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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621720
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gpt
Name: glutamic--pyruvic transaminase
Acc ID: CHEBI:10022
Term: deoxynivalenol
Definition: A trichothecene mycotoxin produced by Fusarium to which wheat, barley, maize (corn) and their products are susceptible to contamination.
Chemical ID: MESH:C007262
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gptincreases expressionEXP 6480464CTDdeoxynivalenol results in increased expression of GPT proteinPMID:26115597
Gptmultiple interactionsEXP 6480464CTDBentonite inhibits the reaction [deoxynivalenol results in increased expression of GPT protein]; Charcoal inhibits the reaction [deoxynivalenol results in increased expression of GPT protein]PMID:26115597
Gptincreases activityISOGpt (Mus musculus)6480464CTDdeoxynivalenol results in increased activity of GPT proteinPMID:25445755 PMID:34400200 PMID:35925383 PMID:36602574
Gptmultiple interactionsISOGpt (Mus musculus)6480464CTDacetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [deoxynivalenol results in increased activity of GPT protein]; benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [deoxynivalenol results in increased activity of GPT protein]; BMAL1 protein inhibits the reaction [deoxynivalenol results in increased activity of GPT protein]; deoxynivalenol promotes the reaction [Aflatoxin B1 results in increased activity of GPT protein]PMID:25445755 PMID:35925383 PMID:36602574
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