RGD Reference Report - A genome scan localizes five non-MHC loci controlling collagen-induced arthritis in rats. - Rat Genome Database

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A genome scan localizes five non-MHC loci controlling collagen-induced arthritis in rats.

Authors: Remmers, EF  Longman, RE  Du, Y  O'Hare, A  Cannon, GW  Griffiths, MM  Wilder, RL 
Citation: Remmers EF, etal., Nat Genet 1996 Sep;14(1):82-5
RGD ID: 61062
Pubmed: (View Article at PubMed) PMID:8782824
DOI: Full-text: DOI:10.1038/ng0996-82

Identification of specific genetic loci that contribute to susceptibility to rheumatoid arthritis (RA) in humans has been hampered by several factors, including: i) multiple interacting genetic loci contributing to susceptibility; ii) complex interactions of environmental and genetic factors; iii) genetic heterogeneity; and iv) low penetrance. We have, therefore, mapped quantitative trait loci (QTLs) that control inflammatory arthritis susceptibility and/or severity in progeny of two inbred rat strains with significantly different susceptibilities to collagen-induced arthritis (CIA), an animal model for RA. Not surprisingly, we identified a major susceptibility factor, Cia1, on chromosome 20 in the vicinity of the rat major histocompatibility complex (MHC). However, by limiting the analysis to animals with arthritis-susceptible MHC genotypes and using genome-wide QTL analytic techniques, we also found four non-MHC QTLs-Cia2, 3, 4 and 5-on chromosomes 1, 4, 7 and 10, that contributed to disease severity. In addition, a QTL on chromosome 8 was suggestive for linkage. Characterization of the genes underlying these QTLs will facilitate the identification of key biochemical pathways regulating experimental autoimmune arthritis in rats and may provide insights into RA and other human autoimmune diseases. These genes may also represent novel targets for therapy.

Annotation

Disease Annotations    

Phenotype Annotations    

Mammalian Phenotype
Objects Annotated

QTLs
Cia1  (Collagen induced arthritis QTL 1)
Cia2  (Collagen induced arthritis QTL 2)
Cia3  (Collagen induced arthritis QTL 3)
Cia4  (Collagen induced arthritis QTL 4)
Cia5  (Collagen induced arthritis QTL 5)
Ciaa1  (CIA Autoantibody QTL 1)

Objects referenced in this article
0 D7Arb17 D7Arb17 All species
0 D1Arb36 D1Arb36 All species
0 D4Arb21 D4Arb21 All species
0 D20Arb2 D20Arb2 All species
0 D20Wox3 D20Wox3 All species
0 D7Rat44 D7Rat44 All species
0 D1Rat212 D1Rat212 All species
0 D20Rat60 D20Rat60 All species
0 D1Arb37 D1Arb37 All species
0 D10Arb22 D10Arb22 All species
0 D4Arb24 D4Arb24 All species
0 D20Arb8 D20Arb8 All species
0 BBDR/Rhw null All species
0 BN BN All species
0 DA DA All species
0 DA/Bkl null All species
0 F344/NHsd F344/NHsd All species
0 F344/NRrrc null All species
0 Gh1 growth hormone 1 All species
0 Il2rb interleukin 2 receptor subunit beta All species
0 Pdgfrb platelet derived growth factor receptor beta All species
0 Prkca protein kinase C, alpha All species
0 Tgfbr1 transforming growth factor, beta receptor 1 All species
0 Timp2 TIMP metallopeptidase inhibitor 2 All species

Additional Information