Fech (ferrochelatase) - Rat Genome Database

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Gene: Fech (ferrochelatase) Rattus norvegicus
Analyze
Symbol: Fech
Name: ferrochelatase
RGD ID: 1307556
Description: Enables ferrochelatase activity. Involved in several processes, including cellular response to dexamethasone stimulus; response to lead ion; and response to platinum ion. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in cutaneous porphyria and erythropoietic protoporphyria. Orthologous to human FECH (ferrochelatase); PARTICIPATES IN acute intermittent porphyria pathway; erythropoietic porphyria pathway; heme biosynthetic pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ferrochelatase, mitochondrial; LOC361338
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81860,215,325 - 60,248,525 (-)NCBIGRCr8
mRatBN7.21857,945,123 - 57,978,327 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1857,945,122 - 57,979,348 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1860,027,156 - 60,060,293 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01860,738,816 - 60,772,068 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01858,568,836 - 58,602,038 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01859,941,992 - 59,975,192 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1859,941,992 - 59,975,192 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01859,152,151 - 59,185,351 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41860,675,217 - 60,708,418 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11860,748,886 - 60,781,609 (-)NCBI
Celera1856,082,277 - 56,115,455 (-)NCBICelera
Cytogenetic Map18q12.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(E)-cinnamyl alcohol  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine  (ISO)
1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxynon-2-enal  (ISO)
5-aminolevulinic acid  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
actinomycin D  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
antirheumatic drug  (ISO)
atrazine  (ISO)
Bandrowski's base  (ISO)
benzo[a]pyrene  (ISO)
benzoic acid  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
chloroacetaldehyde  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
cidofovir anhydrous  (ISO)
cinnamyl alcohol  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (EXP)
desferrioxamine B  (ISO)
diazinon  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
eugenol  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
glafenine  (EXP)
griseofulvin  (ISO)
hexane  (ISO)
hydrogen peroxide  (ISO)
ifosfamide  (ISO)
iron atom  (ISO)
iron trichloride  (ISO)
iron(0)  (ISO)
isoeugenol  (ISO)
isoniazide  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury(0)  (ISO)
metformin  (EXP)
methoxychlor  (EXP)
methyl salicylate  (ISO)
N-ethyl-N-nitrosourea  (ISO)
nefazodone  (EXP)
nickel sulfate  (ISO)
nimesulide  (EXP)
nitrofen  (EXP)
Nutlin-3  (ISO)
ochratoxin A  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
porphobilinogen  (ISO)
propan-2-ol  (ISO)
protoporphyrin  (ISO)
rac-lactic acid  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tauro-beta-muricholic acid  (ISO)
taurochenodeoxycholic acid  (ISO)
taurocholic acid  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trans-isoeugenol  (ISO)
tributylstannane  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Effects of iron deficiency and chronic iron overloading on mitochondrial heme biosynthetic enzymes in rat liver. Abraham NG, etal., Biochim Biophys Acta. 1986 Mar 28;870(2):339-49.
2. Biosynthesis of heme in mammals. Ajioka RS, etal., Biochim Biophys Acta. 2006 Jul;1763(7):723-36. Epub 2006 Jun 3.
3. Synthesis, delivery and regulation of eukaryotic heme and Fe-S cluster cofactors. Barupala DP, etal., Arch Biochem Biophys. 2016 Feb 15;592:60-75. doi: 10.1016/j.abb.2016.01.010. Epub 2016 Jan 16.
4. Level of expression of the nonmutant Ferrochelatase allele is a determinant of biochemical phenotype in a mouse model of erythropoietic protoporphyria. Bloomer J, etal., Gene Regul Syst Bio. 2008 May 29;2:233-41.
5. Heme synthetase deficiency in human protoporphyria. Demonstration of the defect in liver and cultured skin fibroblasts. Bonkowsky HL, etal., J Clin Invest. 1975 Nov;56(5):1139-48.
6. Regulation of phenobarbital-induced ferrochelatase mRNA activity by dibutyryl cAMP and glucose in normal and diabetic rat hepatocytes. Canepa ET, etal., Biochem Cell Biol. 1992 Jan;70(1):26-33.
7. A Novel Mutation in the FECH Gene in a Czech Family with Erythropoietic Protoporphyria and a Population Study of IVS3-48C Variant Contributing to the Disease. Farrag MS, etal., Folia Biol (Praha). 2015;61(6):227-32.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. GenMAPP: Gene Map Annotator and Pathway Profiler GenMAPP
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Four novel mutations in the ferrochelatase gene among erythropoietic protoporphyria patients. Henriksson M, etal., J Invest Dermatol. 1996 Feb;106(2):346-50.
12. Effect of cis-platinum on kidney cytochrome P-450 and heme metabolism: evidence for the regulatory role of the pituitary hormones. Jollie DR and Maines MD, Arch Biochem Biophys. 1985 Jul;240(1):51-9.
13. Erythropoietic protoporphyria a clinical and molecular study from Lebanon: Ferrochelatase a potential tumor suppressor gene in colon cancer. Kadara H, etal., Clin Genet. 2017 Nov;92(5):495-502. doi: 10.1111/cge.12968. Epub 2017 Aug 2.
14. Transformation, growth rate, and the heme biosynthetic pathway in V-abl-transfected fibroblasts. Mamet R, etal., Biochem Med Metab Biol. 1994 Jun;52(1):53-7.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Incomplete erythropoietic protoporphyria caused by a splice site modulator homozygous IVS3-48C polymorphism in the ferrochelatase gene. Mizawa M, etal., Br J Dermatol. 2016 Jan;174(1):172-5. doi: 10.1111/bjd.14078. Epub 2015 Nov 7.
17. Novel regulation of delta-aminolevulinate synthase in the rat harderian gland. Nagai M, etal., Biochem Pharmacol. 1997 Mar 7;53(5):643-50.
18. The site of inhibition of porphyrin biosynthesis by an isomer of diazinon in rats. Nichol AW, etal., Biochem Pharmacol. 1983 Sep 15;32(18):2653-7.
19. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
20. Effects of lead on the heme biosynthetic pathway in rat kidney. Oskarsson A and Fowler BA, Exp Mol Pathol. 1985 Dec;43(3):409-17.
21. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
22. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
23. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
24. GOA pipeline RGD automated data pipeline
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Comprehensive gene review and curation RGD comprehensive gene curation
28. The decrease in uroporphyrinogen decarboxylase activity induced by ethanol predisposes rats to the development of porphyria and accelerates xenobiotic-triggered porphyria, regardless of hepatic damage. Rios de Molina MC, etal., Braz J Med Biol Res. 2002 Nov;35(11):1273-83.
29. Mutations in the iron-sulfur cluster ligands of the human ferrochelatase lead to erythropoietic protoporphyria. Schneider-Yin X, etal., Blood. 2000 Aug 15;96(4):1545-9.
30. Excess generation of endogenous heme inhibits L-alanine:4,5-dioxovalerate transaminase in rat liver mitochondria. Shanker J and Datta K, Biochem Biophys Res Commun. 1986 Jul 31;138(2):751-7.
31. Mechanism of hexachlorobenzene-induced porphyria in rats. Effect of phenobarbitone pretreatment. Wainstok de Calmanovici R, etal., Biochem J. 1984 Mar 15;218(3):753-63.
32. Metal alteration of uroporphyrinogen decarboxylase and coproporphyrinogen oxidase. Woods JS and Fowler BA, Ann N Y Acad Sci. 1987;514:55-64.
33. Effects of chronic arsenic exposure on hematopoietic function in adult mammalian liver. Woods JS and Fowler BA, Environ Health Perspect. 1977 Aug;19:209-13.
34. Alteration of mitochondrial structure and heme biosynthetic parameters in liver and kidney cells by bismuth. Woods JS and Fowler BA, Toxicol Appl Pharmacol. 1987 Sep 15;90(2):274-83.
Additional References at PubMed
PMID:1939658   PMID:7575558   PMID:8325637   PMID:8611576   PMID:8973195   PMID:9989256   PMID:11160364   PMID:12149233   PMID:14651853   PMID:14981080   PMID:15123683   PMID:15496139  
PMID:15931390   PMID:16306232   PMID:16503645   PMID:17003376   PMID:18614015   PMID:23395172   PMID:27599036   PMID:34800366  


Genomics

Comparative Map Data
Fech
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81860,215,325 - 60,248,525 (-)NCBIGRCr8
mRatBN7.21857,945,123 - 57,978,327 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1857,945,122 - 57,979,348 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1860,027,156 - 60,060,293 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01860,738,816 - 60,772,068 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01858,568,836 - 58,602,038 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01859,941,992 - 59,975,192 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1859,941,992 - 59,975,192 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01859,152,151 - 59,185,351 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41860,675,217 - 60,708,418 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11860,748,886 - 60,781,609 (-)NCBI
Celera1856,082,277 - 56,115,455 (-)NCBICelera
Cytogenetic Map18q12.1NCBI
FECH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381857,544,377 - 57,586,702 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1857,544,377 - 57,586,732 (-)EnsemblGRCh38hg38GRCh38
GRCh371855,211,609 - 55,253,934 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361853,366,535 - 53,404,988 (-)NCBINCBI36Build 36hg18NCBI36
Build 341853,366,534 - 53,404,988NCBI
Celera1851,928,883 - 51,970,808 (-)NCBICelera
Cytogenetic Map18q21.31NCBI
HuRef1851,922,248 - 51,964,183 (-)NCBIHuRef
CHM1_11855,207,292 - 55,249,187 (-)NCBICHM1_1
T2T-CHM13v2.01857,744,729 - 57,787,055 (-)NCBIT2T-CHM13v2.0
Fech
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391864,589,613 - 64,622,169 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1864,585,985 - 64,623,322 (-)EnsemblGRCm39 Ensembl
GRCm381864,456,542 - 64,489,098 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1864,452,914 - 64,490,251 (-)EnsemblGRCm38mm10GRCm38
MGSCv371864,616,204 - 64,648,720 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361864,581,919 - 64,614,435 (-)NCBIMGSCv36mm8
Celera1865,723,518 - 65,755,460 (-)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1837.43NCBI
Fech
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540241,902,868 - 41,938,174 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540241,902,868 - 41,938,099 (-)NCBIChiLan1.0ChiLan1.0
FECH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21775,089,145 - 75,126,842 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11860,776,794 - 60,819,446 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01850,934,520 - 50,977,132 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11854,273,527 - 54,312,255 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1854,273,527 - 54,312,378 (-)Ensemblpanpan1.1panPan2
FECH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1118,352,184 - 18,384,251 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl118,345,811 - 18,383,092 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha119,330,379 - 19,366,324 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0118,227,872 - 18,263,839 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl118,227,773 - 18,265,197 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1118,284,504 - 18,320,457 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0118,182,273 - 18,218,239 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0118,451,188 - 18,487,178 (+)NCBIUU_Cfam_GSD_1.0
Fech
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494431,516,610 - 31,549,529 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364976,755,553 - 6,790,944 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364976,755,626 - 6,788,568 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FECH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1106,854,011 - 106,898,591 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11106,861,628 - 106,898,407 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21117,466,662 - 117,487,827 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FECH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11822,143,268 - 22,182,259 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1822,143,483 - 22,182,416 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660603,386,537 - 3,424,620 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fech
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247923,064,841 - 3,102,345 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247923,067,270 - 3,101,698 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fech
226 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:148
Count of miRNA genes:111
Interacting mature miRNAs:122
Transcripts:ENSRNOT00000024328
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)181194429959330563Rat
1331730Scl27Serum cholesterol level QTL 273.826blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)185229287559796643Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1298072Cia26Collagen induced arthritis QTL 263.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)185470976983828827Rat
1331736Bp227Blood pressure QTL 2272.791arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)184671876359796643Rat
1300125Rf26Renal function QTL 263.2urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)185253986365844950Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184334502283828827Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940861698465Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184664067583828827Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184664067583828827Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)182979296574792965Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
61360EaeyExperimental allergic encephalomyelitis QTL y3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)184698893960377753Rat
2300177Bmd65Bone mineral density QTL 6519.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183135940883218561Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)185253976376104388Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183819245583192455Rat
2293658Bmd23Bone mineral density QTL 237.30.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)185146473363636873Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185229287573997283Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18420794160377792Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)182979296574792965Rat
1331752Bw27Body weight QTL 272.963body mass (VT:0001259)body weight (CMO:0000012)185229287565845095Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182979296574792965Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)185253976376104388Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)185253976376104388Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)184852004483828827Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)185253976376104388Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183127168160377755Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)185253976376104388Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185253976376104388Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)185253976376104388Rat
1331780Bp238Blood pressure QTL 2383.269arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671876359796643Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185146473383218561Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183135940859796643Rat
6903359Bp355Blood pressure QTL 3553.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194454459796478Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183587072380870723Rat
6903345Bp349Blood pressure QTL 3493.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671893559796478Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181495133759951337Rat
6903347Bp350Blood pressure QTL 3504.4arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135953059796478Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184664067583828827Rat
6903349Bp351Blood pressure QTL 3513.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671893559796478Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)185253976369140759Rat
2300157Bmd66Bone mineral density QTL 6613.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
738005Anxrr11Anxiety related response QTL 113.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)183003981375039813Rat
6903351Bp352Blood pressure QTL 3523.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671893559796478Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183139332077209694Rat
1358193Emca2Estrogen-induced mammary cancer QTL 21.6mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)181800759963571040Rat
2293704Bss35Bone structure and strength QTL 354.590.0002femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)182896485373964853Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182557098570570985Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181179151863636873Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)182979296574792965Rat
1600375Mcs22Mammary carcinoma susceptibility QTL 223.3mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)185253976363933058Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)184852004483828827Rat
1598826Anxrr20Anxiety related response QTL 203.04body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)184143297183828827Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183135940870263868Rat
7411719Strs5Sensitivity to stroke QTL 59.4cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)184999995865845095Rat

Markers in Region
RH130681  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21857,946,128 - 57,946,310 (+)MAPPERmRatBN7.2
Rnor_6.01859,942,998 - 59,943,179NCBIRnor6.0
Rnor_5.01859,153,157 - 59,153,338UniSTSRnor5.0
RGSC_v3.41860,676,223 - 60,676,404UniSTSRGSC3.4
Celera1856,083,283 - 56,083,464UniSTS
RH 3.4 Map18569.8UniSTS
Cytogenetic Map18q12.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000024328   ⟹   ENSRNOP00000024328
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1857,945,123 - 57,978,327 (-)Ensembl
Rnor_6.0 Ensembl1859,941,992 - 59,975,192 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110759   ⟹   ENSRNOP00000086143
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1857,945,122 - 57,972,929 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112552   ⟹   ENSRNOP00000080790
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1857,945,122 - 57,979,348 (-)Ensembl
RefSeq Acc Id: NM_001108434   ⟹   NP_001101904
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81860,215,325 - 60,248,525 (-)NCBI
mRatBN7.21857,945,123 - 57,978,327 (-)NCBI
Rnor_6.01859,941,992 - 59,975,192 (-)NCBI
Rnor_5.01859,152,151 - 59,185,351 (-)NCBI
RGSC_v3.41860,675,217 - 60,708,418 (-)RGD
Celera1856,082,277 - 56,115,455 (-)RGD
Sequence:
RefSeq Acc Id: XM_006254850   ⟹   XP_006254912
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81860,216,083 - 60,243,894 (-)NCBI
mRatBN7.21857,945,603 - 57,973,287 (-)NCBI
Rnor_6.01859,942,747 - 59,972,091 (-)NCBI
Rnor_5.01859,152,151 - 59,185,351 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039096978   ⟹   XP_038952906
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81860,216,083 - 60,248,477 (-)NCBI
mRatBN7.21857,945,603 - 57,978,305 (-)NCBI
RefSeq Acc Id: NP_001101904   ⟸   NM_001108434
- UniProtKB: D3ZBM3 (UniProtKB/TrEMBL),   A6IXN8 (UniProtKB/TrEMBL),   A0A8I5ZR41 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006254912   ⟸   XM_006254850
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GEM4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024328   ⟸   ENSRNOT00000024328
RefSeq Acc Id: XP_038952906   ⟸   XM_039096978
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZR41 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000080790   ⟸   ENSRNOT00000112552
Ensembl Acc Id: ENSRNOP00000086143   ⟸   ENSRNOT00000110759

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZBM3-F1-model_v2 AlphaFold D3ZBM3 1-422 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700834
Promoter ID:EPDNEW_R11356
Type:initiation region
Name:Fech_1
Description:ferrochelatase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01859,975,196 - 59,975,256EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307556 AgrOrtholog
BioCyc Gene G2FUF-7255 BioCyc
Ensembl Genes ENSRNOG00000018053 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024328.5 UniProtKB/TrEMBL
  ENSRNOT00000110759.1 UniProtKB/TrEMBL
  ENSRNOT00000112552.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1400 UniProtKB/TrEMBL
InterPro Ferrochelatase UniProtKB/TrEMBL
  Ferrochelatase_AS UniProtKB/TrEMBL
  Ferrochelatase_C UniProtKB/TrEMBL
  Ferrochelatase_N UniProtKB/TrEMBL
KEGG Report rno:361338 UniProtKB/TrEMBL
NCBI Gene 361338 ENTREZGENE
PANTHER Ferrochelatase UniProtKB/TrEMBL
  FERROCHELATASE, MITOCHONDRIAL UniProtKB/TrEMBL
Pfam Ferrochelatase UniProtKB/TrEMBL
PhenoGen Fech PhenoGen
PROSITE FERROCHELATASE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018053 RatGTEx
Superfamily-SCOP Chelatase UniProtKB/TrEMBL
UniProt A0A8I5ZR41 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GEM4 ENTREZGENE, UniProtKB/TrEMBL
  A6IXN8 ENTREZGENE, UniProtKB/TrEMBL
  D3ZBM3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Fech  ferrochelatase   Fech_predicted  ferrochelatase (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Fech_predicted  ferrochelatase (predicted)      Symbol and Name status set to approved 70820 APPROVED