GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | GPT | decreases expression | ISO | Gpt (Rattus norvegicus) | 6480464 | CTD | Thioacetamide results in decreased expression of GPT mRNA | PMID:23411599 PMID:34492290 | GPT | increases activity | ISO | Gpt (Rattus norvegicus) | 6480464 | CTD | Thioacetamide results in increased activity of GPT protein | PMID:22899499 PMID:29133031 PMID:29738702 PMID:30138605 PMID:32718261 | GPT | increases activity | ISO | Gpt (Mus musculus) | 6480464 | CTD | Thioacetamide results in increased activity of GPT protein | PMID:28800171 PMID:29763686 PMID:3795300 | GPT | increases expression | ISO | Gpt (Rattus norvegicus) | 6480464 | CTD | Thioacetamide results in increased expression of GPT protein | PMID:15770714 PMID:24704557 PMID:26957569 PMID:28181416 PMID:30526075 PMID:31967703 PMID:33503444 PMID:37008694 PMID:37150287 | GPT | increases expression | ISO | Gpt (Mus musculus) | 6480464 | CTD | Thioacetamide results in increased expression of GPT protein | PMID:30625377 | GPT | multiple interactions | ISO | Gpt (Rattus norvegicus) | 6480464 | CTD | [Melatonin co-treated with Thioacetamide] results in increased expression of GPT protein; AM 1241 inhibits the reaction [Thioacetamide results in increased expression of GPT protein]; Berberine inhibits the reaction [Thioacetamide results in increased activity of GPT protein]; chloroquine diphosphate inhibits the reaction [Thioacetamide results in increased activity of GPT protein]; chloroquine diphosphate promotes the reaction [Doxorubicin inhibits the reaction [Thioacetamide results in increased activity of GPT protein]]; Clodronic Acid promotes the reaction [Thioacetamide results in increased expression of GPT protein]; Coffee inhibits the reaction [Thioacetamide results in increased activity of GPT protein]; Curcumin inhibits the reaction [Thioacetamide results in increased activity of GPT protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of GPT protein]; Cyclosporine inhibits the reaction [Thioacetamide results in increased expression of GPT protein]; Doxorubicin inhibits the reaction [Thioacetamide results in increased activity of GPT protein]; indole-3-carbinol affects the reaction [Thioacetamide results in increased expression of GPT protein]; Mesalamine inhibits the reaction [Thioacetamide results in increased activity of GPT protein]; pomegranate fruit rind inhibits the reaction [Thioacetamide results in increased activity of GPT protein]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased activity of GPT protein]]; silybin-phytosome inhibits the reaction [Thioacetamide results in increased expression of GPT protein]; Silymarin inhibits the reaction [Thioacetamide results in increased expression of GPT protein]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of GPT protein]; Verapamil inhibits the reaction [Thioacetamide results in increased expression of GPT protein] | PMID:15770714 PMID:22899499 PMID:24704557 PMID:26957569 PMID:29133031 PMID:29738702 PMID:30138605 PMID:30526075 PMID:31967703 PMID:32718261 PMID:33503444 PMID:37150287 | GPT | multiple interactions | ISO | Gpt (Mus musculus) | 6480464 | CTD | [TGFBR1 protein results in increased susceptibility to Thioacetamide] which results in increased expression of GPT protein; AKR1A1 protein affects the reaction [Thioacetamide results in increased activity of GPT protein]; diisopropyl 1,3-dithiol-2-ylidenemalonate inhibits the reaction [Thioacetamide results in increased activity of GPT protein] | PMID:28560358 PMID:29763686 PMID:3795300 | | ||||||||||||||||||||||
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