Gpt (glutamic--pyruvic transaminase) - Rat Genome Database

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Gene: Gpt (glutamic--pyruvic transaminase) Rattus norvegicus
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Symbol: Gpt
Name: glutamic--pyruvic transaminase
RGD ID: 621720
Description: Involved in cellular response to insulin stimulus; positive regulation of gluconeogenesis; and response to starvation. Located in cytoplasm and extracellular space. Biomarker of type 2 diabetes mellitus. Orthologous to human GPT (glutamic--pyruvic transaminase); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; alanine metabolic pathway; argininosuccinic aciduria pathway; INTERACTS WITH (+)-schisandrin B; (+)-taxifolin; (-)-epigallocatechin 3-gallate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: alanine aminotransferase 1; ALAT; ALT1; glutamate pyruvate transaminase 1; glutamic pyruvate transaminase; glutamic pyruvic transaminase (alanine aminotrasferase); glutamic pyruvic transaminase 1, soluble; glutamic--alanine transaminase 1; glutamic--pyruvic transaminase 1; glutamic-pyruvate transaminase (alanine aminotransferase); GPT 1; Gpt1
RGD Orthologs
Human
Mouse
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27108,416,646 - 108,419,495 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7108,416,642 - 108,419,494 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7110,158,569 - 110,161,418 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.07112,382,143 - 112,384,992 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.07112,342,892 - 112,345,741 (+)NCBIRnor_WKY
Rnor_6.07117,759,083 - 117,761,932 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7117,759,083 - 117,761,931 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07117,745,308 - 117,749,938 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47114,746,054 - 114,748,903 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7104,766,538 - 104,769,387 (+)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-isoborneol  (ISO)
(+)-pilocarpine  (ISO)
(+)-schisandrin B  (EXP)
(+)-taxifolin  (EXP)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(E)-thiamethoxam  (EXP)
(R)-lipoic acid  (EXP)
(R,R)-tramadol  (EXP)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-naringenin  (EXP)
1,1,2-trichloroethane  (EXP)
1,1-dichloroethene  (ISO)
1,2-dichlorobenzene  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dichloropropan-2-ol  (ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (EXP)
1-bromopropane  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
1H-1,2,4-triazole  (EXP)
2',4',6'-trihydroxyacetophenone  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
2-amino-2-deoxy-D-galactopyranose  (EXP,ISO)
2-chloroethanol  (ISO)
2-methoxyethanol  (EXP)
2-methyl-6-(phenylethynyl)pyridine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-hydroxybutyric acid  (ISO)
3-methyladenine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (EXP,ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (EXP)
5-fluorouracil  (EXP,ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
7,12-dimethyltetraphene  (EXP)
7,8-dihydroxycoumarin  (EXP)
8-Epidiosbulbin E acetate  (ISO)
9,11,13-octadecatrienoic acid  (EXP)
acephate  (EXP)
acetaldehyde  (ISO)
acetamide  (EXP)
acetamiprid  (EXP)
acetylleucyl-leucyl-norleucinal  (ISO)
acetylsalicylic acid  (EXP)
acrolein  (EXP)
acrylamide  (EXP,ISO)
actinomycin D  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP)
alectinib  (ISO)
all-trans-retinol  (EXP)
allethrin  (EXP)
allicin  (ISO)
alloxan  (EXP)
allyl alcohol  (EXP,ISO)
allyl isothiocyanate  (EXP)
allyl methyl disulfide  (ISO)
alpha-amanitin  (ISO)
alpha-D-galactose  (ISO)
alpha-galactosylceramide  (ISO)
alpha-linolenic acid  (EXP)
amiodarone  (ISO)
amlexanox  (ISO)
amlodipine  (EXP)
ammonium chloride  (EXP)
Ammothamnine  (EXP)
amodiaquine  (ISO)
andrographolide  (ISO)
Anetholtrithion  (ISO)
angelicin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
arachidonic acid  (ISO)
aristolochic acid  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenous acid  (EXP,ISO)
astragaloside IV  (EXP)
atorvastatin calcium  (EXP,ISO)
aurantio-obtusin  (ISO)
azathioprine  (ISO)
azure A  (EXP)
baicalin  (EXP)
BAY 60-6583  (ISO)
bentonite  (EXP)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
beraprost  (ISO)
berberine  (EXP,ISO)
beta-naphthoflavone  (EXP)
Betanin  (EXP)
bezafibrate  (ISO)
bicuculline  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
boric acid  (EXP)
boron atom  (EXP)
bosentan  (EXP)
bosutinib  (ISO)
bromobenzene  (EXP,ISO)
bromodichloromethane  (ISO)
brucine  (ISO)
buprenorphine  (EXP)
buspirone  (EXP)
Butralin  (EXP)
cabozantinib  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
calciol  (EXP)
Calpeptin  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP)
carbidopa  (ISO)
carbofuran  (EXP)
carbon nanotube  (EXP,ISO)
carfilzomib  (ISO)
carnosic acid  (ISO)
carnosine  (EXP)
carvedilol  (EXP)
catalpol  (ISO)
celastrol  (ISO)
celecoxib  (ISO)
ceritinib  (ISO)
ceruletide  (ISO)
charcoal  (EXP)
chelerythrine  (EXP)
chenodeoxycholic acid  (EXP,ISO)
chlordecone  (ISO)
chlorhexidine gluconate  (EXP)
Chlorobenzilate  (EXP)
Chlorodibromomethane  (ISO)
chloroethene  (ISO)
chloroform  (EXP,ISO)
chlorogenic acid  (EXP,ISO)
chloroquine  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (EXP,ISO)
choline  (EXP,ISO)
chromium(6+)  (EXP,ISO)
chrysin  (EXP)
ciprofloxacin  (ISO)
cis-caffeic acid  (EXP,ISO)
cisplatin  (EXP,ISO)
citral  (EXP)
clodronic acid  (EXP,ISO)
clotrimazole  (ISO)
cobalt dichloride  (EXP)
cobimetinib  (EXP)
cocaine  (ISO)
coenzyme Q10  (EXP,ISO)
Columbin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
crizotinib  (ISO)
crocin-1  (EXP)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
Curcumol  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP,ISO)
D-gluconic acid  (EXP)
D-glucose  (EXP)
dabrafenib  (ISO)
dantrolene  (ISO)
dapagliflozin  (EXP)
DDT  (EXP)
decabromodiphenyl ether  (ISO)
dehydroacetic acid  (EXP)
deoxynivalenol  (EXP,ISO)
deoxypodophyllotoxin  (ISO)
dexamethasone  (ISO)
dexmedetomidine  (EXP)
dextromethorphan  (ISO)
diallyl disulfide  (EXP,ISO)
Diallyl sulfide  (EXP)
diarsenic trioxide  (EXP,ISO)
dibutyl phthalate  (EXP)
diclofenac  (EXP,ISO)
dicloxacillin  (ISO)
dicofol  (EXP)
dicrotophos  (ISO)
diethyl phthalate  (EXP)
diethylene glycol monoethyl ether  (EXP)
dihydroartemisinin  (ISO)
dimethylmercury  (EXP)
Diosbulbin B  (ISO)
dioscin  (EXP)
dioxygen  (ISO)
diquat  (ISO)
disodium selenite  (EXP,ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
duvoglustat  (ISO)
elemental boron  (EXP)
elemental selenium  (EXP)
Elemicin  (ISO)
ellagic acid  (EXP)
emodin  (ISO)
endosulfan  (EXP)
ergothioneine  (EXP)
eriodictyol  (EXP)
eritoran  (ISO)
ethambutol  (EXP)
ethanol  (EXP,ISO)
fenofibrate  (EXP)
fenthion  (ISO)
fenvalerate  (EXP)
ferroheme b  (ISO)
fipronil  (EXP,ISO)
flucloxacillin  (ISO)
flutamide  (ISO)
folic acid  (EXP,ISO)
fomepizole  (EXP,ISO)
fosinopril  (ISO)
fructooligosaccharide  (ISO)
fructose  (EXP,ISO)
fucoidan  (EXP)
fulvestrant  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
gadolinium trichloride  (EXP,ISO)
galactose  (ISO)
gallic acid  (EXP,ISO)
gamma-aminobutyric acid  (ISO)
gamma-hexachlorocyclohexane  (EXP)
Ganoderic acid A  (ISO)
gefitinib  (ISO)
Gelsemine  (ISO)
gemfibrozil  (ISO)
Geniposide  (ISO)
genistein  (EXP)
geranial  (EXP)
geraniol  (EXP)
Ginkgoic acid  (EXP)
Ginkgolide A  (ISO)
ginkgolide B  (ISO)
ginsenoside Rg1  (ISO)
glafenine  (EXP)
glucose  (EXP)
glyburide  (EXP)
glycyrrhetinate  (EXP,ISO)
glycyrrhetinic acid  (EXP,ISO)
glycyrrhizinic acid  (EXP,ISO)
glyphosate  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
Guanabenz  (ISO)
GW 4064  (EXP)
GW 7647  (EXP)
halothane  (ISO)
heme b  (ISO)
heparin  (EXP)
herbacetin  (ISO)
herbicide  (EXP,ISO)
hesperidin  (EXP,ISO)
hexadecanoic acid  (ISO)
homocysteine  (EXP)
hydralazine  (ISO)
hydrogen peroxide  (EXP)
hydrogen sulfide  (EXP)
hydroquinone O-beta-D-glucopyranoside  (EXP,ISO)
ibrutinib  (ISO)
idelalisib  (ISO)
imidacloprid  (EXP)
imiprothrin  (EXP)
inulin  (EXP)
irbesartan  (ISO)
iron atom  (EXP,ISO)
iron dextran  (EXP)
iron(0)  (EXP,ISO)
iron(3+) sulfate  (EXP)
isoniazide  (EXP,ISO)
isoprenaline  (EXP)
isoproturon  (EXP)
isorhamnetin  (ISO)
kaempferol  (ISO)
ketoconazole  (EXP,ISO)
L-ascorbic acid  (EXP,ISO)
L-methionine  (EXP,ISO)
lapatinib  (ISO)
Lasiocarpine  (EXP)
lead diacetate  (ISO)
Leonurine  (EXP)
leupeptin  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
liquiritigenin  (EXP)
liquiritin  (EXP)
liraglutide  (EXP)
lithium atom  (EXP)
lithium hydride  (EXP)
lithocholic acid  (ISO)
losartan  (EXP,ISO)
lovastatin  (ISO)
magnesium atom  (EXP)
malathion  (EXP)
Malotilate  (EXP,ISO)
mancozeb  (EXP)
manganese dioxide  (EXP)
mangiferin  (EXP)
melatonin  (EXP)
mercury dichloride  (EXP,ISO)
mesalamine  (EXP)
metformin  (EXP,ISO)
methamphetamine  (EXP)
methapyrilene  (EXP)
methidathion  (ISO)
methimazole  (EXP,ISO)
methotrexate  (EXP)
methoxsalen  (EXP)
methylmercury chloride  (EXP)
metronidazole  (ISO)
microcystin RR  (ISO)
microcystin-LR  (EXP)
mifepristone  (ISO)
monocrotaline  (EXP,ISO)
monosodium L-glutamate  (ISO)
morin  (EXP)
Muraglitazar  (EXP)
muscimol  (ISO)
myricetin  (EXP)
myricitrin  (ISO)
N,N-dimethylformamide  (ISO)
N,N-dimethylglycine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
naringin  (EXP)
neohesperidin dihydrochalcone  (ISO)
neomycin  (ISO)
nickel atom  (EXP)
nickel dichloride  (EXP,ISO)
nickel sulfate  (EXP,ISO)
nicotinamide  (EXP)
nicotinic acid  (ISO)
nilotinib  (EXP,ISO)
nimesulide  (EXP)
nobiletin  (EXP)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
octamethylcyclotetrasiloxane  (ISO)
octreotide  (EXP)
olaparib  (ISO)
oleanolic acid  (ISO)
oleic acid  (ISO)
oleuropein  (EXP)
orlistat  (EXP)
oroxylin A  (ISO)
osimertinib  (ISO)
Oxadiazon  (ISO)
oxycodone  (EXP)
ozone  (EXP,ISO)
paclobutrazol  (EXP)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
patulin  (ISO)
penconazole  (ISO)
perfluorodecanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perindopril  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenylhydrazine  (EXP,ISO)
phloretin  (ISO)
phorate  (EXP)
Picroside ii  (ISO)
pinocembrin  (ISO)
pioglitazone  (EXP)
piperine  (EXP)
pirfenidone  (ISO)
pirinixic acid  (ISO)
polymyxin B2  (ISO)
polyphosphates  (ISO)
ponatinib  (ISO)
potassium bromate  (EXP)
potassium dichromate  (EXP,ISO)
progesterone  (EXP)
propacetamol  (ISO)
prostaglandin E2  (ISO)
psoralen  (EXP)
puerarin  (ISO)
pyrazine-2-carboxylic acid  (EXP)
pyrazinecarboxamide  (EXP)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-galactopyranoside  (ISO)
rac-1,2-dichloropropane  (EXP)
regorafenib  (ISO)
resveratrol  (EXP,ISO)
Retrorsine  (ISO)
rifampicin  (EXP,ISO)
rimonabant  (EXP,ISO)
rivaroxaban  (EXP)
rosmarinic acid  (EXP)
rotenone  (EXP,ISO)
rottlerin  (EXP,ISO)
Rutecarpine  (ISO)
rutin  (EXP)
ruxolitinib  (ISO)
ryanodine  (ISO)
S-allylcysteine  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
salvianolic acid B  (EXP,ISO)
sarpogrelate  (ISO)
SB 203580  (ISO)
scopoletin  (EXP)
selenium atom  (EXP)
senecionine  (EXP,ISO)
silibinin  (EXP,ISO)
sinapic acid  (EXP)
sirolimus  (EXP,ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sodium fluoride  (EXP,ISO)
sodium nitrite  (EXP)
sodium sulfite  (ISO)
sodium tungstate  (EXP)
Soman  (EXP)
sorafenib  (ISO)
squalene  (EXP)
stattic  (ISO)
streptozocin  (EXP,ISO)
succimer  (EXP)
sucrose  (EXP)
sulfasalazine  (ISO)
sunitinib  (ISO)
syringic acid  (EXP)
T-2 toxin  (ISO)
tamoxifen  (ISO)
tapentadol  (EXP)
taurine  (EXP,ISO)
telmisartan  (EXP)
tert-butyl hydroperoxide  (EXP,ISO)
Tesaglitazar  (EXP)
testosterone cypionate  (ISO)
tetrachloro-1,4-benzoquinone  (ISO)
tetrachloromethane  (EXP,ISO)
tetrahydrocurcumin  (ISO)
thiacloprid  (EXP)
thiamethoxam  (EXP)
thioacetamide  (EXP,ISO)
thymoquinone  (EXP)
thyroxine  (EXP)
titanium dioxide  (EXP,ISO)
tramadol  (EXP)
trans-caffeic acid  (EXP,ISO)
tranylcypromine  (ISO)
trelagliptin  (ISO)
trichloroethene  (EXP,ISO)
Triptolide  (EXP,ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (EXP)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
ursolic acid  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vandetanib  (ISO)
varespladib  (EXP)
verapamil  (EXP)
vildagliptin  (ISO)
vitamin D  (ISO)
vitamin E  (EXP)
vitamin K  (EXP)
withaferin A  (ISO)
zearalenone  (ISO)
zidovudine  (EXP)
zinc atom  (EXP)
zinc molecular entity  (EXP)
zinc oxide  (EXP,ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP)
zolmitriptan  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IDA)
extracellular space  (IDA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GC-MS Analysis: In Vivo Hepatoprotective and Antioxidant Activities of the Essential Oil of Achillea biebersteinii Afan. Growing in Saudi Arabia. Al-Said MS, etal., Evid Based Complement Alternat Med. 2016;2016:1867048. doi: 10.1155/2016/1867048. Epub 2016 May 12.
2. [Rosiglitazone protects against endotoxin-induced acute liver injury in rats]. Bu Y and Yu J, Zhonghua Yi Xue Za Zhi. 2015 Oct 20;95(39):3180-3.
3. A Chinese herbal medicine, Gexia-Zhuyu Tang (GZT), prevents dimethylnitrosamine-induced liver fibrosis through inhibition of hepatic stellate cells proliferation. Chen JY, etal., J Ethnopharmacol. 2012 Aug 1;142(3):811-8. doi: 10.1016/j.jep.2012.06.005. Epub 2012 Jun 15.
4. ANTIOXIDANT ACTIVITY IN VITRO AND HEPATOPROTECTIVE EFFECTS IN VIVO OF COMPOUND LOBELIA. Cui X, etal., Afr J Tradit Complement Altern Med. 2016 Aug 12;13(5):114-122. doi: 10.21010/ajtcam.v13i5.15. eCollection 2016.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Characteristics and course of chronic hepatitis B e antigen-negative infection. Guardiola Arévalo A, etal., Gastroenterol Hepatol. 2017 Feb;40(2):59-69. doi: 10.1016/j.gastrohep.2016.11.002. Epub 2016 Dec 20.
8. Hepatitis B virus e antigen-negative chronic infection. Treatment based on glutamic pyruvic transaminase and hepatitis B virus deoxyribonucleic acid cut-off values. Guardiola-Arévalo A, etal., Gastroenterol Hepatol. 2018 Mar;41(3):153-162. doi: 10.1016/j.gastrohep.2017.11.003. Epub 2017 Dec 24.
9. [Non-alcoholic fatty liver in children and adolescents with excess weight and obesity]. Guijarro de Armas MG, etal., Med Clin (Barc). 2015 Jan 20;144(2):55-8. doi: 10.1016/j.medcli.2014.02.018. Epub 2014 Apr 24.
10. Fasting for 3 days during the suckling-weaning transient period in male rats induces metabolic abnormalities in the liver and is associated with impaired glucose tolerance in adulthood. Ikeda M, etal., Eur J Nutr. 2016 Apr;55(3):1059-67. doi: 10.1007/s00394-015-0919-9. Epub 2015 May 6.
11. Complete amino acid sequence of human liver cytosolic alanine aminotransferase (GPT) determined by a combination of conventional and mass spectral methods. Ishiguro M, etal., Biochemistry 1991 Oct 29;30(43):10451-7.
12. Complete amino acid sequence of rat liver cytosolic alanine aminotransferase. Ishiguro M, etal., Biochemistry. 1991 Jun 18;30(24):6048-53.
13. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
14. Immunological measurement of aspartate/alanine aminotransferase in predicting liver fibrosis and inflammation. Kim HJ, etal., Korean J Intern Med. 2019 Jan 23. pii: kjim.2018.214. doi: 10.3904/kjim.2018.214.
15. Liver protective activity of a hydroethanolic extract of Arrabidaea chica (Humb. and Bonpl.) B. Verl. (pariri). Lima de Medeiros BJ, etal., Pharmacognosy Res. 2011 Apr;3(2):79-84. doi: 10.4103/0974-8490.81954.
16. Increased hepatic expression is a major determinant of serum alanine aminotransferase elevation in mice with nonalcoholic steatohepatitis. Liu R, etal., Liver Int. 2009 Mar;29(3):337-43. doi: 10.1111/j.1478-3231.2008.01862.x. Epub 2008 Aug 14.
17. Clinical relevance of reporting fatty liver on ultrasound in asymptomatic patients during routine health checkups. Mahale AR, etal., J Int Med Res. 2018 Nov;46(11):4447-4454. doi: 10.1177/0300060518793039. Epub 2018 Sep 5.
18. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. Effects of saikosaponins on hepatic damage induced by halothane and hypoxia in phenobarbital-pretreated rats. Nishiura T, etal., J Anesth. 1994 Mar;8(1):87-92. doi: 10.1007/BF02482762.
20. In Silico Modeling of Liver Metabolism in a Human Disease Reveals a Key Enzyme for Histidine and Histamine Homeostasis. Pagliarini R, etal., Cell Rep. 2016 Jun 7;15(10):2292-2300. doi: 10.1016/j.celrep.2016.05.014. Epub 2016 May 26.
21. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
22. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
23. Hepatic ALT isoenzymes are elevated in gluconeogenic conditions including diabetes and suppressed by insulin at the protein level. Qian K, etal., Diabetes Metab Res Rev. 2015 Sep;31(6):562-71. doi: 10.1002/dmrr.2655. Epub 2015 Jun 17.
24. Isoform-specific alanine aminotransferase measurement can distinguish hepatic from extrahepatic injury in humans. Rafter I, etal., Int J Mol Med. 2012 Nov;30(5):1241-9. doi: 10.3892/ijmm.2012.1106. Epub 2012 Aug 23.
25. GOA pipeline RGD automated data pipeline
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Comprehensive gene review and curation RGD comprehensive gene curation
28. Association between MFN2 gene polymorphisms and the risk and prognosis of acute liver failure: a case-control study in a Chinese population. Wei YL, etal., Braz J Med Biol Res. 2017 May 15;50(6):e5758. doi: 10.1590/1414-431X20175758.
29. Alanine aminotransferase isoenzymes: molecular cloning and quantitative analysis of tissue expression in rats and serum elevation in liver toxicity. Yang RZ, etal., Hepatology. 2009 Feb;49(2):598-607. doi: 10.1002/hep.22657.
Additional References at PubMed
PMID:11863375   PMID:12477932   PMID:17582939   PMID:18850354   PMID:19050265   PMID:19056867   PMID:27430334  


Genomics

Comparative Map Data
Gpt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27108,416,646 - 108,419,495 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7108,416,642 - 108,419,494 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7110,158,569 - 110,161,418 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.07112,382,143 - 112,384,992 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.07112,342,892 - 112,345,741 (+)NCBIRnor_WKY
Rnor_6.07117,759,083 - 117,761,932 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7117,759,083 - 117,761,931 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07117,745,308 - 117,749,938 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47114,746,054 - 114,748,903 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7104,766,538 - 104,769,387 (+)NCBICelera
Cytogenetic Map7q34NCBI
GPT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388144,503,068 - 144,507,172 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl8144,502,973 - 144,507,174 (+)EnsemblGRCh38hg38GRCh38
GRCh378145,728,451 - 145,732,555 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368145,700,231 - 145,703,357 (+)NCBINCBI36Build 36hg18NCBI36
Build 348145,700,232 - 145,703,357NCBI
Celera8141,904,937 - 141,908,027 (+)NCBICelera
Cytogenetic Map8q24.3NCBI
HuRef8140,842,619 - 140,845,709 (+)NCBIHuRef
CHM1_18145,767,740 - 145,770,746 (+)NCBICHM1_1
T2T-CHM13v2.08145,672,833 - 145,676,937 (+)NCBIT2T-CHM13v2.0
Gpt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391576,580,926 - 76,583,875 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1576,579,916 - 76,583,886 (+)EnsemblGRCm39 Ensembl
GRCm381576,696,726 - 76,699,675 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1576,695,716 - 76,699,686 (+)EnsemblGRCm38mm10GRCm38
MGSCv371576,527,194 - 76,530,105 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361576,524,016 - 76,526,930 (+)NCBIMGSCv36mm8
Celera1578,190,374 - 78,193,285 (+)NCBICelera
Cytogenetic Map15D3NCBI
cM Map1536.28NCBI
Gpt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554543,127,997 - 3,132,459 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554543,127,997 - 3,132,459 (+)NCBIChiLan1.0ChiLan1.0
GPT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11337,923,757 - 37,927,843 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1337,924,422 - 37,926,156 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1337,884,479 - 37,888,507 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01338,397,476 - 38,401,488 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1338,398,154 - 38,404,357 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11338,089,429 - 38,093,531 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01338,197,829 - 38,201,856 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01338,674,294 - 38,678,329 (+)NCBIUU_Cfam_GSD_1.0
Gpt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303339,711 - 344,808 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364707,765,703 - 7,768,465 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049364707,765,810 - 7,770,837 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4297,748 - 320,056 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14297,747 - 302,498 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24388,746 - 393,520 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GPT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18138,716,802 - 138,721,421 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8138,718,767 - 138,721,251 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660391,133,510 - 1,138,125 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473512,355,476 - 12,360,028 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473512,355,476 - 12,359,910 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gpt
5 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:109
Count of miRNA genes:91
Interacting mature miRNAs:97
Transcripts:ENSRNOT00000050556
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)780221299109401111Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)780221299112308525Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)794811085116738842Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7103146217116738842Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat

Markers in Region
RH134715  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27108,419,461 - 108,419,658 (+)MAPPERmRatBN7.2
Rnor_6.07117,761,899 - 117,762,095NCBIRnor6.0
Rnor_5.07117,749,878 - 117,750,074UniSTSRnor5.0
RGSC_v3.47114,748,870 - 114,749,066UniSTSRGSC3.4
Celera7104,769,354 - 104,769,550UniSTS
RH 3.4 Map7795.4UniSTS
Cytogenetic Map7q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 18 38 27 4 27 8 11 74 33 32 11 8
Low 25 19 14 15 14 2 9
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000050556   ⟹   ENSRNOP00000044411
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7108,416,642 - 108,419,494 (+)Ensembl
Rnor_6.0 Ensembl7117,759,083 - 117,761,931 (+)Ensembl
RefSeq Acc Id: NM_031039   ⟹   NP_112301
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27108,416,646 - 108,419,495 (+)NCBI
Rnor_6.07117,759,083 - 117,761,932 (+)NCBI
Rnor_5.07117,745,308 - 117,749,938 (+)NCBI
RGSC_v3.47114,746,054 - 114,748,903 (+)RGD
Celera7104,766,538 - 104,769,387 (+)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_112301   ⟸   NM_031039
- UniProtKB: Q4V7F7 (UniProtKB/Swiss-Prot),   P25409 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000044411   ⟸   ENSRNOT00000050556

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P25409-F1-model_v2 AlphaFold P25409 1-496 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695434
Promoter ID:EPDNEW_R5959
Type:multiple initiation site
Name:Gpt_1
Description:glutamic--pyruvic transaminase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07117,759,068 - 117,759,128EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621720 AgrOrtholog
BioCyc Gene G2FUF-32909 BioCyc
BioCyc Pathway ALANINE-DEG3-PWY [L-alanine degradation III] BioCyc
  ALANINE-SYN2-PWY [L-alanine biosynthesis II] BioCyc
Ensembl Genes ENSRNOG00000033915 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000044411 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000050556 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.640.10 UniProtKB/Swiss-Prot
  3.90.1150.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7192757 IMAGE-MGC_LOAD
  IMAGE:7324977 IMAGE-MGC_LOAD
InterPro ALAT1/2-like UniProtKB/Swiss-Prot
  Aminotransferase_I/II UniProtKB/Swiss-Prot
  PyrdxlP-dep_Trfase UniProtKB/Swiss-Prot
  PyrdxlP-dep_Trfase_dom1 UniProtKB/Swiss-Prot
  PyrdxlP-dep_Trfase_major UniProtKB/Swiss-Prot
KEGG Report rno:81670 UniProtKB/Swiss-Prot
MGC_CLONE MGC:116056 IMAGE-MGC_LOAD
  MGC:93386 IMAGE-MGC_LOAD
NCBI Gene 81670 ENTREZGENE
PANTHER PTHR11751 UniProtKB/Swiss-Prot
Pfam Aminotran_1_2 UniProtKB/Swiss-Prot
PharmGKB GPT RGD
PhenoGen Gpt PhenoGen
Superfamily-SCOP SSF53383 UniProtKB/Swiss-Prot
UniProt ALAT1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q4V7F7 ENTREZGENE
UniProt Secondary Q4V7F7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-22 Gpt  glutamic--pyruvic transaminase  Gpt  glutamic-pyruvate transaminase (alanine aminotransferase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-07-11 Gpt  glutamic-pyruvate transaminase (alanine aminotransferase)  Gpt  glutamic-pyruvate transaminase (alanine aminotransferase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-07-10 Gpt  glutamic-pyruvate transaminase (alanine aminotransferase)  Gpt  glutamic pyruvic transaminase (alanine aminotrasferase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-15 Gpt  glutamic pyruvic transaminase (alanine aminotrasferase)  Gpt1  glutamic pyruvic transaminase 1, soluble  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Gpt1  glutamic pyruvic transaminase 1, soluble  Gpt  glutamic-pyruvate transaminase (alanine aminotransferase)  Symbol and Name updated 1299863 APPROVED
2002-08-07 Gpt  glutamic-pyruvate transaminase (alanine aminotransferase)      Symbol and Name status set to provisional 70820 PROVISIONAL