Atp8b1 (ATPase phospholipid transporting 8B1) - Rat Genome Database

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Gene: Atp8b1 (ATPase phospholipid transporting 8B1) Rattus norvegicus
Analyze
Symbol: Atp8b1
Name: ATPase phospholipid transporting 8B1
RGD ID: 1308488
Description: Enables phosphatidylserine flippase activity. Predicted to be involved in several processes, including apical protein localization; lipid transport; and nervous system development. Predicted to act upstream of or within bile acid metabolic process and lipid transport. Located in brush border membrane. Human ortholog(s) of this gene implicated in benign recurrent intrahepatic cholestasis 1; intrahepatic cholestasis; intrahepatic cholestasis of pregnancy 1; and progressive familial intrahepatic cholestasis 1. Orthologous to human ATP8B1 (ATPase phospholipid transporting 8B1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ATPase, aminophospholipid transporter, class I, type 8B, member 1; ATPase, Class I, type 8B, member 1; LOC291555; P4-ATPase flippase complex alpha subunit ATP8B1; phospholipid-transporting ATPase IC; probable phospholipid-transporting ATPase IC
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21858,016,382 - 58,157,213 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1858,018,268 - 58,157,396 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1860,100,745 - 60,181,408 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01860,812,277 - 60,893,191 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01858,641,968 - 58,722,898 (-)NCBIRnor_WKY
Rnor_6.01860,013,388 - 60,152,920 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1860,013,382 - 60,095,354 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01859,223,547 - 59,362,294 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41860,748,738 - 60,829,650 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11860,822,079 - 60,960,656 (-)NCBI
Celera1856,155,326 - 56,236,232 (-)NCBICelera
Cytogenetic Map18q12.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
atazanavir sulfate  (ISO)
ATP  (EXP)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-carotene  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
calcitriol  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chenodeoxycholic acid  (ISO)
chloroprene  (EXP,ISO)
cholic acid  (ISO)
choline  (ISO)
cobalt dichloride  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cyproconazole  (EXP)
deoxycholic acid  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP,ISO)
disodium selenite  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enilconazole  (ISO)
entinostat  (ISO)
epoxiconazole  (EXP,ISO)
fenthion  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
gadodiamide hydrate  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
heptachlor  (ISO)
indometacin  (ISO)
irinotecan  (EXP)
isoprenaline  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lipopolysaccharide  (ISO)
mercury dibromide  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methylmercury chloride  (ISO)
N-ethylmaleimide  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
oxaliplatin  (EXP)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
parathion  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
prochloraz  (EXP)
progesterone  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sodium azide  (EXP)
tartrazine  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
triadimefon  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. A gene encoding a P-type ATPase mutated in two forms of hereditary cholestasis. Bull LN, etal., Nat Genet. 1998 Mar;18(3):219-24.
2. ATP8B1 deficiency disrupts the bile canalicular membrane bilayer structure in hepatocytes, but FXR expression and activity are maintained. Cai SY, etal., Gastroenterology. 2009 Mar;136(3):1060-9. doi: 10.1053/j.gastro.2008.10.025. Epub 2008 Nov 1.
3. FIC1, the protein affected in two forms of hereditary cholestasis, is localized in the cholangiocyte and the canalicular membrane of the hepatocyte. Eppens EF, etal., J Hepatol. 2001 Oct;35(4):436-43.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. Recurrent familial intrahepatic cholestasis in the Faeroe Islands. Phenotypic heterogeneity but genetic homogeneity. Tygstrup N, etal., Hepatology. 1999 Feb;29(2):506-8. doi: 10.1002/hep.510290214.
12. Familial intrahepatic cholestasis 1: studies of localization and function. Ujhazy P, etal., Hepatology. 2001 Oct;34(4 Pt 1):768-75.
Additional References at PubMed
PMID:14976163   PMID:16628629   PMID:19478059   PMID:19731236   PMID:20510206   PMID:20512993   PMID:20852622   PMID:20947505   PMID:21914794   PMID:24643366   PMID:26240149  


Genomics

Comparative Map Data
Atp8b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21858,016,382 - 58,157,213 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1858,018,268 - 58,157,396 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1860,100,745 - 60,181,408 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01860,812,277 - 60,893,191 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01858,641,968 - 58,722,898 (-)NCBIRnor_WKY
Rnor_6.01860,013,388 - 60,152,920 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1860,013,382 - 60,095,354 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01859,223,547 - 59,362,294 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41860,748,738 - 60,829,650 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11860,822,079 - 60,960,656 (-)NCBI
Celera1856,155,326 - 56,236,232 (-)NCBICelera
Cytogenetic Map18q12.1NCBI
ATP8B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381857,646,426 - 57,803,315 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1857,646,426 - 57,803,315 (-)EnsemblGRCh38hg38GRCh38
GRCh371855,313,658 - 55,470,547 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361853,464,656 - 53,550,037 (-)NCBINCBI36Build 36hg18NCBI36
Build 341853,466,585 - 53,550,037NCBI
Celera1852,031,466 - 52,187,934 (-)NCBICelera
Cytogenetic Map18q21.31ENTREZGENE
HuRef1852,024,999 - 52,180,652 (-)NCBIHuRef
CHM1_11855,309,031 - 55,466,164 (-)NCBICHM1_1
T2T-CHM13v2.01857,847,030 - 58,003,571 (-)NCBIT2T-CHM13v2.0
Atp8b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391864,662,050 - 64,794,342 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1864,662,038 - 64,794,338 (-)EnsemblGRCm39 Ensembl
GRCm381864,528,979 - 64,661,272 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1864,528,967 - 64,661,267 (-)EnsemblGRCm38mm10GRCm38
MGSCv371864,688,633 - 64,820,654 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361864,654,348 - 64,786,369 (-)NCBIMGSCv36mm8
Celera1865,795,381 - 65,929,579 (-)NCBICelera
Cytogenetic Map18E1NCBI
Atp8b1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540241,996,001 - 42,113,895 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540241,994,993 - 42,113,380 (-)NCBIChiLan1.0ChiLan1.0
ATP8B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11854,370,844 - 54,522,158 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1854,370,447 - 54,522,196 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01851,035,483 - 51,187,461 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ATP8B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1118,156,664 - 18,279,131 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl118,156,410 - 18,277,904 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha119,140,072 - 19,262,621 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0118,037,713 - 18,160,586 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl118,037,170 - 18,160,558 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1118,094,570 - 18,217,205 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0117,992,383 - 18,114,996 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0118,261,266 - 18,383,909 (+)NCBIUU_Cfam_GSD_1.0
Atp8b1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494431,413,185 - 31,471,774 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364976,652,185 - 6,713,034 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049364976,652,240 - 6,712,960 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATP8B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1162,936,581 - 163,061,612 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11162,936,209 - 163,063,040 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ATP8B1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11821,930,150 - 22,086,371 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1821,930,837 - 22,088,480 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660603,481,874 - 3,637,247 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atp8b1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247923,156,367 - 3,287,751 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247923,154,512 - 3,287,681 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Atp8b1
624 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:64
Count of miRNA genes:51
Interacting mature miRNAs:58
Transcripts:ENSRNOT00000038652
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18420794160377792Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181179151863636873Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)181194429959330563Rat
6903359Bp355Blood pressure QTL 3553.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194454459796478Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181495133759951337Rat
1358193Emca2Estrogen-induced mammary cancer QTL 21.6mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)181800759963571040Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182557098570570985Rat
2293704Bss35Bone structure and strength QTL 354.590.0002femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)182896485373964853Rat
2300157Bmd66Bone mineral density QTL 6613.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
2300177Bmd65Bone mineral density QTL 6519.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)182979296574792965Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)182979296574792965Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)182979296574792965Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182979296574792965Rat
738005Anxrr11Anxiety related response QTL 113.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)183003981375039813Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183127168160377755Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183135940859796643Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940861698465Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183135940870263868Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183135940883218561Rat
6903347Bp350Blood pressure QTL 3504.4arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135953059796478Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183139332077209694Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183587072380870723Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183819245583192455Rat
1598826Anxrr20Anxiety related response QTL 203.04body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)184143297183828827Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184334502283828827Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184664067583828827Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184664067583828827Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184664067583828827Rat
1331736Bp227Blood pressure QTL 2272.791arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)184671876359796643Rat
1331780Bp238Blood pressure QTL 2383.269arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671876359796643Rat
6903345Bp349Blood pressure QTL 3493.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671893559796478Rat
6903349Bp351Blood pressure QTL 3513.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671893559796478Rat
6903351Bp352Blood pressure QTL 3523.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671893559796478Rat
61360EaeyExperimental allergic encephalomyelitis QTL y3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)184698893960377753Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)184852004483828827Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)184852004483828827Rat
7411719Strs5Sensitivity to stroke QTL 59.4cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)184999995865845095Rat
2293658Bmd23Bone mineral density QTL 237.30.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)185146473363636873Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185146473383218561Rat
1331730Scl27Serum cholesterol level QTL 273.826blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)185229287559796643Rat
1331752Bw27Body weight QTL 272.963body mass (VT:0001259)body weight (CMO:0000012)185229287565845095Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185229287573997283Rat
1600375Mcs22Mammary carcinoma susceptibility QTL 223.3mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)185253976363933058Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)185253976369140759Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)185253976376104388Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)185253976376104388Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)185253976376104388Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)185253976376104388Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)185253976376104388Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)185253976376104388Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185253976376104388Rat
1300125Rf26Renal function QTL 263.2urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)185253986365844950Rat
1298072Cia26Collagen induced arthritis QTL 263.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)185470976983828827Rat

Markers in Region
D18Chm97  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21858,085,512 - 58,085,730 (+)MAPPERmRatBN7.2
Rnor_6.01860,081,657 - 60,081,874NCBIRnor6.0
Rnor_5.01859,291,816 - 59,292,033UniSTSRnor5.0
RGSC_v3.41860,815,969 - 60,816,186UniSTSRGSC3.4
Celera1856,222,551 - 56,222,768UniSTS
Cytogenetic Map18q12.1UniSTS
RH140076  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21858,018,069 - 58,018,280 (+)MAPPERmRatBN7.2
Rnor_6.01860,015,049 - 60,015,259NCBIRnor6.0
Rnor_5.01859,225,208 - 59,225,418UniSTSRnor5.0
RGSC_v3.41860,748,540 - 60,748,750UniSTSRGSC3.4
Celera1856,155,128 - 56,155,338UniSTS
RH 3.4 Map18569.2UniSTS
Cytogenetic Map18q12.1UniSTS
AU049633  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21858,046,279 - 58,046,462 (+)MAPPERmRatBN7.2
Rnor_6.01860,042,430 - 60,042,612NCBIRnor6.0
Rnor_5.01859,252,589 - 59,252,771UniSTSRnor5.0
RGSC_v3.41860,776,742 - 60,776,924UniSTSRGSC3.4
Celera1856,183,329 - 56,183,513UniSTS
Cytogenetic Map18q12.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 18 18 18 21 6 4
Low 41 39 23 19 23 8 10 12 14 30 7 8
Below cutoff 2 1 62 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000038652   ⟹   ENSRNOP00000038207
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1858,018,268 - 58,157,396 (-)Ensembl
Rnor_6.0 Ensembl1860,013,382 - 60,095,354 (-)Ensembl
RefSeq Acc Id: NM_001106140   ⟹   NP_001099610
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21858,018,268 - 58,099,197 (-)NCBI
Rnor_6.01860,015,247 - 60,095,334 (-)NCBI
Rnor_5.01859,223,547 - 59,362,294 (-)NCBI
RGSC_v3.41860,748,738 - 60,829,650 (-)RGD
Celera1856,155,326 - 56,236,232 (-)RGD
Sequence:
RefSeq Acc Id: XM_006254842   ⟹   XP_006254904
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21858,016,382 - 58,157,213 (-)NCBI
Rnor_6.01860,013,388 - 60,152,920 (-)NCBI
Rnor_5.01859,223,547 - 59,362,294 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001099610 (Get FASTA)   NCBI Sequence Viewer  
  XP_006254904 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein D4AA47 (Get FASTA)   NCBI Sequence Viewer  
  EDM14675 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001099610   ⟸   NM_001106140
- UniProtKB: A0A8L2QJ69 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006254904   ⟸   XM_006254842
- Peptide Label: isoform X1
- UniProtKB: D4AA47 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000038207   ⟸   ENSRNOT00000038652
Protein Domains
PhoLip_ATPase_C   PhoLip_ATPase_N

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AA47-F1-model_v2 AlphaFold D4AA47 1-1251 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308488 AgrOrtholog
BioCyc Gene G2FUF-7253 BioCyc
Ensembl Genes ENSRNOG00000024952 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000038207 ENTREZGENE
  ENSRNOP00000038207.6 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000038652 ENTREZGENE
  ENSRNOT00000038652.6 UniProtKB/TrEMBL
Gene3D-CATH 3.40.1110.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.1000 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ATP8B1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_P-typ_cyto_dom_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_P-typ_P_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_P-typ_TM_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_P-typ_transduc_dom_A_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HAD-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HAD_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-type_ATPase_IV UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-type_ATPase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P_typ_ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P_typ_ATPase_c UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P_typ_ATPase_HD_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 291555 ENTREZGENE
PANTHER PTHR24092:SF48 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PhoLip_ATPase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PhoLip_ATPase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Atp8b1 PhenoGen
PROSITE ATPASE_E1_E2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56784 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81653 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81660 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81665 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs ATPase-Plipid UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_P-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2QJ69 ENTREZGENE, UniProtKB/TrEMBL
  AT8B1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Atp8b1  ATPase phospholipid transporting 8B1  Atp8b1  ATPase, aminophospholipid transporter, class I, type 8B, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-30 Atp8b1  ATPase, aminophospholipid transporter, class I, type 8B, member 1  Atp8b1  ATPase, Class I, type 8B, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Atp8b1  ATPase, Class I, type 8B, member 1   Atp8b1_predicted  ATPase, Class I, type 8B, member 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Atp8b1_predicted  ATPase, Class I, type 8B, member 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED