Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621720
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gpt
Name: glutamic--pyruvic transaminase
Acc ID: CHEBI:27385
Term: tetrachloromethane
Definition: A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID: MESH:D002251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gptincreases activityEXP 6480464CTDCarbon Tetrachloride results in increased activity of GPT proteinPMID:15506549 PMID:15573910 PMID:15603720 PMID:15673190 PMID:15700767 PMID:15931870 PMID:17200984 PMID:18989868 PMID:22989100 PMID:24293383 PMID:26882442 PMID:26929000 PMID:27241356 PMID:27623180 PMID:31150632 PMID:31168027 PMID:8627517
Gptincreases expressionEXP 6480464CTDCarbon Tetrachloride results in increased expression of GPT proteinPMID:15095147 PMID:23374533 PMID:25478064 PMID:26062544 PMID:26862777 PMID:27452039 PMID:30254303 PMID:30676168 PMID:30719803 PMID:32380060 PMID:37009719
Gptincreases secretionEXP 6480464CTDCarbon Tetrachloride results in increased secretion of GPT proteinPMID:10757424
Gptmultiple interactionsEXP 6480464CTD1,2,4-triazole analog inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased activity of GPT protein]; [allyl sulfide co-treated with dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylene dioxybiphenyl-2,2'-dicarboxylate] inhibits the reaction [[Carbon Tetrachloride co-treated with Buthionine Sulfoximine] results in increased activity of GPT protein]; [Carbon Tetrachloride co-treated with Buthionine Sulfoximine] results in increased expression of and results in increased activity of GPT protein; [Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased activity of GPT protein; [diphenyldiselenide co-treated with diphenyldiselenide] promotes the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; [raspberry ketone co-treated with Resveratrol] inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein]; Allyl Compounds promotes the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; allyl isothiocyanate inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; allyl sulfide inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; almond oil inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; Ascorbic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein]; BP 2-94 inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; Carbon Tetrachloride results in increased expression of and results in increased activity of GPT protein; Carvedilol inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein]; cynandione A inhibits the reaction [Carbon Tetrachloride results in increased secretion of GPT protein]; diallyl disulfide inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; Drugs, Chinese Herbal inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; Ketoconazole inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; Losartan inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; Melatonin inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; oxymatrine inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; Plant Extracts inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased activity of GPT protein]; Plant Extracts inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein]; propyl ether promotes the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; Quercetin inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; Ramipril inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein]; raspberry ketone inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein]; Resveratrol inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein]; Rivaroxaban inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein]; Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein]; schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; Silymarin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased activity of GPT protein]; Taurine inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; Telmisartan inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; thymoquinone inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased activity of GPT protein]; Ursodeoxycholic Acid inhibits the reaction [[Carbon Tetrachloride co-treated with Buthionine Sulfoximine] results in increased activity of GPT protein]PMID:10757424 PMID:15095147 PMID:15506549 PMID:15573910 PMID:15603720 PMID:15673190 PMID:15700767 PMID:15931870 PMID:15950962 PMID:18989868 PMID:22989100 PMID:24293383 PMID:25478064 PMID:26062544 PMID:26862777 PMID:26882442 PMID:26929000 PMID:27241356 PMID:27623180 PMID:28693887 PMID:29923357 PMID:30254303 PMID:30676168 PMID:30719803 PMID:31150632 PMID:31168027 PMID:37009719 PMID:8627517
Gptdecreases expressionISOGpt (Mus musculus)6480464CTDCarbon Tetrachloride results in decreased expression of GPT mRNAPMID:31919559
Gptincreases activityISOGpt (Mus musculus)6480464CTDCarbon Tetrachloride results in increased activity of GPT proteinPMID:10355542 PMID:15720792 PMID:15730626 PMID:19085960 PMID:24530446 PMID:24973641 PMID:24973642 PMID:24975834 PMID:25656916 PMID:26218279 PMID:26853152 PMID:26921287 PMID:27042213 PMID:28286204 PMID:31830547 PMID:32956689 PMID:32996673 PMID:33549628 PMID:35202708 PMID:36526012 PMID:36555680 PMID:37003405 PMID:37573684
Gptincreases expressionISOGpt (Mus musculus)6480464CTDCarbon Tetrachloride results in increased expression of GPT proteinPMID:19085960 PMID:24646716 PMID:24717679 PMID:26763393 PMID:27151496 PMID:27916511 PMID:29964319 PMID:29974145 PMID:30368983 PMID:30502394 PMID:31513885 PMID:31697926 PMID:3196385 PMID:32033504 PMID:32234387 PMID:32344006 PMID:33309619 PMID:34191077 PMID:35101388 PMID:35411647 PMID:37894611 PMID:38042390
Gptincreases secretionISOGPT (Homo sapiens)6480464CTDCarbon Tetrachloride results in increased secretion of GPT proteinPMID:32234387
Gptincreases secretionISOGpt (Mus musculus)6480464CTDCarbon Tetrachloride results in increased secretion of GPT proteinPMID:25747392
Gptmultiple interactionsISOGPT (Homo sapiens)6480464CTDCHRM2 protein inhibits the reaction [Carbon Tetrachloride results in increased secretion of GPT protein]; CHRM4 protein inhibits the reaction [Carbon Tetrachloride results in increased secretion of GPT protein]; POSTN protein promotes the reaction [Carbon Tetrachloride results in increased expression of GPT protein]PMID:32234387 PMID:32344006
Gptmultiple interactionsISOGpt (Mus musculus)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; 3-methylquercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein]; 5-(3-(4-(4-benzylpiperazin-1-yl)-N-(4-phenylthiazol-2-yl))propanamide inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein]; [Dietary Fats co-treated with Carbon Tetrachloride] results in increased expression of and results in increased secretion of GPT protein; [Ethanol co-treated with Carbon Tetrachloride co-treated with 4-O-methylhonokiol] results in increased expression of GPT protein; [GJB1 protein affects the susceptibility to Carbon Tetrachloride] which affects the activity of GPT protein; ADAM8 protein affects the reaction [Carbon Tetrachloride results in increased expression of GPT protein]; alisol B 23-acetate inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; alisol B 23-acetate inhibits the reaction [Carbon Tetrachloride results in increased secretion of GPT protein]; alisol B inhibits the reaction [[Dietary Fats co-treated with Carbon Tetrachloride] results in increased expression of and results in increased secretion of GPT protein]; AM 281 inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein]; Anethole Trithione inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein]; ATG5 protein inhibits the reaction [curcumol inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]]; ATG5 protein promotes the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; ATM protein inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; bicyclol inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; bifendate inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]]; Carbon Tetrachloride results in increased secretion of and results in increased activity of GPT protein; CEBPB protein inhibits the reaction [Carbon Tetrachloride results in increased secretion of and results in increased activity of GPT protein]; Chenodeoxycholic Acid inhibits the reaction [Carbon Tetrachloride results in increased secretion of GPT protein]; Chlordecone promotes the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; Colchicine inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; curcumol inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; curcumol inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein]; fuzheng huayu inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; fuzheng huayu inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein]; gentian root extract inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein]; ginkgolide A inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein]; ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein]; GOT2 protein inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; HAS3 protein affects the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; hemistepsin inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; Ivermectin inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; KLF5 protein inhibits the reaction [curcumol inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]]; KLF5 protein promotes the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; mangostin inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein]; Metformin inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein]; myricitrin inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; neohesperidin dihydrochalcone inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; NFE2L2 protein affects the reaction [Carbon Tetrachloride results in increased expression of GPT protein]; Nicotine inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein]; Oleanolic Acid inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; Plant Extracts inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]]; pyrazolanthrone inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; Quercetin inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; ruxolitinib inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]]; SB 203580 inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; Silymarin inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; SIRT3 protein affects the reaction [Carbon Tetrachloride results in increased expression of GPT protein]; Tamoxifen inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein]; tianhuang inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT mRNA]; TRP53BP2 protein affects the reaction [Carbon Tetrachloride results in increased expression of GPT protein]; Vildagliptin inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; Vitamin D inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein]; Zinc Sulfate inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein]PMID:10355542 PMID:15720792 PMID:15721291 PMID:15730626 PMID:24530446 PMID:24646716 PMID:24717679 PMID:24973641 PMID:24973642 PMID:24975834 PMID:25656916 PMID:25747392 PMID:26218279 PMID:26763393 PMID:26853152 PMID:27042213 PMID:27151496 PMID:27268753 PMID:28689299 PMID:29964319 PMID:29974145 PMID:30368983 PMID:30502394 PMID:31513885 PMID:31697926 PMID:31830547 PMID:3196385 PMID:32033504 PMID:32234387 PMID:32344006 PMID:32956689 PMID:33309619 PMID:33549628 PMID:35101388 PMID:35202708 PMID:35411647 PMID:35745142 PMID:36526012 PMID:36555680 PMID:37003405 PMID:37573684 PMID:37894611 PMID:38042390
Go Back to source page   Continue to Ontology report