RGD Reference Report - Long-term dose-dependent response of Mequindox on aldosterone, corticosterone and five steroidogenic enzyme mRNAs in the adrenal of male rats. - Rat Genome Database

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Long-term dose-dependent response of Mequindox on aldosterone, corticosterone and five steroidogenic enzyme mRNAs in the adrenal of male rats.

Authors: Huang, XJ  Ihsan, A  Wang, X  Dai, MH  Wang, YL  Su, SJ  Xue, XJ  Yuan, ZH 
Citation: Huang XJ, etal., Toxicol Lett. 2009 Dec 15;191(2-3):167-73. Epub 2009 Sep 4.
RGD ID: 4460910
Pubmed: PMID:19733641   (View Abstract at PubMed)
DOI: DOI:10.1016/j.toxlet.2009.08.021   (Journal Full-text)

Mequindox (MEQ) is a synthetic quinoxaline 1,4-dioxides (QdNOs) derivative which can effectively improve growth and feed efficiency in animals. This study was to investigate the dose-dependent long-term toxicity in the adrenal of male rats exposed to 180 days of MEQ feed. Our data demonstrated that high doses of MEQ in the diet for 180 days led to adrenal damage and steroid hormone decrease, combined with sodium decrease and potassium increase in rat plasma. Significant changes of GSH and SOD in plasma were observed in the high doses (110, 275 mg/kg) groups. At the same doses, MEQ treatment down-regulated the mRNA levels of CYP11A1, CYP11B1 and CYP11B2 which located in mitochondria, but up-regulated mRNA levels of CYP21 and 3beta-HSD which located in endoplasmic reticulum. In conclusion, we reported the dose-dependent long-term toxicity of MEQ on adrenal gland in male rats, which raise awareness of its toxic effects to animals and consumers, and its mechanism may involve in oxidative stress and steroid hormone biosynthesis pathway.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Cyp11b1Ratresponse to xenobiotic stimulus  IEP MequindoxRGD 

Objects Annotated

Genes (Rattus norvegicus)
Cyp11b1  (cytochrome P450, family 11, subfamily b, polypeptide 1)

Objects referenced in this article
Gene Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 Rattus norvegicus

Additional Information