Slc22a22 (solute carrier family 22 member 22) - Rat Genome Database

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Gene: Slc22a22 (solute carrier family 22 member 22) Rattus norvegicus
Analyze
Symbol: Slc22a22
Name: solute carrier family 22 member 22
RGD ID: 1304605
Description: Predicted to enable prostaglandin receptor activity. Predicted to be involved in organic anion transport. Predicted to act upstream of or within sodium-independent prostaglandin transport. Predicted to be located in basolateral plasma membrane. Orthologous to human SLC22A10 (solute carrier family 22 member 10); INTERACTS WITH 3-chloropropane-1,2-diol; allopurinol; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical LOC299944; hypothetical protein LOC299944; LOC103692918; LOC299944; oat-pg; prostaglandin transporter OAT-PG; RGD1304605; solute carrier family 22 (organic cation transporter), member 22; uncharacterized LOC103692918
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8790,610,007 - 90,639,718 (-)NCBIGRCr8
mRatBN7.2788,720,425 - 88,750,111 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl788,720,427 - 88,750,111 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx790,603,834 - 90,632,862 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0792,805,110 - 92,834,138 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0792,607,748 - 92,636,778 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0797,042,176 - 97,071,984 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl797,040,507 - 97,071,968 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0797,658,167 - 97,687,760 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4793,866,365 - 93,895,294 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1793,900,596 - 93,929,524 (-)NCBI
Celera785,498,105 - 85,527,177 (-)NCBICelera
Cytogenetic Map7q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:22031854  


Genomics

Comparative Map Data
Slc22a22
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8790,610,007 - 90,639,718 (-)NCBIGRCr8
mRatBN7.2788,720,425 - 88,750,111 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl788,720,427 - 88,750,111 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx790,603,834 - 90,632,862 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0792,805,110 - 92,834,138 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0792,607,748 - 92,636,778 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0797,042,176 - 97,071,984 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl797,040,507 - 97,071,968 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0797,658,167 - 97,687,760 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4793,866,365 - 93,895,294 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1793,900,596 - 93,929,524 (-)NCBI
Celera785,498,105 - 85,527,177 (-)NCBICelera
Cytogenetic Map7q33NCBI
SLC22A10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381163,289,903 - 63,363,144 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1163,268,022 - 63,311,783 (+)EnsemblGRCh38hg38GRCh38
GRCh371163,057,375 - 63,079,255 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361162,814,006 - 62,835,822 (+)NCBINCBI36Build 36hg18NCBI36
Celera1160,381,496 - 60,403,314 (+)NCBICelera
Cytogenetic Map11q12.3NCBI
HuRef1159,386,286 - 59,408,097 (+)NCBIHuRef
CHM1_11162,940,453 - 62,962,269 (+)NCBICHM1_1
T2T-CHM13v2.01163,279,174 - 63,301,052 (+)NCBIT2T-CHM13v2.0
Slc22a22
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391557,107,163 - 57,341,021 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1557,107,163 - 57,341,021 (-)EnsemblGRCm39 Ensembl
GRCm381557,243,767 - 57,477,625 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1557,243,767 - 57,477,625 (-)EnsemblGRCm38mm10GRCm38
MGSCv371557,075,326 - 57,309,180 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361557,073,854 - 57,307,708 (-)NCBIMGSCv36mm8
Celera1558,767,003 - 58,997,011 (-)NCBICelera
Cytogenetic Map15D1NCBI
cM Map1523.88NCBI
LOC100974185
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2964,515,105 - 64,588,116 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11165,560,382 - 65,633,341 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01158,573,286 - 58,668,946 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11161,997,163 - 62,019,507 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1161,997,429 - 62,018,738 (+)Ensemblpanpan1.1panPan2
SLC22A10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11853,597,148 - 53,628,569 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1853,597,533 - 53,628,165 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1852,203,600 - 52,235,510 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01854,643,150 - 54,674,665 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1854,643,210 - 54,673,810 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11853,744,910 - 53,776,822 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01853,319,223 - 53,351,125 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01854,106,500 - 54,138,412 (-)NCBIUU_Cfam_GSD_1.0
LOC100513779
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.128,580,673 - 8,603,553 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:78
Count of miRNA genes:68
Interacting mature miRNAs:71
Transcripts:ENSRNOT00000006596
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)782111245123048330Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)771103011106126789Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)75170064396700643Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
1298525Cm1Cardiac mass QTL 12.7heart mass (VT:0007028)heart wet weight (CMO:0000069)756625161101625161Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)771621154114982716Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)773618702118618702Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)785043242130043242Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)785497398130497398Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)783626689128626689Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)755498584105834451Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)763889858108889858Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74847504993475049Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)773557047118557047Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)782111245123048330Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
1641908Teswt1Testicular weight QTL 13.28testis mass (VT:1000644)both testes wet weight (CMO:0000175)78211124596700643Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
10450862Kidm55Kidney mass QTL 554.9kidney mass (VT:0002707)kidney weight (CMO:0000081)772725037117725037Rat
724537Niddm52Non-insulin dependent diabetes mellitus QTL 520.02blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)78211124595485241Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)762963207107963207Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)763889858108889858Rat
10450856Livw4Liver weight QTL 43.8liver mass (VT:0003402)liver weight (CMO:0000092)772725037117725037Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)778682549123682549Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
2303582Gluco53Glucose level QTL 533blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)74860308793603087Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)771621154119349044Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat


Expression

RNA-SEQ Expression

circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
3 20 27 21 13 1 13 4 61 11 10 37 27 8

Sequence


Ensembl Acc Id: ENSRNOT00000006596   ⟹   ENSRNOP00000006596
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl788,720,427 - 88,750,111 (-)Ensembl
Rnor_6.0 Ensembl797,042,187 - 97,071,968 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000078009   ⟹   ENSRNOP00000068963
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl797,040,507 - 97,067,864 (-)Ensembl
RefSeq Acc Id: NM_001013947   ⟹   NP_001013969
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8790,610,007 - 90,639,695 (-)NCBI
mRatBN7.2788,720,425 - 88,750,111 (-)NCBI
Rnor_6.0797,042,180 - 97,071,968 (-)NCBI
Rnor_5.0797,658,167 - 97,687,760 (-)NCBI
RGSC_v3.4793,866,365 - 93,895,294 (-)RGD
Celera785,498,105 - 85,527,177 (-)RGD
Sequence:
RefSeq Acc Id: XM_063263253   ⟹   XP_063119323
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8790,610,007 - 90,639,718 (-)NCBI
RefSeq Acc Id: XM_063263254   ⟹   XP_063119324
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8790,610,007 - 90,639,715 (-)NCBI
RefSeq Acc Id: XM_063263255   ⟹   XP_063119325
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8790,610,007 - 90,639,718 (-)NCBI
RefSeq Acc Id: NP_001013969   ⟸   NM_001013947
- UniProtKB: Q66H77 (UniProtKB/TrEMBL),   F7F331 (UniProtKB/TrEMBL),   G3XEU5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006596   ⟸   ENSRNOT00000006596
Ensembl Acc Id: ENSRNOP00000068963   ⟸   ENSRNOT00000078009
RefSeq Acc Id: XP_063119325   ⟸   XM_063263255
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063119323   ⟸   XM_063263253
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063119324   ⟸   XM_063263254
- Peptide Label: isoform X2
Protein Domains
Major facilitator superfamily (MFS) profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q66H77-F1-model_v2 AlphaFold Q66H77 1-555 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695340
Promoter ID:EPDNEW_R5864
Type:single initiation site
Name:Slc22a22_1
Description:solute carrier family 22 , member 22
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0797,071,991 - 97,072,051EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304605 AgrOrtholog
BioCyc Gene G2FUF-33360 BioCyc
Ensembl Genes ENSRNOG00000004958 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006596.7 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.20 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7128584 IMAGE-MGC_LOAD
InterPro Major_facilitator_SF UniProtKB/TrEMBL
  MFS_1 UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/TrEMBL
KEGG Report rno:299944 UniProtKB/TrEMBL
MGC_CLONE MGC:94169 IMAGE-MGC_LOAD
NCBI Gene 299944 ENTREZGENE
PANTHER SOLUTE CARRIER FAMILY 22 MEMBER UniProtKB/TrEMBL
  SOLUTE CARRIER FAMILY 22 MEMBER 22 UniProtKB/TrEMBL
Pfam MFS_1 UniProtKB/TrEMBL
PhenoGen Slc22a22 PhenoGen
PROSITE MFS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004958 RatGTEx
Superfamily-SCOP MFS_gen_substrate_transporter UniProtKB/TrEMBL
UniProt F7F331 ENTREZGENE, UniProtKB/TrEMBL
  G3XEU5 ENTREZGENE, UniProtKB/TrEMBL
  Q66H77 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-02-04 Slc22a22  solute carrier family 22 member 22  Slc22a22  solute carrier family 22 (organic cation transporter), member 22  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2021-03-09 Slc22a22  solute carrier family 22 (organic cation transporter), member 22  LOC103692918  uncharacterized LOC103692918  Data merged from RGD:9083599 737654 PROVISIONAL
2014-08-25 LOC103692918  uncharacterized LOC103692918      Symbol and Name status set to provisional 70820 PROVISIONAL
2011-08-02 Slc22a22  solute carrier family 22 (organic cation transporter), member 22  RGD1304605  hypothetical LOC299944  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1304605  hypothetical LOC299944  RGD1304605_predicted  hypothetical LOC299944 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1304605_predicted  hypothetical LOC299944 (predicted)  LOC299944_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC299944_predicted  hypothetical LOC299944 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL