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Gene: Diaph1 (diaphanous-related formin 1) Rattus norvegicus

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Symbol:

Diaph1

Name:

diaphanous-related formin 1

RGD ID:

1310707

Description:

Predicted to enable several functions, including profilin binding activity; small GTPase binding activity; and transmembrane transporter binding activity. Involved in positive regulation of cell migration. Predicted to be located in several cellular components, including brush border; ruffle membrane; and spindle. Predicted to be active in actin filament. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 1 and sensorineural hearing loss. Orthologous to human DIAPH1 (diaphanous related formin 1); PARTICIPATES IN E-cadherin signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Diap1; diaphanous homolog 1; diaphanous homolog 1 (Drosophila); DRF1; LOC307483; mDIA1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DIAPH1 (diaphanous related formin 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Diaph1 (diaphanous related formin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Diaph1 (diaphanous related formin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DIAPH1 (diaphanous related formin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DIAPH1 (diaphanous related formin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Diaph1 (diaphanous related formin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DIAPH1 (diaphanous related formin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	DIAPH1 (diaphanous related formin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Diaph1 (diaphanous related formin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	DIAPH1 (diaphanous related formin 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Diaph1 (diaphanous related formin 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cyk-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	dia	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	29,920,889 - 30,020,280 (-)	NCBI		GRCr8
mRatBN7.2	18	29,669,659 - 29,769,070 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	29,669,659 - 29,769,172 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	29,773,984 - 29,873,376 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	30,535,964 - 30,635,353 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	29,871,305 - 29,970,698 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	30,972,907 - 31,071,371 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	30,972,907 - 31,071,371 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	30,663,859 - 30,762,658 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	30,757,191 - 30,855,548 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	18	30,784,366 - 30,882,101 (-)	NCBI
Celera	18	29,313,748 - 29,412,995 (-)	NCBI		Celera
Cytogenetic Map	18	p11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant intellectual developmental disorder 31 (ISO)

autosomal dominant nonsyndromic deafness 1 (ISO)

autosomal recessive nonsyndromic deafness 9 (ISO)

benign neonatal seizures (ISO)

beta-mannosidosis (ISO)

Deafness (ISO)

Developmental Disabilities (ISO)

epilepsy (ISO)

Failure to Thrive (ISO)

familial adenomatous polyposis 1 (ISO)

genetic disease (ISO)

Hearing Loss (ISO)

Hereditary Neoplastic Syndromes (ISO)

microcephaly (ISO)

Neurodevelopmental Disorders (ISO)

Pendred syndrome (ISO)

Seizures, Cortical Blindness, and Microcephaly Syndrome (ISO)

sensorineural hearing loss (ISO)

vascular dementia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-tribromophenol (ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-palmitoylglycerol (ISO)

3-chloropropane-1,2-diol (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

3-methylcholanthrene (ISO)

4,4'-sulfonyldiphenol (ISO)

4-vinylcyclohexene dioxide (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (EXP)

all-trans-retinoic acid (ISO)

antirheumatic drug (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

caffeine (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chrysene (ISO)

cisplatin (ISO)

dexamethasone (ISO)

dextran sulfate (ISO)

diarsenic trioxide (ISO)

Dibutyl phosphate (ISO)

dicrotophos (ISO)

enzyme inhibitor (ISO)

ethanol (ISO)

Evodiamine (ISO)

finasteride (EXP)

folic acid (ISO)

FR900359 (ISO)

fulvestrant (ISO)

gallic acid (ISO)

indometacin (ISO)

inulin (ISO)

ivermectin (ISO)

jaspamide (ISO)

kanamycin A (ISO)

latrunculin A (ISO)

methimazole (EXP)

methoxychlor (EXP,ISO)

nickel atom (ISO)

paracetamol (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

piroxicam (ISO)

progesterone (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

tetraphene (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

triphenyl phosphate (ISO)

triptonide (ISO)

tungsten (ISO)

valproic acid (ISO)

vinclozolin (EXP)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin cytoskeleton organization (IEA,ISO,ISS)

actin filament polymerization (IBA,ISO,ISS)

actin nucleation (ISO)

axon midline choice point recognition (ISO)

brain development (ISO)

cellular response to histamine (IEA,ISO)

cytoskeleton organization (IEA,ISO,ISS)

ephrin receptor signaling pathway (ISO)

gene expression (ISO)

multicellular organismal locomotion (ISO)

negative regulation of neuron projection regeneration (ISO)

neuron projection development (ISO)

neuron projection retraction (ISO)

positive regulation of cell migration (IMP)

protein localization (ISO)

protein localization to microtubule (IEA,ISO)

regulation of cell shape (IEA,ISO)

regulation of cytoskeleton organization (IEA,ISO)

regulation of microtubule-based process (IEA,ISO)

regulation of release of sequestered calcium ion into cytosol (IEA,ISO)

sensory perception of sound (IEA)

synaptic vesicle endocytosis (ISO)

Cellular Component

actin filament (IBA)

brush border (ISO)

cell projection (IEA)

centrosome (IEA)

cytoplasm (IEA,ISO,ISS)

cytoskeleton (IEA)

membrane (IEA)

microtubule cytoskeleton (ISO)

mitotic spindle (IEA,ISO)

neuron projection (ISO)

nucleus (IEA,ISO,ISS)

plasma membrane (IEA)

presynapse (IEA)

ruffle membrane (IEA,ISO)

spindle (IEA)

spindle microtubule (ISO)

Molecular Function

actin binding (IEA,ISO)

identical protein binding (ISO)

profilin binding (ISO)

protein binding (ISO)

small GTPase binding (IEA,ISO)

transmembrane transporter binding (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

E-cadherin signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Nonsyndromic deafness DFNA1 associated with mutation of a human homolog of the Drosophila gene diaphanous.	Lynch ED, etal., Science. 1997 Nov 14;278(5341):1315-8.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
6.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7.	GOA pipeline	RGD automated data pipeline
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Comprehensive gene review and curation	RGD comprehensive gene curation
11.	The Rho-mDia1 pathway regulates cell polarity and focal adhesion turnover in migrating cells through mobilizing Apc and c-Src.	Yamana N, etal., Mol Cell Biol. 2006 Sep;26(18):6844-58.

Additional References at PubMed

PMID:9214622	PMID:10559899	PMID:12906795	PMID:14992721	PMID:15123714	PMID:16472745	PMID:17170370	PMID:18362183	PMID:18572016	PMID:18651670	PMID:20071339	PMID:20937854
PMID:21834987	PMID:22114352	PMID:22658674	PMID:23558171	PMID:24781755	PMID:26912466	PMID:28877993	PMID:30358011

Genomics

Comparative Map Data

Diaph1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	29,920,889 - 30,020,280 (-)	NCBI		GRCr8
mRatBN7.2	18	29,669,659 - 29,769,070 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	29,669,659 - 29,769,172 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	29,773,984 - 29,873,376 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	30,535,964 - 30,635,353 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	29,871,305 - 29,970,698 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	30,972,907 - 31,071,371 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	30,972,907 - 31,071,371 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	30,663,859 - 30,762,658 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	30,757,191 - 30,855,548 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	18	30,784,366 - 30,882,101 (-)	NCBI
Celera	18	29,313,748 - 29,412,995 (-)	NCBI		Celera
Cytogenetic Map	18	p11	NCBI

DIAPH1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	141,515,021 - 141,619,000 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	141,515,016 - 141,619,055 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	140,894,588 - 140,998,567 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	140,874,772 - 140,978,747 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	140,874,772 - 140,978,691	NCBI
Celera	5	136,971,324 - 137,075,350 (-)	NCBI		Celera
Cytogenetic Map	5	q31.3	NCBI
HuRef	5	136,039,428 - 136,143,262 (-)	NCBI		HuRef
CHM1_1	5	140,327,865 - 140,431,904 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	142,041,005 - 142,145,005 (-)	NCBI		T2T-CHM13v2.0

Diaph1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	37,976,654 - 38,068,573 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	37,976,654 - 38,068,529 (-)	Ensembl		GRCm39 Ensembl
GRCm38	18	37,843,601 - 37,935,622 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	37,843,601 - 37,935,476 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	18	38,004,478 - 38,095,065 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	18	37,970,798 - 38,061,385 (-)	NCBI		MGSCv36	mm8
Celera	18	39,188,303 - 39,278,736 (-)	NCBI		Celera
Cytogenetic Map	18	B3	NCBI
cM Map	18	19.71	NCBI

Diaph1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955415	12,156,152 - 12,272,961 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955415	12,156,152 - 12,272,961 (+)	NCBI	ChiLan1.0	ChiLan1.0

DIAPH1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	136,764,381 - 136,867,993 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	134,960,673 - 135,007,628 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	136,876,396 - 136,980,097 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	142,990,248 - 143,092,558 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

DIAPH1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	36,483,781 - 36,581,390 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	36,485,571 - 36,581,320 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	33,535,791 - 33,633,355 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	36,937,687 - 37,035,539 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	36,937,690 - 37,035,611 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	34,012,555 - 34,110,155 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	34,824,079 - 34,921,683 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	35,631,288 - 35,728,900 (-)	NCBI		UU_Cfam_GSD_1.0

Diaph1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	150,974,209 - 151,071,265 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936504	12,548,452 - 12,643,399 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936504	12,548,452 - 12,645,236 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DIAPH1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	143,158,585 - 143,271,147 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	143,158,691 - 143,271,110 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	149,363,162 - 149,473,567 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DIAPH1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	44,139,495 - 44,244,505 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	44,139,360 - 44,244,490 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666034	33,608,326 - 33,713,597 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Diaph1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624774	739,206 - 845,272 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624774	738,717 - 845,187 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Diaph1
308 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	235
Count of miRNA genes:	103
Interacting mature miRNAs:	109
Transcripts:	ENSRNOT00000060432, ENSRNOT00000060433
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331733	Bp233	Blood pressure QTL 233	3.97196		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	24796977	79788953	Rat
1358358	Sradr6	Stress Responsive Adrenal Weight QTL 6	2.49		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	18	11944299	59330563	Rat
1331735	Rf44	Renal function QTL 44	2.981		urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	18	18234564	31359530	Rat
61382	Bp46	Blood pressure QTL 46	18.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	11941791	31393320	Rat
2301413	Bp318	Blood pressure QTL 318		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	26548082	46969551	Rat
1331741	Bp232	Blood pressure QTL 232	3.59112		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	21372893	83213037	Rat
61388	Bp2	Blood pressure QTL 2	3.23		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	1	35374722	Rat
6903359	Bp355	Blood pressure QTL 355	3.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	11944544	59796478	Rat
12904668	Bw188	Body weight QTL 188		0.03	body mass (VT:0001259)	body weight (CMO:0000012)	18	26548082	46969551	Rat
2313082	Bss85	Bone structure and strength QTL 85	0.8	0.0001	long bone metaphysis morphology trait (VT:0000133)	tibia midshaft total cross-sectional area (CMO:0001715)	18	14951337	59951337	Rat
12904669	Cm125	Cardiac mass QTL 125		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	18	26548082	46969551	Rat
1641923	Colcr8	Colorectal carcinoma resistance QTL 8	3.1	0.0014	intestine integrity trait (VT:0010554)	poorly differentiated malignant colorectal tumor number (CMO:0002076)	18	22066242	52293055	Rat
12904670	Cm126	Cardiac mass QTL 126		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	26548082	46969551	Rat
2312568	Glom21	Glomerulus QTL 21	2	0.005	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	18	5185858	40503530	Rat
2300157	Bmd66	Bone mineral density QTL 66	13.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	18	28964853	73964853	Rat
12904677	Kidm72	Kidney mass QTL 72		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	26548082	46969551	Rat
1331766	Bp236	Blood pressure QTL 236	3.022		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	11944299	31359530	Rat
1358193	Emca2	Estrogen-induced mammary cancer QTL 2	1.6		mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	18	18007599	63571040	Rat
12904673	Cm127	Cardiac mass QTL 127		0.005	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	26548082	46969551	Rat
12904675	Am19	Aortic mass QTL 19		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	26548082	46969551	Rat
631264	Scl22	Serum cholesterol level QTL 22	6.2		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	18	11941791	31393320	Rat
2293704	Bss35	Bone structure and strength QTL 35	4.59	0.0002	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	18	28964853	73964853	Rat
1331775	Bp235	Blood pressure QTL 235	3.201		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	18234564	31359530	Rat
2325839	Bp348	Blood pressure QTL 348		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	25570985	70570985	Rat
1600373	Mamtr6	Mammary tumor resistance QTL 6			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	18	19278901	83218561	Rat
2293708	Bss46	Bone structure and strength QTL 46	8.8	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	18	11791518	63636873	Rat
2300177	Bmd65	Bone mineral density QTL 65	19.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	18	28964853	73964853	Rat
9589153	Insul31	Insulin level QTL 31	7.15	0.05	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	18	1	42547119	Rat
1578667	Bss21	Bone structure and strength QTL 21	3.5		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	18	11791518	83218561	Rat
2312598	Bp340	Blood pressure QTL 340		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	1	30558703	Rat
2300180	Bmd67	Bone mineral density QTL 67	4.8	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	18	1	34291613	Rat
2299160	Iddm35	Insulin dependent diabetes mellitus QTL 35	2.79		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	18	4207941	60377792	Rat
1578661	Bss20	Bone structure and strength QTL 20	3.7		femur morphology trait (VT:0000559)	femoral neck cross-sectional area (CMO:0001697)	18	11791518	83218561	Rat
1331753	Bp231	Blood pressure QTL 231	3.643		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	11944299	52293055	Rat
2293661	Bss50	Bone structure and strength QTL 50	4.64	0.0003	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	18	1	34291613	Rat
61375	Bp41	Blood pressure QTL 41	2.4		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	18	11944299	41122201	Rat

Markers in Region

RH130783

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	29,770,659 - 29,770,857 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	31,072,987 - 31,073,184	NCBI	Rnor6.0
Rnor_5.0	18	30,764,274 - 30,764,471	UniSTS	Rnor5.0
RGSC_v3.4	18	30,857,139 - 30,857,336	UniSTS	RGSC3.4
Celera	18	29,414,611 - 29,414,808	UniSTS
RH 3.4 Map	18	444.2	UniSTS
Cytogenetic Map	18	p11	UniSTS

RH127883

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	29,669,684 - 29,669,893 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	30,972,933 - 30,973,141	NCBI	Rnor6.0
Rnor_5.0	18	30,663,885 - 30,664,093	UniSTS	Rnor5.0
RGSC_v3.4	18	30,756,025 - 30,756,233	UniSTS	RGSC3.4
Celera	18	29,313,774 - 29,313,982	UniSTS
Cytogenetic Map	18	p11	UniSTS

BE119953

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	47,231,083 - 47,231,306 (+)	MAPPER	mRatBN7.2
mRatBN7.2	18	29,730,201 - 29,730,413 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	31,032,769 - 31,032,980	NCBI	Rnor6.0
Rnor_6.0	2	47,876,688 - 47,876,910	NCBI	Rnor6.0
Rnor_5.0	18	30,724,159 - 30,724,370	UniSTS	Rnor5.0
Rnor_5.0	2	66,264,138 - 66,264,360	UniSTS	Rnor5.0
RGSC_v3.4	2	46,345,568 - 46,345,790	UniSTS	RGSC3.4
RGSC_v3.4	18	30,816,539 - 30,816,750	UniSTS	RGSC3.4
Celera	18	29,374,164 - 29,374,375	UniSTS
Celera	2	42,965,202 - 42,965,424	UniSTS
RH 3.4 Map	18	428.3	UniSTS
Cytogenetic Map	18	p11	UniSTS
Cytogenetic Map	2	q14	UniSTS

RH124673

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	29,669,710 - 29,670,024 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	30,972,959 - 30,973,272	NCBI	Rnor6.0
Rnor_5.0	18	30,663,911 - 30,664,224	UniSTS	Rnor5.0
RGSC_v3.4	18	30,756,051 - 30,756,364	UniSTS	RGSC3.4
Celera	18	29,313,800 - 29,314,113	UniSTS
Cytogenetic Map	18	p11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107393	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001395102	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473974	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000060432 ⟹ ENSRNOP00000057176

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	18	29,669,659 - 29,769,044 (-)	Ensembl
Rnor_6.0 Ensembl	18	30,972,907 - 31,071,371 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000102970 ⟹ ENSRNOP00000088426

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	18	29,669,659 - 29,769,172 (-)	Ensembl

RefSeq Acc Id:

NM_001107393 ⟹ NP_001100863

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	29,920,889 - 30,020,280 (-)	NCBI
mRatBN7.2	18	29,669,659 - 29,769,070 (-)	NCBI
Rnor_6.0	18	30,972,907 - 31,071,371 (-)	NCBI
Rnor_5.0	18	30,663,859 - 30,762,658 (-)	NCBI
RGSC_v3.4	18	30,757,191 - 30,855,548 (-)	RGD
Celera	18	29,313,748 - 29,412,995 (-)	NCBI

Sequence:

show sequence

TTGTTGGCTCGGGGCAGCCGGGCGGGAGCGGCGTAGACAAGGGGTCTCTGGCCGGCGCTAACCA
GGACATGGAGCCGTCCGGCGGGGGCCTAGGGCCCGGCCGCGGGACCCGGGACAAGAAGAAGGGT
CGGAGCCCGGATGAGCTGCCTGCGACGGGCGGCGACGGCGGCAAACATAAGAAATTTACTTTGA
AGCGGCTCATGGCAGACGAGCTGGAGAGATTTACCAGCATGAGGATTAAGAAGGAGAAGGAAAA
GCCCAATTCTGCTCATAGAAACTCCTCTGCATCGTATGGAGATGACCCCACTGCTCAGTCACTG
CAGGACATCTCAGATGATCAAGTTCTTGTCCTCTTTGAGCAGATGCTGGTGGATATGAACCTGA
ATGAGGAGAAACAGCAGCCTTTGCGAGAGAAGGACATTGTCATCAAGAGGGAGATGGTGTCCCA
GTATCTGCATACTTCCAAAGCTGGCATGAACCAGAAGGAGAGTTCCAGGTCTGCCATGATGTAC
ATTCAGGAGCTGAGGTCAGGCTTGCGGGATATGCACCTGCTTAGCTGCCTGGAGTCCCTTCGAG
TCTCTCTCAACAATAACCCTGTCAGTTGGGTGCAGACATTTGGTGCTGAGGGCCTAGCCTCCTT
ATTGGACATCCTCAAACGACTCCATGATGAGAAAGAGGAGACTTCTGGAAACTACGACAGCCGG
AACCAGCATGAGATTATCCGCTGTTTGAAAGCTTTCATGAACAACAAGTTTGGAATCAAAACCA
TGTTGGAGACGGAAGAAGGAATCCTACTGCTGGTCAGAGCCATGGATCCTGCTGTTCCCAATAT
GATGATTGATGCAGCAAAGCTGCTGTCTGCCCTCTGTATCCTACCGCAGCCAGAGGACATGAAT
GAACGAGTTTTAGAGGCTATGACAGAGAGAGCTGAAATGGAAGAGGTTGAACGCTTCCAGCCAC
TGCTGGATGGGTTAAAAAGTGGGACGTCTATTGCACTCAAAGTGGGATGCCTACAGCTGATCAA
TGCTCTCATCACTCCCGCTGAGGAACTTGACTTCCGGGTTCACATCCGAAGTGAGCTGATGCGC
TTGGGACTGCATCAAGTGTTGCAGGAGCTTCGAGAGATTGACAATGATGATATGCGAGTACAGC
TCAATGTGTTTGATGAACAAGGGGATGAAGATTTCTTCGATCTGAAGGGACGACTGGATGATAT
CCGCATGGAGATGGATGACTTTGGTGAAGTTTTCCAGATTATTTTAAACACAGTGAAAGATTCC
AAGGCAGAACCACACTTCCTGTCTATCTTGCAGCATCTCCTGTTGGTCCGAAATGATTATGAAG
CTAGGCCGCAGTACTATAAATTGATTGAAGAATGTGTTTCTCAGATAGTTCTACACAAAAATGG
AACTGATCCTGACTTCAAGTGCCGGCACCTGCAGATTGATATTGAGGGGTTGGTTGATCAAATG
ATTGATAAAACGAAGGTGGAAAAATCTGAGGCCAAAGCTACAGAGCTGGAAAAAAAGTTGGACT
CAGAATTAACAGCCCGGCATGAGTTACAAGTAGAAATGAAAAAGATGGAAAATGACTTTGAGCA
GAAACTTCAGGATCTTCAAGGAGAAAAGGATGCCTTGGATTCTGAAAAGCAGCAGATCACTACA
CAAAAACAAGACCTGGAAGCAGAGGTGTCCAAGCTGACAGGAGAGGTTGCCAAGCTGTCAAAAG
AACTAGAAGATGCCAAGAAGGAAATGGCTTCTCTCTCTGCTGTGGCTGTTGCACCTTCAGTTTC
TAGTAGTGCTGCTGTTCCCCAAGCCCCTCCTCTGCCTGGCACTTCAGGCACTGTTATTCCACCT
CCCCCACCACCCCCTCTCCCTGGAGGTGCCGTCCCACCCCCTCCTCCTCCTCCTCTGCCTGCAG
GTACTGGTATCCCTCCACCTCCTCCTTTACCTGGAGGTGCTTGTATATCCTCTTCCCCACAGTT
GTTTGGCAGTACTGCCATTCCCCCACCTCCTCCTTTGCCTGGAGCTACTGCCATCCCCCCACCT
CCCCCTTTGCCTGGAGATACTGCCATCCCCCCACCTCCCCCTTTGCCTGGAGNTACTGCCATCC
CCCCTCCTCCTCCTTTGCCTGGAGCTACTGGTGTACCACCACCTCCTCCCCCTTTACCTGGAAG
TGTTGGTGTTCCCCCACCCCCTCCCTTGCCTGGAGGACCAGGACTGCCTCCTCCTCCTCCCCCC
TTTCCTGGAGCACCTGGCATTCCCCCCCCACCGCCTGGTATGGGCGTGCCTCCACCTCCCCCCT
TTGGATTTGGGATTCCTGCAGCCCCAGTTCTGCCATTTGGATTAACCCCCAAAAAAGTTTATAA
GCCAGAGGTGCAACTCCGGAGGCCAAACTGGTCCAAGTTCGTGGCTGAGGACCTTTCCCAGGAC
TGCTTCTGGACAAAGGTGAAGGAGGACCGCTTTGAGAACAATGAACTATTTGCCAAACTTACCC
TTGCCTTCTCTGCCCAGACCAAGACTTCTAAAGCCAAGAAGGATCAAGAAGGTGGAGAAGAAAA
GAAATCTGTTCAAAAGAAGAAAGTAAAAGAGCTGAAAGTGCTGGATTCAAAGACAGCCCAGAAT
CTCTCAATCTTTTTGGGTTCATTCCGTATGCCCTATCAAGAGATTAAGAACGTTATCCTGGAGG
TGAATGAGGCTGTTCTCACGGAGTCTATGATCCAGAACCTCATTAAGCAGATGCCAGAACCAGA
GCAGTTAAAAATGCTTTCTGAACTGAAGGAGGAGTACGATGATCTGGCTGAGTCAGAGCAGTTC
GGCGTGGTGATGGGCACGGTTCCCCGTCTTCGGCCTCGCCTCAATGCCATCCTTTTCAAGCTAC
AGTTCAGTGAGCAAGTTGAGAATATCAAGCCAGAGATTGTATCTGTCACTGCGGCATGTGAGGA
GCTGCGTAAGAGTGAGAACTTCTCTAGCCTCCTGGAGCTCACACTGCTCGTTGGAAACTATATG
AATGCGGGCTCCAGGAATGCTGGAGCTTTTGGCTTCAATATCAGCTTCCTTTGTAAGCTTCGAG
ACACCAAGTCTGCAGATCAGAAGATGACTCTGTTGCATTTCTTGGCTGAGTTATGTGAGACTGA
CCACCCCGATGTCCTCAAGTTTCCTGATGAGCTTGCCCATGTAGAGAAAGCCAGCAGAGTTTCT
GCTGAGAACTTGCAGAAGAATTTAGATCAGATGAAGAAACAGATTGCTGATGTGGAACGCGATG
TTCAAAATTTCCCAGCTGCCACAGACGAAAAAGACAAGTTTGTTGAGAAGATGACTAGCTTTGT
GAAGGATGCACAGGAACAGTATAACAAGCTACGGATGATGCACTCCAACATGGAGACTCTCTAT
AAGGAGCTAGGCGACTACTTCGTCTTTGACCCTAAGAAGTTGTCTGTAGAAGAATTTTTTATGG
ATCTGCACAACTTTAGGAATATGTTTTTGCAAGCAGTCAAGGAGAACCAGAAGCGCCGGGAAAC
AGAAGAAAAGATGAGGAGAGCAAAACTAGCCAAGGAAAAGGCGGAAAAAGAGCGACTGGAGAAG
CAGCAGAAGCGAGAGCAGCTCATAGACATGAATGCAGAGGGGGATGAGACAGGTGTGATGGACA
GTCTTCTAGAAGCTCTGCAGTCAGGAGCAGCATTCCGACGGAAGAGAGGGCCCCGGCAGGTCAA
CAGGAAAGCTGGGTGTGCAGTCACATCTCTGCTAGCCTCGGAGCTGACCAAGGATGATGCCGTG
GCTGCTAGTTCTGCTAAGGTGCCCAAGAAAAGTGAAGGAGTCACCACAATCCTTGAAGAAGCCA
AGGAACTGGTTGGCCGTGCAAGCTAAGCTGGGCTTTATGGCCGTTGCTGCATCTAGGTGAAGCC
CAGACTGCCTACCTGCAGCATGTGCCTAAATGGTCAAGGAGATATCCCTCTGCAGTGGCCGCTC
CACCACCTGACCCTGTCTCTCTGTCTGGCCTGCTGCTCTCGAACACCACATACAGCTTCAGCTG
CCTGGAGGCCAGAAGGAAGAGGCAGTGTAGGGGTGGCCTGAGCCCAGCCCAGCCAGCCCTGGCT
GTTGTATTACCAAAGCAGGGTCCGTGTTTGCTGCCTTAACCCTGTCTCCTCTATGTTACCCAGA
GGTCCTGGTCTCAGACAGAACCCAGCCTGCTTTCTCAGCCCCACTCTCTAATGGGCCTTCCCCT
AGGTCAATCTTGCTGCATTTGTGCTTTTCTTTTGTGGTTTCTCTGGCCCTGAGAATAGCATGGG
ACTTGTGAACCTTCGGGCTAGATCTTTTCACTGCTGTCACTCACTCTGCTTTTCCTGCTGGCGG
TTATTTATTATTAGTGCTGTGGCATTGGGAGCTGCTTCTGCAAAAACAGGGAGCAGATCCCACC
CTTACCCCACCTTCCTGGGAAAGGTCTCCCGGGAAAAGGGTCTCAACCACTCTCCCCGTTCCAC
TGTGGCCCAGGTCTGAGCCATAGGCAGGTAGCTAGGGCATAGCGACAGTGTGGGGTCCGCCCCC
TGCCCGCTGCCATGCTTCATGCCCTTGCCCCCCTGGTCCCTCTGCACCAGCCTCACCTCTACCC
AGCAACTGAACCCTTCCCCCCCATGCCTTCCCCAGAGCTTTGGTGCATCTCATTTGGAGTGTGG
GCTGTAGTGTGACCATCCCAACACCTCACCCCCACCATCCAAGGAAATGGGAGGTGGAGCCTCC
TGGCTGAGAAATTGTTTTGCAAATGGATCTATTTTTATATGAAAAATTTTTTAAGAAAAATAAC
TTTGATCCCCTTTCCCCTGCGTAATAAAAGAGGCTTTGATGGTAGGTTCAAGCATTCCTGGGGT
CAGTCCTGAACATGGCCTAAATATTGGCCCCACCCCTCAAGACTAAATGGTGAGGCCAAGGCAG
ACAGACCCTTCCTTAGCATCAGTTCTGGGGCAAGAGAAATTCCTCTGGGTGGGCTGGGCCGCAC
CATAGGGTAGCAAGAGCTCAGATGCTGTGTTTTCATGAATGTATTAAATTATCAGCCAAATGTG
CAGATGCTAAGGATGCTGAGAAGTGCACAGGGGTGCCCCCATATAAGCAGTGAGCCAGACTGGG
TGGCCCAAACCTCAGGAAGCTTAGACTCTCTGGCCTGGGAGTCACTGTCTTGTCCTCCTCCAGG
GCCCTTTCAGCTTCCCTCTGAGGCTACAGAGAAGGCTTGACACAGAATTGGAGTTGCCGAGTAT
GAAGGGGTTAGGAAACACAAGGGCCAGTACAGGGGCCTTGTGCCCAGGGAGGATTGGTTGGGTT
GCTCGAGCTTGTGTCTGAGGGACAGTGGCAGCTTCTAGACTACTTCCTGGGAGGACTGAAGAGC
CCGTTCTTCCTGAGCCACCACCTTGCTCGCTGACATCTGGGGCTTTGACCCTTTTCTTTTTTTA
ATCACTTTTGCTAAAATGCATTTAATTAAAAAAATTTTTAAGTAGAGGGGGTAAAATGCAAACC
CCCTTGCCTCTTGGGCTTTTGGGATGTCATCACCTCCAGTTTGATGGGTTTGTTTCCAACTGTC
AATAAAGCATTGAAACAGAA

hide sequence

RefSeq Acc Id:

NM_001395102 ⟹ NP_001382031

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	29,920,889 - 30,020,280 (-)	NCBI
mRatBN7.2	18	29,669,659 - 29,769,070 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001100863	(Get FASTA)	NCBI Sequence Viewer
	NP_001382031	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL76410	(Get FASTA)	NCBI Sequence Viewer
	EDL76411	(Get FASTA)	NCBI Sequence Viewer
	EDL76412	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000057176
	ENSRNOP00000088426
GenBank Protein	F1M775	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001100863 ⟸ NM_001107393
- Peptide Label:	isoform 1
- UniProtKB:	F1M775 (UniProtKB/Swiss-Prot), A0A8L2QTN9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEPSGGGLGPGRGTRDKKKGRSPDELPATGGDGGKHKKFTLKRLMADELERFTSMRIKKEKEKP NSAHRNSSASYGDDPTAQSLQDISDDQVLVLFEQMLVDMNLNEEKQQPLREKDIVIKREMVSQY LHTSKAGMNQKESSRSAMMYIQELRSGLRDMHLLSCLESLRVSLNNNPVSWVQTFGAEGLASLL DILKRLHDEKEETSGNYDSRNQHEIIRCLKAFMNNKFGIKTMLETEEGILLLVRAMDPAVPNMM IDAAKLLSALCILPQPEDMNERVLEAMTERAEMEEVERFQPLLDGLKSGTSIALKVGCLQLINA LITPAEELDFRVHIRSELMRLGLHQVLQELREIDNDDMRVQLNVFDEQGDEDFFDLKGRLDDIR MEMDDFGEVFQIILNTVKDSKAEPHFLSILQHLLLVRNDYEARPQYYKLIEECVSQIVLHKNGT DPDFKCRHLQIDIEGLVDQMIDKTKVEKSEAKATELEKKLDSELTARHELQVEMKKMENDFEQK LQDLQGEKDALDSEKQQITTQKQDLEAEVSKLTGEVAKLSKELEDAKKEMASLSAVAVAPSVSS SAAVPQAPPLPGTSGTVIPPPPPPPLPGGAVPPPPPPPLPAGTGIPPPPPLPGGACISSSPQLF GSTAIPPPPPLPGATAIPPPPPLPGDTAIPPPPPLPGXTAIPPPPPLPGATGVPPPPPPLPGSV GVPPPPPLPGGPGLPPPPPPFPGAPGIPPPPPGMGVPPPPPFGFGIPAAPVLPFGLTPKKVYKP EVQLRRPNWSKFVAEDLSQDCFWTKVKEDRFENNELFAKLTLAFSAQTKTSKAKKDQEGGEEKK SVQKKKVKELKVLDSKTAQNLSIFLGSFRMPYQEIKNVILEVNEAVLTESMIQNLIKQMPEPEQ LKMLSELKEEYDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSVTAACEEL RKSENFSSLLELTLLVGNYMNAGSRNAGAFGFNISFLCKLRDTKSADQKMTLLHFLAELCETDH PDVLKFPDELAHVEKASRVSAENLQKNLDQMKKQIADVERDVQNFPAATDEKDKFVEKMTSFVK DAQEQYNKLRMMHSNMETLYKELGDYFVFDPKKLSVEEFFMDLHNFRNMFLQAVKENQKRRETE EKMRRAKLAKEKAEKERLEKQQKREQLIDMNAEGDETGVMDSLLEALQSGAAFRRKRGPRQVNR KAGCAVTSLLASELTKDDAVAASSAKVPKKSEGVTTILEEAKELVGRAS hide sequence

Ensembl Acc Id:

ENSRNOP00000057176 ⟸ ENSRNOT00000060432

Ensembl Acc Id:

ENSRNOP00000088426 ⟸ ENSRNOT00000102970

RefSeq Acc Id:	NP_001382031 ⟸ NM_001395102
- Peptide Label:	isoform 2
- UniProtKB:	F1M775 (UniProtKB/Swiss-Prot), A0A8I6A828 (UniProtKB/TrEMBL)

Protein Domains

DAD FH1 FH2 GBD/FH3

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700736

Promoter ID:

EPDNEW_R11260

Type:

initiation region

Name:

Diaph1_1

Description:

diaphanous-related formin 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	18	31,071,369 - 31,071,429	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310707	AgrOrtholog
BioCyc Gene	G2FUF-7792	BioCyc
Ensembl Genes	ENSRNOG00000019688	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000060432	ENTREZGENE
	ENSRNOT00000102970	ENTREZGENE
Gene3D-CATH	1.10.20.40	UniProtKB/Swiss-Prot
	1.20.1170.10	UniProtKB/Swiss-Prot
	1.20.58.2220	UniProtKB/Swiss-Prot
	1.20.58.630	UniProtKB/Swiss-Prot
	1.25.10.10	UniProtKB/Swiss-Prot
	6.10.30.30	UniProtKB/Swiss-Prot
	Formin, FH3 diaphanous domain	UniProtKB/Swiss-Prot
InterPro	ARM-like	UniProtKB/Swiss-Prot
	ARM-type_fold	UniProtKB/Swiss-Prot
	DAD_dom	UniProtKB/Swiss-Prot
	DIA_GBD_sf	UniProtKB/Swiss-Prot
	FH2_Formin	UniProtKB/Swiss-Prot
	FH2_Formin_sf	UniProtKB/Swiss-Prot
	FH3_dom	UniProtKB/Swiss-Prot
	Formin_Homology_Diaphanous_sf	UniProtKB/Swiss-Prot
	GBD/FH3_dom	UniProtKB/Swiss-Prot
	GTPase-bd	UniProtKB/Swiss-Prot
NCBI Gene	307483	ENTREZGENE
PANTHER	PROTEIN DIAPHANOUS	UniProtKB/Swiss-Prot
	PTHR45691:SF4	UniProtKB/Swiss-Prot
Pfam	Drf_FH1	UniProtKB/Swiss-Prot
	Drf_FH3	UniProtKB/Swiss-Prot
	Drf_GBD	UniProtKB/Swiss-Prot
	FH2	UniProtKB/Swiss-Prot
PhenoGen	Diaph1	PhenoGen
PROSITE	DAD	UniProtKB/Swiss-Prot
	FH2	UniProtKB/Swiss-Prot
	GBD_FH3	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000019688	RatGTEx
SMART	Drf_FH3	UniProtKB/Swiss-Prot
	Drf_GBD	UniProtKB/Swiss-Prot
	FH2	UniProtKB/Swiss-Prot
Superfamily-SCOP	Formin homology 2 domain (FH2 domain)	UniProtKB/Swiss-Prot
	SSF48371	UniProtKB/Swiss-Prot
UniProt	A0A8I6A828	ENTREZGENE, UniProtKB/TrEMBL
	A0A8L2QTN9	ENTREZGENE, UniProtKB/TrEMBL
	DIAP1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-06-05	Diaph1	diaphanous-related formin 1	Diaph1	diaphanous homolog 1 (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-26	Diaph1	diaphanous homolog 1 (Drosophila)	Diap1	diaphanous homolog 1 (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Diap1	diaphanous homolog 1 (Drosophila)	Diap1_predicted	diaphanous homolog 1 (Drosophila) (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Diap1_predicted	diaphanous homolog 1 (Drosophila) (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - PID (archival)