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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734191
Species: Homo sapiens
RGD Object: Gene
Symbol: GPT
Name: glutamic--pyruvic transaminase
Acc ID: CHEBI:28775
Term: hesperidin
Definition: A disaccharide derivative that consists of hesperetin substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.
Chemical ID: MESH:D006569
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GPTdecreases activityISOGpt (Mus musculus)6480464CTDHesperidin results in decreased activity of GPT proteinPMID:29481770
GPTmultiple interactionsISOGpt (Rattus norvegicus)6480464CTDHesperidin inhibits the reaction [Chlorpyrifos results in increased activity of GPT protein]; Hesperidin inhibits the reaction [Diethylnitrosamine results in increased activity of GPT protein]; Hesperidin inhibits the reaction [sodium arsenite results in increased activity of GPT protein]PMID:30066062 PMID:30779474 PMID:33908150
GPTmultiple interactionsISOGpt (Mus musculus)6480464CTD[Doxorubicin co-treated with Hesperidin] results in decreased activity of GPT proteinPMID:29481770
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