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Gene: Ppp2r2b (protein phosphatase 2, regulatory subunit B, beta) Rattus norvegicus
Symbol: Ppp2r2b
Name: protein phosphatase 2, regulatory subunit B, beta
Description: Predicted to have protein phosphatase regulator activity. Involved in several processes, including mitochondrial fragmentation involved in apoptotic process; nervous system development; and protein targeting to mitochondrion. Localizes to cytosol; mitochondrial outer membrane; and protein phosphatase type 2A complex. Colocalizes with cytoskeleton. Human ortholog(s) of this gene implicated in Alzheimer's disease; brain disease; breast cancer; and spinocerebellar ataxia type 12. Orthologous to human PPP2R2B (protein phosphatase 2 regulatory subunit Bbeta); PARTICIPATES IN platelet-derived growth factor signaling pathway; Chagas disease pathway; hepatitis C pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: BRbeta B-regulatory subunit of protein phosphatase 2A; PP2A subunit B isoform B55-beta; PP2A subunit B isoform beta; PP2A subunit B isoform BRB; PP2A subunit B isoform PR55-beta; PP2A subunit B isoform R2-beta; PP2A, subunit B, B-beta isoform; PP2A, subunit B, B55-beta isoform; PP2A, subunit B, BRB isoform; PP2A, subunit B, PR55-beta isoform; PP2A, subunit B, R2-beta isoform; Pppr2b2; protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform; protein phosphatase 2 (formerly 2A), regulatory subunit B, beta isoform; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
Allele / Splice: Ppp2r2bTn(sb-T2/Bart3)2.239Mcwi  
Genetic Models: F344-Ppp2r2bTn(sb-T2/Bart3)2.239Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01836,985,709 - 37,421,383 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1836,985,714 - 37,245,809 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01836,647,298 - 37,076,455 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41835,865,837 - 36,318,308 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11835,901,503 - 36,179,323 (-)NCBI
Celera1834,248,471 - 34,670,726 (-)NCBICelera
Cytogenetic Map18p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Ppp2r2b
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 631441
Created: 2003-08-13
Species: Rattus norvegicus
Last Modified: 2020-03-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.