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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3285
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pdgfrb
Name: platelet derived growth factor receptor beta
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pdgfrbincreases expressionEXP 6480464CTDHydrogen Peroxide results in increased expression of PDGFRB mRNA; Hydrogen Peroxide results in increased expression of PDGFRB proteinPMID:23022513
Pdgfrbmultiple interactionsEXP 6480464CTDtetramethylpyrazine inhibits the reaction [Hydrogen Peroxide results in increased expression of PDGFRB mRNA]; tetramethylpyrazine inhibits the reaction [Hydrogen Peroxide results in increased expression of PDGFRB protein]PMID:23022513
Pdgfrbaffects expressionISOPDGFRB (Homo sapiens)6480464CTDHydrogen Peroxide affects the expression of PDGFRB mRNAPMID:20044591
Pdgfrbmultiple interactionsISOPdgfrb (Mus musculus)6480464CTD[Hydrogen Peroxide affects the activity of PDGFRB protein] which results in increased activity of MAPK1 protein; [Hydrogen Peroxide affects the activity of PDGFRB protein] which results in increased activity of MAPK3 protein; HSPB1 protein inhibits the reaction [[Hydrogen Peroxide affects the activity of PDGFRB protein] which results in increased activity of MAPK1 protein]; HSPB1 protein inhibits the reaction [[Hydrogen Peroxide affects the activity of PDGFRB protein] which results in increased activity of MAPK3 protein]PMID:14975446
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