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Gene: Diaph1 (diaphanous-related formin 1) Rattus norvegicus

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Symbol:

Diaph1

Name:

diaphanous-related formin 1

RGD ID:

1310707

Description:

Predicted to enable several functions, including profilin binding activity; small GTPase binding activity; and transmembrane transporter binding activity. Involved in positive regulation of cell migration. Predicted to be located in several cellular components, including brush border; ruffle membrane; and spindle. Predicted to be active in actin filament. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 1 and sensorineural hearing loss. Orthologous to human DIAPH1 (diaphanous related formin 1); PARTICIPATES IN E-cadherin signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Diap1; diaphanous homolog 1; diaphanous homolog 1 (Drosophila); DRF1; LOC307483; mDIA1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DIAPH1 (diaphanous related formin 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Diaph1 (diaphanous related formin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Diaph1 (diaphanous related formin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DIAPH1 (diaphanous related formin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DIAPH1 (diaphanous related formin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Diaph1 (diaphanous related formin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DIAPH1 (diaphanous related formin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	DIAPH1 (diaphanous related formin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Diaph1 (diaphanous related formin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	DIAPH1 (diaphanous related formin 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Diaph1 (diaphanous related formin 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cyk-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	dia	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	29,920,889 - 30,020,280 (-)	NCBI		GRCr8
mRatBN7.2	18	29,669,659 - 29,769,070 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	29,669,659 - 29,769,172 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	29,773,984 - 29,873,376 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	30,535,964 - 30,635,353 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	29,871,305 - 29,970,698 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	30,972,907 - 31,071,371 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	30,972,907 - 31,071,371 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	30,663,859 - 30,762,658 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	30,757,191 - 30,855,548 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	18	30,784,366 - 30,882,101 (-)	NCBI
Celera	18	29,313,748 - 29,412,995 (-)	NCBI		Celera
Cytogenetic Map	18	p11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Diaph1	Rat	sensorineural hearing loss	susceptibility	ISO	RGD:1321771	1601058	autosomal dominant nonsyndromic sensorineural deafness 1, OMIM:124900;DNA:splice-site mutation	RGD

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Diaph1	Rat	autosomal dominant intellectual developmental disorder 31		ISO	RGD:1321771	8554872	ClinVar Annotator: match by term: NEURODEVELOPMENTAL DISORDER WITH NEONATAL RESPIRATORY INSUFFICIENCY, HYPOTONIA, AND FEEDING DIFFICULTIES	ClinVar	PMID:28492532
Diaph1	Rat	autosomal dominant nonsyndromic deafness 1		ISO	RGD:1321771	8554872	ClinVar Annotator: match by term: DEAFNESS, AUTOSOMAL DOMINANT 1, WITH OR WITHOUT THROMBOCYTOPENIA \| ClinVar more ...	ClinVar	PMID:16199547\|PMID:17576681\|PMID:22938506\|PMID:23804846\|PMID:24033266\|PMID:24781755\|PMID:25342930\|PMID:25558065\|PMID:25640679\|PMID:25741868\|PMID:26011067\|PMID:26463574\|PMID:26467025\|PMID:26912466\|PMID:27707755\|PMID:27808407\|PMID:27911912\|PMID:28492532\|PMID:28815995\|PMID:28983057\|PMID:29758562\|PMID:30311386\|PMID:30896630\|PMID:32678080\|PMID:33057194\|PMID:33176815\|PMID:33229591\|PMID:33662367\|PMID:34125151\|PMID:34279089\|PMID:34515852\|PMID:35307828\|PMID:35982159\|PMID:36118902\|PMID:37086329\|PMID:9360932\|PMID:9536098
Diaph1	Rat	autosomal recessive nonsyndromic deafness 9		ISO	RGD:1321771	8554872	ClinVar Annotator: match by term: Auditory neuropathy spectrum disorder	ClinVar
Diaph1	Rat	benign neonatal seizures		ISO	RGD:1321771	8554872	ClinVar Annotator: match by term: Neonatal seizure	ClinVar
Diaph1	Rat	beta-mannosidosis		ISO	RGD:1321771	8554872	ClinVar Annotator: match by term: Beta-D-mannosidosis	ClinVar	PMID:28492532\|PMID:30311386
Diaph1	Rat	Deafness		ISO	RGD:1321771	8554872	ClinVar Annotator: match by term: Deafness	ClinVar	PMID:25741868\|PMID:26463574
Diaph1	Rat	Developmental Disabilities		ISO	RGD:1321771	8554872	ClinVar Annotator: match by term: Global developmental delay	ClinVar	PMID:24781755\|PMID:25558065\|PMID:25741868
Diaph1	Rat	epilepsy		ISO	RGD:1321771	8554872	ClinVar Annotator: match by term: Seizure Disorders	ClinVar	PMID:24781755\|PMID:25558065\|PMID:25741868
Diaph1	Rat	epilepsy		ISO	RGD:1321771	8554872	ClinVar Annotator: match by term: Seizure Disorders	ClinVar	PMID:24781755\|PMID:25558065\|PMID:25741868\|PMID:25741916
Diaph1	Rat	Failure to Thrive		ISO	RGD:1321771	8554872	ClinVar Annotator: match by term: Failure to thrive	ClinVar	PMID:24781755\|PMID:25558065\|PMID:25741868
Diaph1	Rat	familial adenomatous polyposis 1		ISO	RGD:1321771	8554872	ClinVar Annotator: match by term: Familial adenomatous polyposis 1	ClinVar	PMID:17963004\|PMID:18487285\|PMID:19279422\|PMID:19409520\|PMID:20685668\|PMID:21643010\|PMID:28492532
Diaph1	Rat	genetic disease		ISO	RGD:1321771	8554872	ClinVar Annotator: match by term: Inborn genetic diseases	ClinVar	PMID:22938506\|PMID:24033266\|PMID:25741868\|PMID:28492532\|PMID:33057194
Diaph1	Rat	Hearing Loss		ISO	RGD:1321771	8554872	ClinVar Annotator: match by term: Hearing impairment \| ClinVar Annotator: match by term: Nonsyndromic Hearing more ...	ClinVar	PMID:24033266\|PMID:24781755\|PMID:25741868\|PMID:26463574\|PMID:28492532\|PMID:30311386\|PMID:32581362
Diaph1	Rat	Hereditary Neoplastic Syndromes		ISO	RGD:1321771	8554872	ClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome	ClinVar	PMID:17963004\|PMID:18487285\|PMID:19279422\|PMID:19409520\|PMID:20685668\|PMID:21643010\|PMID:28492532
Diaph1	Rat	microcephaly		ISO	RGD:1321771	8554872	ClinVar Annotator: match by term: Microcephaly	ClinVar	PMID:24781755\|PMID:25558065\|PMID:25741868\|PMID:28492532\|PMID:34515852
Diaph1	Rat	Neurodevelopmental Disorders		ISO	RGD:1321771	8554872	ClinVar Annotator: match by term: Neurodevelopmental disorder	ClinVar	PMID:25741868
Diaph1	Rat	Pendred syndrome		ISO	RGD:1321771	8554872	ClinVar Annotator: match by term: Pendred syndrome	ClinVar	PMID:30311386
Diaph1	Rat	Seizures, Cortical Blindness, and Microcephaly Syndrome		ISO	RGD:1321771	8554872	ClinVar Annotator: match by term: Seizures, cortical blindness, and microcephaly syndrome	ClinVar	PMID:16199547\|PMID:17576681\|PMID:22938506\|PMID:23804846\|PMID:24033266\|PMID:24781755\|PMID:25342930\|PMID:25558065\|PMID:25640679\|PMID:25741868\|PMID:26011067\|PMID:26463574\|PMID:26467025\|PMID:26912466\|PMID:27707755\|PMID:27808407\|PMID:27911912\|PMID:28492532\|PMID:28815995\|PMID:28983057\|PMID:29758562\|PMID:30311386\|PMID:30896630\|PMID:32678080\|PMID:33057194\|PMID:33176815\|PMID:33229591\|PMID:33662367\|PMID:34125151\|PMID:34279089\|PMID:34515852\|PMID:35307828\|PMID:35982159\|PMID:36118902\|PMID:37086329\|PMID:9360932\|PMID:9536098
Diaph1	Rat	vascular dementia		ISO	RGD:1321771	8554872	ClinVar Annotator: match by term: Vascular dementia	ClinVar	PMID:28492532\|PMID:35307828

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Diaph1	Rat	autosomal dominant nonsyndromic deafness 1		ISO	RGD:1321771	11554173	CTD Direct Evidence: marker/mechanism	CTD

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Diaph1	Rat	autosomal dominant nonsyndromic deafness 1		ISO	RGD:1321771	7240710		OMIM
Diaph1	Rat	Seizures, Cortical Blindness, and Microcephaly Syndrome		ISO	RGD:1321771	7240710		OMIM

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Diaph1	Rat	1,2-dimethylhydrazine	multiple interactions	ISO	RGD:1321772	6480464	[1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of DIAPH1 mRNA	CTD	PMID:22206623
Diaph1	Rat	1-chloro-2,4-dinitrobenzene	affects binding	ISO	RGD:1321771	6480464	Dinitrochlorobenzene binds to DIAPH1 protein	CTD	PMID:32991956
Diaph1	Rat	17beta-estradiol	decreases expression	EXP		6480464	Estradiol results in decreased expression of DIAPH1 mRNA	CTD	PMID:32145629
Diaph1	Rat	17beta-estradiol	increases expression	ISO	RGD:1321771	6480464	Estradiol results in increased expression of DIAPH1 mRNA	CTD	PMID:31614463
Diaph1	Rat	17beta-estradiol	increases expression	ISO	RGD:1321772	6480464	Estradiol results in increased expression of DIAPH1 mRNA	CTD	PMID:39298647
Diaph1	Rat	2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO	RGD:1321772	6480464	Tetrachlorodibenzodioxin affects the expression of DIAPH1 mRNA	CTD	PMID:21570461
Diaph1	Rat	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	EXP		6480464	Tetrachlorodibenzodioxin results in decreased expression of DIAPH1 mRNA	CTD	PMID:33387578
Diaph1	Rat	2,3,7,8-tetrachlorodibenzodioxine	increases expression	EXP		6480464	Tetrachlorodibenzodioxin results in increased expression of DIAPH1 mRNA	CTD	PMID:34747641
Diaph1	Rat	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	ISO	RGD:1321772	6480464	Tetrachlorodibenzodioxin results in decreased expression of DIAP1 mRNA	CTD	PMID:26290441
Diaph1	Rat	2,4,6-tribromophenol	decreases expression	ISO	RGD:1321771	6480464	2,4,6-tribromophenol results in decreased expression of DIAPH1 mRNA	CTD	PMID:31675489
Diaph1	Rat	2,4-dinitrotoluene	affects expression	EXP		6480464	2,4-dinitrotoluene affects the expression of DIAPH1 mRNA	CTD	PMID:21346803
Diaph1	Rat	2,6-dinitrotoluene	affects expression	EXP		6480464	2,6-dinitrotoluene affects the expression of DIAPH1 mRNA	CTD	PMID:21346803
Diaph1	Rat	2-palmitoylglycerol	increases expression	ISO	RGD:1321771	6480464	2-palmitoylglycerol results in increased expression of DIAPH1 mRNA	CTD	PMID:37199045
Diaph1	Rat	3-chloropropane-1,2-diol	increases expression	EXP		6480464	alpha-Chlorohydrin results in increased expression of DIAPH1 protein	CTD	PMID:34915118
Diaph1	Rat	3-isobutyl-1-methyl-7H-xanthine	multiple interactions	ISO	RGD:1321771	6480464	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] more ...	CTD	PMID:28628672
Diaph1	Rat	3-methylcholanthrene	multiple interactions	ISO	RGD:1321771	6480464	Methylcholanthrene promotes the reaction [AHR protein binds to DIAPH1 promoter]	CTD	PMID:20348232
Diaph1	Rat	4,4'-sulfonyldiphenol	multiple interactions	ISO	RGD:1321771	6480464	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] more ...	CTD	PMID:28628672
Diaph1	Rat	4,4'-sulfonyldiphenol	increases expression	ISO	RGD:1321772	6480464	bisphenol S results in increased expression of DIAPH1 mRNA	CTD	PMID:39298647
Diaph1	Rat	4-vinylcyclohexene dioxide	affects expression	ISO	RGD:1321772	6480464	4-vinyl-1-cyclohexene dioxide affects the expression of DIAPH1 mRNA	CTD	PMID:20829426
Diaph1	Rat	6-propyl-2-thiouracil	increases expression	EXP		6480464	Propylthiouracil results in increased expression of DIAPH1 mRNA	CTD	PMID:22504374
Diaph1	Rat	aflatoxin B1	increases mutagenesis	EXP		6480464	Aflatoxin B1 results in increased mutagenesis of DIAPH1 gene	CTD	PMID:36908029
Diaph1	Rat	all-trans-retinoic acid	decreases expression	ISO	RGD:1321771	6480464	Tretinoin results in decreased expression of DIAPH1 mRNA	CTD	PMID:33167477
Diaph1	Rat	antirheumatic drug	decreases expression	ISO	RGD:1321771	6480464	Antirheumatic Agents results in decreased expression of DIAPH1 mRNA	CTD	PMID:24449571
Diaph1	Rat	arsane	multiple interactions	ISO	RGD:1321771	6480464	[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of DIAPH1 more ...	CTD	PMID:39836092
Diaph1	Rat	arsenic atom	multiple interactions	ISO	RGD:1321771	6480464	[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of DIAPH1 more ...	CTD	PMID:39836092
Diaph1	Rat	arsenite(3-)	increases expression	ISO	RGD:1321772	6480464	arsenite results in increased expression of DIAPH1 mRNA	CTD	PMID:18191166
Diaph1	Rat	arsenous acid	decreases expression	ISO	RGD:1321771	6480464	Arsenic Trioxide results in decreased expression of DIAPH1 mRNA	CTD	PMID:19128835
Diaph1	Rat	atrazine	increases expression	ISO	RGD:1321771	6480464	Atrazine results in increased expression of DIAPH1 mRNA	CTD	PMID:22378314
Diaph1	Rat	benzo[a]pyrene	multiple interactions	ISO	RGD:1321772	6480464	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of more ...	CTD	PMID:27858113
Diaph1	Rat	benzo[a]pyrene	increases methylation	ISO	RGD:1321772	6480464	Benzo(a)pyrene results in increased methylation of DIAP1 exon; Benzo(a)pyrene results in increased methylation of DIAP1 more ...	CTD	PMID:27901495
Diaph1	Rat	benzo[b]fluoranthene	multiple interactions	ISO	RGD:1321772	6480464	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of more ...	CTD	PMID:27858113
Diaph1	Rat	bis(2-ethylhexyl) phthalate	increases expression	ISO	RGD:1321771	6480464	Diethylhexyl Phthalate results in increased expression of DIAPH1 mRNA	CTD	PMID:31163220
Diaph1	Rat	bisphenol A	increases methylation	EXP		6480464	bisphenol A results in increased methylation of DIAPH1 gene	CTD	PMID:28505145
Diaph1	Rat	bisphenol A	multiple interactions	ISO	RGD:1321771	6480464	[bisphenol A co-treated with Fulvestrant] results in decreased methylation of DIAPH1 gene	CTD	PMID:31601247
Diaph1	Rat	bisphenol A	decreases expression	EXP		6480464	bisphenol A results in decreased expression of DIAPH1 mRNA	CTD	PMID:34947998
Diaph1	Rat	bisphenol A	affects expression	EXP		6480464	bisphenol A affects the expression of DIAPH1 mRNA	CTD	PMID:32145629
Diaph1	Rat	bisphenol A	decreases expression	ISO	RGD:1321771	6480464	bisphenol A results in decreased expression of DIAPH1 mRNA; bisphenol A results in decreased expression more ...	CTD	PMID:29275510\|PMID:31675489\|PMID:37567409
Diaph1	Rat	bisphenol AF	increases expression	ISO	RGD:1321771	6480464	bisphenol AF results in increased expression of DIAPH1 protein	CTD	PMID:34186270
Diaph1	Rat	caffeine	decreases phosphorylation	ISO	RGD:1321771	6480464	Caffeine results in decreased phosphorylation of DIAPH1 protein	CTD	PMID:35688186
Diaph1	Rat	carbon nanotube	decreases expression	ISO	RGD:1321772	6480464	Nanotubes, Carbon analog results in decreased expression of DIAPH1 mRNA; Nanotubes, Carbon results in decreased more ...	CTD	PMID:25554681
Diaph1	Rat	CGP 52608	multiple interactions	ISO	RGD:1321771	6480464	CGP 52608 promotes the reaction [RORA protein binds to DIAPH1 gene]	CTD	PMID:28238834
Diaph1	Rat	chrysene	multiple interactions	ISO	RGD:1321772	6480464	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of more ...	CTD	PMID:27858113
Diaph1	Rat	cisplatin	decreases expression	ISO	RGD:1321771	6480464	Cisplatin results in decreased expression of DIAPH1 mRNA	CTD	PMID:27594783
Diaph1	Rat	dexamethasone	multiple interactions	ISO	RGD:1321771	6480464	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] more ...	CTD	PMID:28628672
Diaph1	Rat	dextran sulfate	multiple interactions	ISO	RGD:1321772	6480464	evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of DIAPH1 protein]	CTD	PMID:35362542
Diaph1	Rat	dextran sulfate	increases expression	ISO	RGD:1321772	6480464	Dextran Sulfate results in increased expression of DIAPH1 protein	CTD	PMID:35362542
Diaph1	Rat	diarsenic trioxide	decreases expression	ISO	RGD:1321771	6480464	Arsenic Trioxide results in decreased expression of DIAPH1 mRNA	CTD	PMID:19128835
Diaph1	Rat	Dibutyl phosphate	affects expression	ISO	RGD:1321771	6480464	di-n-butylphosphoric acid affects the expression of DIAPH1 mRNA	CTD	PMID:37042841
Diaph1	Rat	dicrotophos	increases expression	ISO	RGD:1321771	6480464	dicrotophos results in increased expression of DIAPH1 mRNA	CTD	PMID:28302478
Diaph1	Rat	enzyme inhibitor	multiple interactions	ISO	RGD:1321771	6480464	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation more ...	CTD	PMID:23301498
Diaph1	Rat	ethanol	increases expression	ISO	RGD:1321772	6480464	Ethanol results in increased expression of DIAP1 mRNA	CTD	PMID:30319688
Diaph1	Rat	Evodiamine	multiple interactions	ISO	RGD:1321772	6480464	evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of DIAPH1 protein]	CTD	PMID:35362542
Diaph1	Rat	finasteride	increases expression	EXP		6480464	Finasteride results in increased expression of DIAPH1 mRNA	CTD	PMID:24136188
Diaph1	Rat	folic acid	decreases expression	ISO	RGD:1321772	6480464	Folic Acid results in decreased expression of DIAP1 mRNA	CTD	PMID:25629700
Diaph1	Rat	folic acid	multiple interactions	ISO	RGD:1321772	6480464	[1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of DIAPH1 mRNA	CTD	PMID:22206623
Diaph1	Rat	FR900359	decreases phosphorylation	ISO	RGD:1321771	6480464	FR900359 results in decreased phosphorylation of DIAPH1 protein	CTD	PMID:37730182
Diaph1	Rat	fulvestrant	multiple interactions	ISO	RGD:1321771	6480464	[bisphenol A co-treated with Fulvestrant] results in decreased methylation of DIAPH1 gene	CTD	PMID:31601247
Diaph1	Rat	gallic acid	increases expression	ISO	RGD:1321771	6480464	Gallic Acid results in increased expression of DIAPH1 mRNA	CTD	PMID:34408198
Diaph1	Rat	indometacin	multiple interactions	ISO	RGD:1321771	6480464	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] more ...	CTD	PMID:28628672
Diaph1	Rat	inulin	multiple interactions	ISO	RGD:1321772	6480464	[perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of DIAPH1 mRNA	CTD	PMID:36331819
Diaph1	Rat	ivermectin	decreases expression	ISO	RGD:1321771	6480464	Ivermectin results in decreased expression of DIAPH1 protein	CTD	PMID:32959892
Diaph1	Rat	jaspamide	affects localization	ISO	RGD:1321772	6480464	jasplakinolide affects the localization of DIAPH1 protein	CTD	PMID:22918941
Diaph1	Rat	kanamycin A	decreases expression	ISO	RGD:1321772	6480464	Kanamycin results in decreased expression of DIAPH1 protein	CTD	PMID:16521128
Diaph1	Rat	kanamycin A	multiple interactions	ISO	RGD:1321772	6480464	Kanamycin inhibits the reaction [DIAPH1 binds to RHOA]	CTD	PMID:16521128
Diaph1	Rat	latrunculin A	affects localization	ISO	RGD:1321772	6480464	latrunculin A affects the localization of DIAPH1 protein	CTD	PMID:22918941
Diaph1	Rat	methimazole	increases expression	EXP		6480464	Methimazole results in increased expression of DIAPH1 mRNA	CTD	PMID:22504374
Diaph1	Rat	methoxychlor	affects expression	ISO	RGD:1321772	6480464	Methoxychlor affects the expression of DIAPH1 mRNA	CTD	PMID:20829426
Diaph1	Rat	methoxychlor	affects methylation	EXP		6480464	Methoxychlor affects the methylation of DIAPH1 gene	CTD	PMID:35440735
Diaph1	Rat	nickel atom	increases expression	ISO	RGD:1321771	6480464	Nickel results in increased expression of DIAPH1 mRNA	CTD	PMID:25583101
Diaph1	Rat	paracetamol	decreases expression	ISO	RGD:1321771	6480464	Acetaminophen results in decreased expression of DIAPH1 mRNA	CTD	PMID:21420995
Diaph1	Rat	perfluorohexanesulfonic acid	decreases expression	ISO	RGD:1321772	6480464	perfluorohexanesulfonic acid results in decreased expression of DIAPH1 mRNA	CTD	PMID:37995155
Diaph1	Rat	perfluorooctane-1-sulfonic acid	multiple interactions	ISO	RGD:1321772	6480464	[perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of DIAPH1 mRNA; [perfluorooctane sulfonic more ...	CTD	PMID:36331819
Diaph1	Rat	piroxicam	decreases expression	ISO	RGD:1321771	6480464	Piroxicam results in decreased expression of DIAPH1 mRNA	CTD	PMID:21858171
Diaph1	Rat	progesterone	decreases expression	ISO	RGD:1321771	6480464	Progesterone results in decreased expression of DIAPH1 mRNA	CTD	PMID:18037150
Diaph1	Rat	sodium arsenite	increases expression	ISO	RGD:1321771	6480464	sodium arsenite results in increased expression of DIAPH1 mRNA	CTD	PMID:34032870
Diaph1	Rat	sodium arsenite	multiple interactions	ISO	RGD:1321771	6480464	[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of DIAPH1 more ...	CTD	PMID:39836092
Diaph1	Rat	sunitinib	decreases expression	ISO	RGD:1321771	6480464	Sunitinib results in decreased expression of DIAPH1 mRNA	CTD	PMID:31533062
Diaph1	Rat	tetraphene	decreases expression	ISO	RGD:1321772	6480464	benz(a)anthracene results in decreased expression of DIAP1 mRNA	CTD	PMID:26377693
Diaph1	Rat	tetraphene	multiple interactions	ISO	RGD:1321772	6480464	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of more ...	CTD	PMID:27858113
Diaph1	Rat	titanium dioxide	increases expression	ISO	RGD:1321772	6480464	titanium dioxide results in increased expression of DIAP1 mRNA; titanium dioxide results in increased expression more ...	CTD	PMID:29128614\|PMID:29264374
Diaph1	Rat	titanium dioxide	decreases methylation	ISO	RGD:1321772	6480464	titanium dioxide results in decreased methylation of DIAP1 gene	CTD	PMID:35295148
Diaph1	Rat	trichloroethene	decreases expression	EXP		6480464	Trichloroethylene results in decreased expression of DIAPH1 mRNA	CTD	PMID:33387578
Diaph1	Rat	triphenyl phosphate	affects expression	ISO	RGD:1321771	6480464	triphenyl phosphate affects the expression of DIAPH1 mRNA	CTD	PMID:37042841
Diaph1	Rat	triptonide	increases expression	ISO	RGD:1321772	6480464	triptonide results in increased expression of DIAPH1 mRNA	CTD	PMID:33045310
Diaph1	Rat	tungsten	decreases expression	ISO	RGD:1321772	6480464	Tungsten results in decreased expression of DIAP1 mRNA	CTD	PMID:30912803
Diaph1	Rat	valproic acid	increases expression	ISO	RGD:1321771	6480464	Valproic Acid results in increased expression of DIAPH1 mRNA	CTD	PMID:23179753
Diaph1	Rat	valproic acid	affects expression	ISO	RGD:1321771	6480464	Valproic Acid affects the expression of DIAPH1 mRNA	CTD	PMID:25979313
Diaph1	Rat	vinclozolin	decreases expression	EXP		6480464	vinclozolin results in decreased expression of DIAPH1 mRNA	CTD	PMID:23034163
Diaph1	Rat	zinc atom	increases expression	ISO	RGD:1321771	6480464	Zinc deficiency results in increased expression of DIAPH1 mRNA	CTD	PMID:18356318
Diaph1	Rat	zinc(0)	increases expression	ISO	RGD:1321771	6480464	Zinc deficiency results in increased expression of DIAPH1 mRNA	CTD	PMID:18356318

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Diaph1	Rat	actin cytoskeleton organization	involved_in	IEA	InterPro:IPR010473	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Diaph1	Rat	actin cytoskeleton organization	acts_upstream_of_or_within	ISO	RGD:1321772	1624291	PMID:9214622	RGD	PMID:9214622
Diaph1	Rat	actin cytoskeleton organization	involved_in	ISO	RGD:1321772	1624291	PMID:23558171	RGD	PMID:23558171
Diaph1	Rat	actin cytoskeleton organization	involved_in	ISS	UniProtKB:O08808	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Diaph1	Rat	actin filament polymerization	involved_in	ISS	UniProtKB:O08808	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Diaph1	Rat	actin filament polymerization	involved_in	ISO	RGD:1321772	1624291	PMID:23558171	RGD	PMID:23558171
Diaph1	Rat	actin filament polymerization	acts_upstream_of_or_within	ISO	RGD:1321772	1624291	PMID:14992721	RGD	PMID:14992721
Diaph1	Rat	actin filament polymerization	involved_in	IBA	MGI:1194490\|MGI:1858500\|MGI:1927222\|PANTHER:PTN000575131\|UniProtKB:A0A8M9PZW8	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Diaph1	Rat	actin nucleation	acts_upstream_of_or_within	ISO	RGD:1321772	1624291	PMID:21278336	RGD	PMID:21278336
Diaph1	Rat	axon midline choice point recognition	acts_upstream_of_or_within	ISO	RGD:1321772	1624291	MGI:1858500 PMID:23890216	RGD	PMID:23890216
Diaph1	Rat	brain development	involved_in	ISO	RGD:1321772	1624291	PMID:24781755	RGD	PMID:24781755
Diaph1	Rat	cellular response to histamine	involved_in	IEA	UniProtKB:O60610\|ensembl:ENSP00000373706	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Diaph1	Rat	cellular response to histamine	involved_in	ISO	RGD:1321771	1624291	PMID:15123714	RGD	PMID:15123714
Diaph1	Rat	cytoskeleton organization	involved_in	ISO	RGD:1321772	1624291	PMID:23558171	RGD	PMID:23558171
Diaph1	Rat	cytoskeleton organization	involved_in	IEA	UniProtKB:O60610\|ensembl:ENSP00000373706	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Diaph1	Rat	cytoskeleton organization	involved_in	ISO	RGD:1321771	1624291	PMID:21834987	RGD	PMID:21834987
Diaph1	Rat	cytoskeleton organization	involved_in	ISS	UniProtKB:O08808	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Diaph1	Rat	ephrin receptor signaling pathway	acts_upstream_of_or_within	ISO	RGD:1321772	1624291	MGI:1858500 PMID:23890216	RGD	PMID:23890216
Diaph1	Rat	gene expression	acts_upstream_of_or_within	ISO	RGD:1321772	1624291	PMID:21278336	RGD	PMID:21278336
Diaph1	Rat	multicellular organismal locomotion	acts_upstream_of_or_within	ISO	RGD:1321772	1624291	MGI:1858500 PMID:23890216	RGD	PMID:23890216
Diaph1	Rat	negative regulation of neuron projection regeneration	acts_upstream_of_or_within	ISO	RGD:1321772	1624291	MGI:1858500 PMID:23890216	RGD	PMID:23890216
Diaph1	Rat	neuron projection development	involved_in	ISO	RGD:1321772	1624291	PMID:18572016	RGD	PMID:18572016
Diaph1	Rat	neuron projection retraction	acts_upstream_of_or_within	ISO	RGD:1321772	1624291	MGI:1858500 PMID:23890216	RGD	PMID:23890216
Diaph1	Rat	positive regulation of cell migration		IMP		1601059		RGD
Diaph1	Rat	protein localization	acts_upstream_of_or_within	ISO	RGD:1321772	1624291	MGI:1858500 PMID:23890216	RGD	PMID:23890216
Diaph1	Rat	protein localization to microtubule	involved_in	IEA	UniProtKB:O60610\|ensembl:ENSP00000373706	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Diaph1	Rat	protein localization to microtubule	involved_in	ISO	RGD:1321771	1624291	PMID:15123714	RGD	PMID:15123714
Diaph1	Rat	regulation of cell shape	involved_in	IEA	UniProtKB:O60610\|ensembl:ENSP00000373706	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Diaph1	Rat	regulation of cell shape	involved_in	ISO	RGD:1321771	1624291	PMID:21834987	RGD	PMID:21834987
Diaph1	Rat	regulation of cytoskeleton organization	involved_in	IEA	UniProtKB:O60610\|ensembl:ENSP00000373706	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Diaph1	Rat	regulation of cytoskeleton organization	involved_in	ISO	RGD:1321771	1624291	PMID:26912466	RGD	PMID:26912466
Diaph1	Rat	regulation of microtubule-based process	involved_in	IEA	UniProtKB:O60610\|ensembl:ENSP00000373706	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Diaph1	Rat	regulation of microtubule-based process	involved_in	ISO	RGD:1321771	1624291	PMID:20937854	RGD	PMID:20937854
Diaph1	Rat	regulation of release of sequestered calcium ion into cytosol	involved_in	IEA	UniProtKB:O60610\|ensembl:ENSP00000373706	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Diaph1	Rat	regulation of release of sequestered calcium ion into cytosol	involved_in	ISO	RGD:1321771	1624291	PMID:15123714	RGD	PMID:15123714
Diaph1	Rat	sensory perception of sound	involved_in	IEA	UniProtKB-KW:KW-1009	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Diaph1	Rat	synaptic vesicle endocytosis	involved_in	ISO	RGD:1321772	1624291	PMID:28231467	RGD	PMID:28231467

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Diaph1	Rat	actin filament	is_active_in	IBA	MGI:1927222\|PANTHER:PTN000575131\|WB:WBGene00019030	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Diaph1	Rat	brush border	located_in	ISO	RGD:1321772	1624291	PMID:22114352	RGD	PMID:22114352
Diaph1	Rat	cell projection	located_in	IEA	UniProtKB-KW:KW-0966	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Diaph1	Rat	centrosome	located_in	IEA	UniProtKB-SubCell:SL-0048	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Diaph1	Rat	cytoplasm	located_in	ISO	RGD:1321772	1624291	PMID:23558171	RGD	PMID:23558171
Diaph1	Rat	cytoplasm	located_in	IEA	UniProtKB-KW:KW-0963	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Diaph1	Rat	cytoplasm	located_in	IEA	UniProtKB-SubCell:SL-0086	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Diaph1	Rat	cytoplasm	located_in	ISS	UniProtKB:O08808	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Diaph1	Rat	cytoskeleton	located_in	IEA	UniProtKB-KW:KW-0206	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Diaph1	Rat	cytoskeleton	located_in	IEA	UniProtKB-SubCell:SL-0090	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Diaph1	Rat	membrane	located_in	IEA	UniProtKB-KW:KW-0472	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Diaph1	Rat	microtubule cytoskeleton	located_in	ISO	RGD:14198523	1624291	PMID:15123714	RGD	PMID:15123714
Diaph1	Rat	mitotic spindle	located_in	IEA	UniProtKB:O60610\|ensembl:ENSP00000373706	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Diaph1	Rat	mitotic spindle	located_in	ISO	RGD:1321771	1624291	PMID:15123714	RGD	PMID:15123714
Diaph1	Rat	neuron projection	located_in	ISO	RGD:1321772	1624291	PMID:18572016	RGD	PMID:18572016
Diaph1	Rat	nucleus	located_in	ISS	UniProtKB:O08808	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Diaph1	Rat	nucleus	located_in	IEA	UniProtKB-KW:KW-0539	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Diaph1	Rat	nucleus	located_in	ISO	RGD:1321772	1624291	PMID:23558171	RGD	PMID:23558171
Diaph1	Rat	nucleus	located_in	IEA	UniProtKB-SubCell:SL-0191	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Diaph1	Rat	plasma membrane	located_in	IEA	UniProtKB-SubCell:SL-0039	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Diaph1	Rat	plasma membrane	located_in	IEA	UniProtKB-KW:KW-1003	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Diaph1	Rat	presynapse	located_in	IEA	GO:0048488	1600115	GO_REF:0000108	GOC	GO_REF:0000108
Diaph1	Rat	ruffle membrane	located_in	ISO	RGD:1321772	1624291	PMID:9214622	RGD	PMID:9214622
Diaph1	Rat	ruffle membrane	located_in	IEA	UniProtKB-SubCell:SL-0301	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Diaph1	Rat	spindle	located_in	IEA	UniProtKB-SubCell:SL-0251	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Diaph1	Rat	spindle microtubule	located_in	ISO	RGD:14198523	1624291	PMID:15123714	RGD	PMID:15123714

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Diaph1	Rat	actin binding	enables	IEA	InterPro:IPR010472\|InterPro:IPR010473	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Diaph1	Rat	actin binding	enables	ISO	RGD:1321772	1624291	PMID:14992721	RGD	PMID:14992721
Diaph1	Rat	actin binding	enables	IEA	UniProtKB-KW:KW-0009	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Diaph1	Rat	identical protein binding	enables	ISO	RGD:1321772	1624291	UniProtKB:O08808 PMID:10559899, PMID:12906795, PMID:16472745	RGD	PMID:10559899\|PMID:12906795\|PMID:16472745
Diaph1	Rat	profilin binding	enables	ISO	RGD:1321772	1624291	PMID:9214622	RGD	PMID:9214622
Diaph1	Rat	protein binding	enables	ISO	RGD:1321771	1624291	UniProtKB:O00212\|UniProtKB:P08134\|UniProtKB:P49593\|UniProtKB:P61586\|UniProtKB:Q15109\|UniProtKB:Q9Q2G4 PMID:18218625, PMID:18230650, PMID:18922799, PMID:22190034, PMID:33961781	RGD	PMID:18218625\|PMID:18230650\|PMID:18922799\|PMID:22190034\|PMID:33961781
Diaph1	Rat	protein binding	enables	ISO	RGD:1321772	1624291	PR:B8QI33\|PR:Q9QUI0\|UniProtKB:P46940\|UniProtKB:P61586\|UniProtKB:Q0GNC1\|UniProtKB:Q8BKX1\|UniProtKB:Q8C8N2\|UniProtKB:Q9Z0E0 PMID:10814512, PMID:17620407, PMID:18572016, PMID:19350017, PMID:21278336, PMID:22266902, PMID:9214622	RGD	PMID:10814512\|PMID:17620407\|PMID:18572016\|PMID:19350017\|PMID:21278336\|PMID:22266902\|PMID:9214622
Diaph1	Rat	small GTPase binding	enables	IEA	InterPro:IPR010473	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Diaph1	Rat	small GTPase binding	enables	ISO	RGD:1321772	1624291	PMID:9214622	RGD	PMID:9214622
Diaph1	Rat	transmembrane transporter binding	enables	IEA	UniProtKB:O60610\|ensembl:ENSP00000373706	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Diaph1	Rat	transmembrane transporter binding	enables	ISO	RGD:1321772	1624291	UniProtKB:Q13563 PMID:15123714	RGD	PMID:15123714
Diaph1	Rat	transmembrane transporter binding	enables	ISO	RGD:1321771	1624291	UniProtKB:Q13563 PMID:15123714	RGD	PMID:15123714

Imported Annotations - PID (archival)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Diaph1	Rat	E-cadherin signaling pathway		ISO	RGD:1321771	6484113		PID	PID:200182

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Nonsyndromic deafness DFNA1 associated with mutation of a human homolog of the Drosophila gene diaphanous.	Lynch ED, etal., Science. 1997 Nov 14;278(5341):1315-8.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
6.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7.	GOA pipeline	RGD automated data pipeline
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Comprehensive gene review and curation	RGD comprehensive gene curation
11.	The Rho-mDia1 pathway regulates cell polarity and focal adhesion turnover in migrating cells through mobilizing Apc and c-Src.	Yamana N, etal., Mol Cell Biol. 2006 Sep;26(18):6844-58.

PMID:9214622	PMID:10559899	PMID:12906795	PMID:14992721	PMID:15123714	PMID:16472745	PMID:17170370	PMID:18362183	PMID:18572016	PMID:18651670	PMID:20071339	PMID:20937854
PMID:21834987	PMID:22114352	PMID:22658674	PMID:23558171	PMID:24781755	PMID:26912466	PMID:28877993	PMID:30358011

Diaph1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	29,920,889 - 30,020,280 (-)	NCBI		GRCr8
mRatBN7.2	18	29,669,659 - 29,769,070 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	29,669,659 - 29,769,172 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	29,773,984 - 29,873,376 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	30,535,964 - 30,635,353 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	29,871,305 - 29,970,698 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	30,972,907 - 31,071,371 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	30,972,907 - 31,071,371 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	30,663,859 - 30,762,658 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	30,757,191 - 30,855,548 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	18	30,784,366 - 30,882,101 (-)	NCBI
Celera	18	29,313,748 - 29,412,995 (-)	NCBI		Celera
Cytogenetic Map	18	p11	NCBI

DIAPH1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	141,515,021 - 141,619,000 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	141,515,016 - 141,619,055 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	140,894,588 - 140,998,567 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	140,874,772 - 140,978,747 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	140,874,772 - 140,978,691	NCBI
Celera	5	136,971,324 - 137,075,350 (-)	NCBI		Celera
Cytogenetic Map	5	q31.3	NCBI
HuRef	5	136,039,428 - 136,143,262 (-)	NCBI		HuRef
CHM1_1	5	140,327,865 - 140,431,904 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	142,041,005 - 142,145,005 (-)	NCBI		T2T-CHM13v2.0

Diaph1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	37,976,654 - 38,068,573 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	37,976,654 - 38,068,529 (-)	Ensembl		GRCm39 Ensembl
GRCm38	18	37,843,601 - 37,935,622 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	37,843,601 - 37,935,476 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	18	38,004,478 - 38,095,065 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	18	37,970,798 - 38,061,385 (-)	NCBI		MGSCv36	mm8
Celera	18	39,188,303 - 39,278,736 (-)	NCBI		Celera
Cytogenetic Map	18	B3	NCBI
cM Map	18	19.71	NCBI

Diaph1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955415	12,156,152 - 12,272,961 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955415	12,156,152 - 12,272,961 (+)	NCBI	ChiLan1.0	ChiLan1.0

DIAPH1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	136,764,381 - 136,867,993 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	134,960,673 - 135,007,628 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	136,876,396 - 136,980,097 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	142,990,248 - 143,092,558 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

DIAPH1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	36,483,781 - 36,581,390 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	36,485,571 - 36,581,320 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	33,535,791 - 33,633,355 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	36,937,687 - 37,035,539 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	36,937,690 - 37,035,611 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	34,012,555 - 34,110,155 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	34,824,079 - 34,921,683 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	35,631,288 - 35,728,900 (-)	NCBI		UU_Cfam_GSD_1.0

Diaph1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	150,974,209 - 151,071,265 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936504	12,548,452 - 12,643,399 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936504	12,548,452 - 12,645,236 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DIAPH1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	143,158,585 - 143,271,147 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	143,158,691 - 143,271,110 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	149,363,162 - 149,473,567 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DIAPH1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	44,139,495 - 44,244,505 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	44,139,360 - 44,244,490 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666034	33,608,326 - 33,713,597 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Diaph1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624774	739,206 - 845,272 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624774	738,717 - 845,187 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in Diaph1
308 total Variants

Predicted Target Of

	Summary Value
Count of predictions:	235
Count of miRNA genes:	103
Interacting mature miRNAs:	109
Transcripts:	ENSRNOT00000060432, ENSRNOT00000060433
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331733	Bp233	Blood pressure QTL 233	3.97196		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	24796977	79788953	Rat
1358358	Sradr6	Stress Responsive Adrenal Weight QTL 6	2.49		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	18	11944299	59330563	Rat
1331735	Rf44	Renal function QTL 44	2.981		urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	18	18234564	31359530	Rat
61382	Bp46	Blood pressure QTL 46	18.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	11941791	31393320	Rat
2301413	Bp318	Blood pressure QTL 318		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	26548082	46969551	Rat
1331741	Bp232	Blood pressure QTL 232	3.59112		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	21372893	83213037	Rat
61388	Bp2	Blood pressure QTL 2	3.23		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	1	35374722	Rat
6903359	Bp355	Blood pressure QTL 355	3.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	11944544	59796478	Rat
12904668	Bw188	Body weight QTL 188		0.03	body mass (VT:0001259)	body weight (CMO:0000012)	18	26548082	46969551	Rat
2313082	Bss85	Bone structure and strength QTL 85	0.8	0.0001	long bone metaphysis morphology trait (VT:0000133)	tibia midshaft total cross-sectional area (CMO:0001715)	18	14951337	59951337	Rat
12904669	Cm125	Cardiac mass QTL 125		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	18	26548082	46969551	Rat
1641923	Colcr8	Colorectal carcinoma resistance QTL 8	3.1	0.0014	intestine integrity trait (VT:0010554)	poorly differentiated malignant colorectal tumor number (CMO:0002076)	18	22066242	52293055	Rat
12904670	Cm126	Cardiac mass QTL 126		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	26548082	46969551	Rat
2312568	Glom21	Glomerulus QTL 21	2	0.005	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	18	5185858	40503530	Rat
2300157	Bmd66	Bone mineral density QTL 66	13.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	18	28964853	73964853	Rat
12904677	Kidm72	Kidney mass QTL 72		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	26548082	46969551	Rat
1331766	Bp236	Blood pressure QTL 236	3.022		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	11944299	31359530	Rat
1358193	Emca2	Estrogen-induced mammary cancer QTL 2	1.6		mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	18	18007599	63571040	Rat
12904673	Cm127	Cardiac mass QTL 127		0.005	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	26548082	46969551	Rat
12904675	Am19	Aortic mass QTL 19		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	26548082	46969551	Rat
631264	Scl22	Serum cholesterol level QTL 22	6.2		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	18	11941791	31393320	Rat
2293704	Bss35	Bone structure and strength QTL 35	4.59	0.0002	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	18	28964853	73964853	Rat
1331775	Bp235	Blood pressure QTL 235	3.201		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	18234564	31359530	Rat
2325839	Bp348	Blood pressure QTL 348		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	25570985	70570985	Rat
1600373	Mamtr6	Mammary tumor resistance QTL 6			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	18	19278901	83218561	Rat
2293708	Bss46	Bone structure and strength QTL 46	8.8	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	18	11791518	63636873	Rat
2300177	Bmd65	Bone mineral density QTL 65	19.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	18	28964853	73964853	Rat
9589153	Insul31	Insulin level QTL 31	7.15	0.05	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	18	1	42547119	Rat
1578667	Bss21	Bone structure and strength QTL 21	3.5		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	18	11791518	83218561	Rat
2312598	Bp340	Blood pressure QTL 340		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	1	30558703	Rat
2300180	Bmd67	Bone mineral density QTL 67	4.8	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	18	1	34291613	Rat
2299160	Iddm35	Insulin dependent diabetes mellitus QTL 35	2.79		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	18	4207941	60377792	Rat
1578661	Bss20	Bone structure and strength QTL 20	3.7		femur morphology trait (VT:0000559)	femoral neck cross-sectional area (CMO:0001697)	18	11791518	83218561	Rat
1331753	Bp231	Blood pressure QTL 231	3.643		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	11944299	52293055	Rat
2293661	Bss50	Bone structure and strength QTL 50	4.64	0.0003	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	18	1	34291613	Rat
61375	Bp41	Blood pressure QTL 41	2.4		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	18	11944299	41122201	Rat

RH130783

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	29,770,659 - 29,770,857 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	31,072,987 - 31,073,184	NCBI	Rnor6.0
Rnor_5.0	18	30,764,274 - 30,764,471	UniSTS	Rnor5.0
RGSC_v3.4	18	30,857,139 - 30,857,336	UniSTS	RGSC3.4
Celera	18	29,414,611 - 29,414,808	UniSTS
RH 3.4 Map	18	444.2	UniSTS
Cytogenetic Map	18	p11	UniSTS

RH127883

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	29,669,684 - 29,669,893 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	30,972,933 - 30,973,141	NCBI	Rnor6.0
Rnor_5.0	18	30,663,885 - 30,664,093	UniSTS	Rnor5.0
RGSC_v3.4	18	30,756,025 - 30,756,233	UniSTS	RGSC3.4
Celera	18	29,313,774 - 29,313,982	UniSTS
Cytogenetic Map	18	p11	UniSTS

BE119953

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	47,231,083 - 47,231,306 (+)	MAPPER	mRatBN7.2
mRatBN7.2	18	29,730,201 - 29,730,413 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	31,032,769 - 31,032,980	NCBI	Rnor6.0
Rnor_6.0	2	47,876,688 - 47,876,910	NCBI	Rnor6.0
Rnor_5.0	18	30,724,159 - 30,724,370	UniSTS	Rnor5.0
Rnor_5.0	2	66,264,138 - 66,264,360	UniSTS	Rnor5.0
RGSC_v3.4	2	46,345,568 - 46,345,790	UniSTS	RGSC3.4
RGSC_v3.4	18	30,816,539 - 30,816,750	UniSTS	RGSC3.4
Celera	18	29,374,164 - 29,374,375	UniSTS
Celera	2	42,965,202 - 42,965,424	UniSTS
RH 3.4 Map	18	428.3	UniSTS
Cytogenetic Map	18	p11	UniSTS
Cytogenetic Map	2	q14	UniSTS

RH124673

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	29,669,710 - 29,670,024 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	30,972,959 - 30,973,272	NCBI	Rnor6.0
Rnor_5.0	18	30,663,911 - 30,664,224	UniSTS	Rnor5.0
RGSC_v3.4	18	30,756,051 - 30,756,364	UniSTS	RGSC3.4
Celera	18	29,313,800 - 29,314,113	UniSTS
Cytogenetic Map	18	p11	UniSTS

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31


RefSeq Transcripts	NM_001107393	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001395102	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473974	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000060432 ⟹ ENSRNOP00000057176

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	18	29,669,659 - 29,769,044 (-)	Ensembl
Rnor_6.0 Ensembl	18	30,972,907 - 31,071,371 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000102970 ⟹ ENSRNOP00000088426

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	18	29,669,659 - 29,769,172 (-)	Ensembl

RefSeq Acc Id:

NM_001107393 ⟹ NP_001100863

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	29,920,889 - 30,020,280 (-)	NCBI
mRatBN7.2	18	29,669,659 - 29,769,070 (-)	NCBI
Rnor_6.0	18	30,972,907 - 31,071,371 (-)	NCBI
Rnor_5.0	18	30,663,859 - 30,762,658 (-)	NCBI
RGSC_v3.4	18	30,757,191 - 30,855,548 (-)	RGD
Celera	18	29,313,748 - 29,412,995 (-)	NCBI

Sequence:

show sequence

TTGTTGGCTCGGGGCAGCCGGGCGGGAGCGGCGTAGACAAGGGGTCTCTGGCCGGCGCTAACCAGGACATGGAGCCGTCCGGCGGGGGCCTAGGGCCCGGCCGCGGGACCCGGGACAAGAAGAAGGGT
CGGAGCCCGGATGAGCTGCCTGCGACGGGCGGCGACGGCGGCAAACATAAGAAATTTACTTTGAAGCGGCTCATGGCAGACGAGCTGGAGAGATTTACCAGCATGAGGATTAAGAAGGAGAAGGAAAA
GCCCAATTCTGCTCATAGAAACTCCTCTGCATCGTATGGAGATGACCCCACTGCTCAGTCACTGCAGGACATCTCAGATGATCAAGTTCTTGTCCTCTTTGAGCAGATGCTGGTGGATATGAACCTGA
ATGAGGAGAAACAGCAGCCTTTGCGAGAGAAGGACATTGTCATCAAGAGGGAGATGGTGTCCCAGTATCTGCATACTTCCAAAGCTGGCATGAACCAGAAGGAGAGTTCCAGGTCTGCCATGATGTAC
ATTCAGGAGCTGAGGTCAGGCTTGCGGGATATGCACCTGCTTAGCTGCCTGGAGTCCCTTCGAGTCTCTCTCAACAATAACCCTGTCAGTTGGGTGCAGACATTTGGTGCTGAGGGCCTAGCCTCCTT
ATTGGACATCCTCAAACGACTCCATGATGAGAAAGAGGAGACTTCTGGAAACTACGACAGCCGGAACCAGCATGAGATTATCCGCTGTTTGAAAGCTTTCATGAACAACAAGTTTGGAATCAAAACCA
TGTTGGAGACGGAAGAAGGAATCCTACTGCTGGTCAGAGCCATGGATCCTGCTGTTCCCAATATGATGATTGATGCAGCAAAGCTGCTGTCTGCCCTCTGTATCCTACCGCAGCCAGAGGACATGAAT
GAACGAGTTTTAGAGGCTATGACAGAGAGAGCTGAAATGGAAGAGGTTGAACGCTTCCAGCCACTGCTGGATGGGTTAAAAAGTGGGACGTCTATTGCACTCAAAGTGGGATGCCTACAGCTGATCAA
TGCTCTCATCACTCCCGCTGAGGAACTTGACTTCCGGGTTCACATCCGAAGTGAGCTGATGCGCTTGGGACTGCATCAAGTGTTGCAGGAGCTTCGAGAGATTGACAATGATGATATGCGAGTACAGC
TCAATGTGTTTGATGAACAAGGGGATGAAGATTTCTTCGATCTGAAGGGACGACTGGATGATATCCGCATGGAGATGGATGACTTTGGTGAAGTTTTCCAGATTATTTTAAACACAGTGAAAGATTCC
AAGGCAGAACCACACTTCCTGTCTATCTTGCAGCATCTCCTGTTGGTCCGAAATGATTATGAAGCTAGGCCGCAGTACTATAAATTGATTGAAGAATGTGTTTCTCAGATAGTTCTACACAAAAATGG
AACTGATCCTGACTTCAAGTGCCGGCACCTGCAGATTGATATTGAGGGGTTGGTTGATCAAATGATTGATAAAACGAAGGTGGAAAAATCTGAGGCCAAAGCTACAGAGCTGGAAAAAAAGTTGGACT
CAGAATTAACAGCCCGGCATGAGTTACAAGTAGAAATGAAAAAGATGGAAAATGACTTTGAGCAGAAACTTCAGGATCTTCAAGGAGAAAAGGATGCCTTGGATTCTGAAAAGCAGCAGATCACTACA
CAAAAACAAGACCTGGAAGCAGAGGTGTCCAAGCTGACAGGAGAGGTTGCCAAGCTGTCAAAAGAACTAGAAGATGCCAAGAAGGAAATGGCTTCTCTCTCTGCTGTGGCTGTTGCACCTTCAGTTTC
TAGTAGTGCTGCTGTTCCCCAAGCCCCTCCTCTGCCTGGCACTTCAGGCACTGTTATTCCACCTCCCCCACCACCCCCTCTCCCTGGAGGTGCCGTCCCACCCCCTCCTCCTCCTCCTCTGCCTGCAG
GTACTGGTATCCCTCCACCTCCTCCTTTACCTGGAGGTGCTTGTATATCCTCTTCCCCACAGTTGTTTGGCAGTACTGCCATTCCCCCACCTCCTCCTTTGCCTGGAGCTACTGCCATCCCCCCACCT
CCCCCTTTGCCTGGAGATACTGCCATCCCCCCACCTCCCCCTTTGCCTGGAGNTACTGCCATCCCCCCTCCTCCTCCTTTGCCTGGAGCTACTGGTGTACCACCACCTCCTCCCCCTTTACCTGGAAG
TGTTGGTGTTCCCCCACCCCCTCCCTTGCCTGGAGGACCAGGACTGCCTCCTCCTCCTCCCCCCTTTCCTGGAGCACCTGGCATTCCCCCCCCACCGCCTGGTATGGGCGTGCCTCCACCTCCCCCCT
TTGGATTTGGGATTCCTGCAGCCCCAGTTCTGCCATTTGGATTAACCCCCAAAAAAGTTTATAAGCCAGAGGTGCAACTCCGGAGGCCAAACTGGTCCAAGTTCGTGGCTGAGGACCTTTCCCAGGAC
TGCTTCTGGACAAAGGTGAAGGAGGACCGCTTTGAGAACAATGAACTATTTGCCAAACTTACCCTTGCCTTCTCTGCCCAGACCAAGACTTCTAAAGCCAAGAAGGATCAAGAAGGTGGAGAAGAAAA
GAAATCTGTTCAAAAGAAGAAAGTAAAAGAGCTGAAAGTGCTGGATTCAAAGACAGCCCAGAATCTCTCAATCTTTTTGGGTTCATTCCGTATGCCCTATCAAGAGATTAAGAACGTTATCCTGGAGG
TGAATGAGGCTGTTCTCACGGAGTCTATGATCCAGAACCTCATTAAGCAGATGCCAGAACCAGAGCAGTTAAAAATGCTTTCTGAACTGAAGGAGGAGTACGATGATCTGGCTGAGTCAGAGCAGTTC
GGCGTGGTGATGGGCACGGTTCCCCGTCTTCGGCCTCGCCTCAATGCCATCCTTTTCAAGCTACAGTTCAGTGAGCAAGTTGAGAATATCAAGCCAGAGATTGTATCTGTCACTGCGGCATGTGAGGA
GCTGCGTAAGAGTGAGAACTTCTCTAGCCTCCTGGAGCTCACACTGCTCGTTGGAAACTATATGAATGCGGGCTCCAGGAATGCTGGAGCTTTTGGCTTCAATATCAGCTTCCTTTGTAAGCTTCGAG
ACACCAAGTCTGCAGATCAGAAGATGACTCTGTTGCATTTCTTGGCTGAGTTATGTGAGACTGACCACCCCGATGTCCTCAAGTTTCCTGATGAGCTTGCCCATGTAGAGAAAGCCAGCAGAGTTTCT
GCTGAGAACTTGCAGAAGAATTTAGATCAGATGAAGAAACAGATTGCTGATGTGGAACGCGATGTTCAAAATTTCCCAGCTGCCACAGACGAAAAAGACAAGTTTGTTGAGAAGATGACTAGCTTTGT
GAAGGATGCACAGGAACAGTATAACAAGCTACGGATGATGCACTCCAACATGGAGACTCTCTATAAGGAGCTAGGCGACTACTTCGTCTTTGACCCTAAGAAGTTGTCTGTAGAAGAATTTTTTATGG
ATCTGCACAACTTTAGGAATATGTTTTTGCAAGCAGTCAAGGAGAACCAGAAGCGCCGGGAAACAGAAGAAAAGATGAGGAGAGCAAAACTAGCCAAGGAAAAGGCGGAAAAAGAGCGACTGGAGAAG
CAGCAGAAGCGAGAGCAGCTCATAGACATGAATGCAGAGGGGGATGAGACAGGTGTGATGGACAGTCTTCTAGAAGCTCTGCAGTCAGGAGCAGCATTCCGACGGAAGAGAGGGCCCCGGCAGGTCAA
CAGGAAAGCTGGGTGTGCAGTCACATCTCTGCTAGCCTCGGAGCTGACCAAGGATGATGCCGTGGCTGCTAGTTCTGCTAAGGTGCCCAAGAAAAGTGAAGGAGTCACCACAATCCTTGAAGAAGCCA
AGGAACTGGTTGGCCGTGCAAGCTAAGCTGGGCTTTATGGCCGTTGCTGCATCTAGGTGAAGCCCAGACTGCCTACCTGCAGCATGTGCCTAAATGGTCAAGGAGATATCCCTCTGCAGTGGCCGCTC
CACCACCTGACCCTGTCTCTCTGTCTGGCCTGCTGCTCTCGAACACCACATACAGCTTCAGCTGCCTGGAGGCCAGAAGGAAGAGGCAGTGTAGGGGTGGCCTGAGCCCAGCCCAGCCAGCCCTGGCT
GTTGTATTACCAAAGCAGGGTCCGTGTTTGCTGCCTTAACCCTGTCTCCTCTATGTTACCCAGAGGTCCTGGTCTCAGACAGAACCCAGCCTGCTTTCTCAGCCCCACTCTCTAATGGGCCTTCCCCT
AGGTCAATCTTGCTGCATTTGTGCTTTTCTTTTGTGGTTTCTCTGGCCCTGAGAATAGCATGGGACTTGTGAACCTTCGGGCTAGATCTTTTCACTGCTGTCACTCACTCTGCTTTTCCTGCTGGCGG
TTATTTATTATTAGTGCTGTGGCATTGGGAGCTGCTTCTGCAAAAACAGGGAGCAGATCCCACCCTTACCCCACCTTCCTGGGAAAGGTCTCCCGGGAAAAGGGTCTCAACCACTCTCCCCGTTCCAC
TGTGGCCCAGGTCTGAGCCATAGGCAGGTAGCTAGGGCATAGCGACAGTGTGGGGTCCGCCCCCTGCCCGCTGCCATGCTTCATGCCCTTGCCCCCCTGGTCCCTCTGCACCAGCCTCACCTCTACCC
AGCAACTGAACCCTTCCCCCCCATGCCTTCCCCAGAGCTTTGGTGCATCTCATTTGGAGTGTGGGCTGTAGTGTGACCATCCCAACACCTCACCCCCACCATCCAAGGAAATGGGAGGTGGAGCCTCC
TGGCTGAGAAATTGTTTTGCAAATGGATCTATTTTTATATGAAAAATTTTTTAAGAAAAATAACTTTGATCCCCTTTCCCCTGCGTAATAAAAGAGGCTTTGATGGTAGGTTCAAGCATTCCTGGGGT
CAGTCCTGAACATGGCCTAAATATTGGCCCCACCCCTCAAGACTAAATGGTGAGGCCAAGGCAGACAGACCCTTCCTTAGCATCAGTTCTGGGGCAAGAGAAATTCCTCTGGGTGGGCTGGGCCGCAC
CATAGGGTAGCAAGAGCTCAGATGCTGTGTTTTCATGAATGTATTAAATTATCAGCCAAATGTGCAGATGCTAAGGATGCTGAGAAGTGCACAGGGGTGCCCCCATATAAGCAGTGAGCCAGACTGGG
TGGCCCAAACCTCAGGAAGCTTAGACTCTCTGGCCTGGGAGTCACTGTCTTGTCCTCCTCCAGGGCCCTTTCAGCTTCCCTCTGAGGCTACAGAGAAGGCTTGACACAGAATTGGAGTTGCCGAGTAT
GAAGGGGTTAGGAAACACAAGGGCCAGTACAGGGGCCTTGTGCCCAGGGAGGATTGGTTGGGTTGCTCGAGCTTGTGTCTGAGGGACAGTGGCAGCTTCTAGACTACTTCCTGGGAGGACTGAAGAGC
CCGTTCTTCCTGAGCCACCACCTTGCTCGCTGACATCTGGGGCTTTGACCCTTTTCTTTTTTTAATCACTTTTGCTAAAATGCATTTAATTAAAAAAATTTTTAAGTAGAGGGGGTAAAATGCAAACC
CCCTTGCCTCTTGGGCTTTTGGGATGTCATCACCTCCAGTTTGATGGGTTTGTTTCCAACTGTCAATAAAGCATTGAAACAGAA

hide sequence

RefSeq Acc Id:

NM_001395102 ⟹ NP_001382031

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	29,920,889 - 30,020,280 (-)	NCBI
mRatBN7.2	18	29,669,659 - 29,769,070 (-)	NCBI


Protein RefSeqs	NP_001100863	(Get FASTA)	NCBI Sequence Viewer
	NP_001382031	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL76410	(Get FASTA)	NCBI Sequence Viewer
	EDL76411	(Get FASTA)	NCBI Sequence Viewer
	EDL76412	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000057176
	ENSRNOP00000088426
GenBank Protein	F1M775	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001100863 ⟸ NM_001107393
- Peptide Label:	isoform 1
- UniProtKB:	F1M775 (UniProtKB/Swiss-Prot), A0A8L2QTN9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEPSGGGLGPGRGTRDKKKGRSPDELPATGGDGGKHKKFTLKRLMADELERFTSMRIKKEKEKPNSAHRNSSASYGDDPTAQSLQDISDDQVLVLFEQMLVDMNLNEEKQQPLREKDIVIKREMVSQY LHTSKAGMNQKESSRSAMMYIQELRSGLRDMHLLSCLESLRVSLNNNPVSWVQTFGAEGLASLLDILKRLHDEKEETSGNYDSRNQHEIIRCLKAFMNNKFGIKTMLETEEGILLLVRAMDPAVPNMM IDAAKLLSALCILPQPEDMNERVLEAMTERAEMEEVERFQPLLDGLKSGTSIALKVGCLQLINALITPAEELDFRVHIRSELMRLGLHQVLQELREIDNDDMRVQLNVFDEQGDEDFFDLKGRLDDIR MEMDDFGEVFQIILNTVKDSKAEPHFLSILQHLLLVRNDYEARPQYYKLIEECVSQIVLHKNGTDPDFKCRHLQIDIEGLVDQMIDKTKVEKSEAKATELEKKLDSELTARHELQVEMKKMENDFEQK LQDLQGEKDALDSEKQQITTQKQDLEAEVSKLTGEVAKLSKELEDAKKEMASLSAVAVAPSVSSSAAVPQAPPLPGTSGTVIPPPPPPPLPGGAVPPPPPPPLPAGTGIPPPPPLPGGACISSSPQLF GSTAIPPPPPLPGATAIPPPPPLPGDTAIPPPPPLPGXTAIPPPPPLPGATGVPPPPPPLPGSVGVPPPPPLPGGPGLPPPPPPFPGAPGIPPPPPGMGVPPPPPFGFGIPAAPVLPFGLTPKKVYKP EVQLRRPNWSKFVAEDLSQDCFWTKVKEDRFENNELFAKLTLAFSAQTKTSKAKKDQEGGEEKKSVQKKKVKELKVLDSKTAQNLSIFLGSFRMPYQEIKNVILEVNEAVLTESMIQNLIKQMPEPEQ LKMLSELKEEYDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSVTAACEELRKSENFSSLLELTLLVGNYMNAGSRNAGAFGFNISFLCKLRDTKSADQKMTLLHFLAELCETDH PDVLKFPDELAHVEKASRVSAENLQKNLDQMKKQIADVERDVQNFPAATDEKDKFVEKMTSFVKDAQEQYNKLRMMHSNMETLYKELGDYFVFDPKKLSVEEFFMDLHNFRNMFLQAVKENQKRRETE EKMRRAKLAKEKAEKERLEKQQKREQLIDMNAEGDETGVMDSLLEALQSGAAFRRKRGPRQVNRKAGCAVTSLLASELTKDDAVAASSAKVPKKSEGVTTILEEAKELVGRAS hide sequence

Ensembl Acc Id:

ENSRNOP00000057176 ⟸ ENSRNOT00000060432

Ensembl Acc Id:

ENSRNOP00000088426 ⟸ ENSRNOT00000102970

RefSeq Acc Id:	NP_001382031 ⟸ NM_001395102
- Peptide Label:	isoform 2
- UniProtKB:	F1M775 (UniProtKB/Swiss-Prot), A0A8I6A828 (UniProtKB/TrEMBL)

Protein Domains

DAD FH1 FH2 GBD/FH3

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

RGD ID:

13700736

Promoter ID:

EPDNEW_R11260

Type:

initiation region

Name:

Diaph1_1

Description:

diaphanous-related formin 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	18	31,071,369 - 31,071,429	EPDNEW

Database	Acc Id	Source(s)
BioCyc Gene	G2FUF-7792	BioCyc
Ensembl Genes	ENSRNOG00000019688	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000060432	ENTREZGENE
	ENSRNOT00000102970	ENTREZGENE
Gene3D-CATH	1.10.20.40	UniProtKB/Swiss-Prot
	1.20.1170.10	UniProtKB/Swiss-Prot
	1.20.58.2220	UniProtKB/Swiss-Prot
	1.20.58.630	UniProtKB/Swiss-Prot
	1.25.10.10	UniProtKB/Swiss-Prot
	6.10.30.30	UniProtKB/Swiss-Prot
	Formin, FH3 diaphanous domain	UniProtKB/Swiss-Prot
InterPro	ARM-like	UniProtKB/Swiss-Prot
	ARM-type_fold	UniProtKB/Swiss-Prot
	DAD_dom	UniProtKB/Swiss-Prot
	DIA_GBD_sf	UniProtKB/Swiss-Prot
	FH2_Formin	UniProtKB/Swiss-Prot
	FH2_Formin_sf	UniProtKB/Swiss-Prot
	FH3_dom	UniProtKB/Swiss-Prot
	Formin_Homology_Diaphanous_sf	UniProtKB/Swiss-Prot
	GBD/FH3_dom	UniProtKB/Swiss-Prot
	GTPase-bd	UniProtKB/Swiss-Prot
NCBI Gene	307483	ENTREZGENE
PANTHER	PROTEIN DIAPHANOUS	UniProtKB/Swiss-Prot
	PTHR45691:SF4	UniProtKB/Swiss-Prot
Pfam	Drf_FH1	UniProtKB/Swiss-Prot
	Drf_FH3	UniProtKB/Swiss-Prot
	Drf_GBD	UniProtKB/Swiss-Prot
	FH2	UniProtKB/Swiss-Prot
PhenoGen	Diaph1	PhenoGen
PROSITE	DAD	UniProtKB/Swiss-Prot
	FH2	UniProtKB/Swiss-Prot
	GBD_FH3	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000019688	RatGTEx
SMART	Drf_FH3	UniProtKB/Swiss-Prot
	Drf_GBD	UniProtKB/Swiss-Prot
	FH2	UniProtKB/Swiss-Prot
Superfamily-SCOP	Formin homology 2 domain (FH2 domain)	UniProtKB/Swiss-Prot
	SSF48371	UniProtKB/Swiss-Prot
UniProt	A0A8I6A828	ENTREZGENE, UniProtKB/TrEMBL
	A0A8L2QTN9	ENTREZGENE, UniProtKB/TrEMBL
	DIAP1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-06-05	Diaph1	diaphanous-related formin 1	Diaph1	diaphanous homolog 1 (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-26	Diaph1	diaphanous homolog 1 (Drosophila)	Diap1	diaphanous homolog 1 (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Diap1	diaphanous homolog 1 (Drosophila)	Diap1_predicted	diaphanous homolog 1 (Drosophila) (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Diap1_predicted	diaphanous homolog 1 (Drosophila) (predicted)			Symbol and Name status set to approved	70820	APPROVED

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InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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Imported Annotations - PID (archival)