent diabetes mellitus QTL 19	4.33	0.00005	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	71448715	145729302	Rat
631540	Bw9	Body weight QTL 9	4.5		body mass (VT:0001259)	body weight (CMO:0000012)	7	77428105	127748511	Rat
1357338	Stl17	Serum triglyceride level QTL 17	3.23		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	7	77428234	122421148	Rat
634331	Pia17	Pristane induced arthritis QTL 17	4.7		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	7	81645773	140745067	Rat
7411607	Foco15	Food consumption QTL 15		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	85595369	130595369	Rat
7411654	Foco25	Food consumption QTL 25	9.3	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	85595369	130595369	Rat
724537	Niddm52	Non-insulin dependent diabetes mellitus QTL 52		0.02	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	88365265	102588450	Rat
1641908	Teswt1	Testicular weight QTL 1	3.28		testis mass (VT:1000644)	both testes wet weight (CMO:0000175)	7	88365265	103867802	Rat
631529	Tls2	T-lymphoma susceptibility QTL 2	0	0.001	thymus integrity trait (VT:0010555)	percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)	7	88365265	119318087	Rat
1331746	Kidm9	Kidney mass QTL 9	3.934		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	7	88365265	121986709	Rat
1331768	Kidm10	Kidney mass QTL 10	4.62096		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	88365265	133365265	Rat
1331728	Bp214	Blood pressure QTL 214	2.825		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	88365265	134673427	Rat
2317052	Aia17	Adjuvant induced arthritis QTL 17	2.13		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	7	91018361	136018361	Rat
1358914	Bp266	Blood pressure QTL 266			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	91832949	145158140	Rat
1358891	Bp265	Blood pressure QTL 265	2.21		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	91832949	145158140	Rat
71114	Niddm14	Non-insulin dependent diabetes mellitus QTL 14	4.5		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	7	93726906	138726906	Rat
2298475	Eau6	Experimental allergic uveoretinitis QTL 6		0.0029	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	7	93726906	138726906	Rat
1558655	Swd4	Spike wave discharge measurement QTL 4	3.68	0.0002	brain electrophysiology trait (VT:0010557)	brain spike-and-wave discharge severity grade (CMO:0001988)	7	96630946	141630946	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	203
Count of miRNA genes:	160
Interacting mature miRNAs:	172
Transcripts:	ENSRNOT00000007484
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	11	74	35	41	11	8
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001014202	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AABR07058002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AAHX01050916	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AAHX01050917	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC085877	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473950	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ218639	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ220628	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000007484 ⟹ ENSRNOP00000007484

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	7	97,737,178 - 97,759,852 (-)	Ensembl

RefSeq Acc Id:

NM_001014202 ⟹ NP_001014224

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	97,737,176 - 97,759,852 (-)	NCBI
Rnor_5.0	7	98,344,206 - 98,366,882 (-)	NCBI
RGSC_v3.4	7	94,573,472 - 94,596,148 (-)	RGD
Celera	7	86,177,037 - 86,199,719 (-)	RGD

Sequence:

show sequence

CACGGGAGGACGCGCGGCGCTGCGCAGCCGTCCACCTGACGGGCGACCATGTCGGACATCGGGG
ACTGGTTCAGGAGCATCCCGGCCATCACGCGCTACTGGTTTGCTGCCACCGTCGCGGTCCCCTT
GATCGGCAAGCTCGGTATTATCAGCCCGGCCTACTTCTTCCTCTGGCCCGAAGCCTTCCTCTAT
CGCTTCCAGATATGGAGGCCGTTCACTGCCACCTTTTATTTCCCCGTGGGGCCCGGAACTGGAT
TTCTTTATTTGGTCAATTTATATTTCTTATATCAGTATTCTACACGGCTTGAGGCAGGAGCTTT
TGACGGGAGGCCAGCAGACTATTTATTCATGCTTCTCTTCAACTGGATCTGCATTGTTATTACT
GGCTTAGCCATGGATATGCAGTTGCTGATGATTCCTCTAATCATGTCAGTACTTTACGTCTGGG
CCCAGCTGAACAGAGACCTGATTGTATCATTTTGGTTTGGAACACGATTTAAGGCCTGTTACTT
ACCTTGGGTTATCCTCGGATTCAACTATATCATTGGAGGCTCGGTCATCAATGAGCTCATTGGA
AACCTTGTCGGACATCTTTATTTCTTCCTGATGTTCAGATACCCAATGGATTTGGGAGGAAGGA
ATTTTCTGTCCACACCTCAGTTTTTGTACCGCTGGCTACCCAGCAGGAGAGGAGGGGTGTCAGG
CTTCGGTGTGCCCCCTGCAAGCATGAGGCGAGCTGCTGATCAGAATGGCGGAGGTGGGAGACAC
AACTGGGGCCAGGGCTTCCGACTTGGAGACCAGTGAGGAGCAGCCCTGGCCTGCTCACCAGCCA
TGCTAAGCAGATGACAGTCTCCTCCCAGTGCTGGGCACGCTTAATGGCCGAGCTCTTGCTGCCG
CTCTTGGACCTGACCCACACTGAATGTAGTCTTTTGGTACAAGACACATTTTTAAATCCCGAAG
GAAAATACAAGTGTTCCTCAAGTTTCATGATTCTCATTCAAGTCCTTTCTGCTGTGAAGAGCAA
ATGTCAGCTGTGCAGATTTCAGAACTGACTCATGTTCTGCTGTCTTCTCCTCTCCCCTTCCTTC
TGATTAATGAACTGGGCAAGAGGGGCTGATGAGTCAAATCCTCTCAGAGGACCCTCTCCTCTCT
CACACGTCCCCAATCCCGTCAGAGGACCCTCTCCTCTCTCACACGTCCCCAGAGCTGCAGCTAG
CATTGTCCACAGAAGGATTTTGCCTTTGACAAACTTACTGACTTGCCAAAGCTTGGTCACAAAG
AGCTGGCTCACACATGGTCCTTGGCCATCACTGGCAGGACTGTAACTGTAGGGAGAAGATTGGA
GCAGCAGAGGAAGAACTTTCTCCGCTGTGGGGCCTGCATTAGCCTGTCAGCAGTGCTGCCATTT
GCTGCCTCTCACATATTTATACACAAAGGCACCTCTGAGTCAGTGAGGGCCCGGACTGGGAGTA
ACGAGGATTAGGACTTGTTGCTAGGCACTCCTATCCCTCTGAGCTGAGTGATCAAAACCATAGT
GGAGTTGCTCCTGACACAGGGGATGGGTTTAATCACAATCCCTTGTGTTTCTTCATGGGGTGAA
CTGGCTTTGTGTGCCCAGAGCAGCTGTGCTGTGCTGTGCTATGTTAGGAGGTTCCTGATCACAT
GGCCAGACAGACACACGTCCCTGGAGGCACTGATTCTGTTTGGTCCTCATTGCGGGTGTGTTCA
TTCAGTCGGTGGAGAAGAGAGGTTTAGACTCTAAATTTTTAGTTAACTGTTTTTTGGACCATGC
CTTTTCTGGTCAAGTGTTTATGTTAATGCTAAGGGAAGTGCCTCTTCAGATGTGTGTTGGTCAG
TTTTTAAGGCTAATGGAGGCACATCTGAAGGGGTCACTCGTAATTAGAGGTTCCAATAGCTTTA
GGATCATTTGCATTTGAAGGTCTTCATTACCTTGGGTCATGCATGTATACACTTTGTGAATCAG
ACCTGCTCCCTTTTTATAGGTGGGCTTTTGCCAGCAGAGCTCAGCTTATCACTAAATAAAGTTT
TCTGAAGGCTCCAGGGCTTTACAGTTACTTTATGCTTTCATTCTGGAATCAGGCTGCTGGCTGC
AGTGGGACGGGCCAGTATGCTCTGAAGGCTTTTGATACTTTGGTTTTTCCCTTGAGGAAATGTG
CCCAAACAGGGTGACTTACCCTTCTCTGCTCATTAAAACTGTGATGTGTATTATATTAGGAAGT
GGGAGTTTGAAAAAGAGCTCCCCCTTTCTCATGTGTACCTCTCCATATTTAATTTATATGATAA
ACTATTGAGTGGAGAGAGGCTGATCCTGAACCATCTGGTTCTCCTGCTGACCTGAGGCTATGAT
AAATGTGTGTCTGTCAGATTCAGGAAGGATTGCCATTTGAGTGAGCAGGAGATTATGCTTCGTC
CTGGTACCAGGCTGTCTCCTGAGAGCACTGGCTTTTCTAAGGATCTGCAAGTACAGAGAGCTTT
TCTGTACAGGGAAAATGTTCAGAAAATTCTTTCTCCTGGACATGATTGGGAAGCTGATAATTTT
ATTATCTTGCCTGGATTACTAGTCCTTCCAAGATAGTTTTACCAAAGTGAGCTGTTTGAGTATT
GACTTCACAAGGTAAGAATTCACAGTGGGTTCTCTTTATGAATGTGAAAAAAAAAAACCCTTAT
TTTGTACAGACAGCTTTCCTTTTTGTAACTAATCCTTTTTACTGGTAAACATTGTAAATTAAAA
TATGCAACTTGAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001014224	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH85877	(Get FASTA)	NCBI Sequence Viewer
	EDM16237	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001014224 ⟸ NM_001014202

- UniProtKB:

Q5RKH9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSDIGDWFRSIPAITRYWFAATVAVPLIGKLGIISPAYFFLWPEAFLYRFQIWRPFTATFYFPV
GPGTGFLYLVNLYFLYQYSTRLEAGAFDGRPADYLFMLLFNWICIVITGLAMDMQLLMIPLIMS
VLYVWAQLNRDLIVSFWFGTRFKACYLPWVILGFNYIIGGSVINELIGNLVGHLYFFLMFRYPM
DLGGRNFLSTPQFLYRWLPSRRGGVSGFGVPPASMRRAADQNGGGGRHNWGQGFRLGDQ

hide sequence

RefSeq Acc Id:

ENSRNOP00000007484 ⟸ ENSRNOT00000007484

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695341

Promoter ID:

EPDNEW_R5865

Type:

initiation region

Name:

Derl1_1

Description:

derlin 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	97,759,906 - 97,759,966	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311835	AgrOrtholog
Ensembl Genes	ENSRNOG00000005551	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000007484	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000007484	ENTREZGENE, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7191715	IMAGE-MGC_LOAD
InterPro	DER1	UniProtKB/TrEMBL
KEGG Report	rno:362912	UniProtKB/TrEMBL
MGC_CLONE	MGC:94650	IMAGE-MGC_LOAD
NCBI Gene	362912	ENTREZGENE
Pfam	DER1	UniProtKB/TrEMBL
PhenoGen	Derl1	PhenoGen
UniGene	Rn.110990	ENTREZGENE
UniProt	F7FNS3_RAT	UniProtKB/TrEMBL
	Q5RKH9	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-07-16	Derl1	derlin 1	Derl1	Der1-like domain family, member 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-02-27	Derl1	Der1-like domain family, member 1	RGD1311835	similar to RIKEN cDNA 1110021N07	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	RGD1311835	similar to RIKEN cDNA 1110021N07	RGD1311835_predicted	similar to RIKEN cDNA 1110021N07 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-20	RGD1311835_predicted	similar to RIKEN cDNA 1110021N07 (predicted)	LOC362912_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC362912_predicted	similar to RIKEN cDNA 1110021N07 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)