Tymp (thymidine phosphorylase) - Rat Genome Database

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Gene: Tymp (thymidine phosphorylase) Rattus norvegicus
Analyze
Symbol: Tymp
Name: thymidine phosphorylase
RGD ID: 1305756
Description: Predicted to enable protein homodimerization activity and thymidine phosphorylase activity. Predicted to be involved in several processes, including dTMP catabolic process; regulation of gastric motility; and regulation of myelination. Predicted to be located in mitochondrial inner membrane and myofibril. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; mitochondrial DNA depletion syndrome 1; mitochondrial encephalomyopathy; pancreatic cancer; and transitional cell carcinoma. Orthologous to human TYMP (thymidine phosphorylase); PARTICIPATES IN beta-ureidopropionase deficiency pathway; capecitabine pharmacodynamics pathway; capecitabine pharmacokinetics pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ecgf1; endothelial cell growth factor 1 (platelet-derived); LOC315219; MGC108801; MGC112734; tdRPase; TP
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87122,318,396 - 122,323,716 (-)NCBIGRCr8
mRatBN7.27120,438,768 - 120,444,088 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7120,438,770 - 120,443,874 (-)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl7120,438,125 - 120,447,429 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7122,190,265 - 122,195,391 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07124,416,419 - 124,421,545 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07124,379,128 - 124,384,252 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07130,342,481 - 130,347,845 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7130,342,483 - 130,347,587 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07130,027,662 - 130,033,050 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47127,666,518 - 127,671,624 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17127,700,749 - 127,705,854 (-)NCBI
Celera7116,911,732 - 116,916,838 (-)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
autism spectrum disorder  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
cervical squamous cell carcinoma  (ISO)
Choroidal Neovascularization  (IEP)
chromosome 22q13 duplication syndrome  (ISO)
Colonic Neoplasms  (ISO)
Colorectal Neoplasms  (ISO)
common bile duct neoplasm  (ISO)
congenital adrenal hyperplasia  (ISO)
congenital disorder of glycosylation Ig  (ISO)
COX deficiency, infantile mitochondrial myopathy  (ISO)
cytochrome-c oxidase deficiency disease  (ISO)
ductal carcinoma in situ  (ISO)
Dysmyelinating Leukodystrophy with Oligodontia  (ISO)
endometrial cancer  (ISO)
esophagus squamous cell carcinoma  (ISO)
gallbladder carcinoma  (ISO)
genetic disease  (ISO)
hypomyelinating leukodystrophy 7  (ISO)
intellectual disability  (ISO)
Lipoyltransferase 1 Deficiency  (ISO)
lung non-small cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
megaconial type congenital muscular dystrophy  (ISO)
metachromatic leukodystrophy  (ISO)
mitochondrial complex IV deficiency nuclear type 1  (ISO)
mitochondrial complex IV deficiency nuclear type 2  (ISO)
mitochondrial DNA depletion syndrome 1  (ISO)
mitochondrial DNA depletion syndrome 8A  (ISO)
mitochondrial DNA depletion syndrome 8b  (ISO)
Mitochondrial DNA Depletion Syndrome, MNGIE Type  (ISO)
mitochondrial encephalomyopathy  (ISO)
Myopia 6  (ISO)
Neoplasm Metastasis  (ISO)
ovarian cancer  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
Phelan-McDermid syndrome  (ISO)
renal cell carcinoma  (ISO)
seminoma  (ISO)
spinal muscular atrophy  (ISO)
Stomach Neoplasms  (ISO)
teratoma  (ISO)
transitional cell carcinoma  (ISO)
urinary bladder cancer  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-amino-4,6-dinitrotoluene  (EXP)
2-deoxy-alpha-D-ribose 1-phosphate  (ISO)
2-deoxy-D-ribofuranose 1-phosphate  (ISO)
4'-epidoxorubicin  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
5-fluorouracil  (ISO)
5-formyltetrahydrofolic acid  (ISO)
acetamide  (EXP)
acetylleucyl-leucyl-norleucinal  (ISO)
acetylsalicylic acid  (ISO)
actinomycin D  (ISO)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
Aurothioglucose  (ISO)
benzo[a]pyrene  (ISO)
beta-carotene  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dioxygen  (ISO)
doxifluridine  (EXP,ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
fenthion  (ISO)
fipronil  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
gemcitabine  (ISO)
glyphosate  (EXP)
gossypol  (ISO)
hydrazine  (ISO)
irinotecan  (ISO)
iron dichloride  (ISO)
ivermectin  (ISO)
Lasiocarpine  (ISO)
lipopolysaccharide  (ISO)
methidathion  (ISO)
mitomycin C  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitrofen  (EXP)
nocodazole  (ISO)
obeticholic acid  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
pemetrexed  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
propiconazole  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salinomycin  (ISO)
SB 203580  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
stavudine  (ISO)
sulfasalazine  (ISO)
tanespimycin  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
thioacetamide  (EXP)
thymidine  (ISO)
thymine  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
vitamin E  (ISO)
zalcitabine  (ISO)
zidovudine  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. The role of thymidine phosphorylase and thrombospondin-1 in angiogenesis and progression of intrahepatic cholangiocarcinoma. Aishima S, etal., Int J Surg Pathol. 2002 Jan;10(1):47-56.
2. Cooperative stimulation of vascular endothelial growth factor expression by hypoxia and reactive oxygen species: the effect of targeting vascular endothelial growth factor and oxidative stress in an orthotopic xenograft model of bladder carcinoma. Brown NS, etal., Br J Cancer. 2005 May 9;92(9):1696-701.
3. Up-regulation of thymidine phosphorylase expression is associated with a discrete pattern of angiogenesis in ductal carcinomas in situ of the breast. Engels K, etal., J Pathol. 1997 Aug;182(4):414-20.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Role of tumor angiogenesis in gallbladder carcinoma: with special reference to thymidine phosphorylase. Harino Y, etal., Int J Clin Oncol. 2008 Oct;13(5):452-7. Epub 2008 Oct 23.
7. Prognostic value of thymidine phosphorylase expression for pancreatic cancer. Hong SP, etal., Hepatogastroenterology. 2009 Jul-Aug;56(93):1178-82.
8. Angiogenesis and lymphangiogenesis in stage 1 germ cell tumours of the testis. Jones A, etal., BJU Int. 2000 Jul;86(1):80-6.
9. The activity of thymidine phosphorylase correlates with tumor size and lymph nodes status in breast carcinoma. Kubiak R, etal., Z Naturforsch C. 1999 Dec;54(12):1096-102.
10. Antiangiogenic and antitumor activity of 6-(2-aminoethyl)amino-5-chlorouracil, a novel small-molecule inhibitor of thymidine phosphorylase, in combination with the vascular endothelial growth factor-trap. Lu H, etal., Clin Cancer Res. 2009 Aug 15;15(16):5136-44. Epub 2009 Aug 11.
11. A role of thymidine phosphorylase and P53 tissue protein expression in biology of endometrial cancer. Mazurek A, etal., Neoplasma. 2008;55(3):261-5.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. The activity of thymidine phosphorylase as a new ovarian tumor marker. Miszczak-Zaborska E, etal., Gynecol Oncol. 2004 Jul;94(1):86-92.
14. Gan to kagaku ryoho. Cancer & chemotherapy Morimoto Y, etal., Gan To Kagaku Ryoho. 2004 Dec;31(13):2195-8.
15. Expression of thymidine phosphorylase as an effect prediction factor for uterine cervical squamous cell carcinoma after radiotherapy: an immunohistochemical study. Nakashima M, etal., Int J Gynecol Cancer. 2006 May-Jun;16(3):1309-13.
16. Thymidine phosphorylase gene mutations in MNGIE, a human mitochondrial disorder. Nishino I, etal., Science. 1999 Jan 29;283(5402):689-92.
17. The expression of thymidine phosphorylase is a prognostic predictor for the intravesical recurrence of superficial bladder cancer. Nonomura N, etal., Int J Clin Oncol. 2006 Aug;11(4):297-302.
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
21. Thymidine phosphorylase expression is associated with time to progression in patients receiving low-dose, docetaxel-modulated capecitabine for metastatic breast cancer. Puglisi F, etal., Ann Oncol. 2008 Apr 25;.
22. GOA pipeline RGD automated data pipeline
23. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Comprehensive gene review and curation RGD comprehensive gene curation
26. High levels of thymidine phosphorylase as an independent prognostic factor in renal cell carcinoma. Takayama T, etal., Jpn J Clin Oncol. 2006 Sep;36(9):564-9. Epub 2006 Jul 22.
27. Thymidine phosphorylase levels as a prognostic factor in renal cell carcinoma. Wada S, etal., BJU Int. 2003 Jan;91(1):105-8.
28. Subconjunctival doxifluridine administration suppresses rat choroidal neovascularization through activated thymidine phosphorylase. Yanagi Y, etal., Invest Ophthalmol Vis Sci. 2003 Feb;44(2):751-4.
29. [Relationships among the expression of thymidylate synthase, thymidine phosphorylase, and dihydropyrimidine dehydrogenase and the prognosis of breast cancer] Yu ZG, etal., Zhonghua Yi Xue Za Zhi. 2006 Jun 13;86(22):1558-63.
30. Significance of thymidine phosphorylase/platelet-derived endothelial cell growth factor in carcinoma of the papilla of Vater. Zhao B, etal., Jpn J Cancer Res. 2000 Mar;91(3):331-6.
Additional References at PubMed
PMID:1590793   PMID:7284378   PMID:12477932   PMID:17681069  


Genomics

Comparative Map Data
Tymp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87122,318,396 - 122,323,716 (-)NCBIGRCr8
mRatBN7.27120,438,768 - 120,444,088 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7120,438,770 - 120,443,874 (-)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl7120,438,125 - 120,447,429 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7122,190,265 - 122,195,391 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07124,416,419 - 124,421,545 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07124,379,128 - 124,384,252 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07130,342,481 - 130,347,845 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7130,342,483 - 130,347,587 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07130,027,662 - 130,033,050 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47127,666,518 - 127,671,624 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17127,700,749 - 127,705,854 (-)NCBI
Celera7116,911,732 - 116,916,838 (-)NCBICelera
Cytogenetic Map7q34NCBI
TYMP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382250,525,752 - 50,530,085 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2250,525,752 - 50,530,032 (-)EnsemblGRCh38hg38GRCh38
GRCh372250,964,181 - 50,968,514 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362249,311,047 - 49,315,321 (-)NCBINCBI36Build 36hg18NCBI36
Build 342249,254,324 - 49,258,599NCBI
Celera2234,840,208 - 34,844,541 (-)NCBICelera
Cytogenetic Map22q13.33ENTREZGENE
HuRef2233,855,199 - 33,859,532 (-)NCBIHuRef
CHM1_12250,922,918 - 50,927,220 (-)NCBICHM1_1
T2T-CHM13v2.02251,036,317 - 51,040,646 (-)NCBIT2T-CHM13v2.0
Tymp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391589,255,834 - 89,261,282 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1589,256,134 - 89,261,242 (-)EnsemblGRCm39 Ensembl
GRCm381589,371,631 - 89,377,036 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1589,371,931 - 89,377,039 (-)EnsemblGRCm38mm10GRCm38
MGSCv371589,202,362 - 89,207,467 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361589,199,698 - 89,204,803 (-)NCBIMGSCv36mm8
Celera1591,501,072 - 91,506,177 (-)NCBICelera
Cytogenetic Map15E3NCBI
cM Map1544.86NCBI
Tymp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541333,505,446 - 33,508,748 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541333,505,424 - 33,509,095 (-)NCBIChiLan1.0ChiLan1.0
TYMP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22360,443,429 - 60,450,209 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12263,136,432 - 63,140,968 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02230,772,088 - 30,776,618 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12249,883,129 - 49,886,996 (-)NCBIpanpan1.1PanPan1.1panPan2
Tymp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945315,033 - 319,093 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936629315,610 - 319,076 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936629315,609 - 320,356 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TYMP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11932,997,337 - 33,001,558 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1932,997,304 - 33,001,215 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604592,341,070 - 92,345,265 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tymp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624752252,937 - 256,244 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624752251,670 - 256,243 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tymp
17 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:100
Count of miRNA genes:84
Interacting mature miRNAs:88
Transcripts:ENSRNOT00000040541
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)7116677189127103496Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
1582240Sffal1Serum free fatty acids level QTL 13.40.0021blood free fatty acid amount (VT:0001553)serum free fatty acids level (CMO:0000547)7116677010124049952Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat

Markers in Region
RH128722  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27120,438,507 - 120,438,709 (+)MAPPERmRatBN7.2
Rnor_6.07130,342,221 - 130,342,422NCBIRnor6.0
Rnor_5.07130,027,402 - 130,027,603UniSTSRnor5.0
RGSC_v3.47127,666,258 - 127,666,459UniSTSRGSC3.4
Celera7116,911,472 - 116,911,673UniSTS
RH 3.4 Map7948.7UniSTS
Cytogenetic Map7q34UniSTS
RH129073  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27120,439,749 - 120,439,903 (+)MAPPERmRatBN7.2
Rnor_6.07130,343,463 - 130,343,616NCBIRnor6.0
Rnor_5.07130,028,644 - 130,028,797UniSTSRnor5.0
RGSC_v3.47127,667,500 - 127,667,653UniSTSRGSC3.4
Celera7116,912,714 - 116,912,867UniSTS
RH 3.4 Map7958.5UniSTS
Cytogenetic Map7q34UniSTS
RH139883  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27120,438,861 - 120,439,050 (+)MAPPERmRatBN7.2
Rnor_6.07130,342,575 - 130,342,763NCBIRnor6.0
Rnor_5.07130,027,756 - 130,027,944UniSTSRnor5.0
RGSC_v3.47127,666,612 - 127,666,800UniSTSRGSC3.4
Celera7116,911,826 - 116,912,014UniSTS
RH 3.4 Map7961.8UniSTS
Cytogenetic Map7q34UniSTS
RH136025  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27120,439,191 - 120,439,377 (+)MAPPERmRatBN7.2
Rnor_6.07130,342,905 - 130,343,090NCBIRnor6.0
Rnor_5.07130,028,086 - 130,028,271UniSTSRnor5.0
RGSC_v3.47127,666,942 - 127,667,127UniSTSRGSC3.4
Celera7116,912,156 - 116,912,341UniSTS
Cytogenetic Map7q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 9 9 169 95 57 95 3 9 158 39 45 41 3
Low 132 58 52 52 33 36 92 76 100 21
Below cutoff

Sequence


Ensembl Acc Id: ENSRNOT00000040541   ⟹   ENSRNOP00000039935
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7120,438,770 - 120,443,874 (-)Ensembl
Rnor_6.0 Ensembl7130,342,483 - 130,347,587 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095915   ⟹   ENSRNOP00000091776
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7120,438,125 - 120,441,206 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096628   ⟹   ENSRNOP00000084065
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7120,438,125 - 120,447,429 (-)Ensembl
RefSeq Acc Id: NM_001012122   ⟹   NP_001012122
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87122,318,396 - 122,323,521 (-)NCBI
mRatBN7.27120,438,768 - 120,443,893 (-)NCBI
Rnor_6.07130,342,481 - 130,347,587 (-)NCBI
Rnor_5.07130,027,662 - 130,033,050 (-)NCBI
RGSC_v3.47127,666,518 - 127,671,624 (-)RGD
Celera7116,911,732 - 116,916,838 (-)RGD
Sequence:
RefSeq Acc Id: XM_006242209   ⟹   XP_006242271
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87122,318,396 - 122,323,586 (-)NCBI
mRatBN7.27120,438,768 - 120,444,088 (-)NCBI
Rnor_6.07130,342,481 - 130,347,685 (-)NCBI
Rnor_5.07130,027,662 - 130,033,050 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008765730   ⟹   XP_008763952
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87122,318,396 - 122,323,586 (-)NCBI
mRatBN7.27120,438,768 - 120,444,088 (-)NCBI
Rnor_6.07130,342,481 - 130,347,685 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039079309   ⟹   XP_038935237
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87122,318,396 - 122,323,586 (-)NCBI
mRatBN7.27120,438,768 - 120,444,088 (-)NCBI
RefSeq Acc Id: XM_039079310   ⟹   XP_038935238
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87122,318,396 - 122,323,586 (-)NCBI
mRatBN7.27120,438,768 - 120,444,088 (-)NCBI
RefSeq Acc Id: XM_039079311   ⟹   XP_038935239
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87122,318,396 - 122,321,760 (-)NCBI
mRatBN7.27120,438,768 - 120,442,030 (-)NCBI
RefSeq Acc Id: XM_039079313   ⟹   XP_038935241
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87122,320,075 - 122,323,716 (-)NCBI
mRatBN7.27120,439,462 - 120,444,088 (-)NCBI
RefSeq Acc Id: XM_063263653   ⟹   XP_063119723
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87122,320,075 - 122,323,716 (-)NCBI
RefSeq Acc Id: NP_001012122   ⟸   NM_001012122
- UniProtKB: Q5FVR2 (UniProtKB/Swiss-Prot),   A6K7M1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242271   ⟸   XM_006242209
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008763952   ⟸   XM_008765730
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000039935   ⟸   ENSRNOT00000040541
RefSeq Acc Id: XP_038935238   ⟸   XM_039079310
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038935237   ⟸   XM_039079309
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038935239   ⟸   XM_039079311
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038935241   ⟸   XM_039079313
- Peptide Label: isoform X7
Ensembl Acc Id: ENSRNOP00000091776   ⟸   ENSRNOT00000095915
Ensembl Acc Id: ENSRNOP00000084065   ⟸   ENSRNOT00000096628
RefSeq Acc Id: XP_063119723   ⟸   XM_063263653
- Peptide Label: isoform X6
Protein Domains
Pyrimidine nucleoside phosphorylase C-terminal   Thioredoxin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5FVR2-F1-model_v2 AlphaFold Q5FVR2 1-476 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695587
Promoter ID:EPDNEW_R6111
Type:multiple initiation site
Name:Tymp_1
Description:thymidine phosphorylase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07130,347,611 - 130,347,671EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305756 AgrOrtholog
BioCyc Gene G2FUF-32439 BioCyc
BioCyc Pathway PWY-7181 [pyrimidine deoxyribonucleosides degradation] BioCyc
BioCyc Pathway Image PWY-7181 BioCyc
Ensembl Genes ENSRNOG00000032394 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00000066458 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00065017079 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000040541.5 UniProtKB/Swiss-Prot
  ENSRNOT00000095915.1 UniProtKB/TrEMBL
  ENSRNOT00000096628.1 UniProtKB/TrEMBL
  ENSRNOT00065028522 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.1030.10 UniProtKB/Swiss-Prot
  3.90.1170.30 UniProtKB/Swiss-Prot
  Glutaredoxin UniProtKB/TrEMBL
  Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain UniProtKB/TrEMBL
  Pyrimidine nucleoside phosphorylase-like, C-terminal domain UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7323197 IMAGE-MGC_LOAD
InterPro Glycosyl_Trfase_fam3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glycosyl_Trfase_fam3_N_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glycosyl_Trfase_fam3_N_dom)sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuc_phospho_transferase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PYNP-like_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PYNP_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyrmidine_PPas_bac/euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SCO1/SenC UniProtKB/TrEMBL
  Synth_of_cyt-c-oxidase_Sco1/2 UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/TrEMBL
  Thioredoxin_domain UniProtKB/TrEMBL
  Thymidine/pyrmidine_PPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:315219 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:108801 IMAGE-MGC_LOAD
NCBI Gene 315219 ENTREZGENE
PANTHER PROTEIN SCO2 HOMOLOG, MITOCHONDRIAL UniProtKB/TrEMBL
  PTHR10515 UniProtKB/Swiss-Prot
  PTHR12151 UniProtKB/TrEMBL
  THYMIDINE PHOSPHORYLASE UniProtKB/Swiss-Prot
  THYMIDINE PHOSPHORYLASE UniProtKB/TrEMBL
  THYMIDINE PHOSPHORYLASE UniProtKB/TrEMBL
Pfam Glycos_trans_3N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glycos_transf_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PYNP_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SCO1-SenC UniProtKB/TrEMBL
PharmGKB TYMP RGD
PhenoGen Tymp PhenoGen
PIRSF SCO1 UniProtKB/TrEMBL
  TP_PyNP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE THIOREDOXIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000032394 RatGTEx
  ENSRNOG00000066458 RatGTEx
  ENSRNOG00065017079 RatGTEx
SMART PYNP_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain UniProtKB/TrEMBL
  Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain UniProtKB/TrEMBL
  Pyrimidine nucleoside phosphorylase C-terminal domain UniProtKB/TrEMBL
  SSF47648 UniProtKB/Swiss-Prot
  SSF52418 UniProtKB/Swiss-Prot
  SSF52833 UniProtKB/TrEMBL
  SSF54680 UniProtKB/Swiss-Prot
UniProt A0A8I5ZWG1_RAT UniProtKB/TrEMBL
  A6K7M1 ENTREZGENE, UniProtKB/TrEMBL
  Q5FVR2 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-04 Tymp  thymidine phosphorylase  Ecgf1  endothelial cell growth factor 1 (platelet-derived)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Ecgf1  endothelial cell growth factor 1 (platelet-derived)  Ecgf1_predicted  endothelial cell growth factor 1 (platelet-derived) (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Ecgf1_predicted  endothelial cell growth factor 1 (platelet-derived) (predicted)      Symbol and Name status set to approved 70820 APPROVED