RGD Reference Report - Decreased CD122 on CD56dim NK associated with its impairment in asymptomatic chronic HBV carriers with high levels of HBV DNA, HBsAg and HBeAg. - Rat Genome Database

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Decreased CD122 on CD56dim NK associated with its impairment in asymptomatic chronic HBV carriers with high levels of HBV DNA, HBsAg and HBeAg.

Authors: Han, Wenzheng  Ni, Qin  Liu, Kezhou  Yao, Yunliang  Zhao, Dejian  Liu, Xia  Chen, Yu 
Citation: Han W, etal., Life Sci. 2018 Feb 15;195:53-60. doi: 10.1016/j.lfs.2018.01.001. Epub 2018 Jan 4.
RGD ID: 42724467
Pubmed: (View Article at PubMed) PMID:29307521
DOI: Full-text: DOI:10.1016/j.lfs.2018.01.001


AIMS: NK cells play important roles in inhibiting HBV replication and preventing HBV infection. However, NK-cell dysfunction has not been fully studied in asymptomatic chronic HBV carriers (ASC). This study aims to assess decreased expression of CD122 associated with impaired NK cells and the restoration of NK cells with IL-2 and IL-15 stimulation.
MAIN METHODS: The experiments were performed by flow cytometer, cytotoxicity assay, ELISA and western blotting.
KEY FINDINGS: The reduced CD122 on CD56+ NK cells and CD56dim NK cells is associated with high levels of HBV DNA, HBsAg or HBeAg in ASCs, in which CD56dim NK-cell impairment is observed. Moreover, decreased IFN-γ and degranulation and low cytotoxicity by CD56dim NK cells after CD122 blockade were revealed. IL-2 and/or IL-15 can restore impaired CD56dim NK cells, together with increased p-STAT5, which can be reversed by CD122 blockade. Additionally, IL-2 or IL-15 can enhance IFN-α2-activated CD56dim NK-cell immune responses via up-regulating interferon alpha and beta receptor subunit 2 (IFNAR2).
SIGNIFICANCE: Down-regulated CD122 on CD56dim NK cell in ASCs with massive viral antigens and high viremia is associated with its impairment, which can be restored by IL-2 and/or IL-15, or combined with IFN-α2.



Disease Annotations    
hepatitis B  (IEP,ISO)
Viremia  (IEP,ISO)

Objects Annotated

Genes (Rattus norvegicus)
Il2rb  (interleukin 2 receptor subunit beta)

Genes (Mus musculus)
Il2rb  (interleukin 2 receptor, beta chain)

Genes (Homo sapiens)
IL2RB  (interleukin 2 receptor subunit beta)


Additional Information