Gpt (glutamic--pyruvic transaminase) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Gpt (glutamic--pyruvic transaminase) Rattus norvegicus
Analyze
Symbol: Gpt
Name: glutamic--pyruvic transaminase
RGD ID: 621720
Description: Predicted to enable L-alanine:2-oxoglutarate aminotransferase activity and pyridoxal phosphate binding activity. Involved in cellular response to insulin stimulus; positive regulation of gluconeogenesis; and response to starvation. Located in extracellular space. Biomarker of acute kidney failure; myocardial infarction; obstructive jaundice; and type 2 diabetes mellitus. Orthologous to human GPT (glutamic--pyruvic transaminase); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; alanine metabolic pathway; argininosuccinic aciduria pathway; INTERACTS WITH (+)-schisandrin B; (+)-taxifolin; (-)-ephedrine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: alanine aminotransferase 1; ALAT; ALT1; glutamate pyruvate transaminase 1; glutamic pyruvate transaminase; glutamic pyruvic transaminase (alanine aminotrasferase); glutamic pyruvic transaminase 1, soluble; glutamic--alanine transaminase 1; glutamic--pyruvic transaminase 1; glutamic-pyruvate transaminase (alanine aminotransferase); GPT 1; Gpt1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87110,295,599 - 110,300,134 (+)NCBIGRCr8
mRatBN7.27108,416,646 - 108,419,495 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7108,416,642 - 108,419,494 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7110,158,569 - 110,161,418 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07112,382,143 - 112,384,992 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07112,342,892 - 112,345,741 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07117,759,083 - 117,761,932 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7117,759,083 - 117,761,931 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07117,745,308 - 117,749,938 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47114,746,054 - 114,748,903 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7104,766,538 - 104,769,387 (+)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-isoborneol  (ISO)
(+)-pilocarpine  (ISO)
(+)-schisandrin B  (EXP)
(+)-taxifolin  (EXP)
(-)-ephedrine  (EXP)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(-)-quinic acid  (ISO)
(1->4)-beta-D-glucan  (ISO)
(E)-thiamethoxam  (EXP)
(R)-carnitine  (EXP)
(R)-lipoic acid  (EXP,ISO)
(R,R)-tramadol  (EXP)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-colchicine  (ISO)
(S)-naringenin  (EXP)
(S)-nicotine  (EXP,ISO)
1,1,2-trichloroethane  (EXP)
1,1-dichloroethene  (ISO)
1,2-dichlorobenzene  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dichloropropan-2-ol  (ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (EXP)
1-aminobenzotriazole  (ISO)
1-bromopropane  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
1H-1,2,4-triazole  (EXP)
1H-pyrazole  (ISO)
2',4',6'-trihydroxyacetophenone  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-D  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
2-(tert-butylimino)-5-phenyl-3-(propan-2-yl)-1,3,5-thiadiazinan-4-one  (ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP,ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
2-chloroethanol  (ISO)
2-methoxyethanol  (EXP)
2-methyl-6-(phenylethynyl)pyridine  (ISO)
2-tert-butylhydroquinone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-hydroxybutyric acid  (ISO)
3-methyladenine  (ISO)
3-methylglutaric acid  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-\{[4-(dimethylamino)phenyl]diazenyl\}phenyl-beta-lactoside  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (EXP,ISO)
5-(2-chloroethyl)-4-methylthiazole  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (EXP)
5-fluorouracil  (EXP,ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
7,12-dimethyltetraphene  (EXP)
7,8-dihydroxycoumarin  (EXP)
8-Epidiosbulbin E acetate  (ISO)
9,11,13-octadecatrienoic acid  (EXP)
acephate  (EXP)
acetaldehyde  (ISO)
acetamide  (EXP)
acetamiprid  (EXP)
acetylleucyl-leucyl-norleucinal  (ISO)
acetylsalicylic acid  (EXP)
acrolein  (EXP)
acrylamide  (EXP,ISO)
actinomycin D  (EXP)
Aescin  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
alectinib  (ISO)
Alisol B  (ISO)
all-trans-retinol  (EXP)
allethrin  (EXP)
allicin  (ISO)
alloxan  (EXP)
allyl alcohol  (EXP,ISO)
allyl isothiocyanate  (EXP)
allyl methyl disulfide  (ISO)
alogliptin  (EXP)
alpha-amanitin  (EXP,ISO)
alpha-D-galactose  (ISO)
alpha-galactosylceramide  (ISO)
alpha-linolenic acid  (EXP)
alpha-mangostin  (ISO)
alpha-Zearalanol  (EXP)
aminoguanidine  (EXP)
amiodarone  (EXP,ISO)
amlexanox  (ISO)
amlodipine  (EXP)
ammonium chloride  (EXP)
Ammothamnine  (EXP)
amodiaquine  (ISO)
amphotericin B  (ISO)
ampicillin  (ISO)
andrographolide  (ISO)
Anetholtrithion  (ISO)
angelicin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
apigenin  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenous acid  (EXP,ISO)
astaxanthin  (EXP)
astragaloside IV  (EXP)
atorvastatin calcium  (EXP,ISO)
atrazine  (EXP)
aucubin  (ISO)
Augmentin  (EXP)
aurantio-obtusin  (ISO)
azathioprine  (ISO)
azure A  (EXP)
baicalin  (EXP,ISO)
barium chloride  (EXP)
Bavachinin  (ISO)
BAY 60-6583  (ISO)
bentonite  (EXP)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
beraprost  (ISO)
berberine  (EXP,ISO)
Bergenin  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP)
Betanin  (EXP)
bezafibrate  (ISO)
bicuculline  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
Boldine  (EXP)
boric acid  (EXP)
boron atom  (EXP)
bosentan  (EXP)
bosutinib  (ISO)
bromobenzene  (EXP,ISO)
bromodichloromethane  (ISO)
brucine  (ISO)
buprenorphine  (EXP)
buprofezin  (ISO)
buspirone  (EXP)
Butralin  (EXP)
Butylbenzyl phthalate  (ISO)
cabozantinib  (ISO)
cadmium acetate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
calciol  (EXP)
calcipotriol  (ISO)
Calpeptin  (ISO)
calycosin-7-O-beta-D-glucoside  (ISO)
cannabidiol  (ISO)
cannabigerol  (EXP)
cantharidin  (EXP)
capsaicin  (EXP)
captopril  (EXP)
carbendazim  (EXP)
carbidopa  (ISO)
carbofuran  (EXP)
carbon nanotube  (EXP,ISO)
carfilzomib  (ISO)
carnosic acid  (ISO)
carnosine  (EXP)
carvacrol  (EXP)
carvedilol  (EXP)
catalpol  (ISO)
celastrol  (EXP,ISO)
celecoxib  (ISO)
ceritinib  (ISO)
ceruletide  (ISO)
charcoal  (EXP)
chelerythrine  (EXP)
chenodeoxycholic acid  (EXP,ISO)
chitosan  (EXP)
chlordecone  (ISO)
chlorhexidine gluconate  (EXP)
Chlorobenzilate  (EXP)
Chlorodibromomethane  (ISO)
chloroethene  (ISO)
chloroform  (EXP,ISO)
chlorogenic acid  (EXP,ISO)
chloroquine  (ISO)
chlorotoluron  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (EXP,ISO)
choline  (EXP,ISO)
chromium(6+)  (EXP,ISO)
chrysin  (EXP)
ciprofloxacin  (EXP,ISO)
cis-caffeic acid  (EXP,ISO)
cisplatin  (EXP,ISO)
citral  (EXP)
clodronic acid  (EXP,ISO)
clomipramine  (EXP)
clotrimazole  (ISO)
clozapine  (ISO)
cobalt dichloride  (EXP)
cobimetinib  (EXP)
cocaine  (ISO)
coenzyme Q10  (EXP,ISO)
Columbin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
corn oil  (EXP)
corynoline  (ISO)
crizotinib  (ISO)
crocin-1  (EXP,ISO)
crotonaldehyde  (EXP)
Cryptotanshinone  (ISO)
cucurbitacin B  (ISO)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
Curcumol  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyfluthrin  (EXP)
cyhalothrin  (EXP,ISO)
cymoxanil  (EXP)
cypermethrin  (EXP,ISO)
D-gluconic acid  (EXP)
D-glucose  (EXP,ISO)
dabrafenib  (ISO)
dantrolene  (ISO)
dapagliflozin  (EXP)
DDE  (ISO)
DDT  (EXP)
decabromodiphenyl ether  (ISO)
dehydroacetic acid  (EXP)
Dendrobine  (ISO)
deoxynivalenol  (EXP,ISO)
deoxypodophyllotoxin  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dexmedetomidine  (EXP)
dextran sulfate  (ISO)
dextromethorphan  (ISO)
Di-n-octyl phthalate  (ISO)
diallyl disulfide  (EXP,ISO)
Diallyl sulfide  (EXP)
diallyl trisulfide  (EXP)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (EXP,ISO)
dicloxacillin  (ISO)
dicofol  (EXP)
dicrotophos  (ISO)
diethyl phthalate  (EXP,ISO)
diethyldithiocarbamic acid  (ISO)
diethylene glycol monoethyl ether  (EXP)
difenoconazole  (EXP,ISO)
digoxin  (ISO)
dihydroartemisinin  (ISO)
Dihydrotanshinone I  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethoate  (EXP)
dimethyl sulfoxide  (EXP)
dimethylarsinic acid  (ISO)
dimethylmercury  (EXP)
Diosbulbin B  (ISO)
dioscin  (EXP)
dioxygen  (ISO)
diphenyl diselenide  (EXP)
diquat  (ISO)
disodium selenite  (EXP,ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
duvoglustat  (ISO)
elemental boron  (EXP)
elemental selenium  (EXP,ISO)
Elemicin  (ISO)
ellagic acid  (EXP,ISO)
emodin  (ISO)
endosulfan  (EXP)
ergothioneine  (EXP)
eriodictyol  (EXP)
eritoran  (ISO)
ethambutol  (EXP)
ethanol  (EXP,ISO)
eugenol  (EXP)
eumelanin  (ISO)
Evodiamine  (ISO)
farnesol  (ISO)
fenitrothion  (EXP)
fenofibrate  (EXP,ISO)
fenthion  (ISO)
fenvalerate  (EXP)
ferrocene  (EXP)
ferroheme b  (ISO)
ferrostatin-1  (ISO)
ferulic acid  (ISO)
Fexaramine  (ISO)
fipronil  (EXP,ISO)
flucloxacillin  (ISO)
flumequine  (ISO)
fluoxetine  (EXP)
flutamide  (ISO)
folic acid  (EXP,ISO)
fomepizole  (EXP,ISO)
fosinopril  (ISO)
fructooligosaccharide  (ISO)
fructose  (EXP,ISO)
fucoidan  (EXP)
fulvestrant  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
gadolinium trichloride  (EXP,ISO)
galactose  (ISO)
gallic acid  (EXP,ISO)
gamma-aminobutyric acid  (ISO)
gamma-hexachlorocyclohexane  (EXP)
Ganoderic acid A  (ISO)
gefitinib  (ISO)
Gelsemine  (ISO)
gemfibrozil  (ISO)
Geniposide  (ISO)
genistein  (EXP)
geranial  (EXP)
geraniol  (EXP)
Ginkgoic acid  (EXP)
Ginkgolide A  (ISO)
ginkgolide B  (ISO)
ginsenoside Rg1  (ISO)
glafenine  (EXP)
glucose  (EXP,ISO)
glutathione  (EXP,ISO)
glyburide  (EXP)
glycine betaine  (ISO)
glycyrrhetinate  (EXP,ISO)
glycyrrhetinic acid  (EXP,ISO)
glycyrrhizinic acid  (EXP,ISO)
glyphosate  (EXP,ISO)
gold atom  (ISO)
gold(0)  (ISO)
Guanabenz  (ISO)
guggulsterone  (ISO)
GW 4064  (EXP,ISO)
GW 7647  (EXP)
halothane  (ISO)
heme b  (ISO)
heparin  (EXP)
herbacetin  (ISO)
herbicide  (EXP,ISO)
heroin  (ISO)
hesperidin  (EXP,ISO)
hexachlorobenzene  (EXP)
hexadecanoic acid  (ISO)
hexaflumuron  (EXP)
homocysteine  (EXP)
hydralazine  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (EXP)
hydroquinone O-beta-D-glucopyranoside  (EXP,ISO)
ibrutinib  (ISO)
icariin  (EXP)
icariside II  (ISO)
idelalisib  (ISO)
imetit  (EXP)
imidacloprid  (EXP,ISO)
imiprothrin  (EXP)
indole-3-methanol  (EXP)
inulin  (EXP)
irbesartan  (ISO)
irinotecan  (ISO)
iron atom  (EXP,ISO)
iron dextran  (EXP)
iron dichloride  (ISO)
iron(0)  (EXP,ISO)
iron(3+) sulfate  (EXP)
isoliquiritigenin  (ISO)
isoniazide  (EXP,ISO)
isoprenaline  (EXP)
isoproturon  (EXP)
isorhamnetin  (ISO)
isotretinoin  (EXP)
itraconazole  (ISO)
ivermectin  (ISO)
Jujuboside A  (ISO)
kaempferol  (ISO)
ketoconazole  (EXP,ISO)
L-ascorbic acid  (EXP,ISO)
L-methionine  (EXP,ISO)
lactucin  (ISO)
lactulose  (EXP)
lapatinib  (ISO)
Lasiocarpine  (EXP)
lead diacetate  (ISO)
lead(0)  (EXP,ISO)
Leonurine  (EXP)
leupeptin  (ISO)
levetiracetam  (EXP)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
liquiritigenin  (EXP)
liquiritin  (EXP,ISO)
liraglutide  (EXP)
lithium atom  (EXP)
lithium hydride  (EXP)
lithocholic acid  (ISO)
losartan  (EXP,ISO)
lovastatin  (ISO)
luteolin  (EXP)
LY294002  (ISO)
lycorine  (ISO)
magnesium atom  (EXP)
malathion  (EXP)
Malotilate  (EXP,ISO)
mancozeb  (EXP)
manganese dioxide  (EXP)
mangiferin  (EXP)
melatonin  (EXP)
mercury atom  (EXP,ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP,ISO)
mesalamine  (EXP)
metformin  (EXP,ISO)
methamphetamine  (EXP)
methapyrilene  (EXP)
methidathion  (ISO)
methimazole  (EXP,ISO)
methotrexate  (EXP,ISO)
methoxsalen  (EXP)
methylmercury chloride  (EXP)
metronidazole  (ISO)
Microcystin la  (ISO)
microcystin RR  (ISO)
microcystin-LR  (EXP)
mifepristone  (ISO)
mirtazapine  (ISO)
Mitoquinone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
monocrotaline  (EXP,ISO)
monosodium L-glutamate  (EXP,ISO)
morin  (EXP)
Muraglitazar  (EXP)
muscimol  (ISO)
myricetin  (EXP)
myricitrin  (ISO)
N(5)-ethyl-L-glutamine  (EXP)
N(gamma)-nitro-L-arginine methyl ester  (EXP)
N,N-dimethylformamide  (ISO)
N,N-dimethylglycine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
naringin  (EXP,ISO)
neohesperidin dihydrochalcone  (ISO)
neomycin  (ISO)
nerolidol  (EXP)
nevirapine  (ISO)
nickel atom  (EXP)
nickel dichloride  (EXP,ISO)
nickel sulfate  (EXP,ISO)
nicotinamide  (EXP)
nicotine  (EXP,ISO)
nicotinic acid  (ISO)
nilotinib  (EXP,ISO)
nimesulide  (EXP)
nitroglycerin  (EXP)
nitroprusside  (EXP)
NMN zwitterion  (ISO)
nobiletin  (EXP)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
octamethylcyclotetrasiloxane  (ISO)
octreotide  (EXP)
okadaic acid  (ISO)
olanzapine  (ISO)
olaparib  (ISO)
oleanolic acid  (ISO)
oleic acid  (ISO)
oleuropein  (EXP)
oltipraz  (ISO)
omaveloxolone  (ISO)
omethoate  (EXP)
orlistat  (EXP)
oroxylin A  (ISO)
osimertinib  (ISO)
Oxadiazon  (ISO)
oxaliplatin  (EXP,ISO)
oxycodone  (EXP)
ozone  (EXP,ISO)
paclobutrazol  (EXP)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
parathion-methyl  (EXP)
paroxetine  (ISO)
patulin  (ISO)
penconazole  (ISO)
pendimethalin  (EXP)
perfluorodecanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perindopril  (ISO)
phenethyl isothiocyanate  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenylhydrazine  (EXP,ISO)
phloretin  (ISO)
phorate  (EXP)
Picroside ii  (ISO)
pinocembrin  (ISO)
pioglitazone  (EXP)
piperine  (EXP)
pirfenidone  (ISO)
pirinixic acid  (ISO)
poly(ethylene)  (ISO)
poly(vinyl chloride)  (ISO)
polymyxin B2  (ISO)
polyphosphates  (ISO)
ponatinib  (ISO)
potassium bromate  (EXP)
potassium dichromate  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
probenecid  (EXP)
progesterone  (EXP)
propacetamol  (ISO)
propiconazole  (EXP)
prostaglandin E2  (ISO)
psoralen  (EXP,ISO)
puerarin  (ISO)
pyrazine-2-carboxylic acid  (EXP)
pyrazinecarboxamide  (EXP)
pyrethrins  (EXP)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-galactopyranoside  (ISO)
rac-1,2-dichloropropane  (EXP)
ramipril  (EXP)
raspberry ketone  (EXP)
regorafenib  (ISO)
resveratrol  (EXP,ISO)
Retrorsine  (ISO)
Rhein  (ISO)
Ribociclib  (ISO)
rifampicin  (EXP,ISO)
rimonabant  (EXP,ISO)
risperidone  (EXP)
rivaroxaban  (EXP)
rosmarinic acid  (EXP)
rotenone  (EXP,ISO)
rottlerin  (EXP,ISO)
Rutecarpine  (ISO)
rutin  (EXP,ISO)
ruxolitinib  (ISO)
ryanodine  (ISO)
S-allylcysteine  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
Salvianolic acid A  (ISO)
salvianolic acid B  (EXP,ISO)
sarpogrelate  (ISO)
SB 203580  (ISO)
scoparone  (ISO)
scopoletin  (EXP)
selenium atom  (EXP,ISO)
senecionine  (EXP,ISO)
sildenafil citrate  (EXP,ISO)
silibinin  (EXP,ISO)
sinapic acid  (EXP)
sirolimus  (EXP,ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sodium fluoride  (EXP,ISO)
sodium nitrite  (EXP)
sodium silicate  (EXP)
sodium sulfite  (ISO)
sodium tungstate  (EXP)
solanesol  (ISO)
Soman  (EXP)
sorafenib  (EXP,ISO)
squalene  (EXP)
stattic  (ISO)
streptozocin  (EXP,ISO)
succimer  (EXP)
sucrose  (EXP)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
syringic acid  (EXP)
T-2 toxin  (ISO)
tadalafil  (EXP)
tamoxifen  (EXP,ISO)
Tanshinone I  (ISO)
tapentadol  (EXP)
taurine  (EXP,ISO)
taurodeoxycholic acid  (EXP)
tauroursodeoxycholic acid  (ISO)
tectorigenin  (ISO)
telmisartan  (EXP)
tert-butyl hydroperoxide  (EXP,ISO)
Tesaglitazar  (EXP)
testosterone cypionate  (ISO)
tetrachloro-1,4-benzoquinone  (ISO)
tetrachloromethane  (EXP,ISO)
tetrahydrocurcumin  (ISO)
thiacloprid  (EXP)
thiamethoxam  (EXP)
thioacetamide  (EXP,ISO)
thymoquinone  (EXP)
thyroxine  (EXP)
titanium dioxide  (EXP,ISO)
toosendanin  (ISO)
tramadol  (EXP)
trans-caffeic acid  (EXP,ISO)
tranylcypromine  (ISO)
trelagliptin  (ISO)
trichloroacetic acid  (EXP)
trichloroethene  (EXP,ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP,ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (EXP)
tuberostemonine  (ISO)
tunicamycin  (EXP)
tyloxapol  (ISO)
ubiquinones  (EXP)
urethane  (ISO)
ursodeoxycholic acid  (EXP,ISO)
ursolic acid  (ISO)
vadimezan  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vandetanib  (ISO)
varespladib  (EXP)
verapamil  (EXP)
verteporfin  (ISO)
vildagliptin  (ISO)
vincristine  (EXP)
Vinpocetine  (EXP)
vitamin D  (ISO)
vitamin E  (EXP)
vitamin K  (EXP)
voriconazole  (EXP)
withaferin A  (ISO)
XAV939  (ISO)
zearalenone  (ISO)
zidovudine  (EXP)
zinc atom  (EXP,ISO)
zinc dichloride  (EXP,ISO)
zinc molecular entity  (EXP)
zinc oxide  (EXP,ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)
zolmitriptan  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
extracellular space  (IDA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GC-MS Analysis: In Vivo Hepatoprotective and Antioxidant Activities of the Essential Oil of Achillea biebersteinii Afan. Growing in Saudi Arabia. Al-Said MS, etal., Evid Based Complement Alternat Med. 2016;2016:1867048. doi: 10.1155/2016/1867048. Epub 2016 May 12.
2. [Rosiglitazone protects against endotoxin-induced acute liver injury in rats]. Bu Y and Yu J, Zhonghua Yi Xue Za Zhi. 2015 Oct 20;95(39):3180-3.
3. A Chinese herbal medicine, Gexia-Zhuyu Tang (GZT), prevents dimethylnitrosamine-induced liver fibrosis through inhibition of hepatic stellate cells proliferation. Chen JY, etal., J Ethnopharmacol. 2012 Aug 1;142(3):811-8. doi: 10.1016/j.jep.2012.06.005. Epub 2012 Jun 15.
4. D-lactate is not a reliable marker of gut ischemia-reperfusion in a rat model of supraceliac aortic clamping. Collange O, etal., Crit Care Med. 2006 May;34(5):1415-9. doi: 10.1097/01.CCM.0000214517.24064.35.
5. ANTIOXIDANT ACTIVITY IN VITRO AND HEPATOPROTECTIVE EFFECTS IN VIVO OF COMPOUND LOBELIA. Cui X, etal., Afr J Tradit Complement Altern Med. 2016 Aug 12;13(5):114-122. doi: 10.21010/ajtcam.v13i5.15. eCollection 2016.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Therapeutic Potential of Biochanin-A Against Isoproterenol-Induced Myocardial Infarction in Rats. Govindasami S, etal., Cardiovasc Hematol Agents Med Chem. 2020;18(1):31-36. doi: 10.2174/1871525718666200206114304.
9. Effects of model traumatic injury on hepatic drug metabolism in the rat. I. In vivo antipyrine metabolism. Griffeth LK, etal., Drug Metab Dispos. 1983 Nov-Dec;11(6):517-25.
10. Characteristics and course of chronic hepatitis B e antigen-negative infection. Guardiola Arévalo A, etal., Gastroenterol Hepatol. 2017 Feb;40(2):59-69. doi: 10.1016/j.gastrohep.2016.11.002. Epub 2016 Dec 20.
11. Hepatitis B virus e antigen-negative chronic infection. Treatment based on glutamic pyruvic transaminase and hepatitis B virus deoxyribonucleic acid cut-off values. Guardiola-Arévalo A, etal., Gastroenterol Hepatol. 2018 Mar;41(3):153-162. doi: 10.1016/j.gastrohep.2017.11.003. Epub 2017 Dec 24.
12. [Non-alcoholic fatty liver in children and adolescents with excess weight and obesity]. Guijarro de Armas MG, etal., Med Clin (Barc). 2015 Jan 20;144(2):55-8. doi: 10.1016/j.medcli.2014.02.018. Epub 2014 Apr 24.
13. New technique for inducing reversible obstructive jaundice in the rat. Hirazawa K, etal., Eur Surg Res. 1997;29(3):195-201.
14. Exogenous heat shock cognate protein 70 pretreatment attenuates cardiac and hepatic dysfunction with associated anti-inflammatory responses in experimental septic shock. Hsu JH, etal., Shock. 2014 Dec;42(6):540-7. doi: 10.1097/SHK.0000000000000254.
15. Fasting for 3 days during the suckling-weaning transient period in male rats induces metabolic abnormalities in the liver and is associated with impaired glucose tolerance in adulthood. Ikeda M, etal., Eur J Nutr. 2016 Apr;55(3):1059-67. doi: 10.1007/s00394-015-0919-9. Epub 2015 May 6.
16. Complete amino acid sequence of human liver cytosolic alanine aminotransferase (GPT) determined by a combination of conventional and mass spectral methods. Ishiguro M, etal., Biochemistry 1991 Oct 29;30(43):10451-7.
17. Complete amino acid sequence of rat liver cytosolic alanine aminotransferase. Ishiguro M, etal., Biochemistry. 1991 Jun 18;30(24):6048-53.
18. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
19. Immunological measurement of aspartate/alanine aminotransferase in predicting liver fibrosis and inflammation. Kim HJ, etal., Korean J Intern Med. 2019 Jan 23. pii: kjim.2018.214. doi: 10.3904/kjim.2018.214.
20. Liver protective activity of a hydroethanolic extract of Arrabidaea chica (Humb. and Bonpl.) B. Verl. (pariri). Lima de Medeiros BJ, etal., Pharmacognosy Res. 2011 Apr;3(2):79-84. doi: 10.4103/0974-8490.81954.
21. Dexamethasone improves heat stroke-induced multiorgan dysfunction and damage in rats. Liu CC, etal., Int J Mol Sci. 2014 Nov 18;15(11):21299-313. doi: 10.3390/ijms151121299.
22. Increased hepatic expression is a major determinant of serum alanine aminotransferase elevation in mice with nonalcoholic steatohepatitis. Liu R, etal., Liver Int. 2009 Mar;29(3):337-43. doi: 10.1111/j.1478-3231.2008.01862.x. Epub 2008 Aug 14.
23. Clinical relevance of reporting fatty liver on ultrasound in asymptomatic patients during routine health checkups. Mahale AR, etal., J Int Med Res. 2018 Nov;46(11):4447-4454. doi: 10.1177/0300060518793039. Epub 2018 Sep 5.
24. Inhibition of matrix metalloproteinase on hepatic transforming growth factor beta1 and caspase-3 activation in hemorrhage. Maitra SR, etal., Acad Emerg Med. 2005 Sep;12(9):797-803. doi: 10.1197/j.aem.2005.04.017.
25. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
26. Effects of saikosaponins on hepatic damage induced by halothane and hypoxia in phenobarbital-pretreated rats. Nishiura T, etal., J Anesth. 1994 Mar;8(1):87-92. doi: 10.1007/BF02482762.
27. In Silico Modeling of Liver Metabolism in a Human Disease Reveals a Key Enzyme for Histidine and Histamine Homeostasis. Pagliarini R, etal., Cell Rep. 2016 Jun 7;15(10):2292-2300. doi: 10.1016/j.celrep.2016.05.014. Epub 2016 May 26.
28. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
29. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
30. Hepatic ALT isoenzymes are elevated in gluconeogenic conditions including diabetes and suppressed by insulin at the protein level. Qian K, etal., Diabetes Metab Res Rev. 2015 Sep;31(6):562-71. doi: 10.1002/dmrr.2655. Epub 2015 Jun 17.
31. Isoform-specific alanine aminotransferase measurement can distinguish hepatic from extrahepatic injury in humans. Rafter I, etal., Int J Mol Med. 2012 Nov;30(5):1241-9. doi: 10.3892/ijmm.2012.1106. Epub 2012 Aug 23.
32. Pretreatment of Tribulus terrestris L. causes anti-ischemic cardioprotection through MAPK mediated anti-apoptotic pathway in rat. Reshma PL, etal., Biomed Pharmacother. 2019 Mar;111:1342-1352. doi: 10.1016/j.biopha.2019.01.033. Epub 2019 Jan 16.
33. GOA pipeline RGD automated data pipeline
34. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
35. Comprehensive gene review and curation RGD comprehensive gene curation
36. Alpha-lipoic acid prevents endotoxic shock and multiple organ dysfunction syndrome induced by endotoxemia in rats. Shen HH, etal., Shock. 2015 Apr;43(4):405-11. doi: 10.1097/SHK.0000000000000295.
37. Association between MFN2 gene polymorphisms and the risk and prognosis of acute liver failure: a case-control study in a Chinese population. Wei YL, etal., Braz J Med Biol Res. 2017 May 15;50(6):e5758. doi: 10.1590/1414-431X20175758.
38. [D-Ala2, D-Leu5] enkephalin (DADLE) protects liver against ischemia-reperfusion injury in the rat. Yamanouchi K, etal., J Surg Res. 2003 Sep;114(1):72-7. doi: 10.1016/s0022-4804(03)00196-3.
39. Recombinant human erythropoietin reduces rhabdomyolysis-induced acute renal failure in rats. Yang FL, etal., Injury. 2012 Mar;43(3):367-73. doi: 10.1016/j.injury.2011.11.013. Epub 2011 Dec 30.
40. Alanine aminotransferase isoenzymes: molecular cloning and quantitative analysis of tissue expression in rats and serum elevation in liver toxicity. Yang RZ, etal., Hepatology. 2009 Feb;49(2):598-607. doi: 10.1002/hep.22657.
41. Liver reperfusion-induced decrease in dynamic compliance and increase in airway resistance are ameliorated by preischemic treatment with melatonin through scavenging hydroxyl radicals in rat lungs. Yeh JH, etal., Transplant Proc. 2012 May;44(4):966-9. doi: 10.1016/j.transproceed.2012.01.076.
42. Influences of Edaravone on Necroptosis-Related Proteins and Oxidative Stress in Rats with Lower Extremity Ischemia/Reperfusion Injury. Zhao G, etal., Cell Mol Biol (Noisy-le-grand). 2022 Jul 31;68(7):95-100. doi: 10.14715/cmb/2022.68.7.16.
Additional References at PubMed
PMID:11863375   PMID:12477932   PMID:17582939   PMID:18850354   PMID:19050265   PMID:19056867   PMID:27430334  


Genomics

Comparative Map Data
Gpt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87110,295,599 - 110,300,134 (+)NCBIGRCr8
mRatBN7.27108,416,646 - 108,419,495 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7108,416,642 - 108,419,494 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7110,158,569 - 110,161,418 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07112,382,143 - 112,384,992 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07112,342,892 - 112,345,741 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07117,759,083 - 117,761,932 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7117,759,083 - 117,761,931 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07117,745,308 - 117,749,938 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47114,746,054 - 114,748,903 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7104,766,538 - 104,769,387 (+)NCBICelera
Cytogenetic Map7q34NCBI
GPT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388144,503,068 - 144,507,172 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8144,502,973 - 144,507,174 (+)EnsemblGRCh38hg38GRCh38
GRCh378145,728,451 - 145,732,555 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368145,700,231 - 145,703,357 (+)NCBINCBI36Build 36hg18NCBI36
Build 348145,700,232 - 145,703,357NCBI
Celera8141,904,937 - 141,908,027 (+)NCBICelera
Cytogenetic Map8q24.3NCBI
HuRef8140,842,619 - 140,845,709 (+)NCBIHuRef
CHM1_18145,767,740 - 145,770,746 (+)NCBICHM1_1
T2T-CHM13v2.08145,672,833 - 145,676,937 (+)NCBIT2T-CHM13v2.0
Gpt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391576,580,926 - 76,583,875 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1576,579,916 - 76,583,886 (+)EnsemblGRCm39 Ensembl
GRCm381576,696,726 - 76,699,675 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1576,695,716 - 76,699,686 (+)EnsemblGRCm38mm10GRCm38
MGSCv371576,527,194 - 76,530,105 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361576,524,016 - 76,526,930 (+)NCBIMGSCv36mm8
Celera1578,190,374 - 78,193,285 (+)NCBICelera
Cytogenetic Map15D3NCBI
cM Map1536.28NCBI
Gpt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554543,127,997 - 3,132,459 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554543,127,997 - 3,132,459 (+)NCBIChiLan1.0ChiLan1.0
GPT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27161,994,411 - 161,999,064 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18137,522,660 - 137,528,193 (+)NCBINHGRI_mPanPan1
PanPan1.1 Ensembl8144,259,991 - 144,263,737 (+)Ensemblpanpan1.1panPan2
GPT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11337,923,757 - 37,927,843 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1337,924,422 - 37,926,156 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1337,884,479 - 37,888,507 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01338,397,476 - 38,401,488 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1338,398,154 - 38,404,357 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11338,089,429 - 38,093,531 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01338,197,829 - 38,201,856 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01338,674,294 - 38,678,329 (+)NCBIUU_Cfam_GSD_1.0
Gpt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303339,711 - 344,808 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364707,765,703 - 7,768,465 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364707,765,810 - 7,770,837 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4297,748 - 320,056 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14297,747 - 302,498 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24388,746 - 393,520 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GPT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18138,716,802 - 138,721,421 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8138,718,767 - 138,721,251 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660391,133,510 - 1,138,125 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473512,355,476 - 12,360,028 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473512,355,476 - 12,359,910 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gpt
5 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:109
Count of miRNA genes:91
Interacting mature miRNAs:97
Transcripts:ENSRNOT00000050556
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7103146217116738842Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)780221299109401111Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)794811085116738842Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)780221299112308525Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat

Markers in Region
RH134715  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27108,419,461 - 108,419,658 (+)MAPPERmRatBN7.2
Rnor_6.07117,761,899 - 117,762,095NCBIRnor6.0
Rnor_5.07117,749,878 - 117,750,074UniSTSRnor5.0
RGSC_v3.47114,748,870 - 114,749,066UniSTSRGSC3.4
Celera7104,769,354 - 104,769,550UniSTS
RH 3.4 Map7795.4UniSTS
Cytogenetic Map7q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000050556   ⟹   ENSRNOP00000044411
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7108,416,642 - 108,419,494 (+)Ensembl
Rnor_6.0 Ensembl7117,759,083 - 117,761,931 (+)Ensembl
RefSeq Acc Id: NM_031039   ⟹   NP_112301
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87110,297,285 - 110,300,134 (+)NCBI
mRatBN7.27108,416,646 - 108,419,495 (+)NCBI
Rnor_6.07117,759,083 - 117,761,932 (+)NCBI
Rnor_5.07117,745,308 - 117,749,938 (+)NCBI
RGSC_v3.47114,746,054 - 114,748,903 (+)RGD
Celera7104,766,538 - 104,769,387 (+)RGD
Sequence:
RefSeq Acc Id: XM_063264295   ⟹   XP_063120365
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87110,295,599 - 110,300,134 (+)NCBI
RefSeq Acc Id: XM_063264296   ⟹   XP_063120366
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87110,295,599 - 110,300,134 (+)NCBI
RefSeq Acc Id: XM_063264297   ⟹   XP_063120367
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87110,295,599 - 110,300,134 (+)NCBI
RefSeq Acc Id: NP_112301   ⟸   NM_031039
- UniProtKB: Q4V7F7 (UniProtKB/Swiss-Prot),   P25409 (UniProtKB/Swiss-Prot),   A6HSC5 (UniProtKB/TrEMBL),   A6HSC6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000044411   ⟸   ENSRNOT00000050556
RefSeq Acc Id: XP_063120365   ⟸   XM_063264295
- Peptide Label: isoform X1
- UniProtKB: Q4V7F7 (UniProtKB/Swiss-Prot),   P25409 (UniProtKB/Swiss-Prot),   A6HSC6 (UniProtKB/TrEMBL),   A6HSC5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063120366   ⟸   XM_063264296
- Peptide Label: isoform X1
- UniProtKB: Q4V7F7 (UniProtKB/Swiss-Prot),   P25409 (UniProtKB/Swiss-Prot),   A6HSC6 (UniProtKB/TrEMBL),   A6HSC5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063120367   ⟸   XM_063264297
- Peptide Label: isoform X1
- UniProtKB: Q4V7F7 (UniProtKB/Swiss-Prot),   P25409 (UniProtKB/Swiss-Prot),   A6HSC6 (UniProtKB/TrEMBL),   A6HSC5 (UniProtKB/TrEMBL)
Protein Domains
Aminotransferase class I/classII large

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P25409-F1-model_v2 AlphaFold P25409 1-496 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695434
Promoter ID:EPDNEW_R5959
Type:multiple initiation site
Name:Gpt_1
Description:glutamic--pyruvic transaminase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07117,759,068 - 117,759,128EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621720 AgrOrtholog
BioCyc Gene G2FUF-32909 BioCyc
BioCyc Pathway ALANINE-DEG3-PWY [L-alanine degradation III] BioCyc
  ALANINE-SYN2-PWY [L-alanine biosynthesis II] BioCyc
BioCyc Pathway Image ALANINE-DEG3-PWY BioCyc
  ALANINE-SYN2-PWY BioCyc
Ensembl Genes ENSRNOG00000033915 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000050556 ENTREZGENE
  ENSRNOT00000050556.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.1970 UniProtKB/Swiss-Prot
  3.40.640.10 UniProtKB/Swiss-Prot
  3.90.1150.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7192757 IMAGE-MGC_LOAD
  IMAGE:7324977 IMAGE-MGC_LOAD
InterPro ALAT1/2-like UniProtKB/Swiss-Prot
  Aminotransferase_I/II UniProtKB/Swiss-Prot
  PyrdxlP-dep_Trfase UniProtKB/Swiss-Prot
  PyrdxlP-dep_Trfase_dom1 UniProtKB/Swiss-Prot
  PyrdxlP-dep_Trfase_major UniProtKB/Swiss-Prot
KEGG Report rno:81670 UniProtKB/Swiss-Prot
MGC_CLONE MGC:116056 IMAGE-MGC_LOAD
  MGC:93386 IMAGE-MGC_LOAD
NCBI Gene 81670 ENTREZGENE
PANTHER ALANINE AMINOTRANSFERASE 1 UniProtKB/Swiss-Prot
  PTHR11751 UniProtKB/Swiss-Prot
Pfam Aminotran_1_2 UniProtKB/Swiss-Prot
PharmGKB GPT RGD
PhenoGen Gpt PhenoGen
RatGTEx ENSRNOG00000033915 RatGTEx
Superfamily-SCOP SSF53383 UniProtKB/Swiss-Prot
UniProt A6HSC5 ENTREZGENE, UniProtKB/TrEMBL
  A6HSC6 ENTREZGENE, UniProtKB/TrEMBL
  ALAT1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q4V7F7 ENTREZGENE
UniProt Secondary Q4V7F7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-22 Gpt  glutamic--pyruvic transaminase  Gpt  glutamic-pyruvate transaminase (alanine aminotransferase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-07-10 Gpt  glutamic-pyruvate transaminase (alanine aminotransferase)  Gpt  glutamic pyruvic transaminase (alanine aminotrasferase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-15 Gpt  glutamic pyruvic transaminase (alanine aminotrasferase)  Gpt1  glutamic pyruvic transaminase 1, soluble  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Gpt1  glutamic pyruvic transaminase 1, soluble  Gpt  glutamic-pyruvate transaminase (alanine aminotransferase)  Symbol and Name updated 1299863 APPROVED
2002-08-07 Gpt  glutamic-pyruvate transaminase (alanine aminotransferase)      Symbol and Name status set to provisional 70820 PROVISIONAL