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Gene: Pdgfrb (platelet derived growth factor receptor, beta polypeptide) Mus musculus
Symbol: Pdgfrb
Name: platelet derived growth factor receptor, beta polypeptide
Description: Exhibits kinase activity and signaling receptor binding activity. Involved in several processes, including animal organ development; positive regulation of intracellular signal transduction; and vasculature development. Localizes to the cell surface and cytoplasm. Used to study basal ganglia calcification; infantile myofibromatosis; myeloproliferative neoplasm; and severe nonproliferative diabetic retinopathy. Human ortholog(s) of this gene implicated in basal ganglia calcification; glioblastoma multiforme; infantile myofibromatosis; myeloproliferative neoplasm (multiple); and renal cell carcinoma. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; nervous system; and sensory organ. Orthologous to human PDGFRB (platelet derived growth factor receptor beta); PARTICIPATES IN platelet-derived growth factor signaling pathway; sphingosine 1-phosphate signaling pathway; glioma pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI528809; beta platelet-derived growth factor receptor; beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; CD140b; PDGF beta chain; PDGF-R-beta; Pdgfr; PDGFR-1; PDGFR-beta; platelet-derived growth factor receptor 1; platelet-derived growth factor receptor beta; platelet-derived growth factor receptor beta variant 1
Homo sapiens (human) : PDGFRB (platelet derived growth factor receptor beta)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Pdgfrb (platelet derived growth factor receptor beta)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pdgfrb (platelet derived growth factor receptor beta)
Pan paniscus (bonobo/pygmy chimpanzee) : PDGFRB (platelet derived growth factor receptor beta)
Canis lupus familiaris (dog) : PDGFRB (platelet derived growth factor receptor beta)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pdgfrb (platelet derived growth factor receptor beta)
Sus scrofa (pig) : PDGFRB (platelet derived growth factor receptor beta)
Chlorocebus sabaeus (green monkey) : PDGFRB (platelet derived growth factor receptor beta)
Heterocephalus glaber (naked mole-rat) : Pdgfrb (platelet derived growth factor receptor beta)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1861,045,150 - 61,085,061 (+)Ensembl
GRCm381861,045,127 - 61,085,067 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371861,204,804 - 61,244,721 (+)NCBIGRCm37mm9NCBIm37
MGSCv361861,170,810 - 61,210,428 (+)NCBImm8
Celera1862,332,161 - 62,372,066 (+)NCBICelera
Cytogenetic Map18 E1NCBI
cM Map1834.41NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Pdgfrb
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 11070
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-02-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.