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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734191
Species: Homo sapiens
RGD Object: Gene
Symbol: GPT
Name: glutamic--pyruvic transaminase
Acc ID: CHEBI:28939
Term: N-acetyl-L-cysteine
Definition: An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.
Chemical ID: MESH:D000111
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GPTmultiple interactionsISOGpt (Rattus norvegicus)6480464CTD[Zinc co-treated with Selenium co-treated with Acetylcysteine] inhibits the reaction [dimethyl mercury results in increased activity of GPT protein]; Acetylcysteine inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased activity of GPT protein]; Acetylcysteine inhibits the reaction [Acetaminophen affects the activity of GPT protein]; Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of GPT protein]; Acetylcysteine inhibits the reaction [Cyclosporine results in increased activity of GPT protein]; Acetylcysteine inhibits the reaction [Ethanol results in increased activity of GPT protein]; Acetylcysteine inhibits the reaction [Glyphosate results in increased activity of GPT protein]; Acetylcysteine inhibits the reaction [Mercuric Chloride results in increased activity of GPT protein]; Acetylcysteine inhibits the reaction [Risperidone results in increased expression of and results in increased secretion of GPT protein]; Selenium promotes the reaction [Acetylcysteine inhibits the reaction [Mercuric Chloride results in increased activity of GPT protein]]PMID:17461432 PMID:20688495 PMID:20804811 PMID:24485406 PMID:27387968 PMID:29704510 PMID:30641872 PMID:32402895 PMID:33797725
GPTmultiple interactionsISOGpt (Mus musculus)6480464CTDAcetylcysteine inhibits the reaction [[Galactosamine co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of GPT protein]; Acetylcysteine inhibits the reaction [Acetaminophen results in increased activity of GPT protein]; Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of GPT protein]; Acetylcysteine inhibits the reaction [Lipopolysaccharides promotes the reaction [PTEN gene mutant form results in increased secretion of GPT protein]]; IL22 protein promotes the reaction [Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of GPT protein]]PMID:23375450 PMID:27022031 PMID:27720869 PMID:28435131 PMID:28887131 PMID:30423402 PMID:37458150 PMID:38042273
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