Synpo (synaptopodin) - Rat Genome Database

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Gene: Synpo (synaptopodin) Rattus norvegicus
Analyze
Symbol: Synpo (Ensembl: Myoz3)
Name: synaptopodin
RGD ID: 620668
Description: Predicted to enable actin binding activity. Predicted to be involved in several processes, including modification of dendritic spine; modulation of chemical synaptic transmission; and regulation of actin filament bundle assembly. Is active in glutamatergic synapse and spine apparatus. Orthologous to human SYNPO (synaptopodin); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21854,048,299 - 54,106,388 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1854,026,152 - 54,102,126 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1856,144,901 - 56,165,878 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01856,859,497 - 56,880,474 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01854,679,863 - 54,700,853 (-)NCBIRnor_WKY
Rnor_6.01855,863,081 - 55,921,412 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1855,865,467 - 55,916,220 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01855,096,559 - 55,154,838 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41856,552,991 - 56,573,981 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11856,625,222 - 56,627,418 (-)NCBI
Celera1852,210,523 - 52,231,513 (-)NCBICelera
Cytogenetic Map18q12.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-schisandrin B  (EXP)
(S)-nicotine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,8-cineole  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2-[4-[(E)-2-(6,8-dichloro-2-phenyl-2H-chromen-3-yl)ethenyl]phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane  (ISO)
2-butoxyethanol  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
cholesterol  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clothianidin  (ISO)
coumarin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dichloroacetic acid  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ergosta-4,6,8(14),22-tetraen-3-one  (ISO)
estriol  (ISO)
ethanol  (ISO)
folic acid  (ISO)
gefitinib  (ISO)
genistein  (ISO)
gentamycin  (EXP)
indometacin  (ISO)
L-methionine  (ISO)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
naphthalene  (ISO)
nicotine  (ISO)
nitrofen  (EXP)
paracetamol  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
propanal  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
tremolite asbestos  (ISO)
Triptolide  (ISO)
valproic acid  (EXP,ISO)
vitamin E  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Actin-associated protein synaptopodin in the rat hippocampal formation: localization in the spine neck and close association with the spine apparatus of principal neurons. Deller T, etal., J Comp Neurol. 2000 Mar 6;418(2):164-81.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Therapeutic potential of human induced pluripotent stem cells and renal progenitor cells in experimental chronic kidney disease. Ribeiro PC, etal., Stem Cell Res Ther. 2020 Dec 9;11(1):530. doi: 10.1186/s13287-020-02060-4.
8. Regulated expression of an actin-associated protein, synaptopodin, during long-term potentiation. Yamazaki M, etal., J Neurochem 2001 Oct;79(1):192-9.
9. Novel retinoic acid receptor alpha agonists for treatment of kidney disease. Zhong Y, etal., PLoS One. 2011;6(11):e27945. doi: 10.1371/journal.pone.0027945. Epub 2011 Nov 18.
Additional References at PubMed
PMID:9314539   PMID:12928494   PMID:15057822   PMID:15841212   PMID:16052494   PMID:16998909   PMID:18424168   PMID:19052472   PMID:21940706   PMID:22871113   PMID:24625528   PMID:25164660  
PMID:26840625   PMID:29476059   PMID:30661770   PMID:30744518   PMID:31371487  


Genomics

Comparative Map Data
Synpo
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21854,048,299 - 54,106,388 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1854,026,152 - 54,102,126 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1856,144,901 - 56,165,878 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01856,859,497 - 56,880,474 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01854,679,863 - 54,700,853 (-)NCBIRnor_WKY
Rnor_6.01855,863,081 - 55,921,412 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1855,865,467 - 55,916,220 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01855,096,559 - 55,154,838 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41856,552,991 - 56,573,981 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11856,625,222 - 56,627,418 (-)NCBI
Celera1852,210,523 - 52,231,513 (-)NCBICelera
Cytogenetic Map18q12.1NCBI
SYNPO
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385150,586,010 - 150,659,207 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl5150,601,080 - 150,659,207 (+)EnsemblGRCh38hg38GRCh38
GRCh375149,980,638 - 150,038,769 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365150,000,433 - 150,017,145 (+)NCBINCBI36Build 36hg18NCBI36
Build 345150,000,432 - 150,017,145NCBI
Celera5146,061,703 - 146,120,135 (+)NCBICelera
Cytogenetic Map5q33.1NCBI
HuRef5145,127,069 - 145,185,217 (+)NCBIHuRef
CHM1_15149,413,067 - 149,471,214 (+)NCBICHM1_1
T2T-CHM13v2.05151,137,582 - 151,195,715 (+)NCBIT2T-CHM13v2.0
Synpo
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391860,727,053 - 60,793,241 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1860,727,045 - 60,793,214 (-)EnsemblGRCm39 Ensembl
GRCm381860,593,981 - 60,660,173 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1860,593,973 - 60,660,142 (-)EnsemblGRCm38mm10GRCm38
MGSCv371860,753,644 - 60,783,959 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361860,719,342 - 60,749,998 (-)NCBIMGSCv36mm8
Celera1861,877,103 - 61,907,329 (-)NCBICelera
Cytogenetic Map18D3- E1NCBI
Synpo
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554153,932,192 - 3,990,022 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554153,929,781 - 3,977,769 (-)NCBIChiLan1.0ChiLan1.0
LOC100970287
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15152,046,461 - 152,087,703 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5152,046,207 - 152,085,595 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05146,048,956 - 146,083,490 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
SYNPO
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1458,501,361 - 58,549,340 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl458,497,734 - 58,550,438 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha458,260,078 - 58,297,258 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0458,974,689 - 59,011,637 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl458,974,684 - 59,029,816 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1458,763,050 - 58,800,212 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0458,877,636 - 58,914,546 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0459,408,732 - 59,445,642 (-)NCBIUU_Cfam_GSD_1.0
Synpo
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213142,748,009 - 142,801,743 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365044,321,962 - 4,358,294 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365044,321,985 - 4,358,757 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SYNPO
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2151,599,597 - 151,632,099 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12151,571,264 - 151,634,103 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SYNPO
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12353,189,617 - 53,261,808 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2353,220,796 - 53,262,103 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603424,452,467 - 24,493,442 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Synpo
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247749,902,851 - 9,910,752 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247749,860,274 - 9,912,722 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Synpo
223 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:224
Count of miRNA genes:112
Interacting mature miRNAs:124
Transcripts:ENSRNOT00000025934, ENSRNOT00000025989, ENSRNOT00000064686
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18420794160377792Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181179151863636873Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)181194429959330563Rat
6903359Bp355Blood pressure QTL 3553.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194454459796478Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181495133759951337Rat
1358193Emca2Estrogen-induced mammary cancer QTL 21.6mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)181800759963571040Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182557098570570985Rat
2293704Bss35Bone structure and strength QTL 354.590.0002femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)182896485373964853Rat
2300157Bmd66Bone mineral density QTL 6613.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
2300177Bmd65Bone mineral density QTL 6519.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)182979296574792965Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)182979296574792965Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)182979296574792965Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182979296574792965Rat
738005Anxrr11Anxiety related response QTL 113.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)183003981375039813Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183127168160377755Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183135940859796643Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940861698465Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183135940870263868Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183135940883218561Rat
6903347Bp350Blood pressure QTL 3504.4arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135953059796478Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183139332077209694Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183587072380870723Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183819245583192455Rat
1598826Anxrr20Anxiety related response QTL 203.04body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)184143297183828827Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184334502283828827Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184664067583828827Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184664067583828827Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184664067583828827Rat
1331806Bp229Blood pressure QTL 2294.36484arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671876357867167Rat
1331736Bp227Blood pressure QTL 2272.791arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)184671876359796643Rat
1331780Bp238Blood pressure QTL 2383.269arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671876359796643Rat
6903345Bp349Blood pressure QTL 3493.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671893559796478Rat
6903349Bp351Blood pressure QTL 3513.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671893559796478Rat
6903351Bp352Blood pressure QTL 3523.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671893559796478Rat
61360EaeyExperimental allergic encephalomyelitis QTL y3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)184698893960377753Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)184852004483828827Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)184852004483828827Rat
7411719Strs5Sensitivity to stroke QTL 59.4cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)184999995865845095Rat
2293658Bmd23Bone mineral density QTL 237.30.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)185146473363636873Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185146473383218561Rat
1331730Scl27Serum cholesterol level QTL 273.826blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)185229287559796643Rat
1331752Bw27Body weight QTL 272.963body mass (VT:0001259)body weight (CMO:0000012)185229287565845095Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185229287573997283Rat
1600375Mcs22Mammary carcinoma susceptibility QTL 223.3mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)185253976363933058Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)185253976369140759Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)185253976376104388Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)185253976376104388Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)185253976376104388Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)185253976376104388Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)185253976376104388Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)185253976376104388Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185253976376104388Rat
1300125Rf26Renal function QTL 263.2urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)185253986365844950Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 38 2 4 7 20 23 29 11 4
Low 2 5 57 41 17 41 4 4 54 12 10 4
Below cutoff 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_021695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB013130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC095289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC111737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AM980944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB769636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB794090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DY313339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EV779156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000025934   ⟹   ENSRNOP00000025934
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1854,049,397 - 54,101,463 (-)Ensembl
Rnor_6.0 Ensembl1855,865,467 - 55,916,220 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000025989   ⟹   ENSRNOP00000025989
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1854,026,152 - 54,046,166 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000064686   ⟹   ENSRNOP00000061109
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1854,055,938 - 54,076,930 (-)Ensembl
Rnor_6.0 Ensembl1855,870,720 - 55,891,710 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093773   ⟹   ENSRNOP00000094210
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1854,048,663 - 54,066,844 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000102376   ⟹   ENSRNOP00000077576
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1854,055,659 - 54,102,126 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000103982   ⟹   ENSRNOP00000087286
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1854,026,152 - 54,101,463 (-)Ensembl
RefSeq Acc Id: NM_021695   ⟹   NP_067727
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21854,055,938 - 54,076,930 (-)NCBI
Rnor_6.01855,870,720 - 55,891,710 (-)NCBI
Rnor_5.01855,096,559 - 55,154,838 (-)NCBI
RGSC_v3.41856,552,991 - 56,573,981 (-)RGD
Celera1852,210,523 - 52,231,513 (-)RGD
Sequence:
RefSeq Acc Id: XM_017601015   ⟹   XP_017456504
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21854,048,299 - 54,105,968 (-)NCBI
Rnor_6.01855,863,081 - 55,921,412 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601016   ⟹   XP_017456505
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21854,048,299 - 54,101,451 (-)NCBI
Rnor_6.01855,863,081 - 55,916,891 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601017   ⟹   XP_017456506
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21854,048,299 - 54,106,388 (-)NCBI
Rnor_6.01855,863,081 - 55,921,412 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601020   ⟹   XP_017456509
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21854,048,299 - 54,076,925 (-)NCBI
Rnor_6.01855,863,081 - 55,891,705 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601021   ⟹   XP_017456510
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21854,048,299 - 54,077,178 (-)NCBI
Rnor_6.01855,863,081 - 55,894,086 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601022   ⟹   XP_017456511
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21854,048,299 - 54,066,524 (-)NCBI
Rnor_6.01855,863,081 - 55,880,201 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601024   ⟹   XP_017456513
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21854,048,299 - 54,066,884 (-)NCBI
Rnor_6.01855,863,081 - 55,881,651 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039097053   ⟹   XP_038952981
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21854,048,299 - 54,102,080 (-)NCBI
RefSeq Acc Id: XM_039097054   ⟹   XP_038952982
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21854,048,299 - 54,066,786 (-)NCBI
RefSeq Acc Id: XM_039097055   ⟹   XP_038952983
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21854,054,209 - 54,101,451 (-)NCBI
RefSeq Acc Id: XM_039097056   ⟹   XP_038952984
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21854,048,299 - 54,063,668 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_067727   ⟸   NM_021695
- UniProtKB: Q9Z327 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017456506   ⟸   XM_017601017
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017456504   ⟸   XM_017601015
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017456505   ⟸   XM_017601016
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017456510   ⟸   XM_017601021
- Peptide Label: isoform X4
- UniProtKB: B1VKB4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456509   ⟸   XM_017601020
- Peptide Label: isoform X4
- UniProtKB: B1VKB4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456513   ⟸   XM_017601024
- Peptide Label: isoform X4
- UniProtKB: B1VKB4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456511   ⟸   XM_017601022
- Peptide Label: isoform X4
- UniProtKB: B1VKB4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000025934   ⟸   ENSRNOT00000025934
RefSeq Acc Id: ENSRNOP00000061109   ⟸   ENSRNOT00000064686
RefSeq Acc Id: XP_038952981   ⟸   XM_039097053
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038952982   ⟸   XM_039097054
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AKF5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038952984   ⟸   XM_039097056
- Peptide Label: isoform X4
- UniProtKB: B1VKB4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038952983   ⟸   XM_039097055
- Peptide Label: isoform X3
- UniProtKB: Q9Z327 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: ENSRNOP00000087286   ⟸   ENSRNOT00000103982
RefSeq Acc Id: ENSRNOP00000025989   ⟸   ENSRNOT00000025989
RefSeq Acc Id: ENSRNOP00000094210   ⟸   ENSRNOT00000093773
RefSeq Acc Id: ENSRNOP00000077576   ⟸   ENSRNOT00000102376

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z327-F1-model_v2 AlphaFold Q9Z327 1-931 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700804
Promoter ID:EPDNEW_R11328
Type:initiation region
Name:Synpo_2
Description:synaptopodin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R11329  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01855,891,583 - 55,891,643EPDNEW
RGD ID:13700811
Promoter ID:EPDNEW_R11329
Type:multiple initiation site
Name:Synpo_1
Description:synaptopodin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R11328  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01855,916,185 - 55,916,245EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620668 AgrOrtholog
BioCyc Gene G2FUF-7361 BioCyc
Ensembl Genes ENSRNOG00000019181 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000025934 ENTREZGENE
  ENSRNOP00000025934.6 UniProtKB/TrEMBL
  ENSRNOP00000061109 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000077576 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000087286 UniProtKB/Swiss-Prot
  ENSRNOP00000094210 ENTREZGENE
  ENSRNOP00000094210.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025934 ENTREZGENE
  ENSRNOT00000025934.6 UniProtKB/TrEMBL
  ENSRNOT00000064686 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000093773 ENTREZGENE
  ENSRNOT00000093773.1 UniProtKB/TrEMBL
  ENSRNOT00000102376 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000103982 UniProtKB/Swiss-Prot
InterPro Synpo UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:60324 UniProtKB/Swiss-Prot
NCBI Gene 60324 ENTREZGENE
PANTHER PTHR24217:SF13 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Synpo PhenoGen
UniProt A0A0H2UHQ9_RAT UniProtKB/TrEMBL
  A0A8I6AKF5 ENTREZGENE, UniProtKB/TrEMBL
  B1VKB4 ENTREZGENE, UniProtKB/TrEMBL
  Q9Z327 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Synpo  synaptopodin      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Synpo  synaptopodin      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression increased mRNA expression occurs in hippocampal granule cells after the induction of long-term potentiation 634104