GPT (glutamic--pyruvic transaminase) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: GPT (glutamic--pyruvic transaminase) Chlorocebus sabaeus
Analyze
Symbol: GPT
Name: glutamic--pyruvic transaminase
RGD ID: 18416032
Description: ENCODES a protein that exhibits L-alanine:2-oxoglutarate aminotransferase activity (inferred); pyridoxal phosphate binding (inferred); transaminase activity (inferred); INVOLVED IN cellular response to insulin stimulus (ortholog); positive regulation of gluconeogenesis (ortholog); response to nutrient levels (ortholog); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; alanine metabolic pathway; argininosuccinic aciduria pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Liver Failure (ortholog); Baller-Gerold syndrome (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: alanine aminotransferase 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18138,716,802 - 138,721,421 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8138,718,767 - 138,721,251 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660391,133,510 - 1,138,125 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
GPT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18138,716,802 - 138,721,421 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8138,718,767 - 138,721,251 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660391,133,510 - 1,138,125 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
GPT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388144,503,068 - 144,507,172 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8144,502,973 - 144,507,174 (+)EnsemblGRCh38hg38GRCh38
GRCh378145,728,451 - 145,732,555 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368145,700,231 - 145,703,357 (+)NCBINCBI36Build 36hg18NCBI36
Build 348145,700,232 - 145,703,357NCBI
Celera8141,904,937 - 141,908,027 (+)NCBICelera
Cytogenetic Map8q24.3NCBI
HuRef8140,842,619 - 140,845,709 (+)NCBIHuRef
CHM1_18145,767,740 - 145,770,746 (+)NCBICHM1_1
T2T-CHM13v2.08145,672,833 - 145,676,937 (+)NCBIT2T-CHM13v2.0
Gpt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391576,580,926 - 76,583,875 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1576,579,916 - 76,583,886 (+)EnsemblGRCm39 Ensembl
GRCm381576,696,726 - 76,699,675 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1576,695,716 - 76,699,686 (+)EnsemblGRCm38mm10GRCm38
MGSCv371576,527,194 - 76,530,105 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361576,524,016 - 76,526,930 (+)NCBIMGSCv36mm8
Celera1578,190,374 - 78,193,285 (+)NCBICelera
Cytogenetic Map15D3NCBI
cM Map1536.28NCBI
Gpt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87110,295,599 - 110,300,134 (+)NCBIGRCr8
mRatBN7.27108,416,646 - 108,419,495 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7108,416,642 - 108,419,494 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7110,158,569 - 110,161,418 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07112,382,143 - 112,384,992 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07112,342,892 - 112,345,741 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07117,759,083 - 117,761,932 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7117,759,083 - 117,761,931 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07117,745,308 - 117,749,938 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47114,746,054 - 114,748,903 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7104,766,538 - 104,769,387 (+)NCBICelera
Cytogenetic Map7q34NCBI
Gpt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554543,127,997 - 3,132,459 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554543,127,997 - 3,132,459 (+)NCBIChiLan1.0ChiLan1.0
GPT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27161,994,411 - 161,999,064 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18137,522,660 - 137,528,193 (+)NCBINHGRI_mPanPan1
PanPan1.1 Ensembl8144,259,991 - 144,263,737 (+)Ensemblpanpan1.1panPan2
GPT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11337,923,757 - 37,927,843 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1337,924,422 - 37,926,156 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1337,884,479 - 37,888,507 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01338,397,476 - 38,401,488 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1338,398,154 - 38,404,357 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11338,089,429 - 38,093,531 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01338,197,829 - 38,201,856 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01338,674,294 - 38,678,329 (+)NCBIUU_Cfam_GSD_1.0
Gpt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303339,711 - 344,808 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364707,765,703 - 7,768,465 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364707,765,810 - 7,770,837 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4297,748 - 320,056 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14297,747 - 302,498 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24388,746 - 393,520 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Gpt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473512,355,476 - 12,360,028 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473512,355,476 - 12,359,910 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 14 31
Low 22 15 29
Below cutoff 5

Sequence


RefSeq Acc Id: ENSCSAT00000006349   ⟹   ENSCSAP00000004557
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl8138,718,767 - 138,721,251 (+)Ensembl
RefSeq Acc Id: XM_008001960   ⟹   XP_008000151
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.18138,716,802 - 138,721,421 (+)NCBI
Vero_WHO_p1.0NW_0236660391,133,510 - 1,138,125 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037999949   ⟹   XP_037855877
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660391,133,510 - 1,138,125 (-)NCBI
RefSeq Acc Id: XM_037999950   ⟹   XP_037855878
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660391,133,510 - 1,138,125 (-)NCBI
RefSeq Acc Id: XM_037999951   ⟹   XP_037855879
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660391,133,510 - 1,138,125 (-)NCBI
RefSeq Acc Id: XM_037999952   ⟹   XP_037855880
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660391,133,510 - 1,138,125 (-)NCBI
RefSeq Acc Id: XM_037999953   ⟹   XP_037855881
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660391,133,510 - 1,138,125 (-)NCBI
RefSeq Acc Id: XM_037999954   ⟹   XP_037855882
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660391,133,510 - 1,138,125 (-)NCBI
RefSeq Acc Id: XM_037999955   ⟹   XP_037855883
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660391,133,510 - 1,138,125 (-)NCBI
RefSeq Acc Id: XP_008000151   ⟸   XM_008001960
- Peptide Label: isoform X8
- UniProtKB: A0A0D9R7G8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000004557   ⟸   ENSCSAT00000006349
RefSeq Acc Id: XP_037855877   ⟸   XM_037999949
- Peptide Label: isoform X1
RefSeq Acc Id: XP_037855883   ⟸   XM_037999955
- Peptide Label: isoform X7
RefSeq Acc Id: XP_037855880   ⟸   XM_037999952
- Peptide Label: isoform X4
RefSeq Acc Id: XP_037855882   ⟸   XM_037999954
- Peptide Label: isoform X6
RefSeq Acc Id: XP_037855881   ⟸   XM_037999953
- Peptide Label: isoform X5
RefSeq Acc Id: XP_037855879   ⟸   XM_037999951
- Peptide Label: isoform X3
RefSeq Acc Id: XP_037855878   ⟸   XM_037999950
- Peptide Label: isoform X2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000008298 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000006349.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.1970 UniProtKB/TrEMBL
  3.40.640.10 UniProtKB/TrEMBL
  3.90.1150.10 UniProtKB/TrEMBL
InterPro ALAT1/2-like UniProtKB/TrEMBL
  Aminotransferase_I/II UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_dom1 UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_major UniProtKB/TrEMBL
NCBI Gene GPT ENTREZGENE
PANTHER ALANINE AMINOTRANSFERASE 1 UniProtKB/TrEMBL
  PTHR11751 UniProtKB/TrEMBL
Pfam Aminotran_1_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF53383 UniProtKB/TrEMBL
UniProt A0A0D9R7G8 ENTREZGENE, UniProtKB/TrEMBL