Fhod3 (formin homology 2 domain containing 3) - Rat Genome Database
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Gene: Fhod3 (formin homology 2 domain containing 3) Rattus norvegicus
Analyze
Symbol: Fhod3
Name: formin homology 2 domain containing 3
RGD ID: 2322319
Description: Predicted to have actin filament binding activity. Involved in sarcomere organization. Localizes to striated muscle thin filament. Orthologous to human FHOD3 (formin homology 2 domain containing 3); INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; aconitine; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: FH1/FH2 domain-containing protein 3; formin homology 2 domain containing 3-like; LOC100360334; LOC291731
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Note: There is an assembly problem in the Rnor_6.0 reference genome assembly, and therefore, annotation of this gene is split across NW_007906026.1 and NW_007906027.1 in NCBI's Rattus norvegicus Annotation Release 105. [19 Jun 2015]
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21815,993,079 - 16,425,796 (+)NCBI
Rnor_6.0 Ensembl1816,650,806 - 17,332,210 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01816,650,786 - 17,332,209 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01816,410,820 - 16,473,813 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01816,842,427 - 17,086,636 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41816,487,052 - 16,952,424 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11816,513,673 - 16,615,841 (+)NCBI
Celera1815,913,907 - 16,336,469 (+)NCBICelera
Cytogenetic Map18p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:22509354   PMID:23052206   PMID:23213483   PMID:24088304   PMID:26912794  


Genomics

Comparative Map Data
Fhod3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21815,993,079 - 16,425,796 (+)NCBI
Rnor_6.0 Ensembl1816,650,806 - 17,332,210 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01816,650,786 - 17,332,209 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01816,410,820 - 16,473,813 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01816,842,427 - 17,086,636 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41816,487,052 - 16,952,424 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11816,513,673 - 16,615,841 (+)NCBI
Celera1815,913,907 - 16,336,469 (+)NCBICelera
Cytogenetic Map18p12NCBI
FHOD3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1836,297,714 - 36,780,055 (+)EnsemblGRCh38hg38GRCh38
GRCh381836,297,713 - 36,780,220 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371833,877,676 - 34,360,183 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361832,131,700 - 32,614,016 (+)NCBINCBI36hg18NCBI36
Celera1830,685,614 - 31,169,391 (+)NCBI
Cytogenetic Map18q12.2NCBI
HuRef1830,735,778 - 31,218,907 (+)NCBIHuRef
CHM1_11833,804,749 - 34,287,214 (+)NCBICHM1_1
Fhod3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391824,841,445 - 25,266,564 (+)NCBIGRCm39mm39
GRCm39 Ensembl1824,841,680 - 25,266,558 (+)Ensembl
GRCm381824,708,388 - 25,133,507 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1824,708,623 - 25,133,501 (+)EnsemblGRCm38mm10GRCm38
MGSCv371824,867,946 - 25,292,002 (+)NCBIGRCm37mm9NCBIm37
MGSCv361824,852,455 - 25,276,511 (+)NCBImm8
Celera1825,190,970 - 25,619,254 (+)NCBICelera
Cytogenetic Map18A2NCBI
Fhod3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540222,821,710 - 23,279,222 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540222,822,060 - 23,277,993 (+)NCBIChiLan1.0ChiLan1.0
FHOD3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11833,163,910 - 33,590,683 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1833,165,819 - 33,590,154 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01829,550,049 - 30,033,130 (+)NCBIMhudiblu_PPA_v0panPan3
FHOD3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1753,477,273 - 53,933,532 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl753,478,930 - 53,934,331 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha752,893,761 - 53,356,825 (-)NCBI
ROS_Cfam_1.0753,438,086 - 53,901,223 (-)NCBI
UMICH_Zoey_3.1753,122,091 - 53,584,883 (-)NCBI
UNSW_CanFamBas_1.0753,144,927 - 53,608,076 (-)NCBI
UU_Cfam_GSD_1.0753,437,853 - 53,900,540 (-)NCBI
Fhod3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_ltri_2NW_02440494449,286,982 - 49,717,492 (-)NCBI
SpeTri2.0NW_0049365178,614,384 - 9,044,894 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FHOD3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6120,036,838 - 120,586,849 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16120,036,824 - 120,585,987 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26112,902,155 - 113,225,109 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FHOD3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11844,053,360 - 44,540,820 (-)NCBI
ChlSab1.1 Ensembl1844,049,837 - 44,540,760 (-)Ensembl
Fhod3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477910,562,319 - 11,069,557 (+)NCBI


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631264Scl22Serum cholesterol level QTL 226.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)181553296332704022Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181553942753861431Rat
1331766Bp236Blood pressure QTL 2363.022arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181553942732670473Rat
1331781Scl28Serum cholesterol level QTL 283.995blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)181553942725961165Rat
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18371954732487870Rat
1641910Colcr3Colorectal carcinoma resistance QTL 35.020.000007intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor surface area measurement (CMO:0002078)18247709623184414Rat
1641910Colcr3Colorectal carcinoma resistance QTL 35.020.000007intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)18247709623184414Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18138195967Rat
2301410Bp317Blood pressure QTL 3170.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181553955127743236Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18138195967Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181569587287080053Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181569587287080053Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181569587268524999Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18440751362570466Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)181553942761499684Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18543013441781619Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181467885259678852Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)181553967129530300Rat
61382Bp46Blood pressure QTL 4618.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181553296332704022Rat
61388Bp2Blood pressure QTL 23.23arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)18135097280Rat
6903359Bp355Blood pressure QTL 3553.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181553967161985648Rat
9589153Insul31Insulin level QTL 317.150.05blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)18138753381Rat
8552968Pigfal19Plasma insulin-like growth factor 1 level QTL 1911.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)18125999214Rat
9590248Scort10Serum corticosterone level QTL 1019.710.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)18125999214Rat
12904680Bw189Body weight QTL 1890.019body mass (VT:0001259)body weight (CMO:0000012)181553955127743236Rat
12904695Kidm73Kidney mass QTL 730.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)181553955127743236Rat
12904691Cm130Cardiac mass QTL 1300.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)181553955127743236Rat
12904690Cm129Cardiac mass QTL 1290.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)181553955127743236Rat
12904689Cm128Cardiac mass QTL 1280.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)181553955127743236Rat
12904693Am20Aortic mass QTL 200.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)181553955127743236Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:488
Count of miRNA genes:168
Interacting mature miRNAs:197
Transcripts:ENSRNOT00000036240, ENSRNOT00000041961, ENSRNOT00000064299, ENSRNOT00000068139
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 43 11 8 11 70 33 18 8
Low 3 22 6 8 6 4 2 23 11
Below cutoff 24 24 24

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000041961   ⟹   ENSRNOP00000044723
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1816,650,806 - 17,332,205 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000068139   ⟹   ENSRNOP00000061693
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1817,043,903 - 17,332,210 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093140   ⟹   ENSRNOP00000076222
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1816,650,898 - 16,969,412 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093285   ⟹   ENSRNOP00000076142
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1817,091,310 - 17,332,205 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093679   ⟹   ENSRNOP00000076213
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1816,650,806 - 17,332,205 (+)Ensembl
RefSeq Acc Id: NM_001271332   ⟹   NP_001258261
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21815,993,324 - 16,425,796 (+)NCBI
Rnor_6.01816,650,898 - 17,332,205 (+)NCBI
Rnor_5.01816,410,820 - 16,473,813 (+)NCBI
Rnor_5.01816,842,427 - 17,086,636 (+)NCBI
Celera1815,913,907 - 16,336,469 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600803   ⟹   XP_017456292
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21815,993,079 - 16,425,796 (+)NCBI
Rnor_6.01816,650,786 - 17,332,209 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600804   ⟹   XP_017456293
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21815,993,079 - 16,425,796 (+)NCBI
Rnor_6.01816,650,786 - 17,332,209 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600805   ⟹   XP_017456294
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21815,993,399 - 16,425,793 (+)NCBI
Rnor_6.01816,650,786 - 17,332,202 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600806   ⟹   XP_017456295
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21815,993,399 - 16,425,796 (+)NCBI
Rnor_6.01816,650,787 - 17,332,209 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600807   ⟹   XP_017456296
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21815,993,399 - 16,425,793 (+)NCBI
Rnor_6.01816,650,788 - 17,332,202 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600808   ⟹   XP_017456297
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01817,180,943 - 17,332,209 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001258261   ⟸   NM_001271332
- Sequence:
RefSeq Acc Id: XP_017456292   ⟸   XM_017600803
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017456293   ⟸   XM_017600804
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017456294   ⟸   XM_017600805
- Peptide Label: isoform X3
- UniProtKB: A0A1W2Q6D5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456295   ⟸   XM_017600806
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017456296   ⟸   XM_017600807
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_017456297   ⟸   XM_017600808
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: ENSRNOP00000044723   ⟸   ENSRNOT00000041961
RefSeq Acc Id: ENSRNOP00000076213   ⟸   ENSRNOT00000093679
RefSeq Acc Id: ENSRNOP00000076222   ⟸   ENSRNOT00000093140
RefSeq Acc Id: ENSRNOP00000061693   ⟸   ENSRNOT00000068139
RefSeq Acc Id: ENSRNOP00000076142   ⟸   ENSRNOT00000093285
Protein Domains
DAD   FH2   Formin_GBD_N   GBD/FH3

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700678
Promoter ID:EPDNEW_R11192
Type:initiation region
Name:Fhod3_1
Description:formin homology 2 domain containing 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01816,650,843 - 16,650,903EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2322319 AgrOrtholog
Ensembl Genes ENSRNOG00000027230 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000044723 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000061693 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000076142 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000076213 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000076222 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000041961 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000068139 UniProtKB/TrEMBL
  ENSRNOT00000093140 UniProtKB/TrEMBL
  ENSRNOT00000093285 UniProtKB/TrEMBL
  ENSRNOT00000093679 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.2220 UniProtKB/TrEMBL
  1.25.10.10 UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  Diaphanous_autoregulatory UniProtKB/TrEMBL
  FH2_actin-bd UniProtKB/TrEMBL
  FH2_Formin_sf UniProtKB/TrEMBL
  FHOD1 UniProtKB/TrEMBL
  FHOD1_GBD_N UniProtKB/TrEMBL
  GTPase-bd/formin_homology_3 UniProtKB/TrEMBL
NCBI Gene Fhod3 ENTREZGENE
PANTHER PTHR45920:SF2 UniProtKB/TrEMBL
Pfam FH2 UniProtKB/TrEMBL
  Formin_GBD_N UniProtKB/TrEMBL
PhenoGen Fhod3 PhenoGen
PROSITE DAD UniProtKB/TrEMBL
  FH2 UniProtKB/TrEMBL
  GBD_FH3 UniProtKB/TrEMBL
SMART FH2 UniProtKB/TrEMBL
Superfamily-SCOP ARM-type_fold UniProtKB/TrEMBL
UniProt A0A1W2Q659_RAT UniProtKB/TrEMBL
  A0A1W2Q6D0_RAT UniProtKB/TrEMBL
  A0A1W2Q6D5 ENTREZGENE, UniProtKB/TrEMBL
  F1LQJ2_RAT UniProtKB/TrEMBL
  F1LRX2_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-08-07 LOC100360334  formin homology 2 domain containing 3-like  Fhod3  formin homology 2 domain containing 3  Data Merged 737654 APPROVED
2012-08-07 Fhod3  formin homology 2 domain containing 3  LOC100360334  formin homology 2 domain containing 3-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-06 LOC100360334  formin homology 2 domain containing 3-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 Fhod3  formin homology 2 domain containing 3   Fhod3_predicted  formin homology 2 domain containing 3 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Fhod3_predicted  formin homology 2 domain containing 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED