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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621720
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gpt
Name: glutamic--pyruvic transaminase
Acc ID: CHEBI:28757
Term: fructose
Definition: A ketohexose that is an isomer of glucose.
Chemical ID: MESH:D005632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gptmultiple interactionsEXP 6480464CTD[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of GPT protein]; [Fructose co-treated with Dietary Fats] results in increased expression of GPT protein; Atorvastatin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of GPT protein]; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of GPT protein]PMID:32259528
Gptincreases activityISOGpt (Mus musculus)6480464CTDFructose results in increased activity of GPT proteinPMID:27531227
Gptmultiple interactionsISOGpt (Mus musculus)6480464CTD[Dietary Fats co-treated with Cholesterol, Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Ethanol] results in increased expression of GPT protein; [Dietary Fats co-treated with Cholesterol, Dietary co-treated with Dietary Sucrose co-treated with Fructose] results in increased expression of GPT protein; [Fructose co-treated with Ethanol] results in increased expression of GPT protein; Plant Preparations inhibits the reaction [Fructose results in increased activity of GPT protein]PMID:26858005 PMID:27531227 PMID:37271273
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