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Gene: Apc (APC regulator of WNT signaling pathway) Rattus norvegicus
Symbol: Apc
Name: APC regulator of WNT signaling pathway
Description: Exhibits microtubule binding activity. Involved in several processes, including cellular response to nerve growth factor stimulus; negative regulation of cardiac muscle cell proliferation; and regulation of glutamate metabolic process. Localizes to several cellular components, including axonal growth cone; cell body fiber; and nuclear membrane. Colocalizes with neuron projection and synapse. Used to study colon adenocarcinoma; colon cancer; and familial adenomatous polyposis. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endometrial cancer (multiple); familial adenomatous polyposis 1; hereditary desmoid disease; and medulloblastoma. Orthologous to human APC (APC regulator of WNT signaling pathway); PARTICIPATES IN altered Wnt signaling, canonical pathway; colorectal cancer pathway; endometrial cancer pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,2',4,4'-Tetrabromodiphenyl ether; 2,6-dinitrotoluene.
Type: protein-coding
Also known as: adenomatosis polyposis coli; adenomatous polyposis coli protein; APC, WNT signaling pathway regulator; RATAPC; WNT signaling pathway regulator
Homo sapiens (human) : APC (APC regulator of WNT signaling pathway)  HGNC  Alliance
Mus musculus (house mouse) : Apc (APC, WNT signaling pathway regulator)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Apc (APC regulator of WNT signaling pathway)
Pan paniscus (bonobo/pygmy chimpanzee) : APC (APC regulator of WNT signaling pathway)
Canis lupus familiaris (dog) : APC (APC regulator of WNT signaling pathway)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Apc (APC regulator of WNT signaling pathway)
Sus scrofa (pig) : APC (APC regulator of WNT signaling pathway)
Chlorocebus sabaeus (African green monkey) : APC (APC regulator of WNT signaling pathway)
Heterocephalus glaber (naked mole-rat) : Apc (APC regulator of WNT signaling pathway)
more info ...
Allele / Splice: ApcPirc   Apcm1Kyo  
Genetic Models: F344-ApcPircUwm ACI.F344-ApcPircUwm BN.F344-ApcPirc F344-Apcm1Kyo
Is Marker For: Strains:   F344-Apcm1Kyo  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01827,011,710 - 27,106,323 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1827,047,382 - 27,105,531 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01826,725,560 - 26,820,837 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41826,732,147 - 26,790,383 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11826,758,792 - 26,817,029 (+)NCBI
Celera1825,606,119 - 25,663,749 (+)NCBICelera
Cytogenetic Map18p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)