Hars1 (histidyl-tRNA synthetase 1)

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Gene: Hars1 (histidyl-tRNA synthetase 1) Rattus norvegicus

Analyze

Symbol:

Hars1

Name:

histidyl-tRNA synthetase 1

RGD ID:

1310695

Description:

Predicted to enable ATP binding activity; histidine-tRNA ligase activity; and protein homodimerization activity. Predicted to be involved in histidyl-tRNA aminoacylation and mitochondrial translation. Predicted to be located in cytoplasm. Predicted to be active in cytosol and mitochondrion. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease, axonal type 2W and Usher syndrome type 3B. Orthologous to human HARS1 (histidyl-tRNA synthetase 1); PARTICIPATES IN histidine metabolic pathway; histidinemia pathway; aminoacyl-tRNA biosynthetic pathway; INTERACTS WITH azoxystrobin; bisphenol A; chlorpyrifos.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

dead end homolog 1; dead end homolog 1 (zebrafish); Dnd1; Hars; histidine--tRNA ligase, cytoplasmic; histidyl-tRNA synthetase; histidyl-tRNA synthetase, cytoplasmic; LOC307492

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	HARS1 (histidyl-tRNA synthetase 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, Panther, Treefam
Mus musculus (house mouse):	Hars1 (histidyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Hars1 (histidyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	HARS1 (histidyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	HARS1 (histidyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Hars1 (histidyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	HARS1 (histidyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	HARS1 (histidyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Hars1 (histidyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	HARS1 (histidyl-tRNA synthetase 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Hars1 (histidyl-tRNA synthetase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	hars (histidyl-tRNA synthetase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	HTS1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	HisRS	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	hars-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	hars2	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	hars1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	18	28,381,649 - 28,398,699 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	28,381,655 - 28,398,740 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	28,508,798 - 28,525,835 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	18	29,270,872 - 29,287,915 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	18	28,606,100 - 28,623,139 (-)	NCBI	Rnor_WKY
Rnor_6.0	18	29,611,545 - 29,629,087 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	29,611,547 - 29,629,087 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	29,315,352 - 29,332,458 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	29,467,648 - 29,483,037 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	18	29,494,295 - 29,509,683 (-)	NCBI
Celera	18	28,102,201 - 28,119,274 (-)	NCBI		Celera
Cytogenetic Map	18	p11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant intellectual developmental disorder 31 (ISO)

cerebellar ataxia (ISO)

Charcot-Marie-Tooth disease, axonal type 2W (ISO)

familial adenomatous polyposis 1 (ISO)

fundus dystrophy (ISO)

genetic disease (ISO)

Hereditary Neoplastic Syndromes (ISO)

Neurodevelopmental Disorders (ISO)

neuropathy (ISO)

peripheral nervous system disease (ISO)

renal cell carcinoma (ISO)

retinitis pigmentosa-deafness syndrome (ISO)

spastic ataxia (ISO)

Talipes Cavus (ISO)

Usher syndrome (ISO)

Usher syndrome type 3 (ISO)

Usher syndrome type 3B (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

4,4'-sulfonyldiphenol (ISO)

acrolein (ISO)

alpha-pinene (ISO)

arsenous acid (ISO)

azoxystrobin (EXP)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

chloropicrin (ISO)

chlorpyrifos (EXP)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

diarsenic trioxide (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

enzyme inhibitor (ISO)

glyphosate (EXP)

imidacloprid (EXP)

ionomycin (ISO)

ivermectin (ISO)

ozone (ISO)

phorbol 13-acetate 12-myristate (ISO)

pyrrolidine dithiocarbamate (ISO)

selenium atom (ISO)

sodium arsenite (ISO)

thiabendazole (EXP)

thioacetamide (EXP)

valproic acid (ISO)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

histidyl-tRNA aminoacylation (IBA,ISO)

mitochondrial translation (IBA)

Cellular Component

cytoplasm (ISO)

cytosol (IBA,ISO)

mitochondrion (IBA)

Molecular Function

ATP binding (ISO)

histidine-tRNA ligase activity (IBA,ISO)

identical protein binding (IBA,ISO)

protein homodimerization activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

aminoacyl-tRNA biosynthetic pathway (IEA)

histidine metabolic pathway (ISO)

histidinemia pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
6.	GOA pipeline	RGD automated data pipeline
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:21464306	PMID:22958643	PMID:29235198

Genomics

Comparative Map Data

Hars1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	18	28,381,649 - 28,398,699 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	28,381,655 - 28,398,740 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	28,508,798 - 28,525,835 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	18	29,270,872 - 29,287,915 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	18	28,606,100 - 28,623,139 (-)	NCBI	Rnor_WKY
Rnor_6.0	18	29,611,545 - 29,629,087 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	29,611,547 - 29,629,087 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	29,315,352 - 29,332,458 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	29,467,648 - 29,483,037 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	18	29,494,295 - 29,509,683 (-)	NCBI
Celera	18	28,102,201 - 28,119,274 (-)	NCBI		Celera
Cytogenetic Map	18	p11	NCBI

HARS1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	140,673,905 - 140,691,370 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	5	140,673,035 - 140,691,537 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	140,053,490 - 140,070,955 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	140,033,674 - 140,051,155 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	140,033,674 - 140,051,155	NCBI
Celera	5	136,130,237 - 136,147,719 (-)	NCBI		Celera
Cytogenetic Map	5	q31.3	NCBI
HuRef	5	135,198,731 - 135,216,563 (-)	NCBI		HuRef
CHM1_1	5	139,486,739 - 139,504,562 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	141,199,302 - 141,216,757 (-)	NCBI		T2T-CHM13v2.0

Hars1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	36,899,581 - 36,916,258 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	36,899,581 - 36,916,258 (-)	Ensembl		GRCm39 Ensembl
GRCm38	18	36,766,528 - 36,783,205 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	36,766,528 - 36,783,205 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	18	36,926,182 - 36,942,859 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	18	36,892,504 - 36,909,094 (-)	NCBI		MGSCv36	mm8
Celera	18	37,218,592 - 37,235,221 (-)	NCBI		Celera
Cytogenetic Map	18	B2	NCBI

Hars1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955418	19,346 - 30,514 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955418	19,346 - 30,514 (+)	NCBI	ChiLan1.0	ChiLan1.0

HARS1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	5	134,071,296 - 134,088,814 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	136,038,575 - 136,056,400 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	142,154,552 - 142,172,371 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	142,154,552 - 142,172,371 (-)	Ensembl	panpan1.1		panPan2

HARS1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	35,828,243 - 35,843,615 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	35,828,260 - 35,843,583 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	32,867,230 - 32,882,606 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	36,283,853 - 36,299,236 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	36,283,855 - 36,299,210 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	33,336,188 - 33,351,339 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	34,203,967 - 34,219,341 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	34,956,682 - 34,972,058 (-)	NCBI		UU_Cfam_GSD_1.0

Hars1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	151,986,346 - 152,001,170 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936531	9,610,306 - 9,625,551 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936531	9,610,335 - 9,625,203 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HARS1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	142,385,872 - 142,401,208 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	142,387,563 - 142,401,232 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	148,331,743 - 148,345,418 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HARS1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	43,307,573 - 43,324,140 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	43,307,415 - 43,323,767 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666034	34,533,071 - 34,576,958 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Hars1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624743	33,423,342 - 33,435,721 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624743	33,424,705 - 33,435,767 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Hars1
60 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	56
Count of miRNA genes:	46
Interacting mature miRNAs:	52
Transcripts:	ENSRNOT00000039291
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2312598	Bp340	Blood pressure QTL 340		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	1	30558703	Rat
2300180	Bmd67	Bone mineral density QTL 67	4.8	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	18	1	34291613	Rat
2293661	Bss50	Bone structure and strength QTL 50	4.64	0.0003	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	18	1	34291613	Rat
61388	Bp2	Blood pressure QTL 2	3.23		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	1	35374722	Rat
9589153	Insul31	Insulin level QTL 31	7.15	0.05	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	18	1	42547119	Rat
2299160	Iddm35	Insulin dependent diabetes mellitus QTL 35	2.79		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	18	4207941	60377792	Rat
2312568	Glom21	Glomerulus QTL 21	2	0.005	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	18	5185858	40503530	Rat
2293708	Bss46	Bone structure and strength QTL 46	8.8	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	18	11791518	63636873	Rat
1578661	Bss20	Bone structure and strength QTL 20	3.7		femur morphology trait (VT:0000559)	femoral neck cross-sectional area (CMO:0001697)	18	11791518	83218561	Rat
1578667	Bss21	Bone structure and strength QTL 21	3.5		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	18	11791518	83218561	Rat
61382	Bp46	Blood pressure QTL 46	18.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	11941791	31393320	Rat
631264	Scl22	Serum cholesterol level QTL 22	6.2		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	18	11941791	31393320	Rat
1331766	Bp236	Blood pressure QTL 236	3.022		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	11944299	31359530	Rat
61375	Bp41	Blood pressure QTL 41	2.4		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	18	11944299	41122201	Rat
1331753	Bp231	Blood pressure QTL 231	3.643		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	11944299	52293055	Rat
1358358	Sradr6	Stress Responsive Adrenal Weight QTL 6	2.49		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	18	11944299	59330563	Rat
6903359	Bp355	Blood pressure QTL 355	3.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	11944544	59796478	Rat
2313082	Bss85	Bone structure and strength QTL 85	0.8	0.0001	long bone metaphysis morphology trait (VT:0000133)	tibia midshaft total cross-sectional area (CMO:0001715)	18	14951337	59951337	Rat
1358193	Emca2	Estrogen-induced mammary cancer QTL 2	1.6		mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	18	18007599	63571040	Rat
1331735	Rf44	Renal function QTL 44	2.981		urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	18	18234564	31359530	Rat
1331775	Bp235	Blood pressure QTL 235	3.201		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	18234564	31359530	Rat
1600373	Mamtr6	Mammary tumor resistance QTL 6			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	18	19278901	83218561	Rat
1331741	Bp232	Blood pressure QTL 232	3.59112		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	21372893	83213037	Rat
1641923	Colcr8	Colorectal carcinoma resistance QTL 8	3.1	0.0014	intestine integrity trait (VT:0010554)	poorly differentiated malignant colorectal tumor number (CMO:0002076)	18	22066242	52293055	Rat
1331733	Bp233	Blood pressure QTL 233	3.97196		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	24796977	79788953	Rat
2325839	Bp348	Blood pressure QTL 348		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	25570985	70570985	Rat
12904673	Cm127	Cardiac mass QTL 127		0.005	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	26548082	46969551	Rat
12904675	Am19	Aortic mass QTL 19		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	26548082	46969551	Rat
12904677	Kidm72	Kidney mass QTL 72		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	26548082	46969551	Rat
12904668	Bw188	Body weight QTL 188		0.03	body mass (VT:0001259)	body weight (CMO:0000012)	18	26548082	46969551	Rat
12904669	Cm125	Cardiac mass QTL 125		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	18	26548082	46969551	Rat
12904670	Cm126	Cardiac mass QTL 126		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	26548082	46969551	Rat
2301413	Bp318	Blood pressure QTL 318		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	26548082	46969551	Rat

Markers in Region

RH143518

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	54,414,064 - 54,414,339 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	61,299,691 - 61,299,965	NCBI	Rnor6.0
Rnor_5.0	15	64,964,332 - 64,964,606	UniSTS	Rnor5.0
RGSC_v3.4	15	60,155,584 - 60,155,858	UniSTS	RGSC3.4
Celera	15	54,003,757 - 54,004,031	UniSTS
RH 3.4 Map	15	458.3	UniSTS
Cytogenetic Map	18	p11	UniSTS
Cytogenetic Map	15	q11-q12	UniSTS
Cytogenetic Map	15	q11	UniSTS

Hars

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	54,415,320 - 54,415,449 (+)	MAPPER	mRatBN7.2
mRatBN7.2	18	28,382,080 - 28,382,413 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	29,611,977 - 29,612,309	NCBI	Rnor6.0
Rnor_6.0	15	61,300,947 - 61,301,075	NCBI	Rnor6.0
Rnor_5.0	18	29,315,784 - 29,316,116	UniSTS	Rnor5.0
Rnor_5.0	15	64,965,588 - 64,965,716	UniSTS	Rnor5.0
RGSC_v3.4	18	29,468,080 - 29,468,412	UniSTS	RGSC3.4
RGSC_v3.4	15	60,156,840 - 60,156,968	UniSTS	RGSC3.4
Celera	15	54,005,013 - 54,005,141	UniSTS
Celera	18	28,102,633 - 28,102,965	UniSTS
Cytogenetic Map	18	p11	UniSTS
Cytogenetic Map	15	q11	UniSTS
Cytogenetic Map	15	q11-q12	UniSTS

RH130568

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	28,381,729 - 28,381,937 (+)	MAPPER	mRatBN7.2
mRatBN7.2	15	54,415,592 - 54,415,947 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	61,301,219 - 61,301,573	NCBI	Rnor6.0
Rnor_6.0	18	29,611,626 - 29,611,833	NCBI	Rnor6.0
Rnor_5.0	18	29,315,433 - 29,315,640	UniSTS	Rnor5.0
Rnor_5.0	15	64,965,860 - 64,966,214	UniSTS	Rnor5.0
RGSC_v3.4	15	60,157,112 - 60,157,466	UniSTS	RGSC3.4
RGSC_v3.4	18	29,467,729 - 29,467,936	UniSTS	RGSC3.4
Celera	18	28,102,282 - 28,102,489	UniSTS
Celera	15	54,005,285 - 54,005,639	UniSTS
RH 3.4 Map	18	417.7	UniSTS
Cytogenetic Map	18	p11	UniSTS
Cytogenetic Map	15	q11-q12	UniSTS
Cytogenetic Map	15	q11	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	11	74	35	40	11	8
Low											1
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001025414	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC097969	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473974	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ231837	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000299	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000039291 ⟹ ENSRNOP00000034118

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	18	28,381,655 - 28,398,740 (-)	Ensembl
Rnor_6.0 Ensembl	18	29,611,547 - 29,629,087 (-)	Ensembl

RefSeq Acc Id:

NM_001025414 ⟹ NP_001020585

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	18	28,381,649 - 28,398,699 (-)	NCBI
Rnor_6.0	18	29,611,545 - 29,629,087 (-)	NCBI
Rnor_5.0	18	29,315,352 - 29,332,458 (-)	NCBI
RGSC_v3.4	18	29,467,648 - 29,483,037 (-)	RGD
Celera	18	28,102,201 - 28,119,274 (-)	RGD

Sequence:

show sequence

TTCCGGTTGGCAGACAGGATGGCAGATCGTGCTGCGCTGGAGGAGCTGGTGCGACTCCAGGGAG
CGCATGTGAGGGGCCTTAAGGAGCAGAAAGCGTCCGCTGAGCAGATCGAGGAGGAGGTGACGAA
ACTCCTAAAACTGAAGGCACAGCTGGGCCATGATGAAGGCAAACAGAAGTTCGTCCTCAAAACC
CCCAAGGGCACGAGAGACTATAGTCCCCGGCAGATGGCAGTCCGAGAAAAGGTGTTTGATGTCA
TCATCCGCTGTTTCAAACGCCATGGAGCAGAAGTGATCGATACACCTGTGTTTGAACTAAAGGA
GACACTAACTGGAAAATACGGAGAAGACTCAAAGCTTATCTATGACCTGAAGGACCAGGGTGGG
GAGCTGCTGTCCCTCCGTTATGACCTCACTGTCCCTTTTGCTCGGTATCTAGCAATGAATAAAC
TGACCAACATTAAACGCTACCACATAGCAAAGGTGTATCGCCGGGACAACCCAGCTATGACCCG
AGGCCGTTACCGTGAATTCTATCAGTGTGATTTTGACATTGCTGGACAGTTCGACCCCATGATT
CCTGATGCAGAGTGCCTAAAGATTATGTGTGAGATCCTGAGTTCACTTCAGATTGGCAACTTCC
AGGTCAAGGTAAATGATAGGCGCATCCTAGACGGGATGTTTGCTGTCTGTGGTGTCCCTGATAG
CAAGTTCCGTACCATCTGCTCCTCCGTGGACAAGCTAGACAAGGTTTCCTGGGAGGAAGTGAAG
AATGAGATGGTGGGAGAGAAGGGCCTCGCACCTGAAGTGGCTGATCGCATCGGGGACTATGTCC
AGCAGCATGGTGGGGTGTCTCTGGTGGAACAGTTACTCCAGGATCCTAAACTCTCCCAAAACAA
ACAGGCTGTAGAGGGCTTGGGAGACCTAAAGCTGCTCTTTGAGTATCTAACCCTATTTGGCATT
GATGACAAGATCTCCTTTGACTTGAGCCTTGCTCGAGGGCTGGACTACTACACTGGGGTCATCT
ATGAGGCAGTGCTGCTACAAATGCCAACCCAAGCTGGGGAAGAGCCCTTGGGTGTGGGCAGCAT
AGCTGCTGGAGGGCGCTACGATGGACTAGTAGGCATGTTTGACCCCAAAGGGCGCAAGGTGCCA
TGTGTTGGGCTCAGTATTGGAGTGGAACGGATCTTCTCCATTGTAGAGCAAAAATTAGAGGCTT
CAGAGGAAAAGGTGCGGACCACAGAGACGCAGGTGCTTGTGGCATCTGCACAGAAGAAGCTGCT
GGAGGAGAGACTGAAGCTTATCTCAGAGTTATGGGATGCTGGGATCAAGGCTGAGCTGCTGTAC
AAGAAGAACCCAAAGTTACTGAACCAGTTGCAGTACTGTGAGGAAGCAGGCATCCCACTGGTGG
CCATCATTGGTGAGCAGGAGCTTAAGGATGGTGTCATCAAGCTCCGTTCAGTGACGAGCAGAGA
AGAGGTGGATGTCCGAAGAGAAGACCTTGTGGAGGAGATCAGAAGAAGAACAAGTCAGCCCCTC
TCCATGTGATGAACTGAGCAAACTAGTGGAAGAAACAGGATTGGCCTTAACTGAGCTAAAACAA
AACTGCATATGTACTTAAACAGTTTGGACGTTTCTGATCCAGCAGAAGACTGAAGGGTGGTCAG
AACAGAGGCTTTGTGGGGGGTTGGGGTTTTTTGTTTTTGTTTTTTATCATTATTATTATTATTA
CGTTATTATCCGTAATCACTGGCAAGAAATGGCTAGGCACTACACTTTCCTTGTGTGGGGGATG
GGGTCAAGCAGTATAGTGGATTAATCAAGTCTCTGCCTCCTAAACTCCTGTTTGGACTTGAGAT
GGCTTCATTGAAAAGCCACACCTCAGATGAACAACCTCCGGCCAAAAATTCCAATAAACGTCTC
TGCCGCTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001020585	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH97969	(Get FASTA)	NCBI Sequence Viewer
	EDL76319	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001020585 ⟸ NM_001025414

- UniProtKB:

Q4QQV4 (UniProtKB/TrEMBL), F1LPB1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MADRAALEELVRLQGAHVRGLKEQKASAEQIEEEVTKLLKLKAQLGHDEGKQKFVLKTPKGTRD
YSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLTGKYGEDSKLIYDLKDQGGELLSLR
YDLTVPFARYLAMNKLTNIKRYHIAKVYRRDNPAMTRGRYREFYQCDFDIAGQFDPMIPDAECL
KIMCEILSSLQIGNFQVKVNDRRILDGMFAVCGVPDSKFRTICSSVDKLDKVSWEEVKNEMVGE
KGLAPEVADRIGDYVQQHGGVSLVEQLLQDPKLSQNKQAVEGLGDLKLLFEYLTLFGIDDKISF
DLSLARGLDYYTGVIYEAVLLQMPTQAGEEPLGVGSIAAGGRYDGLVGMFDPKGRKVPCVGLSI
GVERIFSIVEQKLEASEEKVRTTETQVLVASAQKKLLEERLKLISELWDAGIKAELLYKKNPKL
LNQLQYCEEAGIPLVAIIGEQELKDGVIKLRSVTSREEVDVRREDLVEEIRRRTSQPLSM

hide sequence

RefSeq Acc Id:

ENSRNOP00000034118 ⟸ ENSRNOT00000039291

Protein Domains

Aminoacyl-transfer RNA synthetases class-II family WHEP-TRS

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q4QQV4-F1-model_v2	AlphaFold	Q4QQV4	1-508	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700730

Promoter ID:

EPDNEW_R11254

Type:

multiple initiation site

Name:

Hars_1

Description:

histidyl-tRNA synthetase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	18	29,629,076 - 29,629,136	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310695	AgrOrtholog
BioCyc Gene	G2FUF-7858	BioCyc
BioCyc Pathway	TRNA-CHARGING-PWY [tRNA charging]	BioCyc
Ensembl Genes	ENSRNOG00000028105	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000034118	ENTREZGENE
	ENSRNOP00000034118.6	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000039291	ENTREZGENE
	ENSRNOT00000039291.6	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.800	UniProtKB/TrEMBL
	S15/NS1, RNA-binding	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7442005	IMAGE-MGC_LOAD
InterPro	aa-tRNA-synth_II	UniProtKB/TrEMBL
	aa-tRNA-synth_II/BPL/LPL	UniProtKB/TrEMBL
	Anticodon-bd	UniProtKB/TrEMBL
	Anticodon-bd_dom_sf	UniProtKB/TrEMBL
	His-tRNA-ligase	UniProtKB/TrEMBL
	His-tRNA_synth_IIA	UniProtKB/TrEMBL
	HisRS-like_core	UniProtKB/TrEMBL
	HisRS_anticodon	UniProtKB/TrEMBL
	S15_NS1_RNA-bd	UniProtKB/TrEMBL
	WHEP-TRS	UniProtKB/TrEMBL
KEGG Report	rno:307492	UniProtKB/TrEMBL
MGC_CLONE	MGC:116099	IMAGE-MGC_LOAD
NCBI Gene	307492	ENTREZGENE
PANTHER	HISTIDINE--TRNA LIGASE, CYTOPLASMIC	UniProtKB/TrEMBL
	HISTIDYL-TRNA SYNTHETASE	UniProtKB/TrEMBL
Pfam	HGTP_anticodon	UniProtKB/TrEMBL
	tRNA-synt_His	UniProtKB/TrEMBL
	WHEP-TRS	UniProtKB/TrEMBL
PhenoGen	Hars1	PhenoGen
PIRSF	His-tRNA_synth	UniProtKB/TrEMBL
PROSITE	AA_TRNA_LIGASE_II	UniProtKB/TrEMBL
	WHEP_TRS_1	UniProtKB/TrEMBL
	WHEP_TRS_2	UniProtKB/TrEMBL
SMART	WHEP-TRS	UniProtKB/TrEMBL
Superfamily-SCOP	Class II aaRS ABD-related	UniProtKB/TrEMBL
	S15/NS1_bind	UniProtKB/TrEMBL
	SSF55681	UniProtKB/TrEMBL
TIGRFAMs	hisS	UniProtKB/TrEMBL
UniProt	A0A8J8YFS5_RAT	UniProtKB/TrEMBL
	F1LPB1	ENTREZGENE
	Q4QQV4	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	F1LPB1	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-09-03	Hars1	histidyl-tRNA synthetase 1	Hars	histidyl-tRNA synthetase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-04	Hars	histidyl-tRNA synthetase	Dnd1	dead end homolog 1 (zebrafish)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Dnd1	dead end homolog 1 (zebrafish)	Dnd1_predicted	dead end homolog 1 (zebrafish) (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Dnd1_predicted	dead end homolog 1 (zebrafish) (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)