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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734191
Species: Homo sapiens
RGD Object: Gene
Symbol: GPT
Name: glutamic--pyruvic transaminase
Acc ID: CHEBI:2504
Term: aflatoxin B1
Definition: An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.
Chemical ID: MESH:D016604
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GPTaffects expressionEXP 6480464CTDAflatoxin B1 affects the expression of GPT proteinPMID:20106945
GPTdecreases expressionEXP 6480464CTDAflatoxin B1 results in decreased expression of GPT mRNAPMID:22100608 PMID:32234424
GPTincreases activityISOGpt (Rattus norvegicus)6480464CTDAflatoxin B1 results in increased activity of GPT proteinPMID:27288928 PMID:34015426 PMID:35608386
GPTincreases activityISOGpt (Mus musculus)6480464CTDAflatoxin B1 results in increased activity of GPT proteinPMID:25445755 PMID:35063475
GPTincreases expressionISOGpt (Rattus norvegicus)6480464CTDAflatoxin B1 results in increased expression of GPT proteinPMID:23423819 PMID:32418920
GPTincreases secretionISOGpt (Mus musculus)6480464CTDAflatoxin B1 results in increased secretion of GPT proteinPMID:37030333
GPTmultiple interactionsISOGpt (Rattus norvegicus)6480464CTD[Aflatoxin B1 co-treated with Ethanol] results in increased expression of GPT protein; [Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in increased activity of GPT protein]; [Resveratrol co-treated with Niacinamide] inhibits the reaction [[Aflatoxin B1 co-treated with Ethanol] results in increased expression of GPT protein]; Resveratrol inhibits the reaction [[Aflatoxin B1 co-treated with Ethanol] results in increased expression of GPT protein]; Sildenafil Citrate inhibits the reaction [Aflatoxin B1 results in increased activity of GPT protein]; Tadalafil inhibits the reaction [Aflatoxin B1 results in increased activity of GPT protein]PMID:27288928 PMID:32894639 PMID:35608386
GPTmultiple interactionsISOGpt (Mus musculus)6480464CTDCurcumin inhibits the reaction [Aflatoxin B1 results in increased activity of GPT protein]; deoxynivalenol promotes the reaction [Aflatoxin B1 results in increased activity of GPT protein]; fexaramine inhibits the reaction [Aflatoxin B1 results in increased secretion of GPT protein]; Zearalenone inhibits the reaction [Aflatoxin B1 results in increased activity of GPT protein]PMID:25445755 PMID:35063475 PMID:37030333
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