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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621720
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gpt
Name: glutamic--pyruvic transaminase
Acc ID: CHEBI:6030
Term: isoniazide
Definition: A carbohydrazide obtained by formal condensation between pyridine-4-carboxylic acid and hydrazine.
Chemical ID: MESH:D007538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gptincreases activityEXP 6480464CTDIsoniazid results in increased activity of GPT proteinPMID:28619387
Gptmultiple interactionsEXP 6480464CTD[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of GPT protein; [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in increased expression of GPT protein; [Lipopolysaccharides co-treated with Isoniazid] results in increased activity of GPT protein; HIF1A protein affects the reaction [[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in increased expression of GPT protein]; Isoniazid promotes the reaction [Zidovudine results in increased activity of GPT protein]; Silybin inhibits the reaction [Isoniazid promotes the reaction [Zidovudine results in increased activity of GPT protein]]PMID:25331106 PMID:28619387 PMID:35835356 PMID:36878459
Gptincreases activityISOGpt (Mus musculus)6480464CTDIsoniazid results in increased activity of GPT proteinPMID:25886055
Gptincreases expressionISOGPT (Homo sapiens)6480464CTDIsoniazid results in increased expression of GPT proteinPMID:31332904
Gptmultiple interactionsISOGPT (Homo sapiens)6480464CTDQuercetin inhibits the reaction [Isoniazid results in increased expression of GPT protein]PMID:31332904
Gptmultiple interactionsISOGpt (Mus musculus)6480464CTD[Rifampin co-treated with Isoniazid] results in increased activity of GPT proteinPMID:25886055
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