Eaez QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL: Eaez (Experimental allergic encephalomyelitis QTL z) Rattus norvegicus

Symbol: Eaez
Name: Experimental allergic encephalomyelitis QTL z
RGD ID: 70178
Previously known as: Eaez; Experimental Allergic (autoimmune) Encephalomyelitis suggestive QTL; Eae18; Experimental allergic encephalomyelitis QTL 18
Trait: nervous system integrity trait   (VT:0010566)    
Measurement Type: experimental autoimmune encephalomyelitis severity score   (CMO:0001419)    
LOD Score: 2.4
P Value: Not Available
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21812,357,786 - 12,874,620RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01812,597,179 - 15,099,007RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01812,385,472 - 14,882,610RGDRnor5.0
RGSC_v3.41813,239,641 - 58,239,641RGDRGSC3.4
RGSC_v3.11813,266,288 - 58,266,288RGD
Cross Type: F2
Strains Crossed: DA E3 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Experimental Condition

Measurement Method

Vertebrate Trait

Rat Strain
DA  (IEA)
E3  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Evidence for common autoimmune disease genes controlling onset, severity, and chronicity based on experimental models for multiple sclerosis and rheumatoid arthritis. Bergsteinsdottir K, etal., J Immunol 2000 Feb 1;164(3):1564-8
2. QTL Data Transfer QTL data import from the RatMap database

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
3081Mep1bmeprin A subunit beta181236612612392840Rat
1591842Garem1GRB2 associated regulator of MAPK1 subtype 1181242016912585323Rat
41250271LOC120098265uncharacterized LOC120098265181249349512509604Rat
41219354LOC120098431U6 spliceosomal RNA181268326212683364Rat
1566178Klhl14kelch-like family member 14181280425312917828Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
33971D18Mit7204181287462012874824Ratregion
60774D18Wox193181235769312357786Ratregion
1578864D18Chm89242181260885612609094Ratregion
1579032D18Chm90219181271057612710797Ratregion
5031744AU047296199181245421012454409Ratregion
5032151RH94561100181239270512392805Ratregion
5032563WI-14403148181242390512424053Ratregion
5084234AI013305123181241309512414338Ratregion
5090311AU049676240181244233412442576Ratregion
Position Markers

Flank 1: (D18Mit7)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21812,874,620 - 12,874,824 (+)MAPPER
Rnor_6.01812,597,179 - 12,597,382NCBI
Rnor_5.01812,385,472 - 12,385,675UniSTS
RGSC_v3.41813,239,641 - 13,239,845RGD
RGSC_v3.41813,239,642 - 13,239,845UniSTS
RGSC_v3.11813,266,288 - 13,266,491RGD
Celera1812,856,104 - 12,856,307UniSTS
RH 3.4 Map18133.6UniSTS
RH 3.4 Map18133.6RGD
RH 2.0 Map18752.7RGD
Cytogenetic Map18p12UniSTS
Flank 2: (D18Wox1)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21812,357,693 - 12,357,786 (-)MAPPER
Rnor_6.01815,098,915 - 15,099,007NCBI
Rnor_5.01814,882,518 - 14,882,610UniSTS
Celera1812,349,382 - 12,349,474UniSTS
Cytogenetic Map18 RGD


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552968Pigfal19Plasma insulin-like growth factor 1 level QTL 1911.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)18125758124Rat
9590248Scort10Serum corticosterone level QTL 1019.710.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)18125758124Rat
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18130558703Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134291613Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134291613Rat
61388Bp2Blood pressure QTL 23.23arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)18135374722Rat
9589153Insul31Insulin level QTL 317.150.05blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)18142547119Rat
1641910Colcr3Colorectal carcinoma resistance QTL 35.020.000007intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor surface area measurement (CMO:0002078)18224947722066430Rat
1641910Colcr3Colorectal carcinoma resistance QTL 35.020.000007intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)18224947722066430Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18420794160377792Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18518585840503530Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181179151863636873Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
61382Bp46Blood pressure QTL 4618.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194179131393320Rat
631264Scl22Serum cholesterol level QTL 226.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)181194179131393320Rat
12904690Cm129Cardiac mass QTL 1290.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)181194427326548295Rat
12904689Cm128Cardiac mass QTL 1280.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)181194427326548295Rat
12904693Am20Aortic mass QTL 200.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)181194427326548295Rat
12904695Kidm73Kidney mass QTL 730.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)181194427326548295Rat
12904691Cm130Cardiac mass QTL 1300.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)181194427326548295Rat
12904680Bw189Body weight QTL 1890.019body mass (VT:0001259)body weight (CMO:0000012)181194427326548295Rat
2301410Bp317Blood pressure QTL 3170.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181194427326548295Rat
1331781Scl28Serum cholesterol level QTL 283.995blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)181194429924797117Rat
1331766Bp236Blood pressure QTL 2363.022arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181194429931359530Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)181194429941122201Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194429952293055Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)181194429959330563Rat
6903359Bp355Blood pressure QTL 3553.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194454459796478Rat
70178EaezExperimental allergic encephalomyelitis QTL z2.4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)181235778612874620Rat


Additional Information

Database Acc Id Source(s)
NCBI Gene Eaez


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-07-24 Eaez  Experimental allergic encephalomyelitis QTL z  Eaez  Experimental allergic encephalomyelitis QTL z  Name updated 68913 APPROVED
2006-04-14 Eaez  Experimental allergic encephalomyelitis QTL z  Eae18  Experimental allergic encephalomyelitis QTL 18  Symbol and Name updated 1299863 APPROVED
2004-09-08 Eae18  Experimental Autoimmune (allergic) Encephalomyelitis QTL 18  Eaez  Experimental Allergic (autoimmune) Encephalomyelitis suggestive QTL  Symbol and Name updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
qtl_statistics_details QTL is also significant for duration of disease (LOD = 2.3) 61031