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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621720
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gpt
Name: glutamic--pyruvic transaminase
Acc ID: CHEBI:47519
Term: ketoconazole
Definition: A racemate consisting of equimolar amounts of (2R,4S)- and (2S,4R)-ketoconazole.
Chemical ID: MESH:D007654
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gptmultiple interactionsEXP 6480464CTDKetoconazole inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]PMID:31168027
Gptincreases expressionISOGpt (Mus musculus)6480464CTDKetoconazole results in increased expression of GPT proteinPMID:31099283
Gptmultiple interactionsISOGpt (Mus musculus)6480464CTDKetoconazole inhibits the reaction [columbin results in increased activity of GPT protein]; Ketoconazole promotes the reaction [gelsemine results in increased expression of GPT protein]PMID:32162908 PMID:34627953
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