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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734191
Species: Homo sapiens
RGD Object: Gene
Symbol: GPT
Name: glutamic--pyruvic transaminase
Acc ID: CHEBI:33234
Term: vitamin E
Definition: Any member of a group of fat-soluble chromanols that exhibit biological activity against vitamin E deficiency. The vitamers in this class consists of a chroman-6-ol core which is substituted at position 2 by a methyl group and (also at position 2) either a saturated or a triply-unsaturated hydrocarbon chain consisting of three isoprenoid units. The major function of vitamin E is to act as a natural antioxidant by scavenging free radicals and molecular oxygen.
Chemical ID: MESH:D024502
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GPTmultiple interactionsISOGpt (Rattus norvegicus)6480464CTD[Quercetin co-treated with Vitamin E] inhibits the reaction [Cyclosporine results in increased activity of GPT protein]; Vitamin E inhibits the reaction [Cyclophosphamide results in increased expression of GPT protein]; Vitamin E inhibits the reaction [Cyclosporine results in increased activity of GPT protein]; Vitamin E inhibits the reaction [Food Additives results in increased activity of GPT protein]; Vitamin E inhibits the reaction [Hexachlorobenzene results in increased activity of GPT protein]; Vitamin E inhibits the reaction [Tramadol results in increased expression of GPT protein]PMID:16758767 PMID:17927767 PMID:25779342 PMID:30064338 PMID:31618080
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