Cyp11b1 (cytochrome P450, family 11, subfamily b, polypeptide 1) - Rat Genome Database

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Gene: Cyp11b1 (cytochrome P450, family 11, subfamily b, polypeptide 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Cyp11b1 (Ensembl: LOC120093683)
Name: cytochrome P450, family 11, subfamily b, polypeptide 1 (Ensembl:cytochrome P450 11B1, mitochondrial)
RGD ID: 2453
Description: Enables steroid 11-beta-monooxygenase activity and steroid binding activity. Involved in several processes, including cellular response to type II interferon; response to dexamethasone; and steroid hormone biosynthetic process. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial inner membrane. Used to study hypertension. Biomarker of brain infarction and hypertension. Human ortholog(s) of this gene implicated in several diseases, including congenital adrenal hyperplasia; corticosterone methyloxidase deficiency 1; diabetes mellitus (multiple); hypertension (multiple); and primary hyperaldosteronism (multiple). Orthologous to human CYP11B1 (cytochrome P450 family 11 subfamily B member 1) and CYP11B2 (cytochrome P450 family 11 subfamily B member 2); PARTICIPATES IN aldosterone biosynthetic pathway; cortisol biosynthetic pathway; steroid hormone biosynthetic pathway; .
Type: protein-coding
Previously known as: aldosterone synthase; Cp11ba; CYPXIB1; cytochrome P450 11B1, mitochondrial; cytochrome P450 11B1, mitochondrial-like; cytochrome P450(11 beta)-DS; cytochrome P450, subfamily 11B, polypeptide 1; cytochrome P450, subfamily XIB, polypeptide 1; Cytochrome P450, subfamily XIB, polypeptide 1 (steroid 11-beta-hydroxylase); cytochrome P450C11; LOC100910462; P450(11 beta)-DS; P450C11; RATCP11BA; steroid 11-beta-hydroxylase; steroid 11-beta-hydroxylase, CYP11B1
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Is Marker For: Strains:   SD   SS.LEW-(D7Rat73-D7Rat128)/Ayd   LEW.SS-(D7Rat73-D7Rat128)/Ayd  
Candidate Gene For: Bp61 Bp335
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87108,653,385 - 108,660,062 (-)NCBIGRCr8
mRatBN7.27106,772,597 - 106,780,536 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7106,718,274 - 106,779,278 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7108,498,616 - 108,505,298 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07110,722,290 - 110,728,972 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07110,668,224 - 110,674,905 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07116,195,976 - 116,201,829 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07116,098,795 - 116,104,649 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47112,977,395 - 112,984,080 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17113,077,602 - 113,083,995 (-)NCBI
Celera7103,180,684 - 103,186,532 (-)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Fetal adrenal gland alterations in a rat model of adverse intrauterine environment. Bibeau K, etal., Am J Physiol Regul Integr Comp Physiol. 2010 Apr;298(4):R899-911. Epub 2009 Nov 18.
2. Identification of new therapeutic targets by genome-wide analysis of gene expression in the ipsilateral cortex of aged rats after stroke. Buga AM, etal., PLoS One. 2012;7(12):e50985. doi: 10.1371/journal.pone.0050985. Epub 2012 Dec 12.
3. Protein kinase Cmu mediates adenosine-stimulated steroidogenesis in primary rat adrenal cells. Chen YC, etal., FEBS Lett. 2010 Nov 5;584(21):4442-8. Epub 2010 Oct 13.
4. Linkage of 11 beta-hydroxylase mutations with altered steroid biosynthesis and blood pressure in the Dahl rat. Cicila GT, etal., Nat Genet 1993 Apr;3(4):346-53.
5. Rat complement factor H: molecular cloning, sequencing and quantification with a newly established ELISA. Demberg T, etal., Scand J Immunol 2002 Aug;56(2):149-60.
6. Quantitative assessment of CYP11B1 and CYP11B2 expression in aldosterone-producing adenomas. Fallo F, etal., Eur J Endocrinol. 2002 Dec;147(6):795-802.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Aldosterone synthesis in the brain contributes to Dahl salt-sensitive rat hypertension. Gomez-Sanchez EP, etal., Exp Physiol. 2010 Jan;95(1):120-30. Epub 2009 Oct 16.
10. Frame shift by insertion of 2 basepairs in codon 394 of CYP11B1 causes congenital adrenal hyperplasia due to steroid 11 beta-hydroxylase deficiency. Helmberg A, etal., J Clin Endocrinol Metab 1992 Nov;75(5):1278-81.
11. Long-term dose-dependent response of Mequindox on aldosterone, corticosterone and five steroidogenic enzyme mRNAs in the adrenal of male rats. Huang XJ, etal., Toxicol Lett. 2009 Dec 15;191(2-3):167-73. Epub 2009 Sep 4.
12. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
13. A chimaeric 11 beta-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension. Lifton RP, etal., Nature. 1992 Jan 16;355(6357):262-5.
14. Direct effects of IL-15 on corticosterone secretion by rat adrenocortical cells. Lo MJ and Lee SD, Immunol Cell Biol. 2006 Feb;84(1):38-43.
15. Molecular cloning and expression of cDNAS encoding rat aldosterone synthase: variants of cytochrome P-450(11 beta). Matsukawa N, etal., Biochem Biophys Res Commun 1990 May 31;169(1):245-52.
16. Dahl's salt-resistant normotensive rat has mutations in cytochrome P450(11 beta), but the salt-sensitive hypertensive rat does not. Matsukawa N, etal., J Biol Chem 1993 Apr 25;268(12):9117-21.
17. Fetal pituitary gonadotropin as an initial target of dioxin in its impairment of cholesterol transportation and steroidogenesis in rats. Mutoh J, etal., Endocrinology. 2006 Feb;147(2):927-36. Epub 2005 Oct 27.
18. Ontogeny of immunoreactive and bioactive microsomal steroidogenic enzymes during adrenocortical development in rats. Nagaya M, etal., Mol Cell Endocrinol. 1995 Oct 30;114(1-2):27-34.
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. Development of relevant assay system to identify steroidogenic enzyme inhibitors. Nishizato Y, etal., Toxicol In Vitro. 2010 Mar;24(2):677-85. Epub 2009 Aug 7.
21. Cardiac steroidogenesis and glucocorticoid in the development of cardiac hypertrophy during the progression to heart failure. Ohtani T, etal., J Hypertens. 2009 May;27(5):1074-83.
22. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
23. Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. Payne AH and Hales DB, Endocr Rev. 2004 Dec;25(6):947-70.
24. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
25. GOA pipeline RGD automated data pipeline
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Single strand conformation polymorphism (SSCP) analysis for the detection of mutations in the CYP11B1 gene. Skinner CA, etal., J Clin Endocrinol Metab. 1996 Jun;81(6):2389-93.
28. Regulation of aldosterone and cortisol production by the transcriptional repressor neuron restrictive silencer factor. Somekawa S, etal., Endocrinology. 2009 Jul;150(7):3110-7. Epub 2009 Apr 2.
29. Expression of 11beta-hydroxylase in rat Leydig cells. Wang GM, etal., Endocrinology 2002 Feb;143(2):621-6.
30. The aldosterone synthase (CYP11B2) and 11beta-hydroxylase (CYP11B1) genes are not expressed in the rat heart. Ye P, etal., Endocrinology. 2005 Dec;146(12):5287-93. Epub 2005 Sep 22.
31. Effects of ACTH, dexamethasone, and adrenalectomy on 11beta-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) gene expression in the rat central nervous system. Ye P, etal., J Endocrinol. 2008 Feb;196(2):305-11.
Additional References at PubMed
PMID:2551730   PMID:2738055   PMID:7626522   PMID:8468320   PMID:8473352   PMID:12459034  


Genomics

Variants

.
Variants in Cyp11b1
21 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7103146217116738842Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)793595647106839474Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)780221299109401111Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)794811085116738842Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)780221299112308525Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat

Markers in Region
D7Wox19  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27106,839,225 - 106,839,474 (+)MAPPERmRatBN7.2
Rnor_6.07116,249,395 - 116,249,643NCBIRnor6.0
Rnor_5.07116,151,764 - 116,152,012UniSTSRnor5.0
RGSC_v3.47113,044,000 - 113,044,249RGDRGSC3.4
RGSC_v3.47113,044,001 - 113,044,249UniSTSRGSC3.4
RGSC_v3.17113,078,230 - 113,078,479RGD
Celera7103,211,613 - 103,211,868UniSTS
RH 3.4 Map7772.3UniSTS
RH 3.4 Map7772.3RGD
RH 2.0 Map7606.1RGD
Cytogenetic Map7q34UniSTS
D7Wox16  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.07116,151,707 - 116,151,991NCBIRnor5.0
Rnor_5.07116,098,481 - 116,098,761NCBIRnor5.0
Rnor_5.07116,058,408 - 116,058,688NCBIRnor5.0
RGSC_v3.47113,012,736 - 113,013,015RGDRGSC3.4
RGSC_v3.47113,043,945 - 113,044,228RGDRGSC3.4
RGSC_v3.47112,977,966 - 112,978,266RGDRGSC3.4
RGSC_v3.17113,012,196 - 113,012,496RGD
Celera7103,211,558 - 103,211,847UniSTS
Celera7103,180,377 - 103,180,655UniSTS
RH 3.4 Map7771.9RGD
RH 3.4 Map7771.9UniSTS
RH 2.0 Map7605.5RGD
Cytogenetic Map7q34UniSTS
D7Wox18  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27106,741,074 - 106,741,295 (+)MAPPERmRatBN7.2
mRatBN7.27106,773,255 - 106,773,476 (+)MAPPERmRatBN7.2
Rnor_6.07116,226,796 - 116,227,016NCBIRnor6.0
Rnor_5.07116,129,165 - 116,129,385UniSTSRnor5.0
RGSC_v3.47112,978,051 - 112,978,272RGDRGSC3.4
RGSC_v3.47112,978,052 - 112,978,272UniSTSRGSC3.4
RGSC_v3.17113,012,281 - 113,012,502RGD
RH 3.4 Map7764.8RGD
RH 3.4 Map7764.8UniSTS
RH 2.0 Map7608.7RGD
Cytogenetic Map7q34UniSTS
D7Mco7  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.07116,059,683 - 116,060,096NCBIRnor5.0
Rnor_5.07116,059,684 - 116,060,096NCBIRnor5.0
Rnor_5.07116,099,756 - 116,100,169NCBIRnor5.0
RGSC_v3.47112,979,257 - 112,979,667UniSTSRGSC3.4
RGSC_v3.47112,979,256 - 112,979,667RGDRGSC3.4
RGSC_v3.47113,014,011 - 113,014,423RGDRGSC3.4
RGSC_v3.17113,048,241 - 113,048,653RGD
Cytogenetic Map7q34UniSTS


Related Rat Strains
The following Strains have been annotated to Cyp11b1
LEW.SS-(D7Rat73-D7Rat128)/Ayd     SD     SS.LEW-(D7Rat73-D7Rat128)/Ayd     SS.SR-Cyp11b1/Jr    


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide D00567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000038109   ⟹   ENSRNOP00000035538
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7106,773,762 - 106,779,278 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000068707   ⟹   ENSRNOP00000062325
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7106,741,581 - 106,747,485 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000091401   ⟹   ENSRNOP00000075065
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7106,740,418 - 106,779,278 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097748   ⟹   ENSRNOP00000094187
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7106,718,274 - 106,723,103 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099698   ⟹   ENSRNOP00000078853
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7106,718,274 - 106,747,485 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105810   ⟹   ENSRNOP00000078562
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7106,718,274 - 106,723,103 (-)Ensembl
RefSeq Acc Id: NM_012537   ⟹   NP_036669
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87108,653,385 - 108,660,062 (-)NCBI
mRatBN7.27106,772,599 - 106,779,278 (-)NCBI
RGSC_v3.47112,977,395 - 112,984,080 (-)RGD
Protein Sequences
GenBank Protein BAA00444 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000035538.6
  ENSRNOP00000075065.2
  ENSRNOP00000078562.1
  ENSRNOP00000078853.1
  ENSRNOP00000094187.1
GenBank Protein P15393 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036669   ⟸   NM_012537
- Peptide Label: precursor
Ensembl Acc Id: ENSRNOP00000094187   ⟸   ENSRNOT00000097748
Ensembl Acc Id: ENSRNOP00000035538   ⟸   ENSRNOT00000038109
Ensembl Acc Id: ENSRNOP00000078853   ⟸   ENSRNOT00000099698
Ensembl Acc Id: ENSRNOP00000062325   ⟸   ENSRNOT00000068707
Ensembl Acc Id: ENSRNOP00000078562   ⟸   ENSRNOT00000105810
Ensembl Acc Id: ENSRNOP00000075065   ⟸   ENSRNOT00000091401

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P15393-F1-model_v2 AlphaFold P15393 1-499 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2453 AgrOrtholog
BioCyc Gene G2FUF-33008 BioCyc
Ensembl Genes ENSRNOG00000068909 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000038109.6 UniProtKB/TrEMBL
  ENSRNOT00000091401.2 UniProtKB/TrEMBL
  ENSRNOT00000097748.1 UniProtKB/TrEMBL
  ENSRNOT00000099698.1 UniProtKB/TrEMBL
  ENSRNOT00000105810.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CYP11_CYP27_families UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/TrEMBL
  Cyt_P450_mitochondrial UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:500892 UniProtKB/TrEMBL
NCBI Gene Cyp11b1 ENTREZGENE
PANTHER PTHR24279 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STEROID 11-BETA-MONOOXYGENASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cyp11b1 PhenoGen
PRINTS EP450I UniProtKB/TrEMBL
  MITP450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000068909 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K9N5_RAT UniProtKB/TrEMBL
  A0A8I5ZL64_RAT UniProtKB/TrEMBL
  A0A8I5ZLT2_RAT UniProtKB/TrEMBL
  A0A8I6AMK4_RAT UniProtKB/TrEMBL
  C11B1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A0A0G2QC14 UniProtKB/TrEMBL
  Q64655 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Cyp11b1  cytochrome P450, family 11, subfamily b, polypeptide 1  LOC100910462  cytochrome P450 11B1, mitochondrial-like  Data merged from RGD:6498232 737654 PROVISIONAL
2012-07-05 LOC100910462  cytochrome P450 11B1, mitochondrial-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-04-19 Cyp11b1  cytochrome P450, family 11, subfamily b, polypeptide 1  Cyp11b1  cytochrome P450, subfamily 11B, polypeptide 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Cyp11b1  cytochrome P450, subfamily 11B, polypeptide 1    Cytochrome P450, subfamily XIB, polypeptide 1 (steroid 11-beta-hydroxylase)  Name updated 625702 APPROVED
2002-06-10 Cyp11b1  Cytochrome P450, subfamily XIB, polypeptide 1 (steroid 11-beta-hydroxylase)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease upregulated in Cushings syndrome 70385
gene_disease candidate gene for a QTL affecting blood pressure (Bp61) 69709
gene_expression expressed in leydig cells 70385
gene_function catalyzes 11-beta-hydroxylation of steroids to produce 11-beta-OH-steroid derivatives 70385
gene_mutations_overexpression mutant allele that may play a role in salt hypertension resistance is found in Dahl salt resistant strain SR/Jr 69709
gene_mutations_overexpression mutant allele found in SR/Jr rat encodes five amino acid substitutions and is associated with reduced synthesis of 18-hydroxy-11-deoxycorticosterone (18-OH-DOC) 69709
gene_process functions in glucocorticoid biosynthesis 70385