Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	734191
Species:	Homo sapiens
RGD Object:	Gene
Symbol:	GPT
Name:	glutamic--pyruvic transaminase

Acc ID:	CHEBI:27899
Term:	cisplatin
Definition:	A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID:	MESH:D002945

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
GPT	decreases expression	EXP		6480464	CTD	Cisplatin results in decreased expression of GPT mRNA	PMID:27392435
GPT	increases expression	EXP		6480464	CTD	Cisplatin results in increased expression of GPT protein	PMID:28073184
GPT	multiple interactions	EXP		6480464	CTD	[Cisplatin co-treated with Palmitic Acid] results in increased expression of GPT protein	PMID:28073184
GPT	increases activity	ISO	Gpt (Rattus norvegicus)	6480464	CTD	Cisplatin results in increased activity of GPT protein	PMID:32259551 PMID:33393703 PMID:36122812
GPT	increases activity	ISO	Gpt (Mus musculus)	6480464	CTD	Cisplatin results in increased activity of GPT protein	PMID:28606469
GPT	increases expression	ISO	Gpt (Rattus norvegicus)	6480464	CTD	Cisplatin results in increased expression of GPT protein	PMID:17604343 PMID:28371137 PMID:30842369 PMID:33661552
GPT	increases expression	ISO	Gpt (Mus musculus)	6480464	CTD	Cisplatin results in increased expression of GPT protein	PMID:37956922
GPT	multiple interactions	ISO	Gpt (Rattus norvegicus)	6480464	CTD	6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [betanin inhibits the reaction [Cisplatin results in increased expression of GPT protein]]; [epigallocatechin gallate co-treated with coenzyme Q10] inhibits the reaction [Cisplatin results in increased activity of GPT protein]; astragaloside A inhibits the reaction [Cisplatin results in increased expression of GPT protein]; betanin inhibits the reaction [Cisplatin results in increased expression of GPT protein]; crocin inhibits the reaction [Cisplatin results in increased activity of GPT protein]; Grape Seed Proanthocyanidins inhibits the reaction [Cisplatin results in increased expression of GPT protein]; Rivaroxaban inhibits the reaction [Cisplatin results in increased activity of GPT protein]	PMID:28371137 PMID:30842369 PMID:32259551 PMID:33393703 PMID:33661552 PMID:36122812
GPT	multiple interactions	ISO	Gpt (Mus musculus)	6480464	CTD	resveratrol affects the reaction [Cisplatin results in increased activity of GPT protein]	PMID:28606469

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