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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621720
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gpt
Name: glutamic--pyruvic transaminase
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gptincreases activityEXP 6480464CTDDexamethasone results in increased activity of GPT proteinPMID:35866224
Gptmultiple interactionsEXP 6480464CTDUbiquinone inhibits the reaction [Dexamethasone results in increased activity of GPT protein]PMID:35866224
Gptincreases expressionISOGpt (Mus musculus)6480464CTDDexamethasone results in increased expression of GPT proteinPMID:25900201
Gptmultiple interactionsISOGpt (Mus musculus)6480464CTD1-aminobenzotriazole promotes the reaction [Amiodarone promotes the reaction [Dexamethasone results in increased expression of GPT protein]]; [Dexamethasone co-treated with Acetaminophen] results in increased expression of GPT protein; [Dexamethasone results in increased susceptibility to Amiodarone] which results in increased expression of GPT protein; Amiodarone promotes the reaction [Dexamethasone results in increased expression of GPT protein]; Dexamethasone inhibits the reaction [Acetaminophen results in increased expression of GPT protein]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of GPT protein]; Dexamethasone promotes the reaction [IL10 protein inhibits the reaction [Lipopolysaccharides results in increased expression of GPT protein]]; FGF21 protein affects the reaction [Dexamethasone inhibits the reaction [Acetaminophen results in increased expression of GPT protein]]; gadolinium chloride inhibits the reaction [Amiodarone promotes the reaction [Dexamethasone results in increased expression of GPT protein]]PMID:25900201 PMID:28088388 PMID:37177863
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