Cyp11b1 (cytochrome P450, family 11, subfamily b, polypeptide 1) - Rat Genome Database

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Gene: Cyp11b1 (cytochrome P450, family 11, subfamily b, polypeptide 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Cyp11b1
Name: cytochrome P450, family 11, subfamily b, polypeptide 1
RGD ID: 2453
Description: Enables steroid 11-beta-monooxygenase activity and steroid binding activity. Involved in several processes, including cellular response to type II interferon; response to dexamethasone; and steroid hormone biosynthetic process. Predicted to be located in mitochondrial membrane. Predicted to be active in mitochondrial inner membrane. Used to study hypertension. Biomarker of brain infarction and hypertension. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia; glucocorticoid-remediable aldosteronism; and primary hyperaldosteronism. Orthologous to human CYP11B1 (cytochrome P450 family 11 subfamily B member 1); PARTICIPATES IN aldosterone biosynthetic pathway; cortisol biosynthetic pathway; steroid hormone biosynthetic pathway; .
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: aldosterone synthase; Cp11ba; CYPXIB1; cytochrome P450 11B1, mitochondrial; cytochrome P450 11B1, mitochondrial-like; cytochrome P450(11 beta)-DS; cytochrome P450, subfamily 11B, polypeptide 1; cytochrome P450, subfamily XIB, polypeptide 1; Cytochrome P450, subfamily XIB, polypeptide 1 (steroid 11-beta-hydroxylase); cytochrome P450C11; LOC100910462; P450(11 beta)-DS; P450C11; RATCP11BA; steroid 11-beta-hydroxylase; steroid 11-beta-hydroxylase, CYP11B1
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Is Marker For: Strains:   SD   SS.LEW-(D7Rat73-D7Rat128)/Ayd   LEW.SS-(D7Rat73-D7Rat128)/Ayd  
Candidate Gene For: Bp61 Bp335
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87108,653,385 - 108,660,062 (-)NCBIGRCr8
mRatBN7.27106,772,597 - 106,780,536 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7106,718,274 - 106,779,278 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7108,498,616 - 108,505,298 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07110,722,290 - 110,728,972 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07110,668,224 - 110,674,905 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07116,195,976 - 116,201,829 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07116,098,795 - 116,104,649 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47112,977,395 - 112,984,080 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17113,077,602 - 113,083,995 (-)NCBI
Celera7103,180,684 - 103,186,532 (-)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 9 of 9 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cyp11b1Ratadrenal cortical adenoma  ISOCYP11B1 (Homo sapiens)4891170mRNA:decreased expression:adrenal gland (human)RGD 
Cyp11b1Ratbrain infarction  IEP 329845556mRNA:decreased expression:brain (rat)RGD 
Cyp11b1Ratcongenital adrenal hyperplasia  ISOCYP11B1 (Homo sapiens)734864DNA:frameshift mutation:cds:p.394fsX469 (human)RGD 
Cyp11b1Ratcongenital adrenal hyperplasia  ISOCYP11B1 (Homo sapiens)160079911-beta-hydroxylase deficiency more ...RGD 
Cyp11b1RatFetal Growth Retardation  IEP 4891147protein:decreased expression:fetus and adrenal gland (rat)RGD 
Cyp11b1Rathypertension  IEP 4891156mRNA:decreased expression:hypothalamus more ...RGD 
Cyp11b1Rathypertension  IAGP 69709 RGD 
Cyp11b1RatLeft Ventricular Hypertrophy  IEP 4145630mRNA:increased expression:cardiac muscle tissue and left ventricle (rat)RGD 
Cyp11b1Ratprimary hyperaldosteronism  ISOCYP11B1 (Homo sapiens)4891155DNA:gene fusion:intron:Cyp11b2 (human)RGD 
1 to 9 of 9 rows


Biological Process
1 to 17 of 17 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cyp11b1Rataldosterone biosynthetic process involved_inIMP 4891166PMID:19342457UniProt 
Cyp11b1Rataldosterone biosynthetic process involved_inIBAMGI:88584 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cyp11b1Ratcellular response to peptide hormone stimulus involved_inIBAPANTHER:PTN001547321 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cyp11b1Ratcellular response to type II interferon  IEP 632369 RGD 
Cyp11b1Ratcholesterol metabolic process involved_inIBAPANTHER:PTN001547321 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cyp11b1Ratcortisol biosynthetic process involved_inIMP 4891166PMID:19342457UniProt 
Cyp11b1Ratcortisol metabolic process involved_inIBAPANTHER:PTN001547321 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cyp11b1Ratdibenzo-p-dioxin metabolic process  IEP 4889135 RGD 
Cyp11b1Ratglucocorticoid biosynthetic process  IDA 4891164corticosteroneRGD 
Cyp11b1Ratglucocorticoid biosynthetic process involved_inIEAUniPathway:UPA007881600115GO_REF:0000041UniProtGO_REF:0000041
Cyp11b1Ratglucocorticoid biosynthetic process involved_inIBAMGI:88583 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cyp11b1Ratresponse to dexamethasone  IEP 2307305 RGD 
Cyp11b1Ratresponse to xenobiotic stimulus  IEP 4460910MequindoxRGD 
Cyp11b1Ratsteroid biosynthetic process  IDA 1624284 RGD 
Cyp11b1Ratsteroid biosynthetic process involved_inIEAUniProtKB-KW:KW-07551600115GO_REF:0000043UniProtGO_REF:0000043
Cyp11b1Ratsteroid metabolic process  TAS 1600809 RGD 
Cyp11b1Ratsteroid metabolic process involved_inIEAARBA:ARBA000273091600115GO_REF:0000117UniProtGO_REF:0000117
1 to 17 of 17 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cyp11b1Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Cyp11b1Ratmitochondrial inner membrane located_inIEAUniProtKB-KW:KW-09991600115GO_REF:0000043UniProtGO_REF:0000043
Cyp11b1Ratmitochondrial inner membrane located_inIEAUniProtKB-SubCell:SL-01681600115GO_REF:0000044UniProtGO_REF:0000044
Cyp11b1Ratmitochondrial inner membrane is_active_inIBAPANTHER:PTN001547321 and Cyp11a1 (Rattus norvegicus)1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cyp11b1Ratmitochondrial membrane located_inIEAUniProtKB-SubCell:SL-01711600115GO_REF:0000044UniProtGO_REF:0000044
Cyp11b1Ratmitochondrion located_inIEAUniProtKB-KW:KW-04961600115GO_REF:0000043UniProtGO_REF:0000043
Cyp11b1Ratmitochondrion located_inIEAInterPro:IPR0023991600115GO_REF:0000002InterProGO_REF:0000002
Cyp11b1Ratmitochondrion located_inIEAUniProtKB-SubCell:SL-01731600115GO_REF:0000044UniProtGO_REF:0000044

Molecular Function
1 to 18 of 18 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cyp11b1Ratcorticosterone 18-monooxygenase activity enablesIBAMGI:88583 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cyp11b1Ratheme binding enablesIEAInterPro:IPR001128 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Cyp11b1Ratheme binding enablesIEAInterPro:IPR001128 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Cyp11b1Ratiron ion binding enablesIEAInterPro:IPR001128 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Cyp11b1Ratiron ion binding enablesIEAInterPro:IPR001128 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Cyp11b1Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Cyp11b1Ratmonooxygenase activity enablesIEAUniProtKB-KW:KW-05031600115GO_REF:0000043UniProtGO_REF:0000043
Cyp11b1Ratmonooxygenase activity enablesIEAInterPro:IPR001128 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Cyp11b1Ratmonooxygenase activity enablesIEAInterPro:IPR001128 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Cyp11b1Ratoxidoreductase activity enablesIEAUniProtKB-KW:KW-05601600115GO_REF:0000043UniProtGO_REF:0000043
Cyp11b1Ratoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen enablesIEAInterPro:IPR001128 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Cyp11b1Ratoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen enablesIEAInterPro:IPR001128 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Cyp11b1Ratsteroid 11-beta-monooxygenase activity  IDA 1624284 RGD 
Cyp11b1Ratsteroid 11-beta-monooxygenase activity enablesIEARHEA:156291600115GO_REF:0000116RHEAGO_REF:0000116
Cyp11b1Ratsteroid 11-beta-monooxygenase activity enablesIBAMGI:88584 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cyp11b1Ratsteroid 11-beta-monooxygenase activity enablesIEAARBA:ARBA000292641600115GO_REF:0000117UniProtGO_REF:0000117
Cyp11b1Ratsteroid 11-beta-monooxygenase activity enablesIEAEC:1.14.15.41600115GO_REF:0000003UniProtGO_REF:0000003
Cyp11b1Ratsteroid binding  IDA 1624284 RGD 
1 to 18 of 18 rows

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cyp11b1Rataldosterone biosynthetic pathway   ISOCYP11B1 (Homo sapiens)4889549 RGD 
Cyp11b1Ratcortisol biosynthetic pathway   ISOCYP11B1 (Homo sapiens)4889549 RGD 

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cyp11b1Ratsteroid hormone biosynthetic pathway   IEArno:001506907045 KEGGrno:00140
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cyp11b1Ratincreased systemic arterial systolic blood pressure  IAGP 69709 RGD 

1 to 20 of 31 rows
#
Reference Title
Reference Citation
1. Fetal adrenal gland alterations in a rat model of adverse intrauterine environment. Bibeau K, etal., Am J Physiol Regul Integr Comp Physiol. 2010 Apr;298(4):R899-911. Epub 2009 Nov 18.
2. Identification of new therapeutic targets by genome-wide analysis of gene expression in the ipsilateral cortex of aged rats after stroke. Buga AM, etal., PLoS One. 2012;7(12):e50985. doi: 10.1371/journal.pone.0050985. Epub 2012 Dec 12.
3. Protein kinase Cmu mediates adenosine-stimulated steroidogenesis in primary rat adrenal cells. Chen YC, etal., FEBS Lett. 2010 Nov 5;584(21):4442-8. Epub 2010 Oct 13.
4. Linkage of 11 beta-hydroxylase mutations with altered steroid biosynthesis and blood pressure in the Dahl rat. Cicila GT, etal., Nat Genet 1993 Apr;3(4):346-53.
5. Rat complement factor H: molecular cloning, sequencing and quantification with a newly established ELISA. Demberg T, etal., Scand J Immunol 2002 Aug;56(2):149-60.
6. Quantitative assessment of CYP11B1 and CYP11B2 expression in aldosterone-producing adenomas. Fallo F, etal., Eur J Endocrinol. 2002 Dec;147(6):795-802.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Aldosterone synthesis in the brain contributes to Dahl salt-sensitive rat hypertension. Gomez-Sanchez EP, etal., Exp Physiol. 2010 Jan;95(1):120-30. Epub 2009 Oct 16.
10. Frame shift by insertion of 2 basepairs in codon 394 of CYP11B1 causes congenital adrenal hyperplasia due to steroid 11 beta-hydroxylase deficiency. Helmberg A, etal., J Clin Endocrinol Metab 1992 Nov;75(5):1278-81.
11. Long-term dose-dependent response of Mequindox on aldosterone, corticosterone and five steroidogenic enzyme mRNAs in the adrenal of male rats. Huang XJ, etal., Toxicol Lett. 2009 Dec 15;191(2-3):167-73. Epub 2009 Sep 4.
12. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
13. A chimaeric 11 beta-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension. Lifton RP, etal., Nature. 1992 Jan 16;355(6357):262-5.
14. Direct effects of IL-15 on corticosterone secretion by rat adrenocortical cells. Lo MJ and Lee SD, Immunol Cell Biol. 2006 Feb;84(1):38-43.
15. Molecular cloning and expression of cDNAS encoding rat aldosterone synthase: variants of cytochrome P-450(11 beta). Matsukawa N, etal., Biochem Biophys Res Commun 1990 May 31;169(1):245-52.
16. Dahl's salt-resistant normotensive rat has mutations in cytochrome P450(11 beta), but the salt-sensitive hypertensive rat does not. Matsukawa N, etal., J Biol Chem 1993 Apr 25;268(12):9117-21.
17. Fetal pituitary gonadotropin as an initial target of dioxin in its impairment of cholesterol transportation and steroidogenesis in rats. Mutoh J, etal., Endocrinology. 2006 Feb;147(2):927-36. Epub 2005 Oct 27.
18. Ontogeny of immunoreactive and bioactive microsomal steroidogenic enzymes during adrenocortical development in rats. Nagaya M, etal., Mol Cell Endocrinol. 1995 Oct 30;114(1-2):27-34.
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. Development of relevant assay system to identify steroidogenic enzyme inhibitors. Nishizato Y, etal., Toxicol In Vitro. 2010 Mar;24(2):677-85. Epub 2009 Aug 7.
1 to 20 of 31 rows
PMID:2551730   PMID:8473352   PMID:12459034   PMID:22217827  



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Variants in Cyp11b1
35 total Variants

1 to 10 of 36 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7103146217116738842Rat

1 to 10 of 36 rows
D7Wox19  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27106,839,225 - 106,839,474 (+)MAPPERmRatBN7.2
Rnor_6.07116,249,395 - 116,249,643NCBIRnor6.0
Rnor_5.07116,151,764 - 116,152,012UniSTSRnor5.0
RGSC_v3.47113,044,000 - 113,044,249RGDRGSC3.4
RGSC_v3.47113,044,001 - 113,044,249UniSTSRGSC3.4
RGSC_v3.17113,078,230 - 113,078,479RGD
Celera7103,211,613 - 103,211,868UniSTS
RH 3.4 Map7772.3UniSTS
RH 3.4 Map7772.3RGD
RH 2.0 Map7606.1RGD
Cytogenetic Map7q34UniSTS
D7Wox16  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.07116,151,707 - 116,151,991NCBIRnor5.0
Rnor_5.07116,098,481 - 116,098,761NCBIRnor5.0
Rnor_5.07116,058,408 - 116,058,688NCBIRnor5.0
RGSC_v3.47113,012,736 - 113,013,015RGDRGSC3.4
RGSC_v3.47113,043,945 - 113,044,228RGDRGSC3.4
RGSC_v3.47112,977,966 - 112,978,266RGDRGSC3.4
RGSC_v3.17113,012,196 - 113,012,496RGD
Celera7103,211,558 - 103,211,847UniSTS
Celera7103,180,377 - 103,180,655UniSTS
RH 3.4 Map7771.9RGD
RH 3.4 Map7771.9UniSTS
RH 2.0 Map7605.5RGD
Cytogenetic Map7q34UniSTS
D7Wox18  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27106,741,074 - 106,741,295 (+)MAPPERmRatBN7.2
mRatBN7.27106,773,255 - 106,773,476 (+)MAPPERmRatBN7.2
Rnor_6.07116,226,796 - 116,227,016NCBIRnor6.0
Rnor_5.07116,129,165 - 116,129,385UniSTSRnor5.0
RGSC_v3.47112,978,051 - 112,978,272RGDRGSC3.4
RGSC_v3.47112,978,052 - 112,978,272UniSTSRGSC3.4
RGSC_v3.17113,012,281 - 113,012,502RGD
RH 3.4 Map7764.8RGD
RH 3.4 Map7764.8UniSTS
RH 2.0 Map7608.7RGD
Cytogenetic Map7q34UniSTS
D7Mco7  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.07116,059,683 - 116,060,096NCBIRnor5.0
Rnor_5.07116,059,684 - 116,060,096NCBIRnor5.0
Rnor_5.07116,099,756 - 116,100,169NCBIRnor5.0
RGSC_v3.47112,979,257 - 112,979,667UniSTSRGSC3.4
RGSC_v3.47112,979,256 - 112,979,667RGDRGSC3.4
RGSC_v3.47113,014,011 - 113,014,423RGDRGSC3.4
RGSC_v3.17113,048,241 - 113,048,653RGD
Cytogenetic Map7q34UniSTS


The following Strains have been annotated to Cyp11b1
LEW.SS-(D7Rat73-D7Rat128)/Ayd     SD     SS.LEW-(D7Rat73-D7Rat128)/Ayd     SS.SR-Cyp11b1/Jr    






RefSeq Transcripts NM_012537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000038109   ⟹   ENSRNOP00000035538
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7106,773,762 - 106,779,278 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000068707   ⟹   ENSRNOP00000062325
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7106,741,581 - 106,747,485 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000091401   ⟹   ENSRNOP00000075065
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7106,740,418 - 106,779,278 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097748   ⟹   ENSRNOP00000094187
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7106,718,274 - 106,723,103 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099698   ⟹   ENSRNOP00000078853
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7106,718,274 - 106,747,485 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105810   ⟹   ENSRNOP00000078562
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7106,718,274 - 106,723,103 (-)Ensembl
RefSeq Acc Id: NM_012537   ⟹   NP_036669
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87108,653,385 - 108,660,062 (-)NCBI
mRatBN7.27106,772,599 - 106,779,278 (-)NCBI
RGSC_v3.47112,977,395 - 112,984,080 (-)RGD
Protein RefSeqs NP_036669 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM16081 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000062325
GenBank Protein P15393 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036669   ⟸   NM_012537
- Peptide Label: precursor
- UniProtKB: Q64655 (UniProtKB/Swiss-Prot),   P15393 (UniProtKB/Swiss-Prot),   A0A0G2K9N5 (UniProtKB/TrEMBL),   A0A0G2QC14 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000094187   ⟸   ENSRNOT00000097748
Ensembl Acc Id: ENSRNOP00000035538   ⟸   ENSRNOT00000038109
Ensembl Acc Id: ENSRNOP00000078853   ⟸   ENSRNOT00000099698
Ensembl Acc Id: ENSRNOP00000062325   ⟸   ENSRNOT00000068707

Name Modeler Protein Id AA Range Protein Structure
AF-P15393-F1-model_v2 AlphaFold P15393 1-499 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 29 of 29 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-33008 BioCyc
Ensembl Genes ENSRNOG00000068909 Ensembl
  ENSRNOG00000071398 ENTREZGENE
Ensembl Transcript ENSRNOT00000068707 ENTREZGENE
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot
InterPro CYP11_CYP27_families UniProtKB/Swiss-Prot
  Cyt_P450 UniProtKB/Swiss-Prot
  Cyt_P450_CS UniProtKB/Swiss-Prot
  Cyt_P450_mitochondrial UniProtKB/Swiss-Prot
  Cyt_P450_sf UniProtKB/Swiss-Prot
NCBI Gene Cyp11b1 ENTREZGENE
PANTHER PTHR24279 UniProtKB/Swiss-Prot
  STEROID 11-BETA-MONOOXYGENASE UniProtKB/Swiss-Prot
Pfam p450 UniProtKB/Swiss-Prot
PhenoGen Cyp11b1 PhenoGen
PRINTS MITP450 UniProtKB/Swiss-Prot
  P450 UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000068909 RatGTEx
  ENSRNOG00000071398 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot
UniProt A0A0G2K9N5 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2QC14 ENTREZGENE
  A0A8I5ZL64_RAT UniProtKB/TrEMBL
  A0A8I5ZLT2_RAT UniProtKB/TrEMBL
  A0A8I6AMK4_RAT UniProtKB/TrEMBL
  C11B1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q64655 ENTREZGENE
UniProt Secondary Q64655 UniProtKB/Swiss-Prot
1 to 29 of 29 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Cyp11b1  cytochrome P450, family 11, subfamily b, polypeptide 1  LOC100910462  cytochrome P450 11B1, mitochondrial-like  Data merged from RGD:6498232 737654 PROVISIONAL
2012-07-05 LOC100910462  cytochrome P450 11B1, mitochondrial-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-04-19 Cyp11b1  cytochrome P450, family 11, subfamily b, polypeptide 1  Cyp11b1  cytochrome P450, subfamily 11B, polypeptide 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Cyp11b1  cytochrome P450, subfamily 11B, polypeptide 1    Cytochrome P450, subfamily XIB, polypeptide 1 (steroid 11-beta-hydroxylase)  Name updated 625702 APPROVED
2002-06-10 Cyp11b1  Cytochrome P450, subfamily XIB, polypeptide 1 (steroid 11-beta-hydroxylase)      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_disease upregulated in Cushings syndrome 70385
gene_disease candidate gene for a QTL affecting blood pressure (Bp61) 69709
gene_expression expressed in leydig cells 70385
gene_function catalyzes 11-beta-hydroxylation of steroids to produce 11-beta-OH-steroid derivatives 70385
gene_mutations_overexpression mutant allele that may play a role in salt hypertension resistance is found in Dahl salt resistant strain SR/Jr 69709
gene_mutations_overexpression mutant allele found in SR/Jr rat encodes five amino acid substitutions and is associated with reduced synthesis of 18-hydroxy-11-deoxycorticosterone (18-OH-DOC) 69709
gene_process functions in glucocorticoid biosynthesis 70385