Spry4 (sprouty RTK signaling antagonist 4) - Rat Genome Database

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Gene: Spry4 (sprouty RTK signaling antagonist 4) Rattus norvegicus
Analyze
Symbol: Spry4
Name: sprouty RTK signaling antagonist 4
RGD ID: 1305324
Description: Predicted to enable protein kinase inhibitor activity. Predicted to be involved in animal organ development; negative regulation of signal transduction; and negative regulation of substrate adhesion-dependent cell spreading. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 17 with or without anosmia. Orthologous to human SPRY4 (sprouty RTK signaling antagonist 4); PARTICIPATES IN Jak-Stat signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC291610; sprouty homolog 4; sprouty homolog 4 (Drosophila)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81830,687,633 - 30,702,546 (-)NCBIGRCr8
mRatBN7.21830,436,513 - 30,451,426 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1830,436,443 - 30,453,004 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1830,540,734 - 30,555,640 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01831,301,144 - 31,316,041 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01830,636,445 - 30,651,342 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01832,593,370 - 32,609,890 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1832,594,958 - 32,609,864 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01832,271,207 - 32,287,673 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41831,532,680 - 31,547,586 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11831,561,542 - 31,563,842 (-)NCBI
Celera1830,074,673 - 30,089,579 (-)NCBICelera
Cytogenetic Map18p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
C60 fullerene  (EXP)
caffeine  (ISO)
carbon nanotube  (ISO)
cerium trichloride  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
cocaine  (EXP)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
glycidol  (EXP)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
Licochalcone B  (ISO)
manganese(II) chloride  (EXP)
menadione  (ISO)
mercury dibromide  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methylarsonic acid  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-Nitrosopyrrolidine  (ISO)
nitrofen  (EXP)
ozone  (ISO)
paracetamol  (ISO)
PCB138  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propiconazole  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
tert-butyl hydroperoxide  (ISO)
Theaflavin 3,3'-digallate  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
triclosan  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (EXP,ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
cytosol  (IBA)
membrane  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16339969   PMID:20439489   PMID:21423176   PMID:22384148   PMID:23982388  


Genomics

Comparative Map Data
Spry4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81830,687,633 - 30,702,546 (-)NCBIGRCr8
mRatBN7.21830,436,513 - 30,451,426 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1830,436,443 - 30,453,004 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1830,540,734 - 30,555,640 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01831,301,144 - 31,316,041 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01830,636,445 - 30,651,342 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01832,593,370 - 32,609,890 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1832,594,958 - 32,609,864 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01832,271,207 - 32,287,673 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41831,532,680 - 31,547,586 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11831,561,542 - 31,563,842 (-)NCBI
Celera1830,074,673 - 30,089,579 (-)NCBICelera
Cytogenetic Map18p11NCBI
SPRY4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385142,310,430 - 142,325,021 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5142,310,427 - 142,326,455 (-)EnsemblGRCh38hg38GRCh38
GRCh375141,689,995 - 141,704,586 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365141,670,189 - 141,684,750 (-)NCBINCBI36Build 36hg18NCBI36
Build 345141,670,190 - 141,684,750NCBI
Celera5137,771,260 - 137,785,910 (-)NCBICelera
Cytogenetic Map5q31.3NCBI
HuRef5136,836,448 - 136,851,092 (-)NCBIHuRef
CHM1_15141,123,564 - 141,138,189 (-)NCBICHM1_1
T2T-CHM13v2.05142,841,037 - 142,855,632 (-)NCBIT2T-CHM13v2.0
Spry4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391838,719,300 - 38,734,400 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1838,719,300 - 38,734,468 (-)EnsemblGRCm39 Ensembl
GRCm381838,586,247 - 38,601,347 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1838,586,247 - 38,601,415 (-)EnsemblGRCm38mm10GRCm38
MGSCv371838,745,919 - 38,760,922 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361838,712,239 - 38,727,242 (-)NCBIMGSCv36mm8
Celera1839,928,878 - 39,943,870 (-)NCBICelera
Cytogenetic Map18B3NCBI
cM Map1820.5NCBI
Spry4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541511,489,439 - 11,504,247 (+)NCBIChiLan1.0ChiLan1.0
SPRY4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24137,555,079 - 137,569,735 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15135,694,633 - 135,709,294 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05137,667,280 - 137,683,578 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15143,778,785 - 143,793,518 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5143,778,785 - 143,791,939 (-)Ensemblpanpan1.1panPan2
SPRY4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1237,199,890 - 37,213,710 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl237,203,609 - 37,208,858 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha234,251,922 - 34,265,782 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0237,655,748 - 37,669,607 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl237,655,756 - 37,669,556 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1234,729,962 - 34,743,810 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0235,546,901 - 35,560,761 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0236,348,824 - 36,362,690 (-)NCBIUU_Cfam_GSD_1.0
Spry4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213150,333,698 - 150,348,542 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650411,907,681 - 11,922,469 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650411,907,667 - 11,922,487 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPRY4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2143,875,355 - 143,892,292 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12143,877,334 - 143,891,280 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22150,062,423 - 150,076,497 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPRY4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12344,931,967 - 44,946,838 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603432,902,675 - 32,917,563 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Spry4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247741,508,315 - 1,523,456 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Spry4
42 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1732
Count of miRNA genes:375
Interacting mature miRNAs:545
Transcripts:ENSRNOT00000018511
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)181194429959330563Rat
1331735Rf44Renal function QTL 442.981urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)181823456431359530Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182654808246969551Rat
61382Bp46Blood pressure QTL 4618.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194179131393320Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
61388Bp2Blood pressure QTL 23.23arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)18135374722Rat
6903359Bp355Blood pressure QTL 3553.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194454459796478Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182654808246969551Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181495133759951337Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182654808246969551Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)182206624252293055Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182654808246969551Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18518585840503530Rat
738005Anxrr11Anxiety related response QTL 113.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)183003981375039813Rat
2300157Bmd66Bone mineral density QTL 6613.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182654808246969551Rat
1331766Bp236Blood pressure QTL 2363.022arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181194429931359530Rat
1358193Emca2Estrogen-induced mammary cancer QTL 21.6mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)181800759963571040Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182654808246969551Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182654808246969551Rat
631264Scl22Serum cholesterol level QTL 226.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)181194179131393320Rat
2293704Bss35Bone structure and strength QTL 354.590.0002femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)182896485373964853Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)182979296574792965Rat
1331775Bp235Blood pressure QTL 2353.201arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181823456431359530Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182557098570570985Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181179151863636873Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)182979296574792965Rat
2300177Bmd65Bone mineral density QTL 6519.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
9589153Insul31Insulin level QTL 317.150.05blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)18142547119Rat
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18130558703Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134291613Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18420794160377792Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)182979296574792965Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194429952293055Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182979296574792965Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134291613Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)181194429941122201Rat

Markers in Region
RH141022  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21830,436,660 - 30,436,826 (-)MAPPERmRatBN7.2
Rnor_6.01832,609,558 - 32,609,723NCBIRnor6.0
Rnor_5.01832,287,360 - 32,287,525UniSTSRnor5.0
RGSC_v3.41831,532,821 - 31,532,986UniSTSRGSC3.4
Celera1830,074,814 - 30,074,979UniSTS
RH 3.4 Map11392.39UniSTS
Cytogenetic Map18p11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 22 2 2 2 16 21 17 11
Low 3 21 55 39 19 39 8 11 58 14 23 8
Below cutoff 1

Sequence


RefSeq Acc Id: ENSRNOT00000018511   ⟹   ENSRNOP00000018511
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1830,436,443 - 30,451,398 (-)Ensembl
Rnor_6.0 Ensembl1832,594,958 - 32,609,864 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000100060   ⟹   ENSRNOP00000082843
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1830,436,559 - 30,453,004 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111029   ⟹   ENSRNOP00000080541
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1830,436,443 - 30,450,448 (-)Ensembl
RefSeq Acc Id: NM_001106150   ⟹   NP_001099620
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81830,687,640 - 30,702,546 (-)NCBI
mRatBN7.21830,436,520 - 30,451,426 (-)NCBI
Rnor_6.01832,594,958 - 32,609,864 (+)NCBI
Rnor_5.01832,271,207 - 32,287,673 (+)NCBI
RGSC_v3.41831,532,680 - 31,547,586 (-)RGD
Celera1830,074,673 - 30,089,579 (-)RGD
Sequence:
RefSeq Acc Id: XM_039096705   ⟹   XP_038952633
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81830,687,633 - 30,701,489 (-)NCBI
mRatBN7.21830,436,513 - 30,451,147 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001099620 (Get FASTA)   NCBI Sequence Viewer  
  XP_038952633 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL76453 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000018511
  ENSRNOP00000018511.2
  ENSRNOP00000080541
  ENSRNOP00000080541.1
  ENSRNOP00000082843.1
RefSeq Acc Id: NP_001099620   ⟸   NM_001106150
- UniProtKB: D3ZJA3 (UniProtKB/TrEMBL),   A6J3H1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000018511   ⟸   ENSRNOT00000018511
RefSeq Acc Id: XP_038952633   ⟸   XM_039096705
- Peptide Label: isoform X1
- UniProtKB: D3ZJA3 (UniProtKB/TrEMBL),   A6J3H1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000082843   ⟸   ENSRNOT00000100060
RefSeq Acc Id: ENSRNOP00000080541   ⟸   ENSRNOT00000111029

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZJA3-F1-model_v2 AlphaFold D3ZJA3 1-300 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700743
Promoter ID:EPDNEW_R11267
Type:single initiation site
Name:Spry4_1
Description:sprouty RTK signaling antagonist 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01832,595,030 - 32,595,090EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305324 AgrOrtholog
BioCyc Gene G2FUF-7764 BioCyc
Ensembl Genes ENSRNOG00000013851 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018511 ENTREZGENE
  ENSRNOT00000018511.4 UniProtKB/TrEMBL
  ENSRNOT00000100060.1 UniProtKB/TrEMBL
  ENSRNOT00000111029.1 UniProtKB/TrEMBL
InterPro Sprouty UniProtKB/TrEMBL
KEGG Report rno:291610 UniProtKB/TrEMBL
NCBI Gene 291610 ENTREZGENE
PANTHER PTHR12365:SF6 UniProtKB/TrEMBL
  SPROUTY UniProtKB/TrEMBL
Pfam Sprouty UniProtKB/TrEMBL
PhenoGen Spry4 PhenoGen
PROSITE SPR UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013851 RatGTEx
UniProt A6J3H1 ENTREZGENE, UniProtKB/TrEMBL
  D3ZJA3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-01 Spry4  sprouty RTK signaling antagonist 4  Spry4  sprouty homolog 4 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Spry4  sprouty homolog 4 (Drosophila)   Spry4_predicted  sprouty homolog 4 (Drosophila) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Spry4_predicted  sprouty homolog 4 (Drosophila) (predicted)      Symbol and Name status set to approved 70820 APPROVED