Ppargc1b (PPARG coactivator 1 beta) - Rat Genome Database

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Gene: Ppargc1b (PPARG coactivator 1 beta) Rattus norvegicus
Analyze
Symbol: Ppargc1b
Name: PPARG coactivator 1 beta
RGD ID: 727948
Description: Predicted to enable AF-2 domain binding activity; nuclear estrogen receptor binding activity; and nuclear receptor coactivator activity. Involved in response to cAMP and response to glucocorticoid. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of mediator complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in obesity. Orthologous to human PPARGC1B (PPARG coactivator 1 beta); INTERACTS WITH (R)-lipoic acid; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Perc; peroxisome proliferative activated receptor, gamma, coactivator 1 beta; peroxisome proliferator-activated receptor gamma coactivator 1 beta; peroxisome proliferator-activated receptor gamma coactivator 1-beta; peroxisome proliferator-activated receptor gamma coactivator 1beta-2a; peroxisome proliferator-activated receptor gamma, coactivator 1 beta; PGC-1-beta; PGC1beta; PPAR-gamma coactivator 1-beta; PPARGC-1-beta
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21854,758,891 - 54,861,103 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1854,758,902 - 54,861,194 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1856,852,399 - 56,954,689 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01857,567,002 - 57,669,290 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01855,382,768 - 55,484,982 (-)NCBIRnor_WKY
Rnor_6.01856,626,725 - 56,650,524 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1856,626,712 - 56,728,968 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01855,857,439 - 55,880,661 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41857,277,749 - 57,301,024 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11857,349,991 - 57,451,796 (-)NCBI
Celera1852,911,177 - 52,934,708 (-)NCBICelera
Cytogenetic Map18q12.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-lipoic acid  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP)
amiodarone  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
atorvastatin calcium  (EXP,ISO)
atrazine  (EXP)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
cadmium atom  (EXP)
carbon nanotube  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
diclofenac  (ISO)
diethyl maleate  (EXP)
dioxygen  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
duvoglustat  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
etoposide  (ISO)
formaldehyde  (ISO)
genistein  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
isoprenaline  (ISO)
linoleic acid  (EXP)
lipoic acid  (EXP)
lipopolysaccharide  (ISO)
meldonium  (EXP)
menadione  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
oxaloacetic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phosphatidylcholine  (ISO)
phosphatidylethanolamine  (ISO)
phytol  (ISO)
phytosterols  (ISO)
pirinixic acid  (ISO)
propiconazole  (ISO)
quercetin  (EXP,ISO)
rotenone  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
testosterone enanthate  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
trans-piceid  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
Triptolide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
very-low-density lipoprotein triglyceride  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cellular_component  (ND)
cytosol  (IEA,ISO)
mediator complex  (ISO)
mitochondrion  (IEA)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity. Andersen G, etal., J Med Genet. 2005 May;42(5):402-7.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Peroxisome proliferator-activated receptor-gamma coactivator-1 and insulin resistance: acute effect of fatty acids. Hoeks J, etal., Diabetologia. 2006 Oct;49(10):2419-26. Epub 2006 Aug 1.
4. Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance. Lelliott CJ, etal., PLoS Biol. 2006 Nov;4(11):e369. doi: 10.1371/journal.pbio.0040369.
5. PGC-1beta in the regulation of hepatic glucose and energy metabolism. Lin J, etal., J Biol Chem. 2003 Aug 15;278(33):30843-8. Epub 2003 Jun 13.
6. Sepsis and glucocorticoids downregulate the expression of the nuclear cofactor PGC-1beta in skeletal muscle. Menconi MJ, etal., Am J Physiol Endocrinol Metab. 2010 Oct;299(4):E533-43. Epub 2010 Jul 20.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. Putative association of peroxisome proliferator-activated receptor gamma co-activator 1beta (PPARGC1B) polymorphism with Type 2 diabetes mellitus. Park KS, etal., Diabet Med. 2006 Jun;23(6):635-42.
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:11854298   PMID:12678921   PMID:15057822   PMID:17932310   PMID:19252502   PMID:19254570   PMID:19542216   PMID:21331471   PMID:22008020   PMID:23264620   PMID:23836911   PMID:27631411  
PMID:30635067  


Genomics

Comparative Map Data
Ppargc1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21854,758,891 - 54,861,103 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1854,758,902 - 54,861,194 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1856,852,399 - 56,954,689 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01857,567,002 - 57,669,290 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01855,382,768 - 55,484,982 (-)NCBIRnor_WKY
Rnor_6.01856,626,725 - 56,650,524 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1856,626,712 - 56,728,968 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01855,857,439 - 55,880,661 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41857,277,749 - 57,301,024 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11857,349,991 - 57,451,796 (-)NCBI
Celera1852,911,177 - 52,934,708 (-)NCBICelera
Cytogenetic Map18q12.1NCBI
PPARGC1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385149,730,310 - 149,857,959 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl5149,730,298 - 149,855,022 (+)EnsemblGRCh38hg38GRCh38
GRCh375149,109,873 - 149,234,585 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365149,090,057 - 149,207,474 (+)NCBINCBI36Build 36hg18NCBI36
Build 345149,090,056 - 149,207,460NCBI
Celera5145,191,258 - 145,315,947 (+)NCBICelera
Cytogenetic Map5q32NCBI
HuRef5144,256,984 - 144,381,544 (+)NCBIHuRef
CHM1_15148,542,243 - 148,667,243 (+)NCBICHM1_1
T2T-CHM13v2.05150,266,870 - 150,391,497 (+)NCBIT2T-CHM13v2.0
Ppargc1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391861,424,516 - 61,533,846 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1861,431,207 - 61,533,502 (-)EnsemblGRCm39 Ensembl
GRCm381861,291,445 - 61,400,756 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1861,298,136 - 61,400,431 (-)EnsemblGRCm38mm10GRCm38
MGSCv371861,457,790 - 61,560,085 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361861,423,505 - 61,525,800 (-)NCBIMGSCv36mm8
Celera1862,581,981 - 62,683,996 (-)NCBICelera
Cytogenetic Map18E1NCBI
Ppargc1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554154,644,998 - 4,757,093 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554154,638,057 - 4,756,885 (-)NCBIChiLan1.0ChiLan1.0
PPARGC1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15151,172,020 - 151,286,285 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5151,203,088 - 151,278,837 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05145,154,517 - 145,315,567 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PPARGC1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1459,167,041 - 59,278,977 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl459,174,604 - 59,279,464 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha458,935,873 - 59,044,751 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0459,651,179 - 59,761,207 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl459,651,182 - 59,761,176 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1459,439,467 - 59,548,290 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0459,553,927 - 59,662,788 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0460,085,118 - 60,194,024 (-)NCBIUU_Cfam_GSD_1.0
Ppargc1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213143,518,121 - 143,624,571 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365045,099,470 - 5,198,584 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365045,099,334 - 5,198,279 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPARGC1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2150,823,373 - 150,919,376 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12150,823,338 - 150,924,871 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22157,649,522 - 157,739,519 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPARGC1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12352,337,802 - 52,462,553 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2352,428,052 - 52,455,089 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603425,255,708 - 25,379,965 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppargc1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247749,056,322 - 9,174,388 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247749,056,138 - 9,178,645 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ppargc1b
424 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:176
Count of miRNA genes:78
Interacting mature miRNAs:83
Transcripts:ENSRNOT00000023661, ENSRNOT00000066048
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18420794160377792Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181179151863636873Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)181194429959330563Rat
6903359Bp355Blood pressure QTL 3553.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194454459796478Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181495133759951337Rat
1358193Emca2Estrogen-induced mammary cancer QTL 21.6mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)181800759963571040Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182557098570570985Rat
2293704Bss35Bone structure and strength QTL 354.590.0002femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)182896485373964853Rat
2300157Bmd66Bone mineral density QTL 6613.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
2300177Bmd65Bone mineral density QTL 6519.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)182979296574792965Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)182979296574792965Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)182979296574792965Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182979296574792965Rat
738005Anxrr11Anxiety related response QTL 113.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)183003981375039813Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183127168160377755Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183135940859796643Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940861698465Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183135940870263868Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183135940883218561Rat
6903347Bp350Blood pressure QTL 3504.4arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135953059796478Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183139332077209694Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183587072380870723Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183819245583192455Rat
1598826Anxrr20Anxiety related response QTL 203.04body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)184143297183828827Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184334502283828827Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184664067583828827Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184664067583828827Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184664067583828827Rat
1331806Bp229Blood pressure QTL 2294.36484arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671876357867167Rat
1331736Bp227Blood pressure QTL 2272.791arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)184671876359796643Rat
1331780Bp238Blood pressure QTL 2383.269arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671876359796643Rat
6903345Bp349Blood pressure QTL 3493.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671893559796478Rat
6903349Bp351Blood pressure QTL 3513.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671893559796478Rat
6903351Bp352Blood pressure QTL 3523.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671893559796478Rat
61360EaeyExperimental allergic encephalomyelitis QTL y3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)184698893960377753Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)184852004483828827Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)184852004483828827Rat
7411719Strs5Sensitivity to stroke QTL 59.4cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)184999995865845095Rat
2293658Bmd23Bone mineral density QTL 237.30.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)185146473363636873Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185146473383218561Rat
1331730Scl27Serum cholesterol level QTL 273.826blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)185229287559796643Rat
1331752Bw27Body weight QTL 272.963body mass (VT:0001259)body weight (CMO:0000012)185229287565845095Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185229287573997283Rat
1600375Mcs22Mammary carcinoma susceptibility QTL 223.3mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)185253976363933058Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)185253976369140759Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)185253976376104388Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)185253976376104388Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)185253976376104388Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)185253976376104388Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)185253976376104388Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)185253976376104388Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185253976376104388Rat
1300125Rf26Renal function QTL 263.2urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)185253986365844950Rat
1298072Cia26Collagen induced arthritis QTL 263.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)185470976983828827Rat

Markers in Region
D18Chm35  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21854,780,558 - 54,780,754 (+)MAPPERmRatBN7.2
Rnor_6.01856,648,393 - 56,648,590NCBIRnor6.0
Rnor_5.01855,878,530 - 55,878,727UniSTSRnor5.0
RGSC_v3.41857,298,893 - 57,299,090UniSTSRGSC3.4
Celera1852,932,504 - 52,932,774UniSTS
Cytogenetic Map18q12.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 28 4 2 1 1 6 1 8 1
Low 3 15 53 41 17 41 7 10 68 34 33 11 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000023661   ⟹   ENSRNOP00000023661
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1854,758,902 - 54,861,194 (-)Ensembl
Rnor_6.0 Ensembl1856,626,712 - 56,728,968 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000066048   ⟹   ENSRNOP00000058932
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1854,758,902 - 54,861,039 (-)Ensembl
Rnor_6.0 Ensembl1856,626,736 - 56,728,185 (-)Ensembl
RefSeq Acc Id: NM_176075   ⟹   NP_788264
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21854,758,891 - 54,861,103 (-)NCBI
Rnor_6.01856,626,725 - 56,650,524 (-)NCBI
Rnor_5.01855,857,439 - 55,880,661 (-)NCBI
RGSC_v3.41857,277,749 - 57,301,024 (-)RGD
Celera1852,911,177 - 52,934,708 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_788264 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAO40026 (Get FASTA)   NCBI Sequence Viewer  
  EDM14598 (Get FASTA)   NCBI Sequence Viewer  
  EDM14599 (Get FASTA)   NCBI Sequence Viewer  
  Q811R2 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_788264   ⟸   NM_176075
- UniProtKB: Q811R2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000023661   ⟸   ENSRNOT00000023661
RefSeq Acc Id: ENSRNOP00000058932   ⟸   ENSRNOT00000066048
Protein Domains
RRM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q811R2-F1-model_v2 AlphaFold Q811R2 1-1010 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727948 AgrOrtholog
BioCyc Gene G2FUF-7334 BioCyc
Ensembl Genes ENSRNOG00000017503 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000023661 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000058932.4 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023661 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000066048.4 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.330 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Nucleotide-bd_a/b_plait_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PGC-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PGC-1beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PPARGC1B_RRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RRM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:291567 UniProtKB/Swiss-Prot
NCBI Gene 291567 ENTREZGENE
PANTHER PTHR15528 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR15528:SF12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RRM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ppargc1b PhenoGen
PROSITE RRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54928 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2QTA8_RAT UniProtKB/TrEMBL
  PRGC2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 Ppargc1b  PPARG coactivator 1 beta  Ppargc1b  peroxisome proliferator-activated receptor gamma, coactivator 1 beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Ppargc1b  peroxisome proliferator-activated receptor gamma, coactivator 1 beta  Ppargc1b  peroxisome proliferative activated receptor, gamma, coactivator 1 beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Ppargc1b  peroxisome proliferative activated receptor, gamma, coactivator 1 beta      Symbol and Name updated 1299863 APPROVED
2004-02-11 Il1rapl1  peroxisome proliferator-activated receptor gamma coactivator 1 beta  Perc  peroxisome proliferator-activated receptor gamma coactivator 1beta-2a  Name updated to reflect Human and Mouse nomenclature 625702 APPROVED