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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621720
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gpt
Name: glutamic--pyruvic transaminase
Acc ID: CHEBI:27744
Term: glyphosate
Definition: A phosphonic acid resulting from the formal oxidative coupling of the methyl group of methylphosphonic acid with the amino group of glycine. It is one of the most commonly used herbicides worldwide, and the only one to target the enzyme 5-enolpyruvyl-3-shikimate phosphate synthase (EPSPS).
Chemical ID: MESH:C010974
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gptdecreases activityEXP 6480464CTDGlyphosate results in decreased activity of GPT proteinPMID:24636977
Gptincreases activityEXP 6480464CTDGlyphosate results in increased activity of GPT proteinPMID:33797725
Gptincreases expressionEXP 6480464CTDGlyphosate results in increased expression of GPT proteinPMID:25067936
Gptmultiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [Glyphosate results in increased activity of GPT protein]; Zinc inhibits the reaction [Glyphosate results in increased expression of GPT protein]PMID:25067936 PMID:33797725
Gptincreases expressionISOGpt (Mus musculus)6480464CTDGlyphosate results in increased expression of GPT proteinPMID:36608876
Gptmultiple interactionsISOGPT (Homo sapiens)6480464CTD[Glyphosate results in increased abundance of aminomethylphosphonic acid (AMPA)] which results in increased activity of GPT protein; [imidacloprid co-treated with fipronil co-treated with Glyphosate] results in increased activity of and results in increased secretion of GPT protein; Glyphosate results in increased activity of and results in increased secretion of GPT proteinPMID:35850439 PMID:36856429
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