Mocos (molybdenum cofactor sulfurase) - Rat Genome Database

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Gene: Mocos (molybdenum cofactor sulfurase) Rattus norvegicus
Analyze
Symbol: Mocos
Name: molybdenum cofactor sulfurase
RGD ID: 1308496
Description: Predicted to enable Mo-molybdopterin cofactor sulfurase activity. Predicted to be involved in molybdopterin cofactor metabolic process. Human ortholog(s) of this gene implicated in xanthinuria. Orthologous to human MOCOS (molybdenum cofactor sulfurase); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC361300
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21815,931,654 - 15,977,415 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1815,931,654 - 15,977,187 (+)Ensembl
Rnor_6.01816,590,086 - 16,636,312 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1816,590,197 - 16,636,084 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01816,349,169 - 16,395,056 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41816,420,503 - 16,466,040 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11816,447,589 - 16,492,609 (+)NCBI
Celera1815,859,448 - 15,904,747 (+)NCBICelera
Cytogenetic Map18p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,7-dihydropurine-6-thione  (ISO)
4-hydroxynon-2-enal  (ISO)
6-propyl-2-thiouracil  (EXP)
6-Thiourate  (ISO)
8-Br-cAMP  (ISO)
amphetamine  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
butan-1-ol  (ISO)
cadmium sulfate  (ISO)
carbamazepine  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
etoposide  (ISO)
genistein  (ISO)
isotretinoin  (ISO)
lead diacetate  (ISO)
lucanthone  (ISO)
mercaptopurine  (ISO)
metformin  (EXP)
mitoxantrone  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
purine-6-thiol  (ISO)
quercetin  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
succimer  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
tioguanine  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

Additional References at PubMed
PMID:11302742  


Genomics

Comparative Map Data
Mocos
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21815,931,654 - 15,977,415 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1815,931,654 - 15,977,187 (+)Ensembl
Rnor_6.01816,590,086 - 16,636,312 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1816,590,197 - 16,636,084 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01816,349,169 - 16,395,056 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41816,420,503 - 16,466,040 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11816,447,589 - 16,492,609 (+)NCBI
Celera1815,859,448 - 15,904,747 (+)NCBICelera
Cytogenetic Map18p12NCBI
MOCOS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381836,187,497 - 36,272,157 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1836,187,497 - 36,272,157 (+)EnsemblGRCh38hg38GRCh38
GRCh371833,767,460 - 33,852,120 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361832,021,478 - 32,102,683 (+)NCBINCBI36hg18NCBI36
Build 341832,021,479 - 32,102,682NCBI
Celera1830,575,346 - 30,656,592 (+)NCBI
Cytogenetic Map18q12.2NCBI
HuRef1830,626,379 - 30,707,547 (+)NCBIHuRef
CHM1_11833,694,591 - 33,775,784 (+)NCBICHM1_1
T2T-CHM13v2.01836,379,059 - 36,463,756 (+)NCBI
Mocos
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391824,786,538 - 24,834,634 (+)NCBIGRCm39mm39
GRCm39 Ensembl1824,786,748 - 24,834,632 (+)Ensembl
GRCm381824,653,492 - 24,701,577 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1824,653,691 - 24,701,575 (+)EnsemblGRCm38mm10GRCm38
MGSCv371824,812,192 - 24,860,057 (+)NCBIGRCm37mm9NCBIm37
MGSCv361824,796,497 - 24,844,587 (+)NCBImm8
Celera1825,135,661 - 25,183,078 (+)NCBICelera
Cytogenetic Map18A2NCBI
Mocos
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540222,754,064 - 22,808,167 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540222,754,034 - 22,808,428 (+)NCBIChiLan1.0ChiLan1.0
MOCOS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11832,998,527 - 33,080,053 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1832,998,769 - 33,080,053 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01829,440,016 - 29,542,105 (+)NCBIMhudiblu_PPA_v0panPan3
MOCOS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1753,950,561 - 54,002,046 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl753,945,436 - 54,002,252 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha753,373,914 - 53,427,347 (-)NCBI
ROS_Cfam_1.0753,918,314 - 53,971,999 (-)NCBI
ROS_Cfam_1.0 Ensembl753,913,166 - 53,972,004 (-)Ensembl
UMICH_Zoey_3.1753,601,974 - 53,655,234 (-)NCBI
UNSW_CanFamBas_1.0753,625,167 - 53,678,696 (-)NCBI
UU_Cfam_GSD_1.0753,917,631 - 53,971,177 (-)NCBI
Mocos
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494449,728,523 - 49,778,989 (-)NCBI
SpeTri2.0NW_0049365179,059,042 - 9,105,304 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MOCOS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6119,945,076 - 120,018,120 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16119,945,076 - 120,018,332 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26112,471,601 - 112,544,699 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MOCOS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11844,570,277 - 44,627,641 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1844,581,987 - 44,627,557 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605019,026,451 - 19,088,270 (-)NCBIVero_WHO_p1.0
Mocos
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477910,500,772 - 10,545,503 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462477910,500,696 - 10,547,452 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
D18Chm6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21815,934,010 - 15,934,209 (+)MAPPERmRatBN7.2
Rnor_6.01816,592,554 - 16,592,748NCBIRnor6.0
Rnor_5.01816,351,526 - 16,351,720UniSTSRnor5.0
RGSC_v3.41816,422,860 - 16,423,054UniSTSRGSC3.4
Celera1815,861,805 - 15,862,005UniSTS
Cytogenetic Map18p12UniSTS
BE110321  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21815,976,997 - 15,977,148 (+)MAPPERmRatBN7.2
Rnor_6.01816,635,895 - 16,636,045NCBIRnor6.0
Rnor_5.01816,394,867 - 16,395,017UniSTSRnor5.0
RGSC_v3.41816,465,851 - 16,466,001UniSTSRGSC3.4
Celera1815,904,558 - 15,904,708UniSTS
RH 3.4 Map18186.0UniSTS
Cytogenetic Map18p12UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552968Pigfal19Plasma insulin-like growth factor 1 level QTL 1911.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)18125758124Rat
9590248Scort10Serum corticosterone level QTL 1019.710.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)18125758124Rat
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18130558703Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134291613Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134291613Rat
61388Bp2Blood pressure QTL 23.23arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)18135374722Rat
9589153Insul31Insulin level QTL 317.150.05blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)18142547119Rat
1641910Colcr3Colorectal carcinoma resistance QTL 35.020.000007intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor surface area measurement (CMO:0002078)18224947722066430Rat
1641910Colcr3Colorectal carcinoma resistance QTL 35.020.000007intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)18224947722066430Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18420794160377792Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18518585840503530Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181179151863636873Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
61382Bp46Blood pressure QTL 4618.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194179131393320Rat
631264Scl22Serum cholesterol level QTL 226.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)181194179131393320Rat
12904690Cm129Cardiac mass QTL 1290.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)181194427326548295Rat
12904689Cm128Cardiac mass QTL 1280.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)181194427326548295Rat
12904693Am20Aortic mass QTL 200.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)181194427326548295Rat
12904695Kidm73Kidney mass QTL 730.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)181194427326548295Rat
12904691Cm130Cardiac mass QTL 1300.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)181194427326548295Rat
12904680Bw189Body weight QTL 1890.019body mass (VT:0001259)body weight (CMO:0000012)181194427326548295Rat
2301410Bp317Blood pressure QTL 3170.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181194427326548295Rat
1331781Scl28Serum cholesterol level QTL 283.995blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)181194429924797117Rat
1331766Bp236Blood pressure QTL 2363.022arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181194429931359530Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)181194429941122201Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194429952293055Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)181194429959330563Rat
6903359Bp355Blood pressure QTL 3553.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194454459796478Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181495133759951337Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:33
Count of miRNA genes:33
Interacting mature miRNAs:33
Transcripts:ENSRNOT00000066583
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 5 5 5 5
Low 3 19 46 30 19 30 8 11 20 23 26 6 8
Below cutoff 24 6 6 6 52 12 14

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000066583   ⟹   ENSRNOP00000061024
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1815,931,654 - 15,977,187 (+)Ensembl
Rnor_6.0 Ensembl1816,590,197 - 16,636,084 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093190
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1816,590,590 - 16,624,520 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093441   ⟹   ENSRNOP00000076247
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1816,590,602 - 16,609,554 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093449
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1816,613,591 - 16,616,947 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093641   ⟹   ENSRNOP00000076169
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1816,616,937 - 16,636,082 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093715   ⟹   ENSRNOP00000076171
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1815,931,654 - 15,977,187 (+)Ensembl
Rnor_6.0 Ensembl1816,590,408 - 16,636,064 (+)Ensembl
RefSeq Acc Id: NM_001108425   ⟹   NP_001101895
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21815,931,654 - 15,977,187 (+)NCBI
Rnor_6.01816,590,197 - 16,636,084 (+)NCBI
Rnor_5.01816,349,169 - 16,395,056 (+)NCBI
RGSC_v3.41816,420,503 - 16,466,040 (+)RGD
Celera1815,859,448 - 15,904,747 (+)RGD
Sequence:
RefSeq Acc Id: XM_006254466   ⟹   XP_006254528
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21815,931,659 - 15,977,185 (+)NCBI
Rnor_6.01816,590,109 - 16,636,082 (+)NCBI
Rnor_5.01816,349,169 - 16,395,056 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600988   ⟹   XP_017456477
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21815,931,659 - 15,977,415 (+)NCBI
Rnor_6.01816,590,107 - 16,635,984 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039096954   ⟹   XP_038952882
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21815,931,984 - 15,977,185 (+)NCBI
RefSeq Acc Id: XR_001842027
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21815,931,659 - 15,977,415 (+)NCBI
Rnor_6.01816,590,108 - 16,635,984 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001101895   ⟸   NM_001108425
- Sequence:
RefSeq Acc Id: XP_006254528   ⟸   XM_006254466
- Peptide Label: isoform X1
- UniProtKB: A0A1W2Q693 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456477   ⟸   XM_017600988
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000076171   ⟸   ENSRNOT00000093715
RefSeq Acc Id: ENSRNOP00000076169   ⟸   ENSRNOT00000093641
RefSeq Acc Id: ENSRNOP00000076247   ⟸   ENSRNOT00000093441
RefSeq Acc Id: ENSRNOP00000061024   ⟸   ENSRNOT00000066583
RefSeq Acc Id: XP_038952882   ⟸   XM_039096954
- Peptide Label: isoform X2
Protein Domains
MOSC   MOSC_N

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A1W2Q693-F1-model_v2 AlphaFold A0A1W2Q693 1-862 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700672
Promoter ID:EPDNEW_R11191
Type:initiation region
Name:Mocos_1
Description:molybdenum cofactor sulfurase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01816,590,590 - 16,590,650EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
18 16590671 16590672 C T snv MR/N (2020), M520/NRrrcMcwi (2019), WN/N (2020), ACI/EurMcwi (MCW), ACI/N (MCW), M520/N (MCW), MR/N (MCW), WN/N (MCW), ACI/EurMcwi (RGD), BBDP/Wor (RGD), ACI/EurMcwi (2019), ACI/N (2020), BUF/N (2020), FXLE16/Stm (2020), LEXF3/Stm (2020), LE/Stm (2019), LEXF10A/StmMcwi (2020), M520/N (2020)
18 16630346 16630347 G A snv PVG/Seac (2019), SBN/Ygl (MCW), SBN/Ygl (RGD)
18 16635940 16635941 C T snv SBN/Ygl (MCW), SBN/Ygl (RGD), PVG/Seac (2019)


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
18 16349643 16349644 C T snv LE/Stm (SOLiD) (KNAW), LE/Stm (Illumina) (KNAW), M520/N (KNAW), ACI/EurMcwi (MCW), BUF/N (KNAW), MR/N (KNAW), ACI/N (KNAW), ACI/EurMcwi (KNAW), BBDP/WorN (KNAW), WN/N (KNAW)
18 16389318 16389319 G A snv ZFDM (KyushuU), SBN/Ygl (MCW), SBN/Ygl (KNAW)
18 16394912 16394913 C T snv SBN/Ygl (MCW), SBN/Ygl (KNAW), ZF (KyushuU), ZFDM (KyushuU)


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
18 16460302 16460303 G A snv SBN/Ygl (ICL)
18 16465896 16465897 C T snv SBN/Ygl (ICL)


Assembly: mRatBN7.2

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
18 15932128 15932129 C T snv ACI/EurMcwi (2019), ACI/N (2020), BUF/N (2020), FXLE16/Stm (2020), LEXF3/Stm (2020), LE/Stm (2019), LEXF10A/StmMcwi (2020), WN/N (2020), M520/NRrrcMcwi (2019), M520/N (2020), MR/N (2020)
18 15971449 15971450 G A snv PVG/Seac (2019)
18 15977043 15977044 C T snv PVG/Seac (2019)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308496 AgrOrtholog
BioCyc Gene G2FUF-8144 BioCyc
BioCyc Pathway PWY-5963 [molybdenum cofactor sulfulylation (eukaryotes)] BioCyc
Ensembl Genes ENSRNOG00000015113 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000061024 UniProtKB/TrEMBL
  ENSRNOP00000076169 UniProtKB/TrEMBL
  ENSRNOP00000076171 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000076247 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000066583 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000093441 UniProtKB/TrEMBL
  ENSRNOT00000093641 UniProtKB/TrEMBL
  ENSRNOT00000093715 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 3.40.640.10 UniProtKB/TrEMBL
  3.90.1150.10 UniProtKB/TrEMBL
InterPro Aminotrans_V/Cys_dSase UniProtKB/TrEMBL
  MoCF_Sase_C UniProtKB/TrEMBL
  MoCo_sulfurase UniProtKB/TrEMBL
  MOSC_N UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_major_dom UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_major_sub1 UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_major_sub2 UniProtKB/TrEMBL
  Pyrv_Knase_b-brl-like UniProtKB/TrEMBL
KEGG Report rno:361300 UniProtKB/TrEMBL
NCBI Gene 361300 ENTREZGENE
Pfam Aminotran_5 UniProtKB/TrEMBL
  MOSC UniProtKB/TrEMBL
  MOSC_N UniProtKB/TrEMBL
PhenoGen Mocos PhenoGen
PROSITE MOSC UniProtKB/TrEMBL
Superfamily-SCOP PK_B_barrel_like UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_major UniProtKB/TrEMBL
UniProt A0A1W2Q677_RAT UniProtKB/TrEMBL
  A0A1W2Q693 ENTREZGENE, UniProtKB/TrEMBL
  A0A1W2Q6E8_RAT UniProtKB/TrEMBL
  D4A1G3_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Mocos  molybdenum cofactor sulfurase   Mocos_predicted  molybdenum cofactor sulfurase (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Mocos_predicted  molybdenum cofactor sulfurase (predicted)      Symbol and Name status set to approved 70820 APPROVED