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Gene: Spink5 (serine peptidase inhibitor, Kazal type 5) Rattus norvegicus
Symbol: Spink5
Name: serine peptidase inhibitor, Kazal type 5
RGD ID: 1306540
Description: Predicted to have serine-type endopeptidase inhibitor activity. Predicted to be involved in several processes, including epidermal cell differentiation; negative regulation of antibacterial peptide production; and negative regulation of serine-type endopeptidase activity. Predicted to localize to several cellular components, including endoplasmic reticulum membrane; epidermal lamellar body; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in Netherton syndrome. Orthologous to human SPINK5 (serine peptidase inhibitor Kazal type 5); INTERACTS WITH 17beta-estradiol; 3,7-dihydropurine-6-thione; 7,12-dimethyltetraphene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: LOC361319; serine protease inhibitor, Kazal type 5
Homo sapiens (human) : SPINK5 (serine peptidase inhibitor Kazal type 5)  HGNC  Alliance
Mus musculus (house mouse) : Spink5 (serine peptidase inhibitor, Kazal type 5)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Spink5 (serine peptidase inhibitor Kazal type 5)
Pan paniscus (bonobo/pygmy chimpanzee) : SPINK5 (serine peptidase inhibitor Kazal type 5)
Canis lupus familiaris (dog) : SPINK5 (serine peptidase inhibitor Kazal type 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Spink5 (serine peptidase inhibitor Kazal type 5)
Sus scrofa (pig) : SPINK5 (serine peptidase inhibitor Kazal type 5)
Chlorocebus sabaeus (African green monkey) : SPINK5 (serine peptidase inhibitor Kazal type 5)
Heterocephalus glaber (naked mole-rat) : Spink5 (serine peptidase inhibitor Kazal type 5)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01835,118,300 - 35,190,458 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1835,121,967 - 35,191,069 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1229,267,916 - 229,343,584 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01834,787,562 - 34,856,081 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41837,563,911 - 37,631,579 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11837,599,079 - 37,648,851 (+)NCBI
Cytogenetic Map18p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Spink5
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1306540
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.