Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: GPT (glutamic--pyruvic transaminase) Homo sapiens
Symbol: GPT
Name: glutamic--pyruvic transaminase
RGD ID: 734191
Description: Predicted to have pyridoxal phosphate binding activity. Predicted to be involved in cellular amino acid biosynthetic process. Localizes to extracellular exosome. Biomarker of fatty liver disease; liver cancer; liver cirrhosis; and non-alcoholic fatty liver disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AAT1; alanine aminotransferase; alanine aminotransferase 1; alanine transaminase; ALT1; glutamate pyruvate transaminase 1; glutamic--alanine transaminase 1; glutamic--pyruvic transaminase 1; glutamic-alanine transaminase 1; glutamic-pyruvate transaminase (alanine aminotransferase); GPT 1; GPT1
Mus musculus (house mouse) : Gpt (glutamic pyruvic transaminase, soluble)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gpt (glutamic--pyruvic transaminase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gpt (glutamic--pyruvic transaminase)
Canis lupus familiaris (dog) : GPT (glutamic--pyruvic transaminase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gpt (glutamic--pyruvic transaminase)
Sus scrofa (pig) : GPT (glutamic--pyruvic transaminase)
Chlorocebus sabaeus (African green monkey) : GPT (glutamic--pyruvic transaminase)
Heterocephalus glaber (naked mole-rat) : Gpt (glutamic--pyruvic transaminase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is relevant for disease process.
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl8144,502,973 - 144,507,174 (+)EnsemblGRCh38hg38GRCh38
GRCh388144,503,068 - 144,507,172 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh378145,729,465 - 145,732,555 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368145,700,231 - 145,703,357 (+)NCBINCBI36hg18NCBI36
Build 348145,700,232 - 145,703,357NCBI
Celera8141,904,937 - 141,908,027 (+)NCBI
Cytogenetic Map8q24.3NCBI
HuRef8140,842,619 - 140,845,709 (+)NCBIHuRef
CHM1_18145,767,740 - 145,770,746 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on GPT
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 734191
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.