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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621720
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gpt
Name: glutamic--pyruvic transaminase
Acc ID: CHEBI:16755
Term: chenodeoxycholic acid
Definition: A dihydroxy-5beta-cholanic acid that is (5beta)-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 7 respectively.
Chemical ID: MESH:D002635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gptmultiple interactionsEXP 6480464CTDChenodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in increased activity of GPT protein]PMID:27743861
Gptmultiple interactionsISOGpt (Mus musculus)6480464CTDChenodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of GPT protein]; Chenodeoxycholic Acid inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of GPT protein]; Chenodeoxycholic Acid inhibits the reaction [Carbon Tetrachloride results in increased secretion of GPT protein]; Chenodeoxycholic Acid inhibits the reaction [tris(chloroethyl)phosphate results in increased activity of GPT protein]PMID:25747392 PMID:27773935 PMID:32976922 PMID:35780845
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