Oplah (5-oxoprolinase (ATP-hydrolysing)) - Rat Genome Database

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Gene: Oplah (5-oxoprolinase (ATP-hydrolysing)) Rattus norvegicus
Analyze
Symbol: Oplah
Name: 5-oxoprolinase (ATP-hydrolysing)
RGD ID: 620956
Description: Predicted to enable 5-oxoprolinase (ATP-hydrolyzing) activity and identical protein binding activity. Predicted to be involved in glutathione metabolic process. Predicted to be active in cytosol. Orthologous to human OPLAH (5-oxoprolinase, ATP-hydrolysing); PARTICIPATES IN glutathione metabolic pathway; glutathione synthase deficiency pathway; glutathionuria disease pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 5-OPase; 5-oxo-L-prolinase; 5-oxoprolinase; MGC105359; pyroglutamase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27108,011,472 - 108,051,751 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7108,011,475 - 108,035,297 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7109,755,124 - 109,770,384 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07111,978,808 - 111,994,070 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07111,937,356 - 111,952,625 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07117,353,951 - 117,394,205 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7117,353,786 - 117,369,159 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07117,339,710 - 117,355,461 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47114,326,739 - 114,341,949 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17114,360,968 - 114,376,179 (-)NCBI
Celera7104,364,174 - 104,379,376 (-)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
aflatoxin B1  (EXP,ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
azoxystrobin  (EXP)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
buspirone  (EXP)
cadmium dichloride  (EXP)
chlorpyrifos  (EXP)
cisplatin  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
corticosterone  (EXP)
Cuprizon  (EXP)
cyclosporin A  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
fenthion  (ISO)
finasteride  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
glafenine  (EXP)
glyphosate  (EXP,ISO)
imidacloprid  (EXP)
ivermectin  (ISO)
ketamine  (EXP)
lidocaine  (EXP)
mercury dibromide  (ISO)
Mesaconitine  (EXP)
methapyrilene  (EXP)
methidathion  (ISO)
methoxychlor  (EXP)
Muraglitazar  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
Tesaglitazar  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
triptonide  (ISO)
troglitazone  (EXP)
trovafloxacin  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA,IEA,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
10. The amino acid sequence of rat kidney 5-oxo-L-prolinase determined by cDNA cloning. Ye GJ, etal., J Biol Chem 1996 Dec 13;271(50):32293-300.
Additional References at PubMed
PMID:15489334  


Genomics

Comparative Map Data
Oplah
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27108,011,472 - 108,051,751 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7108,011,475 - 108,035,297 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7109,755,124 - 109,770,384 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07111,978,808 - 111,994,070 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07111,937,356 - 111,952,625 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07117,353,951 - 117,394,205 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7117,353,786 - 117,369,159 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07117,339,710 - 117,355,461 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47114,326,739 - 114,341,949 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17114,360,968 - 114,376,179 (-)NCBI
Celera7104,364,174 - 104,379,376 (-)NCBICelera
Cytogenetic Map7q34NCBI
OPLAH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388144,050,322 - 144,063,961 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8144,051,266 - 144,063,965 (-)EnsemblGRCh38hg38GRCh38
GRCh378145,106,167 - 145,115,595 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368145,178,155 - 145,186,959 (-)NCBINCBI36Build 36hg18NCBI36
Build 348145,178,164 - 145,186,923NCBI
Cytogenetic Map8q24.3NCBI
HuRef8140,381,985 - 140,391,401 (-)NCBIHuRef
CHM1_18145,146,427 - 145,155,843 (-)NCBICHM1_1
T2T-CHM13v2.08145,211,172 - 145,224,785 (-)NCBIT2T-CHM13v2.0
Oplah
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391576,180,803 - 76,215,381 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1576,180,801 - 76,212,215 (-)EnsemblGRCm39 Ensembl
GRCm381576,296,603 - 76,331,181 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1576,296,601 - 76,328,015 (-)EnsemblGRCm38mm10GRCm38
MGSCv371576,127,033 - 76,137,675 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361576,123,858 - 76,134,500 (-)NCBIMGSCv36mm8
Celera1577,796,663 - 77,807,305 (-)NCBICelera
Cytogenetic Map15D3NCBI
cM Map1535.67NCBI
Oplah
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554542,707,819 - 2,720,992 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554542,707,819 - 2,735,375 (-)NCBIChiLan1.0ChiLan1.0
OPLAH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan18137,070,229 - 137,083,283 (-)NCBINHGRI_mPanPan1
PanPan1.1 Ensembl8143,809,440 - 143,818,219 (-)Ensemblpanpan1.1panPan2
OPLAH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11337,555,035 - 37,564,241 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1337,555,045 - 37,564,810 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1337,518,691 - 37,530,749 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01338,031,277 - 38,041,053 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1338,031,278 - 38,043,273 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11337,703,380 - 37,715,418 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01337,831,555 - 37,843,631 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01338,308,149 - 38,320,210 (-)NCBIUU_Cfam_GSD_1.0
Oplah
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303700,500 - 713,457 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364708,130,548 - 8,143,021 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364708,126,677 - 8,139,556 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OPLAH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4629,870 - 639,406 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14629,901 - 639,420 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24774,806 - 790,325 (+)NCBISscrofa10.2Sscrofa10.2susScr3
OPLAH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18138,263,419 - 138,273,279 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8138,259,670 - 138,273,179 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660391,599,630 - 1,609,555 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Oplah
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473512,766,179 - 12,776,098 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473512,743,369 - 12,776,098 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Oplah
139 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:31
Count of miRNA genes:31
Interacting mature miRNAs:31
Transcripts:ENSRNOT00000016424
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)780221299109401111Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)780221299112308525Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)794811085116738842Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7103146217116738842Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat

Markers in Region
RH138244  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27108,011,466 - 108,011,680 (+)MAPPERmRatBN7.2
Rnor_6.07117,353,944 - 117,354,157NCBIRnor6.0
Rnor_5.07117,339,702 - 117,339,915UniSTSRnor5.0
RGSC_v3.47114,326,729 - 114,326,942UniSTSRGSC3.4
Celera7104,364,164 - 104,364,377UniSTS
RH 3.4 Map7789.8UniSTS
Cytogenetic Map7q34UniSTS
AI232872  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27108,025,995 - 108,026,154 (+)MAPPERmRatBN7.2
Rnor_6.07117,368,470 - 117,368,628NCBIRnor6.0
Rnor_5.07117,354,228 - 117,354,386UniSTSRnor5.0
RGSC_v3.47114,341,260 - 114,341,418UniSTSRGSC3.4
Celera7104,378,687 - 104,378,845UniSTS
RH 3.4 Map7786.4UniSTS
Cytogenetic Map7q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 32 25 21 13 21 3 22 29 31 11
Low 3 11 32 20 6 20 8 8 52 6 10 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006241771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006241772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006241773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006241774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006241775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005486538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005486539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC107096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC072530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC085330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U70825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000016424   ⟹   ENSRNOP00000016424
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7108,011,475 - 108,022,221 (-)Ensembl
Rnor_6.0 Ensembl7117,353,954 - 117,369,159 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000077314   ⟹   ENSRNOP00000074664
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7108,011,475 - 108,022,221 (-)Ensembl
Rnor_6.0 Ensembl7117,353,950 - 117,364,697 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000080724   ⟹   ENSRNOP00000074523
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7108,011,475 - 108,035,297 (-)Ensembl
Rnor_6.0 Ensembl7117,353,786 - 117,364,322 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000110169   ⟹   ENSRNOP00000084556
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7108,011,475 - 108,024,974 (-)Ensembl
RefSeq Acc Id: NM_053904   ⟹   NP_446356
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27108,011,477 - 108,026,685 (-)NCBI
Rnor_6.07117,353,954 - 117,369,159 (-)NCBI
Rnor_5.07117,339,710 - 117,355,461 (-)NCBI
RGSC_v3.47114,326,739 - 114,341,949 (-)RGD
Celera7104,364,174 - 104,379,376 (-)RGD
Sequence:
RefSeq Acc Id: XM_006241771   ⟹   XP_006241833
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27108,011,474 - 108,026,794 (-)NCBI
Rnor_6.07117,353,951 - 117,368,418 (-)NCBI
Rnor_5.07117,339,710 - 117,355,461 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006241772   ⟹   XP_006241834
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27108,011,474 - 108,026,794 (-)NCBI
Rnor_6.07117,353,951 - 117,368,418 (-)NCBI
Rnor_5.07117,339,710 - 117,355,461 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006241773   ⟹   XP_006241835
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27108,011,474 - 108,026,794 (-)NCBI
Rnor_6.07117,353,951 - 117,368,418 (-)NCBI
Rnor_5.07117,339,710 - 117,355,461 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006241774   ⟹   XP_006241836
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27108,011,472 - 108,022,488 (-)NCBI
Rnor_6.07117,353,951 - 117,364,969 (-)NCBI
Rnor_5.07117,339,710 - 117,355,461 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006241775   ⟹   XP_006241837
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27108,011,474 - 108,027,268 (-)NCBI
Rnor_6.07117,353,951 - 117,369,734 (-)NCBI
Rnor_5.07117,339,710 - 117,355,461 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594577   ⟹   XP_017450066
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27108,011,474 - 108,051,748 (-)NCBI
Rnor_6.07117,353,951 - 117,394,205 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039078256   ⟹   XP_038934184
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27108,011,474 - 108,024,371 (-)NCBI
RefSeq Acc Id: XM_039078257   ⟹   XP_038934185
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27108,011,474 - 108,027,268 (-)NCBI
RefSeq Acc Id: XM_039078258   ⟹   XP_038934186
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27108,011,474 - 108,051,751 (-)NCBI
RefSeq Acc Id: XM_039078259   ⟹   XP_038934187
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27108,011,474 - 108,051,751 (-)NCBI
RefSeq Acc Id: XM_039078260   ⟹   XP_038934188
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27108,011,474 - 108,027,267 (-)NCBI
RefSeq Acc Id: XR_005486538
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27108,013,057 - 108,026,795 (-)NCBI
RefSeq Acc Id: XR_005486539
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27108,013,057 - 108,026,795 (-)NCBI
RefSeq Acc Id: NP_446356   ⟸   NM_053904
- UniProtKB: A0A8L2Q8T4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241836   ⟸   XM_006241774
- Peptide Label: isoform X4
- UniProtKB: Q5U3Z8 (UniProtKB/Swiss-Prot),   P97608 (UniProtKB/Swiss-Prot),   A6HS77 (UniProtKB/TrEMBL),   A0A8L2Q8T4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241837   ⟸   XM_006241775
- Peptide Label: isoform X4
- UniProtKB: Q5U3Z8 (UniProtKB/Swiss-Prot),   P97608 (UniProtKB/Swiss-Prot),   A6HS77 (UniProtKB/TrEMBL),   A0A8L2Q8T4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241834   ⟸   XM_006241772
- Peptide Label: isoform X2
- UniProtKB: A0A8L2R932 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241833   ⟸   XM_006241771
- Peptide Label: isoform X1
- UniProtKB: A0A8L2R932 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241835   ⟸   XM_006241773
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZZD3 (UniProtKB/TrEMBL),   A0A8L2R932 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450066   ⟸   XM_017594577
- Peptide Label: isoform X4
- UniProtKB: Q5U3Z8 (UniProtKB/Swiss-Prot),   P97608 (UniProtKB/Swiss-Prot),   A6HS77 (UniProtKB/TrEMBL),   A0A8L2Q8T4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074523   ⟸   ENSRNOT00000080724
RefSeq Acc Id: ENSRNOP00000074664   ⟸   ENSRNOT00000077314
RefSeq Acc Id: ENSRNOP00000016424   ⟸   ENSRNOT00000016424
RefSeq Acc Id: XP_038934186   ⟸   XM_039078258
- Peptide Label: isoform X4
- UniProtKB: P97608 (UniProtKB/Swiss-Prot),   Q5U3Z8 (UniProtKB/Swiss-Prot),   A6HS77 (UniProtKB/TrEMBL),   A0A8L2Q8T4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934187   ⟸   XM_039078259
- Peptide Label: isoform X4
- UniProtKB: P97608 (UniProtKB/Swiss-Prot),   Q5U3Z8 (UniProtKB/Swiss-Prot),   A6HS77 (UniProtKB/TrEMBL),   A0A8L2Q8T4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934185   ⟸   XM_039078257
- Peptide Label: isoform X4
- UniProtKB: P97608 (UniProtKB/Swiss-Prot),   Q5U3Z8 (UniProtKB/Swiss-Prot),   A6HS77 (UniProtKB/TrEMBL),   A0A8L2Q8T4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934188   ⟸   XM_039078260
- Peptide Label: isoform X5
- UniProtKB: A0A8L2Q8T4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934184   ⟸   XM_039078256
- Peptide Label: isoform X4
- UniProtKB: P97608 (UniProtKB/Swiss-Prot),   Q5U3Z8 (UniProtKB/Swiss-Prot),   A6HS77 (UniProtKB/TrEMBL),   A0A8L2Q8T4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000084556   ⟸   ENSRNOT00000110169
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97608-F1-model_v2 AlphaFold P97608 1-1288 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695412
Promoter ID:EPDNEW_R5936
Type:multiple initiation site
Name:Oplah_1
Description:5-oxoprolinase (ATP-hydrolysing)
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07117,369,189 - 117,369,249EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620956 AgrOrtholog
BioCyc Gene G2FUF-32940 BioCyc
BioCyc Pathway PWY-7942 [5-oxo-L-proline metabolism] BioCyc
BioCyc Pathway Image PWY-7942 BioCyc
Ensembl Genes ENSRNOG00000011781 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055025481 UniProtKB/Swiss-Prot
  ENSRNOG00060024830 UniProtKB/Swiss-Prot
  ENSRNOG00065009686 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000016424.4 UniProtKB/TrEMBL
  ENSRNOT00000077314 ENTREZGENE
  ENSRNOT00000077314.2 UniProtKB/Swiss-Prot
  ENSRNOT00000080724 ENTREZGENE
  ENSRNOT00000080724.2 UniProtKB/TrEMBL
  ENSRNOT00000110169 ENTREZGENE
  ENSRNOT00000110169.1 UniProtKB/TrEMBL
  ENSRNOT00055044116 UniProtKB/Swiss-Prot
  ENSRNOT00060043338 UniProtKB/Swiss-Prot
  ENSRNOT00065015558 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7096390 IMAGE-MGC_LOAD
  IMAGE:7097016 IMAGE-MGC_LOAD
InterPro Hydant_A_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hydantoinase_A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hydantoinase_B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Oxoprolinase_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Speriolin_N UniProtKB/TrEMBL
KEGG Report rno:116684 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105359 IMAGE-MGC_LOAD
  MGC:91552 IMAGE-MGC_LOAD
NCBI Gene 116684 ENTREZGENE
PANTHER 5-OXOPROLINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11365 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hydant_A_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hydant_A_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hydantoinase_A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hydantoinase_B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Speriolin_N UniProtKB/TrEMBL
PhenoGen Oplah PhenoGen
RatGTEx ENSRNOG00000011781 RatGTEx
  ENSRNOG00055025481 RatGTEx
  ENSRNOG00060024830 RatGTEx
  ENSRNOG00065009686 RatGTEx
UniProt A0A8I5ZZD3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q8T4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2R932 ENTREZGENE, UniProtKB/TrEMBL
  A6HS77 ENTREZGENE, UniProtKB/TrEMBL
  OPLA_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5U3Z8 ENTREZGENE
UniProt Secondary Q5U3Z8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Oplah  5-oxoprolinase (ATP-hydrolysing)      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Oplah  5-oxoprolinase (ATP-hydrolysing)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction homodimerizes to form complete enzyme 729066
gene_protein 1,288 amino acid residues 729066